Sorafenib-13C,d3 is a stable isotope-labeled derivative of Sorafenib, a potent and orally bioavailable inhibitor of the mitogen-activated protein kinase (MAPK) pathway. Sorafenib exhibits strong biological activity, with IC50 values of 6 nM and 20 nM for Raf-1 and B-Raf, respectively, in addition to notable inhibition of multiple kinases such as VEGFR2 and PDGFRβ. This compound promotes autophagy and apoptosis and is recognized for its anti-tumor properties, serving as a valuable tool in cancer research and therapeutic studies exploring ferroptosis mechanisms.
Sorafenib-13C,d3 is a stable isotope-labeled derivative of Sorafenib, a potent and orally bioavailable inhibitor of the mitogen-activated protein kinase (MAPK) pathway. Sorafenib exhibits strong biological activity, with IC50 values of 6 nM and 20 nM for Raf-1 and B-Raf, respectively, in addition to notable inhibition of multiple kinases such as VEGFR2 and PDGFRβ. This compound promotes autophagy and apoptosis and is recognized for its anti-tumor properties, serving as a valuable tool in cancer research and therapeutic studies exploring ferroptosis mechanisms.
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