Catalog No.
Product Name
Application
Product Information
Citations
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Fungal Melanization Inhibitor
Coniferin is a glucoside derivative of coniferyl alcohol that functions as a fungal melanization inhibitor. It effectively disrupts the melanin biosynthesis pathway in fungi, making it useful for studies of fungal growth and pathogenicity. Additionally, Coniferin has been shown to inhibit the release of inflammatory mediators such as Prostaglandin E2 and Thromboxane B2, highlighting its potential in research focused on cellular signaling and inflammation. -
Cytochrome bc1 Inhibitor
Inz-5 is a selective inhibitor of the mitochondrial cytochrome bc1 complex, targeting fungal pathogens. This compound effectively impairs fungal virulence and may prevent the development of resistance to antifungal agents. Its unique mechanism of action makes it a valuable tool for research in mycology and antifungal drug development. -
Bacterial Inhibitor
Tricyclazole is a pentaketone compound that acts as a bacterial inhibitor primarily by disrupting melanin biosynthesis in fungi. This unique fungicide is effective in controlling rice blast disease by altering the structure and function of fungal cell walls, thereby reducing pathogenicity and penetration. Tricyclazole’s mechanism of action also highlights its potential for studying fungal biology and the effects of melanin on fungal virulence. -
Aromatic Aldehyde
Octanal is an aromatic aldehyde known for its antioxidant and antibacterial properties. It exhibits antifungal activity against G. citri-aurantii, potentially through the disruption of cell membrane integrity, leading to cellular component leakage. Furthermore, Octanal demonstrates cytotoxic effects on HeLa cells, with an IC50 value of 3.5 μg/mL, making it a valuable compound for research in cell biology and pharmacology. -
Fungal Inhibitor
Enfumafungin is a triterpene glycoside that acts as a potent fungal inhibitor by targeting (1,3)-beta-D-glucan synthase in the fungal cell wall. This compound exhibits selective antifungal activity against yeasts and filamentous fungi, excluding Cryptococcus, and is not active against Bacillus subtilis. Enfumafungin is valuable for research applications focused on fungal pathogenesis and the development of antifungal therapeutics. -
Anti-bacterial/fungal Agent
Eugenol acetate is an antibacterial and antifungal agent that targets multiple biological pathways. It exhibits significant anti-inflammatory and antioxidant properties, acting through the inhibition of NF-κB while enhancing the expression of tumor suppressor proteins such as p53 and p21 (WAF1). Eugenol acetate is also implicated in cancer research, demonstrating the ability to prevent chemically induced skin cancer, inhibit cancer cell proliferation, and induce apoptosis in various cancer cell lines. Its diverse biological activities make it a valuable tool in chemical and biomedical research applications. -
Organic Ligand
2,5-Dihydroxy-1,4-benzoquinone (DHBQ) is a redox-active organic ligand known for its antibacterial properties. This compound is derived from fungal metabolites and plays a significant role in enhancing the performance of Li+-ion battery cathodes through a two-electron redox process when incorporated into Fe (dhbq) metal-organic frameworks. Additionally, 2,5-Dihydroxy-1,4-benzoquinone is utilized in the construction of conductive metal-organic frameworks, making it valuable for research in energy storage and related applications. -
Antifungal Agent
Datiscetin is a natural antifungal agent derived from the cultivar "Roland." It exhibits potent fungitoxic activity against Fusarium oxysporum f. sp. dianthi, making it a valuable compound for research into fungal infections and plant pathology. This compound is of particular interest for studies aimed at developing new antifungal strategies and understanding fungal resistance mechanisms. -
Antibiotic
Piperlonguminine is an alkaloid amide derived from Piper species, exhibiting significant antibacterial properties. Furthermore, it demonstrates a range of biological activities, including anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, and antifungal effects. This compound is of interest in various research applications, particularly in the fields of pharmaceutical development and disease prevention. -
Episterol Derivative
5-Dehydroepisterol is an episterol derivative involved in steroid biosynthesis. It is produced by the action of C-5 sterol desaturase and can be further converted into 24-methylenecholesterol through the activity of 7-dehydrocholesterol reductase. This compound exhibits notable antifungal properties, making it valuable for research applications focused on steroidogenesis and antifungal mechanisms. -
Antifungal Agent
Poacic Acid is a plant-derived stilbenoid that serves as a potent antifungal agent. It disrupts the production and assembly of β-1,3-glucan within the cell walls of fungi by localizing to the yeast cell wall. Poacic Acid demonstrates fungicidal activity against Saccharomyces cerevisiae and Candida albicans mutants with compromised plasma membranes, making it valuable for antifungal research and therapeutic studies. -
Stress Enhancer
Galactinol is a disaccharide carbohydrate that functions as a galactosyl donor, primarily acting as an osmoprotectant. It enhances plant disease resistance against fungal and bacterial pathogens while improving tolerance to abiotic stresses such as drought, high salinity, low temperatures, and oxidative damage. Additionally, Galactinol scavenges hydroxyl radicals and plays a role in root colonization-induced systemic resistance. Its positive correlation with seed longevity positions Galactinol as a potential biomarker for seed vigor, making it valuable in researching various plant diseases, including fungal leaf spot and bacterial angular leaf spot. -
SDH Inhibitor
SDH-IN-1 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 4.53 μM. This compound demonstrates significant antifungal properties, particularly effective against S. sclerotiorum with an EC50 of 0.14 mg/L. SDH-IN-1 is a valuable tool for researchers studying fungal pathogenesis and metabolism, providing insights into SDH's role in cellular respiration and therapeutic strategies against fungal infections. -
Quorum Sensing Molecule
(E,E)-Farnesol is a quorum-sensing molecule that plays a crucial role in regulating the growth and behavior of Candida species. It effectively inhibits the growth, metabolism, and biofilm formation of various Candida strains while also impacting their morphology and invasiveness. This compound is valuable for research focused on fungal pathogenesis and the development of antifungal strategies. -
Broad-spectrum foliar fungicide
Chlorothalonil is a broad-spectrum foliar fungicide that primarily targets fungal pathogens in agricultural settings. This compound is effective in controlling a wide range of fungal diseases affecting vegetable and crop leaves, contributing to improved plant health and yield. Additionally, chlorothalonil has been shown to interfere with spermatogenesis and can induce intestinal epithelial barrier dysfunction, as well as fetal toxicity, making it a subject of study in developmental and reproductive biology. -
Antifungal Agent
3,5-Di-tert-butylphenol is a volatile organic compound that serves as an antifungal agent by inhibiting biofilm formation. It effectively induces the accumulation of reactive oxygen species (ROS) in Candida albicans cells, contributing to its antifungal properties. Additionally, 3,5-Di-tert-butylphenol exhibits antibacterial activities, making it a valuable tool for research in microbial pathogenesis and the development of anti-infective strategies. -
Fungal Inhibitor
Thiophanate-Methyl is a systemic fungicide that targets fungal pathogens by inhibiting mycelial growth and spore germination. This compound exhibits broad-spectrum activity against a variety of fungi, making it useful in agricultural applications for disease management in crops. Its mechanism of action involves the disruption of cellular processes within the target fungi, providing an effective solution for controlling fungal infections in plants. -
Antibiotic Agent
Tyrothricin is a polypeptide antibiotic mixture derived from Bacillus brevis, comprising tyrocidines and gramicidins. This compound exhibits broad-spectrum antimicrobial activity, effectively targeting bacteria, fungi, and some viruses. Tyrothricin is commonly used in formulations for the treatment of sore throat and the healing of infected superficial and small-area wounds, making it valuable in both clinical and research settings. -
Fungicide
Metalaxyl is a systemic fungicide that targets protein synthesis in fungi, effectively disrupting cellular functions. It demonstrates significant activity against downy mildews and soil-borne pathogens, particularly those caused by Phytophthora and Pythium species. This compound is widely utilized in agricultural research for the management of fungal diseases, providing essential insights into plant disease resistance and control strategies. -
Lysosomotropic Detergent
1-Dodecylimidazole is a lysosomotropic detergent that induces cytotoxic effects through acid-dependent accumulation in lysosomes, leading to membrane disruption and the release of cysteine proteases into the cytoplasm. This compound exhibits hypocholesterolemic properties and demonstrates broad-spectrum antifungal activity. It is valuable for research applications involving cell death mechanisms, lysosomal function studies, and antifungal investigations. -
Fungal Inhibitor
Deoxylapachol is a significant cytotoxic compound derived from the New Zealand brown alga Landsburgia quercifolia, primarily acting as a fungal inhibitor. It exhibits notable antifungal properties, making it a valuable agent in the study of fungal infections. Additionally, deoxylapachol demonstrates anti-cancer activity, positioning it as a candidate for research applications in oncology and pathogen interaction studies. -
Fungal CYP51 Inhibitor
VT-1598 is an orally active and selective inhibitor of fungal cytochrome P450 51 (CYP51). It exhibits potent antifungal activity against Candida auris, making it a valuable tool for research into fungal infections. Additionally, VT-1598 contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for click chemistry applications, facilitating the study of various biological interactions. -
Fungal
Aegeline is a natural alkaloid that targets fungal pathways by mimicking the yeast SNARE protein Sec22p to inhibit α-synuclein and Bax toxicity in yeast models. This compound effectively restores growth in yeast cells impaired by these toxic proteins. Additionally, Aegeline exhibits antioxidant properties, making it a valuable reagent for studying cellular stress responses and neurodegenerative mechanisms in fungal systems. -
Fungicide
Fenpropimorph is a fungicide that targets the sterol biosynthesis pathway by inhibiting δ8-δ7-sterol isomerase in yeast at low concentrations, while δ14-sterol reductase is inhibited at higher concentrations. This action disrupts ergosterol production, an essential component of fungal cell membranes. Additionally, Fenpropimorph affects sterol synthesis in select plant species and mammalian cells, making it valuable for both agricultural and biomedical research applications. -
Bacterial/Fungal Inhibitor
2-Methoxybenzaldehyde, also known as o-Anisaldehyde, serves as a bacterial and fungal inhibitor, with a BA50 value of 0.19 against Salmonella. This compound is utilized in the investigation of bacterial and fungal infectious diseases, providing insights into their mechanisms and potential therapeutics. Its effectiveness in hindering microbial growth makes it a valuable reagent for microbiological research. -
Anionic Surfactant
Sodium laureth sulfate (70% in water) is an anionic surfactant known for its versatile biological activities. This compound exhibits effective decontamination, emulsification, dispersion, and wetting properties, making it valuable for various research applications. Additionally, its antifungal capabilities expand its utility in both biotechnological and pharmaceutical studies. -
Antifungal Agent
trans-2-Hexenal is a volatile compound recognized for its antifungal properties. This compound effectively inhibits the growth of various fungal organisms and can also suppress the germination of soybean seeds and the growth of seedlings. Additionally, trans-2-Hexenal serves as a valuable reagent for the identification of low-molecular-weight carbonyl compounds that interact with biological nucleophiles in biological samples, making it useful in various research applications in plant and environmental sciences. -
Antifungal Triazole
PC945 is a potent antifungal triazole that targets the sterol 14α-demethylase enzymes CYP51A and CYP51B in Aspergillus fumigatus, demonstrating strong inhibitory activity with IC50 values of 0.23 μM and 0.22 μM, respectively. This compound exhibits efficacy against a wide variety of both azole-susceptible and azole-resistant strains of A. fumigatus. PC945 is of significant interest in antifungal research and offers potential applications in the treatment of invasive fungal infections. -
Antiseptic Agent; Fungal Inhibitor
Hexetidine, an orally active antiseptic agent, exhibits broad-spectrum antibacterial and antifungal activity. It is particularly effective in inhibiting fungal growth, especially when combined with IPBC. At concentrations exceeding 0.1%, hexetidine may lead to oral ulceration; however, it enhances plaque inhibition in conjunction with zinc. Additionally, its efficacy in treating purulent wounds has been demonstrated alongside ultrasound treatment. Hexetidine is a valuable candidate for research focusing on fungal infections and soft tissue purulent-inflammatory conditions. -
Serine Palmitoyltransferase Inhibitor
Lipoxamycin hemisulfate is a potent inhibitor of serine palmitoyltransferase, exhibiting an IC50 of 21 nM. This compound displays antifungal properties, making it valuable for research in the development of antifungal therapies. Its ability to modulate sphingolipid metabolism further supports its use in studies investigating underlying mechanisms of fungal infections and potential treatment strategies. -
Fungal Inhibitor
Myclobutanil is a systemic fungicide belonging to the conazole class that targets fungal sterol biosynthesis. It exhibits potent antifungal activity against a range of pathogenic fungi, making it valuable in agricultural applications. Myclobutanil is utilized in research for studying fungal resistance mechanisms and evaluating the efficacy of fungicides in crop protection. -
Antifungal Agent
Haloprogin is a potent antifungal agent that targets a range of fungal pathogens. It demonstrates significant activity against dermatophytes and Candida species, as well as limited efficacy against certain Gram-positive bacteria. Haloprogin is utilized in research applications focused on antifungal resistance and the development of novel antifungal treatments. -
Phytoalexin
Camalexin is a phytoalexin derived from Camelina sativa that exhibits potent antibacterial, antifungal, antiproliferative, and anticancer properties. Its mechanism of action involves the induction of reactive oxygen species (ROS) production, which contributes to its biological activity. Camalexin is utilized in research applications exploring plant defense mechanisms, as well as potential therapeutic effects against various cancers and microbial infections. -
Antibiotic
α-Terpineol is an antimicrobial compound primarily targeting periodontopathic and cariogenic bacteria. This compound demonstrates significant antifungal activity against Trichophyton mentagrophytes, potentially causing irreversible cellular damage. Additionally, α-Terpineol exhibits antineuropathic and anti-inflammatory properties, making it a valuable reagent for research involving diarrhea, neuropathic pain, infections, and inflammation. -
Fungal Inhibitor
Terconazole is a broad-spectrum antifungal agent that targets fungal cell membrane synthesis. It exhibits significant activity against various Candida species, making it effective in treating vaginal yeast infections. This compound is used in research applications to study antifungal mechanisms and drug resistance in pathogenic fungi. -
ASADH Inhibitor
Naphthalene-2,3-Dicarboxaldehyde functions as a potent inhibitor of Aspergillus nidulans succinate semialdehyde dehydrogenase (ASADH), with a reported inhibition constant (Ki) of 45 μM. Its biological activity extends to inhibiting the growth of Candida albicans strain CAF2-1, exhibiting an IC50 of 58.2 μM and a minimum inhibitory concentration (MIC) of 12 μg/mL. This compound is valuable for research applications focused on antifungal mechanisms and metabolic pathway studies involving ASADH. -
Antimalarial Agent
Halofantrine hydrochloride is an antimalarial agent that primarily targets human ERG channels, inhibiting the delayed rectifier potassium current. This compound demonstrates significant antimalarial activity against Plasmodium strains in both in vitro and animal models, while also exhibiting antifungal properties by inhibiting the Cap1-dependent oxidative stress response in Candida albicans. Its effectiveness extends to enhancing the antifungal activity of agents inducing oxidative damage and is particularly relevant for research on invasive candidiasis, falciparum malaria, and vivax malaria. -
Polyene Macrolide
Lagosin is a polyene macrolide antibiotic that targets fungal cell membranes. It exhibits broad-spectrum antifungal activity, making it effective against various fungal pathogens. Due to its unique mechanism of action, Lagosin remains resistant to many common antifungal resistance mechanisms, making it a valuable reagent for research in mycology and antifungal drug development. -
Antifungal Agent
Nikkomycin Z is a nucleoside peptide that functions as an orally active antifungal agent. It acts as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine, thereby inhibiting chitin synthesis. This mechanism contributes to its notable antifungal activity, making Nikkomycin Z a valuable tool for research in fungal infections and chitin metabolism. -
Glucanase
Endo-1,3-β-glucanase is an endoenzyme that specifically targets β-1,3-glycosidic bonds within glucan chains. Its catalytic activity hydrolyzes polysaccharides into oligosaccharides, making it valuable in research focused on fungal infections, notably Candida spp. This enzyme is particularly applicable in studies related to recurrent Candida vaginitis, where it can aid in understanding the pathogen's cell wall composition and potential therapeutic strategies. -
Antibacterial Agent
Germacrene D is an antibacterial agent derived from Solidago canadensis. It exhibits significant antibacterial and antifungal activities, demonstrating potential as an adjuvant in enhancing the efficacy of aminoglycosides and azoles. This compound is valuable for research applications focused on combating microbial infections and exploring synergistic effects in antimicrobial therapies. -
β-1,3-glucan Inhibitor
Ibrexafungerp citrate is a potent β-1,3-glucan synthesis inhibitor with promising antifungal properties. This compound demonstrates efficacy against a range of fungal infections, specifically targeting Candida and Aspergillus species. Ibrexafungerp citrate is currently under investigation for its therapeutic potential in the treatment of these serious infections. -
Antifungal Agent
4-Isopropylbenzoic acid is an aromatic monoterpenoid known for its antifungal properties. Isolated from the stem bark of Bridelia retusa, this compound demonstrates significant activity against various fungal strains. Additionally, it acts as a reversible and uncompetitive inhibitor of mushroom tyrosinase, making it relevant in studies related to enzymatic inhibition and fungal pathogen research. -
Fungal Inhibitor
Paclobutrazol is a triazole-based compound that functions primarily as a fungal inhibitor by disrupting the biosynthesis of gibberellins. Its antifungal properties make it useful in investigating plant-pathogen interactions and enhancing plant resilience. Additionally, Paclobutrazol can suppress abscisic acid synthesis and promote chilling tolerance in various plant species, supporting research into plant stress responses and growth regulation. -
Antibacterial Agent
GI261520A functions as an antibacterial agent primarily by inhibiting the PhoQ phosphorylation pathway. This compound exhibits a dose-dependent suppression of PhoP/PhoQ activity and demonstrates an IC50 value of 3.2 μM in inhibiting pagC reporter expression levels. Additionally, GI261520A effectively reduces PhoQc autokinase activity by 80%, allowing it to penetrate eukaryotic cell membranes and target intravacuolar Salmonella, thereby preventing intramacrophage proliferation. It serves as a valuable tool for research into antibacterial mechanisms and intracellular bacterial behavior. -
HER2 Ligand
Camelliaside A is a phytochemical that functions as a HER2 ligand. It plays a significant role in breast cancer-related research, contributing to the understanding of HER2 signaling pathways. Notably, Camelliaside A does not exhibit antifungal activity against the pathogen Rhizoctonia solani, demonstrating its specificity in targeting HER2 without adversely affecting mycelial growth. -
Anticancer/antifungal Agent
Echinoside A is a saponin that primarily targets Topoisomerase II alpha (Top2α), inhibiting its catalytic activity and reducing its noncovalent binding to DNA. This compound activates Caspase-3 and induces PARP cleavage, thereby promoting apoptosis. Echinoside A exhibits significant anticancer properties against various cancers, including prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Additionally, it displays antifungal activity across a spectrum of fungi, with a minimum inhibitory concentration ranging from 3.12 to 50.0 μg/mL, demonstrating particularly strong effects against Aspergillus and Penicillium species. -
Histone Acetyltransferase Inhibitor
Rtt109 inhibitor 1 is a potent inhibitor of the histone acetyltransferase Rtt109, functioning through a tight-binding, uncompetitive mechanism. This compound demonstrates significant antifungal activity by specifically targeting acetylation at the H3K56 site. Rtt109 inhibitor 1 is suitable for research applications focused on histone modifications and their roles in fungal pathogenesis. -
HDM Inhibitor
HDM-IN-1 is a potent inhibitor of histone demethylases (HDM), specifically targeting H3K27me3 methylation in fungal pathogens such as Cryptococcus neoformans and Candida auris, with IC50 values of 134 nM and 12 nM, respectively. This compound demonstrates significant antifungal activity, achieving MIC80 values between 0.5-2 μg/mL by disrupting biofilm and capsule formation. In vivo studies in an ICR mouse model further confirm its efficacy as an antifungal agent. HDM-IN-1 is a valuable tool for research on histone modifications and their implications in fungal virulence and drug resistance. -
Bacterial Inhibitor
Enoxacin is a fluoroquinolone antibacterial that primarily targets bacterial DNA gyrase and topoisomerase IV, with reported IC50 values of 126 µg/ml and 26.5 µg/ml, respectively. It exhibits strong inhibitory activity against both gram-positive and gram-negative bacteria. Additionally, Enoxacin acts as a miRNA processing activator, facilitating siRNA-mediated mRNA degradation and promoting the biogenesis of endogenous miRNAs. Notably, Enoxacin serves as a cancer-specific growth inhibitor through the enhancement of TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing, making it valuable for research in bacterial inhibition and cancer biology.
