Catalog No.
Product Name
Application
Product Information
Citations
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5-HT3 Antagonist
Palonosetron is a selective 5-HT3 antagonist that effectively prevents acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition to its primary application in oncology, Palonosetron demonstrates moderate activity against flaviviruses and exhibits potent antiviral effects against Zika virus in mammalian cells. Furthermore, this compound has been associated with antidepressant properties, making it a valuable tool for diverse research applications in both oncology and virology. -
5-HT3 Antagonist
Palonosetron hydrochloride is a selective 5-HT3 receptor antagonist that primarily functions to prevent acute and delayed nausea and vomiting associated with chemotherapy. Beyond its primary application, Palonosetron hydrochloride demonstrates moderate activity against flaviviruses, including potent efficacy against the Zika virus in mammalian cells. Additionally, this compound has been associated with antidepressant effects, expanding its potential therapeutic applications in neurological research. -
Antibacterial Preservative
Imidazolidinyl urea functions as an antibacterial preservative by releasing formaldehyde through its decomposition. It exhibits broad-spectrum antibacterial activity, effectively inhibiting the growth of both gram-negative and gram-positive bacteria, as well as limiting yeast and mold proliferation. Additionally, it can be utilized in the formulation of multifunctional hydrogels for managing infectious wounds. Notably, Imidazolidinyl urea may also induce non-histaminergic allergic responses via the activation of MRGPRX2 in mast cells. -
Antibacterial Agent
Ornidazole is a nitroimidazole derivative primarily used as an antibacterial agent. It demonstrates anti-trichomonad activity and is effective against a range of anaerobic bacteria in vitro. Additionally, Ornidazole inhibits the Sonic hedgehog (Shh) signaling pathway and exhibits antitumor properties, making it a valuable tool in the investigation of conditions such as Crohn’s disease. -
Bacterial Inhibitor
X-Neu5Ac sodium is a neuraminidase substrate that facilitates the chromogenic assay of neuraminidase activity in bacterial expression systems. This compound has a Km value of 0.89 mM for neuraminidase, making it an effective tool for studying neuraminidase function and inhibition. Its use in research applications provides insights into bacterial mechanisms and potential therapeutic targets for bacterial infections. -
Antibiotic
Cefaclor monohydrate is an orally active cephalosporin antibiotic that targets penicillin-binding protein 3 (PBP3). It is effective against a variety of bacterial infections, including respiratory tract infections, bacterial bronchitis, pharyngitis, and skin infections. Additionally, Cefaclor has potential applications in research related to depression and other bacterial pathologies. -
Antibacterial Agent
Domiphen bromide is a cationic quaternary ammonium salt primarily known for its antibacterial activity. It exhibits potent inhibition of HERG channels (IC50: 9 nM), aminopeptidase-like enzymes, and various bacterial phosphatases, making it versatile for medicinal applications. Due to its antibacterial and antimalarial properties, Domiphen bromide is utilized as a preservative and disinfectant and serves as a research tool in the study of bacterial infections such as pharyngitis, thrush, and oral ulcers. -
Antibiotic
Erythromycin Ethylsuccinate is an antibiotic that primarily targets bacterial infections by inhibiting protein synthesis in susceptible microorganisms. It demonstrates an antimicrobial spectrum that is comparable to, or slightly broader than, that of penicillin, making it effective against a variety of Gram-positive and some Gram-negative bacteria. Additionally, Erythromycin Ethylsuccinate exhibits antiviral activity against HIV-1, providing a versatile option for researchers studying bacterial and viral pathogens. Its applications include exploring antimicrobial resistance and developing new therapeutic strategies. -
Antibiotic
Oxolinic acid is an antibiotic effective against both Gram-negative and Gram-positive bacteria. It is primarily utilized in research focused on acute and chronic urinary tract infections. Additionally, Oxolinic acid functions as a DNA/RNA synthesis inhibitor and acts as a dopamine uptake inhibitor, demonstrating stimulatory effects on locomotor activity in murine models. -
Antibiotic
Pefloxacin mesylate dihydrate is a broad-spectrum antibiotic that primarily inhibits DNA gyrase, disrupting DNA replication. This compound demonstrates significant antibacterial activity against both Escherichia coli and Pseudomonas aeruginosa, with MIC90 values of 0.12 mg/L and 4 mg/L, respectively, and also targets Bacteroides fragilis with an MIC90 of 16 mg/L. Additionally, Pefloxacin mesylate dihydrate exhibits anti-Plasmodium yoelii activity and can enhance UVA-induced edema and immunosuppression. Its diverse profile makes it a valuable tool for infection studies and related research applications. -
Antibiotic
Succinylsulfathiazole is a sulfonamide antibiotic that targets bacterial folate synthesis, providing localized, gut-specific antibacterial activity. This compound effectively reduces coliform counts, suppresses intestinal bacterial growth, and depletes gut folate-producing bacteria while modulating hepatic mTOR signaling. Succinylsulfathiazole is utilized in research focused on nutrient deficiency and its implications, as it induces folate deficiency and related nutritional symptoms in animal models such as rats and C57BL/6 mice. This antibiotic is valuable for understanding the mechanisms of gut flora modulation and the impact on nutritional status. -
Bacterial Inhibitor
Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic that primarily targets bacterial growth by inhibiting dihydropteroate synthase and disrupting folate synthesis. This compound exhibits significant antibacterial activity and is primarily utilized in research applications focused on understanding bacterial infections and exploring antibiotic resistance mechanisms. Suitable for studies related to dermatological conditions, it aids in exploring therapeutic strategies for diseases like dermatitis herpetiformis. -
Ansamycin Antibiotic
Rifamycin sodium is an orally active ansamycin antibiotic that inhibits DNA-dependent RNA synthesis. It demonstrates significant antibacterial activity against Mycobacterium tuberculosis and modulates hepatic bile acid metabolism. Additionally, Rifamycin sodium exhibits anti-inflammatory properties, making it valuable for studying Mycobacterium tuberculosis, Bacteroides fragilis infections, and inflammation induced by lipopolysaccharides. -
Bacterial Inhibitor
Enoxacin hydrate, a fluoroquinolone antibiotic, targets bacterial DNA gyrase and topoisomerase IV, disrupting DNA replication with IC50 values of 126 µg/ml and 26.5 µg/ml, respectively. This compound exhibits significant antibacterial activity against both gram-positive and gram-negative bacteria. Additionally, Enoxacin hydrate functions as an activator of miRNA processing, facilitating siRNA-mediated mRNA degradation and enhancing the biogenesis of endogenous miRNAs. Its unique mode of action also includes the inhibition of cancer cell growth through the enhancement of TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing. -
Antibiotic
Erythromycin thiocyanate is a macrolide antibiotic that targets bacterial protein synthesis by binding to the 50S ribosomal subunit, effectively inhibiting RNA-dependent protein synthesis through interference with transpeptidation and translocation processes. This compound exhibits broad-spectrum antimicrobial activity, making it valuable in research applications related to bacterial infections. Additionally, erythromycin thiocyanate has been shown to possess antitumor and neuroprotective properties, expanding its potential utility across various biomedical research fields. -
Bacterial Inhibitor
Chlorprothixene hydrochloride functions as an antagonist of dopamine and histamine receptors, exhibiting Kis of 18 nM for hD1, 2.96 nM for hD2, 4.56 nM for hD3, 9 nM for hD5, and 3.75 nM for hH1 receptors. This compound demonstrates significant antipsychotic activity, making it a valuable tool for research into neuropharmacology and the mechanisms underlying psychotic disorders. Its receptor modulation also indicates potential applications in the study of bacterial inhibition mechanisms, providing insights into the interplay between neurotransmitter systems and microbial pathogenesis. -
Quinolone Antibiotic
Lomefloxacin is a difluoroquinolone antibiotic that primarily targets bacterial topoisomerase II, inhibiting DNA supercoiling and replication. This compound exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria and is effective in inducing reactive oxygen species (ROS) production and apoptosis. Additionally, Lomefloxacin demonstrates promising anticancer efficacy against melanoma, making it a valuable tool for research applications involving systemic bacterial infections and skin cancer studies. -
Stable Isotope
Palonosetron-d3 hydrochloride is a deuterium-labeled derivative of Palonosetron hydrochloride, functioning primarily as a 5-HT3 receptor antagonist. It is widely utilized in research to investigate mechanisms of chemotherapy-induced nausea and vomiting and is known for its ability to prevent both acute and delayed episodes. Additionally, Palonosetron hydrochloride demonstrates moderate activity against flavivirus and potent efficacy against Zika virus in mammalian cells, contributing to its relevance in virology studies. Its potential antidepressant properties also make it a compound of interest in neuropharmacology research. -
Anticancer/Antifungal Agent
Schinifoline is a 4-quinolinone that primarily targets cancer cell proliferation and fungal infections. It exhibits potent anticancer activity by inducing G2/M phase arrest and promoting apoptosis in cancer cells, as well as enhancing their radiosensitivity. Additionally, Schinifoline demonstrates significant antifungal properties, making it relevant for research in cancer therapies and infections, particularly regarding lung cancer and Candida albicans. -
Antibiotic
Bafilomycin C1 is a macrolide antibiotic that functions as a specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). It exhibits potent antibacterial and antifungal activity, particularly against gram-positive organisms. Additionally, Bafilomycin C1 has been shown to induce apoptosis, making it a valuable tool for research into hepatocellular carcinoma (HCC) and related cellular processes. -
Myrothecium Fungus Metabolite
Verrucarin J, a metabolite derived from the Myrothecium fungus, primarily targets the induction of reactive oxygen species (ROS) in various cancer cell lines. It has demonstrated significant apoptotic activity in A549, HCT 116, and SW-620 cells. Additionally, Verrucarin J exhibits antifungal properties against Candida albicans and Mucor miehei, and effectively inhibits the arenavirus Junin (JUNV) with an IC50 value of 1.2 ng/mL, highlighting its potential for research in oncology and virology. -
Bacterial Inhibitor
Aeroplysinin 1 is a secondary metabolite with a primary target as a bacterial inhibitor. It exhibits significant antibiotic activity against Gram-positive bacteria and demonstrates antiviral efficacy against HIV-1, with an IC50 of 14.6 μM. Additionally, Aeroplysinin 1 possesses anti-inflammatory, anti-angiogenic, and anti-tumor properties, and has been shown to induce apoptosis in endothelial cells. This compound is valuable for research applications in microbiology, virology, and cancer studies. -
Antibacterial Growth Promoter
Nitrovin hydrochloride is an antibacterial growth promoter that targets thioredoxin reductase 1 (TrxR1) to induce reactive oxygen species (ROS)-mediated cell death. This compound exhibits both non-apoptotic and apoptotic-like mechanisms of action. It also demonstrates anticancer activity, with IC50 values ranging from 1.31 to 6.60 μM in various tumor and normal cell lines, making it a valuable tool for cancer research and therapeutic development. -
Antiphlogistic Agent
Tomentosin is an orally active natural sesquiterpenoid lactone with primary applications as an antiphlogistic agent. It demonstrates a range of biological activities, including anti-tumor, anti-fungal, anti-inflammatory, anti-oxidant, and neuroprotective effects. Tomentosin has been shown to inhibit tumor cell proliferation, migration, and invasion, while also inducing apoptosis. This compound is valuable for research related to tumors, inflammatory conditions, and neurological disorders. -
Antifungal Agent
Reveromycin A is a benzoquinoid antibiotic that exhibits antifungal properties through its mechanism as a selective inhibitor of protein synthesis in eukaryotic cells. It effectively inhibits bone resorption by inducing apoptosis in osteoclasts and demonstrates antiproliferative activity against various tumor cell lines. This compound is valuable for research applications in studying fungal infections and bone metabolism. -
Antithrombotic/Antifungal Agent
Ajoene is a garlic-derived compound that functions as both an antithrombotic and antifungal agent. It exhibits significant inhibition of cell proliferation and induction of apoptosis in human leukemia cells, including HL-60, U937, HEL, and OCIM-I. This compound is relevant for research in cancer biology and antifungal therapies. -
Antibiotic
Metronidazole hydrochloride is a nitroimidazole antibiotic with a primary mechanism of action against anaerobic bacteria. It is effective in the treatment of various anaerobic infections and possesses the ability to penetrate the blood-brain barrier. Research applications include studying its effects on inflammation and skeletal muscle contraction associated with long-term use. -
Polyether Antibiotic
Monensin, a polyether antibiotic, functions primarily as an ionophore that mediates Na+/H+ exchange. It has been identified as a potent inhibitor of Wnt signaling, leading to significant enlargement of multivesicular bodies (MVBs) and modulating exosome secretion. This compound is utilized in research focused on bacterial, fungal, and parasitic infections, and it also exhibits anticancer properties, making it a valuable tool in various biological studies. -
Antibiotic/FOXM1 Inhibitor
Siomycin A is a thiopeptide antibiotic that selectively inhibits Forkhead box M1 (FOXM1), while sparing other Forkhead box family members. It exhibits significant anti-tumor activity and promotes apoptosis, making it a valuable tool for cancer research. This compound is particularly useful for studies focused on the role of FOXM1 in tumorigenesis and therapeutic resistance. -
Apoptosis Activator
Nortrachelogenin, also known as (-)-Wikstromol, is an apoptosis activator isolated from Partrinia scabiosaefolia. It has been shown to induce apoptotic responses in the fungal pathogen Candida albicans, making it a valuable reagent for research on fungal apoptosis and related cellular processes. This compound can facilitate the investigation of therapeutic strategies targeting fungal infections. -
Bacterial/Fungal Inhibitor, Preservative Agent
Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor, primarily functioning as a preservative agent. It activates matrix metalloproteinases (MMPs) in human bronchial epithelial cells, leading to apoptosis and an inflammatory response. Research indicates that it may promote the development of atopic dermatitis in murine models by disrupting Th2/Th17 immune responses. Additionally, Methylisothiazolinone hydrochloride has been shown to cause mitochondrial damage in the endothelium of rat cerebral blood vessels, highlighting its cellular impact. -
Bacterial Inhibitor
K-252c is a staurosporine analog that selectively inhibits protein kinase C (PKC), exhibiting an IC50 value of 2.45 µM. This compound is known for its ability to induce apoptosis in human chronic myelogenous leukemia cells, making it a valuable tool in cancer research. Additionally, K-252c demonstrates inhibitory effects on β-lactamase, chymotrypsin, and malate dehydrogenase, further expanding its utility in studying bacterial resistance and enzyme activity. -
Anticancer/Antifungal Agent
Ilicicolin H is a selective inhibitor of phosphoglycerate kinase 1 (PGK1) and mitochondrial cytochrome bc1 reductase, with an IC50 of 9.02 μM and 2-3 ng/mL, respectively. It effectively inhibits cell proliferation and induces apoptosis in cancer cells, particularly hepatocellular carcinoma (HCC), by reducing lactate production and glucose uptake. Additionally, Ilicicolin H displays broad antifungal activity against pathogens such as Candida albicans, Cryptococcus species, and Aspergillus fumigatus. This compound is suitable for research applications in oncology and infectious diseases. -
Styryl Lactone
Goniothalamin is a styryl lactone that demonstrates insecticidal, anti-tumor, and antibacterial properties. It induces cell cycle arrest and apoptosis in tumor cells, while exhibiting larvicidal effects against Culex quinquefasciatus larvae and cytotoxicity against brine shrimp larvae. Additionally, Goniothalamin shows antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as antifungal efficacy against pathogens such as Candida albicans and Trichophyton species. This compound is relevant for research in breast cancer, lymphatic filariasis, and the treatment of bacterial and fungal infections. -
Antibiotic
Terrein is an antibiotic that functions as a melanogenesis inhibitor. It induces apoptosis in breast cancer cell lines and acts as an inhibitor of quorum sensing and cyclic di-GMP levels in Pseudomonas aeruginosa. This compound is valuable in studying mechanisms of cancer cell regulation and bacterial communication processes. -
Cytochrome P450 Inhibitor
Thujopsene is a potent inhibitor of cytochrome P450 enzymes, specifically targeting CYP2B6, CYP3A4, CYP2C19, CYP2C8, and CYP2C9, with IC50 values of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. In addition to its role as a metabolic inhibitor, thujopsene binds to PKM2, disrupting cancer cell metabolic pathways and inducing apoptosis in MKN45 cells, thereby demonstrating significant antitumor activity. This compound also exhibits notable anti-termite and antifungal properties through its autoxidation process, broadening its potential applications in both cancer research and pest control. -
Antibiotic/DNA Inhibitor
Bleomycin A5 (hydrochloride) is a glycopeptide antibiotic that primarily functions as a DNA inhibitor. This compound exerts its cytotoxic effects by chelating Fe2+, which leads to the formation of reactive species that induce both single-strand and double-strand breaks in DNA, thereby disrupting DNA replication. Additionally, Bleomycin A5 (hydrochloride) inhibits Drp1-mediated mitochondrial fission and modulates the PINK1/Parkin pathway, contributing to mitochondria-mediated apoptosis. It is widely utilized in cancer research applications. -
Apoptosis Inducer
2-Methoxyjuglone is a naphthoquinone that functions primarily as an apoptosis inducer. It activates caspase-9 and caspase-3 through the mitochondrial cytochrome c-dependent intrinsic apoptosis pathway, leading to increased pro-apoptotic Bax levels and decreased anti-apoptotic Bcl-2 levels. 2-Methoxyjuglone also induces apoptosis by promoting mitochondrial cytochrome c release and is associated with morphological changes of apoptosis, early apoptotic signals, cell cycle arrest in S-phase and G2/M-phase, as well as DNA double-strand breaks. Additionally, it exhibits antimicrobial properties against Gram-positive bacteria and pathogenic fungi, making it valuable in the research of various cancers, including hepatocellular carcinoma and breast cancer, as well as in studies of fungal and bacterial infections. -
Antifungal Peptide
Periplanetasin-2 is an antifungal peptide that exerts its effects primarily through the induction of oxidative stress by generating reactive oxygen species (ROS) and promoting lipid peroxidation. In addition to its antifungal activity, Periplanetasin-2 can also trigger apoptosis in target cells. This compound is valuable for research applications aimed at understanding fungal pathogenesis and evaluating potential therapeutic strategies against fungal infections. -
FASN Inhibitor
Cerulenin is a potent natural inhibitor of fatty acid synthase (FASN), derived from the fungus Cephalosporium caeruleus. It acts by inhibiting topoisomerase I catalytic activity, consequently enhancing apoptosis induced by SN-38. Cerulenin exhibits both antifungal and antitumor properties, making it a valuable tool for research in cancer therapies and fungal infections. -
Antibiotic and APN Inhibitor
Actinonin is a naturally occurring antibiotic that functions primarily as an aminopeptidase N inhibitor. It exhibits potent antimicrobial activity and acts as a reversible peptide deformylase (PDF) inhibitor with a Ki value of 0.28 nM. Additionally, Actinonin shows inhibitory effects on matrix metalloproteinases MMP-1, MMP-3, MMP-8, and MMP-9, with respective Ki values of 300 nM, 1,700 nM, 190 nM, and 330 nM. It also possesses pro-apoptotic properties and has demonstrated antiproliferative and antitumor activities, making it a valuable tool for cancer research and therapeutic exploration. -
Antibacterial Agent
Lasalocid is an antibacterial and anticoccidial agent that functions as a feed additive in agricultural applications. It has demonstrated antitumor activity, suggesting potential utility in oncological research. Additionally, Lasalocid is orally bioactive, making it suitable for studies involving gastrointestinal absorption and pharmacokinetics. -
Bacterial Agent And Polyamine Transport System Inhibitor
AMXT-1501 is an antibacterial agent and polyamine transport system inhibitor that targets membrane phospholipids. It exhibits significant antibacterial activity against a range of multidrug-resistant Gram-positive and Gram-negative bacteria, specifically inhibiting capsular biosynthesis in Streptococcus pneumoniae. Additionally, AMXT-1501 interferes with ornithine decarboxylase and polyamine pathways, leading to the inhibition of neuroblastoma cell proliferation. Research applications include studies on multidrug-resistant bacterial infections, pneumococcal infections, and neuroblastoma therapeutics. -
Antifungal Agent
Iturin A is a cyclic lipopeptide that exhibits potent antifungal activity. Iturin A disrupts fungal cell membranes and induces the production of reactive oxygen species (ROS), leading to apoptosis and autophagy in tumor cells. This compound holds promise for research applications in antifungal therapeutics and cancer biology, showcasing notable antitumor effects. -
Antibiotic
Bleomycin A5 is a glycopeptide antibiotic that exerts cytotoxic effects primarily through its interaction with Fe2+, leading to the formation of a complex that induces both single-strand and double-strand DNA breaks, while inhibiting DNA replication. Additionally, it targets Drp1-mediated mitochondrial fission and suppresses the PINK1/Parkin pathway-mediated mitophagy, ultimately promoting mitochondria-mediated cellular apoptosis. This compound is valuable in cancer research, particularly in studies focused on mechanisms of apoptosis and DNA damage responses. -
Antibacterial Agent
Lasalocid sodium is an antibacterial and anticoccidial agent primarily utilized in veterinary medicine as a feed additive. This compound exhibits significant antitumor activity, demonstrating potential for additional therapeutic applications. Its oral bioactivity further enhances its utility in various research studies focused on microbial resistance and cancer biology. -
Fungicide Agent
Epoxiconazole is a demethylation inhibitor targeting the Ergosterol biosynthesis pathway. It demonstrates significant inhibitory activity against both carbendazim-resistant and phenamacril-resistant fungal isolates. This compound is widely utilized in agricultural research for the control of various crop diseases, contributing to effective crop management strategies. -
Fungicide
Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide that primarily targets the cytochrome bc1 complex, inhibiting mitochondrial respiration through binding at the Qo site. This mechanism disrupts electron transfer, leading to the generation of reactive oxygen species (ROS) and subsequent induction of apoptosis in fungal cells. Azoxystrobin is essential for research applications focusing on fungal physiology, plant pathology, and the development of disease management strategies. -
Fungicide
Fludioxonil is a phenylpyrrole fungicide that targets fungal cell growth by inhibiting the development of plant pathogens such as Sclerotinia sclerotiorum. It exhibits significant biological activity through its ability to disrupt cytoskeletal integrity, induce DNA damage, and promote apoptosis in mouse glioma cells. Additionally, Fludioxonil has been observed to influence tumor growth and metastasis, alongside potential cardiotoxic effects. This compound serves as a valuable tool in agricultural research and studies related to cellular mechanisms of toxicity and cancer progression. -
Apoptosis Inducer
Hirsutine, an indole alkaloid derived from Uncaria rhynchophylla, serves as an apoptosis inducer with notable anti-cancer properties. It effectively triggers apoptotic pathways while demonstrating significant inhibitory effects against Dengue virus, all with low cytotoxicity. This compound is valuable for research in cancer biology and virology, enabling studies on apoptotic mechanisms and antiviral strategies.
