KK14(R)

Catalog No.: A27925
Antifungal Peptide
KK14(R) is an analog of the synthetic antifungal peptide KK14, demonstrating potent antifungal activity against Fusarium culmorum, Penicillium expansum, and Aspergillus niger, with minimum inhibitory concentrations (MICs) of 6.25 μg/mL, 12.5 μg/mL, and 12.5 μg/mL, respectively. This compound also exhibits stability under various heat and pH conditions. Additionally, KK14(R) shows cytotoxic effects on Caco-2 and RAW264.7 cell lines, making it a valuable tool for research in fungal infections and cytotoxicity studies.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKK14(R) is an analog of the synthetic antifungal peptide KK14, demonstrating potent antifungal activity against Fusarium culmorum, Penicillium expansum, and Aspergillus niger, with minimum inhibitory concentrations (MICs) of 6.25 μg/mL, 12.5 μg/mL, and 12.5 μg/mL, respectively. This compound also exhibits stability under various heat and pH conditions. Additionally, KK14(R) shows cytotoxic effects on Caco-2 and RAW264.7 cell lines, making it a valuable tool for research in fungal infections and cytotoxicity studies.
Product Information
Catalog NumA27925
FormulaC96H138N26O14
Molecular Weight1880.29
CAS Number2415098-35-8
SequenceLys-Lys-Phe-Phe-Arg-Ala-Trp-Trp-Ala-Pro-Arg-Phe-Leu-Lys-NH2
Sequence shorteningKKFFRAWWAPRFLK-NH2
SMILESC([C@H](NC([C@H](CC=1C=2C(NC1)=CC=CC2)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@H](CCCCN)N)=O)CCCCN)=O)=O)=O)CCCNC(=N)N)=O)C)=O)=O)C(N[C@H](C(=O)N5[C@H](C(N[C@H](C(N[C@@H](CC6=CC=CC=C6)C(N[C@H](C(N[C@@H](CCCCN)C(N)=O)=O)CC(C)C)=O)=O)CCCNC(=N)N)=O)CCC5)C)=O)C=7C=8C(NC7)=CC=CC8
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