SDH-IN-25 is a selective inhibitor of succinate dehydrogenase (SDH), with an IC50 value of 4.82 mg/L. This compound displays significant antifungal activity by disrupting respiratory metabolism through its binding to complex II, consequently inducing hyphal morphology changes, generating reactive oxygen species (ROS), and affecting mitochondrial membrane potential (MMP) in fungal mycelia. SDH-IN-25 is suitable for research applications focused on agricultural disease management and the development of novel antifungal strategies.
SDH-IN-25 is a selective inhibitor of succinate dehydrogenase (SDH), with an IC50 value of 4.82 mg/L. This compound displays significant antifungal activity by disrupting respiratory metabolism through its binding to complex II, consequently inducing hyphal morphology changes, generating reactive oxygen species (ROS), and affecting mitochondrial membrane potential (MMP) in fungal mycelia. SDH-IN-25 is suitable for research applications focused on agricultural disease management and the development of novel antifungal strategies.
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