Catalog No.
Product Name
Application
Product Information
Citations
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Antifungal Agent
1-O-Methylemodin is a natural product derived from Zopfiella longicaudata with demonstrated antifungal properties. It acts by inhibiting fungal growth, making it a valuable compound for research on fungal infections and potential therapeutic applications. Its unique structure contributes to its effectiveness in combating various fungal species, supporting studies in mycology and pharmacology. -
CHS Inhibitor
Chitin Synthase Inhibitor 11 is a potent inhibitor of chitin synthase, demonstrating significant inhibitory activity with an IC50 value of 0.10 mM. This compound exhibits broad-spectrum antifungal properties in vitro, making it a valuable tool for investigating invasive fungal infections (IFIs). Its ability to disrupt chitin biosynthesis positions it as a promising candidate for enhancing understanding of antifungal mechanisms and therapies. -
Drug Derivative
Lindetannin is an A-type trimer of proanthocyanidin primarily derived from the bark of Cinnamomum trees. This polyphenolic compound exhibits significant antioxidant and anti-cancer properties, making it valuable in cancer research. Additionally, Lindetannin demonstrates anti-inflammatory, cardioprotective, antibacterial, and antifungal activities, providing potential therapeutic benefits for conditions such as chronic venous insufficiency, capillary fragility, sunburn, and retinopathy. -
Antifungal Agent
Antifungal Agent 34 (Compound 6i) targets fungal pathogens, demonstrating potent antifungal activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 4 µg/mL. This compound significantly inhibits both hyphal growth and biofilm formation of Candida albicans, making it a valuable tool for investigating fungal pathogenesis and treatment methodologies. Importantly, Antifungal Agent 34 displays no cytotoxic effects on mammalian cells, indicating its potential for therapeutic applications. -
CHS Inhibitor
Chitin Synthase Inhibitor 12 targets chitin synthase, demonstrating potent inhibitory activity with an IC50 of 0.16 mM. This compound serves as a broad-spectrum antifungal agent, exhibiting significant efficacy against drug-resistant strains, including Candida albicans and Cryptococcus neoformans. Chitin Synthase Inhibitor 12 is suitable for research applications involving invasive fungal infections (IFIs). -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 14 is a selective inhibitor of chitin synthase (CHS), which plays a critical role in the synthesis of chitin, a key component of fungal cell walls. This compound exhibits significant antifungal activity and demonstrates effectiveness against drug-resistant fungal strains. It is valuable for research applications focused on fungal biology, drug resistance mechanisms, and the development of new antifungal therapies. -
Antifungal Agent
Antifungal Agent 52 is a tetrazole derivative that targets ergosterol synthesis. It exhibits significant antifungal activity against Candida albicans, effectively permeabilizing the cell membrane of sessile C. albicans. This compound is valuable for research applications focused on pathogenic fungi and the mechanisms of antifungal resistance. -
Antifungal Drug
Antifungal agent 100 (compound 3i) targets Succinate dehydrogenase (SDH) and demonstrates potent antifungal activity against S. sclerotiorum, with an EC50 value of 0.33 mg/L. Additionally, it displays an IC50 of 0.63 mg/mL against SDH, indicating its potential for disrupting key metabolic processes in fungal cells. This compound is particularly valuable for research applications aimed at understanding fungal pathogenesis and developing antifungal therapies. -
Fas1 Inhibitor
(Rac)-NPD6433 is a Fas1 inhibitor targeting the enoyl reductase domain of fatty acid synthase 1. As a triazenyl indole, it demonstrates broad-spectrum antifungal activity against various screening fungal strains. By covalently inhibiting flavin mononucleotide-dependent NADPH-oxidation activity, (Rac)-NPD6433 effectively disrupts essential fatty acid biosynthesis, making it a valuable tool for research in fungal metabolism and potential therapeutic applications. -
β-Glucanase
Beta-Glucanase is an enzyme from the glycosyl hydrolase family that catalyzes the hydrolysis of β-glucan polysaccharides. This reaction results in the formation of 3-O-cellotriosyl-d-glucose and 3-O-cellobiosyl-d-glucose. Beta-Glucanase plays a crucial role in plant defense mechanisms by providing resistance against various fungal pathogens, making it valuable for research in plant biology and disease resistance studies. -
Fungicide
Fosetyl-aluminum is a foliar-applied fungicide that primarily targets downy mildew and other diseases caused by Phytophthora spp. It exhibits significant biological activity in preventing and controlling various plant pathogens, making it essential for protecting agricultural and horticultural crops. Its application is crucial for maintaining crop health and yield in environments prone to fungal infections. -
Fungal Inhibitor
Antifungal agent 15 is a potent fungal inhibitor that exhibits significant biological activity, demonstrated by EC50 values of 0.52 μg/mL against Sclerotinia sclerotiorum and 0.50 μg/mL against Botrytis cinerea. This compound is suitable for research applications aimed at understanding fungal pathogenesis and developing antifungal therapies. Its high efficacy makes it a valuable tool for investigating fungal resistance mechanisms and optimizing treatment strategies in agricultural and clinical settings. -
CaMdr1p Inhibitor
CaMdr1p-IN-1 is a specific inhibitor of the major facilitator superfamily transporter CaMdr1p. This compound demonstrates significant chemosensitizing effects, particularly in enhancing the efficacy of Fluconazole against CaMdr1p-overexpressing Candida albicans, achieving a minimum inhibitory concentration (MIC) of 10 μM. CaMdr1p-IN-1 is valuable for research focused on antifungal drug resistance mechanisms and the development of combination therapies against fungal pathogens. -
Fungal Inhibitor
Neocnidilide is an alkylphthalide that acts as a fungal inhibitor, specifically targeting mycotoxin-producing fungi to suppress their growth. Additionally, it exhibits larvicidal properties against Drosophila melanogaster, with a lethal concentration (LC50) of 9.9 μmol/mL. This compound is relevant for research applications focused on mycology and pest control in agricultural settings. -
Fungicide
Flutianil is a targeted fungicide that primarily inhibits the growth of powdery mildew species. Its mode of action involves interfering with haustorium formation, leading to reduced mycelial development. Flutianil is of particular interest in agricultural research for its efficacy in managing fungal diseases in crops, contributing to improved plant health and yield. -
Hydroxyflavan
4-Hydroxyflavan is a hydroxyflavan compound that demonstrates antifungal activity, specifically exhibiting efficacy against sporelings of Botrytis cinerea with an effective dose (ED50) of 216 μM. This compound is utilized in antifungal research and may serve as a valuable tool for studying the mechanisms of fungal inhibition and pathogenicity. -
Antifungal Agent
Pygenic acid B is a triterpenoid compound isolated from the leaves of Glochidion obliquum, exhibiting significant antifungal activity against Candida musae. Additionally, it demonstrates ONOO- scavenging properties, making it a valuable tool for research in antifungal mechanisms and oxidative stress studies. This compound can aid in the development of novel antifungal agents and enhance understanding of reactive nitrogen species in biological systems. -
Antifungal Agent
Antifungal agent 158 is an α-pyrone derivative that targets plant-pathogenic fungi, exhibiting notable antifungal activity against species such as Chaetomium spp., Curvularia lunata, and Aspergillus flavus. This compound is characterized by its non-toxic profile towards greenhouse-grown crops, including bean, corn, and tobacco plants. Antifungal agent 158 is an effective tool for research focused on the treatment and study of Aspergillus flavus infections. -
Antifungal Agent
5-Heptadec-cis-8-enylresorcinol is a 5-alkylresorcinol with antifungal properties, primarily targeting the rice blast fungus. Isolated from etiolated rice seedlings, this compound exhibits mechanisms that mediate DNA relaxation, contributing to its antifungal activity. It is valuable for research applications focused on plant pathology and antifungal agent development. -
NSAIA
Tropesin, a nonsteroidal anti-inflammatory agent (NSAIA), exhibits significant inhibitory activity against the growth of Trichoderma viride. Its mechanism of action involves the modulation of inflammatory pathways, making it a valuable tool for studying fungal growth and related biological processes. This compound is suitable for research applications focused on inflammation and antifungal activity in diverse biological systems. -
Fungal
Zaragozic acid A trisodium is a fungal metabolite that functions as a reversible competitive inhibitor of squalene synthase. This compound exhibits potent antifungal activity by disrupting sterol biosynthesis, making it valuable in the study of fungal pathogens. Its applications include research in antifungal drug development and investigations into the mechanistic pathways of sterol biosynthesis in various fungi. -
Antifungal Agent
Bis(methylthio)gliotoxin is an antifungal agent with enhanced stability compared to gliotoxin, making it a more reliable biomarker for invasive aspergillosis. Its application in clinical diagnostics provides improved accuracy in the identification of Aspergillus infections, facilitating timely intervention and management. This compound is essential for research into fungal pathogenesis and the development of antifungal therapies. -
Antifungal Agent
Amphotericin X1 is a 13-O-methyl derivative of Amphotericin B, acting as a potent antifungal agent. It demonstrates significant inhibitory activity against various fungal pathogens, including Candida albicans, C. parapsilosis, Cryptococcus neoformans, Aspergillus niger, and A. fumigatus, with minimum inhibitory concentration (MIC) values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL, and 2 μg/mL, respectively. This compound is particularly valuable for research applications focused on fungal infections and the development of antifungal therapies. -
Antibacterial And Antifungal Agent
5CF2PB is an antibacterial and antifungal agent that targets the 5O4L protein. This compound demonstrates potent activity against a range of bacterial and fungal pathogens, particularly exhibiting significant efficacy against Pseudomonas aeruginosa and Aspergillus niger. 5CF2PB is valuable for research applications focused on infections and resistance mechanisms in microbial agents. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 3 is a selective inhibitor of chitin synthase, exhibiting an IC50 value of 0.16 mM. This compound demonstrates significant antifungal activity, with a minimum inhibitory concentration (MIC) of 1 µg/mL against Candida albicans. It is primarily utilized in research applications focusing on antifungal drug development and the study of chitin biosynthesis pathways in pathogenic fungi. -
Antifungal Agent
Antifungal agent 73 (compound A32) is an effective antifungal agent targeting azole-resistant candidiasis. It disrupts the integrity of the fungal cell wall and cell membrane, demonstrating significant in vivo antifungal activity against pathogenic fungi, including fluconazole-resistant strains. This compound is valuable for research applications focusing on antifungal resistance mechanisms and therapeutic strategies. -
Antifungal Agent
Galanolactone is a natural compound derived from the seeds of Alpinia galanga, primarily recognized for its antifungal properties. This agent exhibits significant cytotoxic effects against KB cells, with an EC50 value of 38.5 µg/ml. Galanolactone serves as a valuable tool in research focused on fungal inhibition and cytotoxicity studies. -
Antifungal Agent
Antifungal Agent 37 is a heterocyclic disulfide compound that exhibits significant antifungal activity. It is primarily utilized in research focused on fungal pathogens, providing insights into mechanisms of action and potential therapeutic applications. This compound serves as an essential tool in the development of novel antifungal agents for combating resistant strains. -
Antifungal Agent
Antifungal agent 51 (Compound 5c) is a potent antifungal agent primarily targeting various Candida species, including Candida albicans, Candida parapsilosis, and Candida tropicalis. It exhibits exceptional antifungal activity with a minimum inhibitory concentration (MIC) of less than 0.063 μg/mL. Notably, it demonstrates low cellular toxicity and possesses no carcinogenic properties, making it a valuable tool for antifungal research and development. -
Antifungal Agent
Antifungal Agent 84 is a potent antifungal compound that targets candidiasis through a CNB1-dependent mechanism. This reagent effectively reduces the viability of Candida albicans biofilms, making it a valuable tool for research in fungal pathogenesis and biofilm formation. Its application is particularly relevant in studies focused on antifungal resistance and treatment strategies. -
Antifungal Agent
Anisocoumarin H is a coumarin derivative known for its antifungal activity. It effectively inhibits the growth of fungal pathogens, including Microsporum gypseum, Trichophyton rubrum, and Trichophyton mentagrophytes, with minimum inhibitory concentrations (MICs) of 62.5 µg/mL. This compound is valuable for research applications in studying fungal infections and developing antifungal therapeutics. -
Antifungal Activity
1,5-Hexadien-3-ol is a green leaf volatile (GLV) alcohol known for its antifungal activity, specifically targeting Botrytis cinerea. This compound plays a significant role in plant defense mechanisms, particularly in tomato plants, where it offers protection against grey mould disease. Its applications extend to research focused on fungal pathogens and plant resilience, making it a valuable tool for investigating plant defense strategies. -
Fungal Inhibitor
Antifungal Agent 16 is a potent fungal inhibitor, demonstrating significant antifungal activity compared to established agents such as ciprofloxacin and fluconazole. This compound is ideal for research aimed at exploring new antifungal therapies and addressing drug resistance in fungal pathogens. Its robust efficacy makes it a valuable tool in the investigation of fungal infections and therapeutics. -
Antimicrobial Agent
Antimicrobial agent-4 (compound 6a) is a potent antimicrobial agent targeting a range of microbial pathogens. It demonstrates significant antibacterial and antifungal activities, effectively eliminating harmful bacteria and fungi. With a high binding energy value of −10.0 kcal/mole against its target enzyme, Antimicrobial agent-4 is a valuable tool for research applications in microbiology and infectious diseases. -
Antifungal Agent
Medicagenic acid 3-O-glucoside is a monosaccharide-chain triterpenoid saponin that acts as an antifungal agent, primarily targeting fungal cell membranes. With a minimum inhibitory concentration (MIC) of 0.03 mg/mL and a minimum fungicidal concentration (MFC) of 0.125 mg/mL against *Pyricularia oryzae*, it disrupts membrane permeability, leading to cell rupture and growth inhibition. This compound is suitable for research applications focused on rice blast disease and fungal pathogenicity studies. -
Fungal Inhibitor
Antifungal agent 12 is a fluconazole-based compound that functions as a fungal inhibitor by disrupting fungal cell membrane synthesis. It demonstrates significant antifungal activity, making it suitable for research applications focused on fungal infections and resistance mechanisms. This compound can be utilized in studies aimed at developing new antifungal therapies. -
Fungal Inhibitor
3,5-Dimethyl-4-phenylisoxazole acts as a fungal inhibitor by disrupting fungal cell function. This heterocyclic compound demonstrates significant anti-fungal activity, making it a valuable tool for research in mycology and infectious disease studies. Additionally, it has shown promise in anti-inflammatory and anti-bacterial applications, indicating its potential for broader biological research. Its ability to modulate immune responses further highlights its versatility in various scientific investigations. -
Fungal
Alternapyrone is an α-pyrone compound with significant antifungal properties, predominantly derived from certain fungal species. This compound is known to affect wheat seed germination, exhibiting phytotoxicity that can be valuable for research into plant-fungal interactions and phytopathology. Its biosynthesis involves a simple enzymatic pathway, making it of interest for studies on metabolic processes in fungi. -
Ribosome/EF2 Stabilizer
Sordarin is an antifungal agent that specifically targets Elongation Factor 2 (EF2). It possesses a tetracyclic diterpene structure and is derived from the fungus Sordaria araneosa. Sordarin exhibits strong antifungal activity against Saccharomyces cerevisiae and Candida albicans by inhibiting protein synthesis in fungi. It does so by preventing the translocation of the ribosome along mRNA during elongation, effectively stabilizing the ribosome/EF2 complex. This compound is valuable for research focused on fungal protein synthesis and antifungal drug development. -
Antimicrobial/Anticancer Agent
Isocryptomerin primarily targets fungal membranes as a membrane-active antifungal compound derived from Selaginella tamariscina. It exerts its antimicrobial effects by depolarizing the plasma membrane of fungi. Additionally, isocryptomerin demonstrates notable anticancer and antibacterial activities, making it a valuable agent for research in both oncology and infectious diseases. -
Antifungal Agent
D0870 is an antifungal agent that effectively inhibits Candida neoformans, as well as strains associated with vaginal candidiasis and other viable yeasts. Its primary mechanism involves disrupting fungal cell viability, making it a valuable tool for research into fungal infections and developing therapeutic applications against opportunistic fungal pathogens. D0870 is suitable for studies aimed at understanding antifungal resistance and the mechanisms underlying yeast-related infections. -
Antifungal Agent
Antifungal Agent 86 (Compound 41F5) is an effective antifungal targeting pathogenic fungi. It demonstrates significant activity against Histoplasma yeast and Cryptococcus neoformans, with a MIC50 range of 0.4-0.8 μM. This compound is valuable for research focusing on fungal infections and developing therapeutic strategies against fungal pathogens. -
Amides
Dehydropipernonaline is an amide compound that exhibits significant cytotoxicity against L5178Y mouse lymphoma cells, with an IC50 value of 8.9 μM. This compound is valuable in research applications involving antifungal screening and the investigation of cytotoxic agents. -
Antifungal Agent
Nudicaucin B is a triterpenoid saponin extracted from Hedyotis nudicaulis, primarily known for its antifungal properties. This compound demonstrates significant activity against various fungal strains, making it a valuable tool for research focused on antifungal drug development and identifying potential therapeutic agents for fungal infections. Its unique structure and biological activity contribute to its relevance in exploring new treatments in mycology and related fields. -
Antioxidant
Dihydro-N-caffeoyltyramine is a phenolic amide known for its potent antioxidant properties. It exhibits strong antioxidant activity and demonstrates antifungal effects. Mechanistically, Dihydro-N-caffeoyltyramine downregulates cyclooxygenase-2 expression by inhibiting the activity of C/EBP and AP-1 transcription factors, making it a valuable compound for research in oxidative stress and inflammatory responses. -
Antifungal Agent
Antifungal Agent 70 is a dihydroeugenol-imidazole compound that demonstrates potent activity against multi-resistant Candida auris, with an MIC of 36.4 μM. This agent effectively inhibits fungal growth and is valuable in research applications focused on developing treatments for resistant fungal infections. Its unique mechanism makes it a promising candidate for further exploration in antifungal drug development. -
Fungal Inhibitor
Fumigaclavine A is a clavine alkaloid that acts as a fungal inhibitor targeting Aspergillus species. This mycotoxin, produced by Aspergillus fumigatus, is significant in studies related to fungal contamination and plant disease management. Research applications include investigating the pathogenicity of A. fumigatus and assessing the efficacy of antifungal agents in various environments. -
Fungal Inhibitor
(-)-Zonarol is a potent antifungal agent that targets and inhibits fungal growth. This compound exhibits diverse translational potential in research applications, particularly in the study of fungal infections and resistance mechanisms. As an isomer of Zonarol and related to the natural product (-)-Yahazunol, (-)-Zonarol provides valuable insights into fungal biology and therapeutic strategies. -
Antifungal Agent
Antifungal Agent 33 is a potent inhibitor of Lanosterol 14α-demethylase (CYP51), exhibiting an IC50 of 0.19 μg/mL. This compound demonstrates significant antifungal activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 16 μg/mL. Antifungal Agent 33 is valuable for research applications focused on the development of new antifungal therapies and the study of fungal resistance mechanisms. -
Germination Self-inhibitor
Methyl (Z)-ferulate is a natural germination self-inhibitor primarily derived from the leaves of Tetragonia tetragonoides. It effectively blocks germination in rust fungi by reversibly inhibiting the degradation of the germination pore plug through modulation of existing enzyme activity. In addition to its antifungal properties, Methyl (Z)-ferulate exhibits antioxidant activity, demonstrating significant scavenging capabilities against DPPH and ABTS+ radicals. This compound is valuable for research applications focused on plant defense mechanisms and antioxidant strategies.
