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Catalog No.
Product Name
Application
Product Information
Citations
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Antifungal Agent/C-4 Sterol Methyl Oxidase Inhibitor
PF-1163A is an antifungal agent that functions as a C-4 sterol methyl oxidase inhibitor, effectively disrupting ergosterol synthesis with an IC50 of 12 ng/mL. This compound demonstrates notable antifungal activity, characterized by a minimum inhibitory concentration (MIC) of 12.5 µg/mL. PF-1163A is valuable for research applications focused on fungal infections and the mechanistic understanding of ergosterol biosynthesis. -
Chitin Deacetylase Inhibitor
AnCDA-IN-1 is a selective inhibitor of chitin deacetylase (CDA), demonstrating significant antifungal properties. It exhibits an IC50 value of 4.24 μM against AnCDA from Aspergillus nidulans and shows a minimum inhibitory concentration (MIC) of 260 μg/mL against various food spoilage and plant pathogenic fungi, with a minimum fungicidal concentration (MFC) of 520 μg/mL. This compound is valuable for research in the antifungal domain, particularly in understanding CDA's role in fungal cell wall integrity and potential therapeutic applications. -
Hyphal Formation Inhibitor
2-Dodecanol is an effective hyphal formation inhibitor with targeted activity against Candida albicans. By inhibiting SIR2 expression, it disrupts the morphological transition essential for pathogenicity. This compound is valuable for researchers studying fungal biology and the mechanisms of infection, as well as for developing potential antifungal strategies. -
Glutamate Transport Inhibitor
Avenaciolide is a bis-γ-lactone derived from Aspergillus avenaceus that acts as a specific inhibitor of glutamate transport. This compound demonstrates antifungal and antibacterial properties while also interfering with the stimulatory effect of ADP on glutamate oxidation in rat liver mitochondria. Avenaciolide's unique mechanism makes it valuable for studying metabolic processes and the regulation of glutamate transport in cellular and mitochondrial contexts. -
Succinate Dehydrogenase Inhibitor
SDH-IN-3 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 of 7.2 μg/mL. This compound exhibits significant antifungal activity against Nigrospora oryzae, with an EC50 of 1.9 μg/mL. SDH-IN-3 is suitable for research applications focused on anti-infection studies and the modulation of metabolic pathways in fungal pathogens. -
SARS CoV-2 3CLpro Inhibitor
SARS-CoV-2 3CLpro-IN-4 is a potent inhibitor of the SARS-CoV-2 3CL protease, a critical enzyme for viral replication. This compound exhibits significant antiviral activity, making it relevant for research in COVID-19 therapeutics. Its broad-spectrum impact also extends to antibacterial and antifungal activities, aiding investigations into multi-faceted infectious disease mechanisms. -
Ras Inhibitor
Antifungal agent 46 is a potent Ras inhibitor that targets protein farnesyltransferase, effectively disrupting Ras signaling pathways. This compound demonstrates significant antifungal activity and holds potential for research applications focused on understanding Ras-related mechanisms in fungal infections. Studies may explore its utility in elucidating the role of Ras in cellular signaling and its implications in therapeutic developments. -
Fungal Inhibitor
Antibacterial agent 188 is a potent fungal inhibitor that targets dermatophyte activity. This compound demonstrates significant antifungal properties, making it suitable for research applications focused on fungal infections and dermatological studies. Its mechanism of action involves disrupting fungal cell processes, thereby inhibiting growth and proliferation. -
Succinate Dehydrogenase Inhibitor
Harzianopyridone is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 80 nM. Isolated from the fungus Trichoderma harzianum, this compound demonstrates significant antifungal, antibacterial, and herbicidal properties. Harzianopyridone is valuable for research applications exploring metabolic modulation and the study of fungal and bacterial pathways. -
Gamma-Glutamyl Transferase Inhibitor
Gamma-Glutamyl Transferase-IN-1 is a potent inhibitor of gamma-glutamyl transferase, specifically designed to disrupt its enzymatic function. This β-carboline 1-hydrazide compound exhibits significant antifungal and antibacterial activities by promoting the accumulation of reactive oxygen species, leading to cell membrane disruption and alterations in histone acetylation. It serves as a valuable tool for research investigating the roles of gamma-glutamyl transferase in various biological processes and disease states. -
Antifungal Agent/LOX-1 Inhibitor
Sclerotiorin is a reversible uncompetitive inhibitor of soybean lipoxygenase-1 (LOX-1), with an IC50 value of 4.2 μM. This compound exhibits significant antioxidant activity by scavenging free radicals (ED50: 0.12 μM) and inhibiting nonenzymatic lipid peroxidation. Additionally, Sclerotiorin demonstrates antifungal properties and the ability to inhibit platelet aggregation. It can be isolated from the fermented broth of Penicillium frequentans, making it a valuable reagent for research in antifungal mechanisms and oxidative stress studies. -
SDH Inhibitor
SDH-IN-18 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 8.70 mg/L. This compound demonstrates significant antifungal activity, disrupting the morphology and reproduction of fungi. It is particularly effective against Rhizoctonia solani and Sclerotinia sclerotiorum, with EC50 values of 0.48 mg/L and 1.4 mg/L, respectively. SDH-IN-18 can be utilized in research studying fungal pathology and SDH-related metabolic pathways. -
Pdr1-KIX Inhibitor
Antifungal agent 72 is a selective Pdr1-KIX inhibitor that effectively suppresses efflux pump function and down-regulates resistance-related genes through disruption of the Pdr1-KIX interaction, with a Ki value of 11.7 μM. This compound demonstrates significant antifungal activity against Fluconazole-resistant strains, exhibiting a minimum inhibitory concentration (MIC) of 63 ng/mL and showing synergistic effects when used in combination with Fluconazole. Antifungal agent 72 is particularly valuable for research focused on C. glabrata infections and the development of novel antifungal strategies. -
Fungal Inhibitor
Alteconazole is an azole derivative that acts as a potent antifungal agent. It exerts its action by inhibiting the enzyme lanosterol demethylase, which is essential for ergosterol synthesis in fungal membranes. This compound is valuable for research in the study of fungal pathogens and the development of antifungal therapies. Its mechanism of action makes it suitable for investigations into cellular responses to fungal infections and resistance mechanisms. -
PLA2 Inhibitor
Plipastatin B1 is a lipopeptide antibiotic that acts as an inhibitor of phospholipase A2 (PLA2). This compound exhibits antifungal activity, making it a valuable tool in investigating fungal pathogenesis and potential therapeutic interventions. It is applicable in research focusing on the modulation of PLA2-related pathways and the development of antifungal drugs. -
SDH Inhibitor
Succinate dehydrogenase-IN-1 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.94 μM and a KD of 22.4 μM. This compound demonstrates significant antifungal activity against various pathogens, including Rhizoctonia solani, Sclerotinia sclerotiorum, Monilinia fructicola, and Botrytis cinerea, with EC50 values of 0.04 μM, 1.13 μM, 1.61 μM, and 1.21 μM, respectively. Succinate dehydrogenase-IN-1 can be utilized in studies focusing on fungal infections and metabolic pathways involving SDH inhibition. -
Fungal Inhibitor
Antifungal Agent 120 is a potent fungal inhibitor targeting S. dermatitidis, a pathogenic fungus associated with skin infections. This reagent demonstrates significant antifungal activity and serves as a valuable tool for researchers studying fungal biology and therapeutic interventions. Further investigation may reveal efficacy against additional fungal species, expanding its potential applications in mycology research. -
SDH Inhibitor
Y12196 is a potent succinate dehydrogenase inhibitor (SDHI) that demonstrates strong fungicidal activity against Fusarium graminearum. This compound targets the mitochondrial metabolic pathway, disrupting energy production in fungal cells. Y12196 is valuable for investigating the role of SDH in fungal metabolism and can be utilized in studies aimed at controlling plant pathogens. -
1,3-β-glucan Synthase Inhibitor
Arborcandin F is a potent inhibitor of 1,3-β-glucan synthase, acting as an effective antifungal antibiotic. It displays IC50 values of 0.012 μg/mL against Candida albicans and Aspergillus fumigatus, demonstrating significant antifungal activity. Arborcandin F also exhibits a minimum inhibitory concentration (MIC) of 2-4 μg/mL against the genus Candida, making it a valuable reagent for research into fungal infections and therapeutic applications. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 7 is a potent inhibitor of chitin synthase (CHS) with an IC50 value of 0.37 mM. This compound demonstrates broad-spectrum antifungal activity, particularly against drug-resistant fungi. It is valuable for research applications focused on fungal infections and understanding the role of chitin biosynthesis in fungal pathogens. -
Fungal Inhibitor
Antifungal Agent 14, a potent fungal inhibitor, demonstrates broad-spectrum activity against various fungal strains with impressive minimum inhibitory concentration values. This compound is designed for use in research applications focusing on antifungal treatment and the investigation of fungal pathogenesis, making it a valuable tool for studying fungal infections and developing therapeutic strategies. -
CHS Inhibitor
Chitin Synthase Inhibitor 11 is a potent inhibitor of chitin synthase, demonstrating significant inhibitory activity with an IC50 value of 0.10 mM. This compound exhibits broad-spectrum antifungal properties in vitro, making it a valuable tool for investigating invasive fungal infections (IFIs). Its ability to disrupt chitin biosynthesis positions it as a promising candidate for enhancing understanding of antifungal mechanisms and therapies. -
CHS Inhibitor
Chitin Synthase Inhibitor 12 targets chitin synthase, demonstrating potent inhibitory activity with an IC50 of 0.16 mM. This compound serves as a broad-spectrum antifungal agent, exhibiting significant efficacy against drug-resistant strains, including Candida albicans and Cryptococcus neoformans. Chitin Synthase Inhibitor 12 is suitable for research applications involving invasive fungal infections (IFIs). -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 14 is a selective inhibitor of chitin synthase (CHS), which plays a critical role in the synthesis of chitin, a key component of fungal cell walls. This compound exhibits significant antifungal activity and demonstrates effectiveness against drug-resistant fungal strains. It is valuable for research applications focused on fungal biology, drug resistance mechanisms, and the development of new antifungal therapies. -
Fas1 Inhibitor
(Rac)-NPD6433 is a Fas1 inhibitor targeting the enoyl reductase domain of fatty acid synthase 1. As a triazenyl indole, it demonstrates broad-spectrum antifungal activity against various screening fungal strains. By covalently inhibiting flavin mononucleotide-dependent NADPH-oxidation activity, (Rac)-NPD6433 effectively disrupts essential fatty acid biosynthesis, making it a valuable tool for research in fungal metabolism and potential therapeutic applications. -
Fungal Inhibitor
Antifungal agent 15 is a potent fungal inhibitor that exhibits significant biological activity, demonstrated by EC50 values of 0.52 μg/mL against Sclerotinia sclerotiorum and 0.50 μg/mL against Botrytis cinerea. This compound is suitable for research applications aimed at understanding fungal pathogenesis and developing antifungal therapies. Its high efficacy makes it a valuable tool for investigating fungal resistance mechanisms and optimizing treatment strategies in agricultural and clinical settings. -
CaMdr1p Inhibitor
CaMdr1p-IN-1 is a specific inhibitor of the major facilitator superfamily transporter CaMdr1p. This compound demonstrates significant chemosensitizing effects, particularly in enhancing the efficacy of Fluconazole against CaMdr1p-overexpressing Candida albicans, achieving a minimum inhibitory concentration (MIC) of 10 μM. CaMdr1p-IN-1 is valuable for research focused on antifungal drug resistance mechanisms and the development of combination therapies against fungal pathogens. -
Fungal Inhibitor
Neocnidilide is an alkylphthalide that acts as a fungal inhibitor, specifically targeting mycotoxin-producing fungi to suppress their growth. Additionally, it exhibits larvicidal properties against Drosophila melanogaster, with a lethal concentration (LC50) of 9.9 μmol/mL. This compound is relevant for research applications focused on mycology and pest control in agricultural settings. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 3 is a selective inhibitor of chitin synthase, exhibiting an IC50 value of 0.16 mM. This compound demonstrates significant antifungal activity, with a minimum inhibitory concentration (MIC) of 1 µg/mL against Candida albicans. It is primarily utilized in research applications focusing on antifungal drug development and the study of chitin biosynthesis pathways in pathogenic fungi. -
Fungal Inhibitor
Antifungal Agent 16 is a potent fungal inhibitor, demonstrating significant antifungal activity compared to established agents such as ciprofloxacin and fluconazole. This compound is ideal for research aimed at exploring new antifungal therapies and addressing drug resistance in fungal pathogens. Its robust efficacy makes it a valuable tool in the investigation of fungal infections and therapeutics. -
Fungal Inhibitor
Antifungal agent 12 is a fluconazole-based compound that functions as a fungal inhibitor by disrupting fungal cell membrane synthesis. It demonstrates significant antifungal activity, making it suitable for research applications focused on fungal infections and resistance mechanisms. This compound can be utilized in studies aimed at developing new antifungal therapies. -
Fungal Inhibitor
3,5-Dimethyl-4-phenylisoxazole acts as a fungal inhibitor by disrupting fungal cell function. This heterocyclic compound demonstrates significant anti-fungal activity, making it a valuable tool for research in mycology and infectious disease studies. Additionally, it has shown promise in anti-inflammatory and anti-bacterial applications, indicating its potential for broader biological research. Its ability to modulate immune responses further highlights its versatility in various scientific investigations. -
Fungal Inhibitor
Fumigaclavine A is a clavine alkaloid that acts as a fungal inhibitor targeting Aspergillus species. This mycotoxin, produced by Aspergillus fumigatus, is significant in studies related to fungal contamination and plant disease management. Research applications include investigating the pathogenicity of A. fumigatus and assessing the efficacy of antifungal agents in various environments. -
Fungal Inhibitor
(-)-Zonarol is a potent antifungal agent that targets and inhibits fungal growth. This compound exhibits diverse translational potential in research applications, particularly in the study of fungal infections and resistance mechanisms. As an isomer of Zonarol and related to the natural product (-)-Yahazunol, (-)-Zonarol provides valuable insights into fungal biology and therapeutic strategies. -
Germination Self-inhibitor
Methyl (Z)-ferulate is a natural germination self-inhibitor primarily derived from the leaves of Tetragonia tetragonoides. It effectively blocks germination in rust fungi by reversibly inhibiting the degradation of the germination pore plug through modulation of existing enzyme activity. In addition to its antifungal properties, Methyl (Z)-ferulate exhibits antioxidant activity, demonstrating significant scavenging capabilities against DPPH and ABTS+ radicals. This compound is valuable for research applications focused on plant defense mechanisms and antioxidant strategies. -
C. albicans Nmt Inhibitor
SC-58272 is a potent and selective inhibitor of N-myristoyltransferase (Nmt) in Candida albicans, exhibiting an IC50 of 56 nM against the strain B311. This compound demonstrates a 250-fold selectivity for the fungal enzyme when compared to the human counterpart. SC-58272 is valuable for research applications involving fungal pathogenesis and the study of myristoylation processes in C. albicans. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 2 selectively targets chitin synthase, demonstrating potent inhibitory effects with an IC50 of 0.09 mM and a Ki of 0.12 mM. This compound exhibits significant antimicrobial activity in vitro and can enhance the effects of fluconazole and polyoxin B, making it a valuable tool for investigating chitin biosynthesis and potential applications in antifungal research. -
Succinate Dehydrogenase Inhibitor
Succinate dehydrogenase-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH). This indene amino acid derivative exhibits significant antifungal activity in vitro, with effective concentrations against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L). It is a valuable tool for research applications focused on inhibiting SDH in microbial pathogens. -
SDH Inhibitor/Antifungal Agent
SDH-IN-13 (Compound 5IIIh) is an inhibitor of succinate dehydrogenase (SDH) with an IC50 of 13.7 μg/mL. This compound exhibits antifungal activity, making it a valuable tool in the study of fungal pathogens and mitochondrial function. Its selective targeting of SDH positions it as a promising candidate for further research in antifungal therapies. -
SDH Inhibitor
SDH-IN-4 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.28 μg/mL. This compound demonstrates potent antifungal activity, specifically against Rhizoctonia solani, with an EC50 value of 0.23 μg/mL. SDH-IN-4 is primarily utilized in research applications involving fungal pathogen studies and metabolic pathway analysis. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 6 is a potent inhibitor of chitin synthase (CHS) with an IC50 value of 0.21 mM. This compound exhibits broad-spectrum antifungal activity against drug-resistant fungi, making it a valuable tool in the study of fungal infections. It is applicable in research focused on understanding fungal pathogenesis and developing antifungal therapies. -
Fungal Inhibitor
Antifungal Agent 68 is a potent inhibitor targeting fungal ergosterol biosynthesis, with demonstrated efficacy against Candida species and Cryptococcus gattii. This compound likely exerts its antifungal effects by inhibiting lanosterol 14α-demethylase (CYP51), wherein its imidazole ring interacts with the heme group of the enzyme. It serves as a valuable tool for research into fungal infections and the development of novel antifungal therapies. -
β-1,3-Glucan Inhibitor
Ibrexafungerp phosphate is a selective inhibitor of β-1,3-glucan synthesis, exhibiting notable antifungal activity. This compound is primarily utilized in research related to fungal pathogens, particularly for investigating infections caused by Candida and Aspergillus species. Its mechanism of action disrupts the integrity of the fungal cell wall, making it a valuable tool for exploring antifungal therapies. -
Ole1p Inhibitor
N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is an inhibitor of Ole1p desaturase, an important enzyme in the biosynthesis of unsaturated fatty acids. This compound exhibits antifungal activity, making it a valuable tool for research in antifungal drug development and lipid metabolism studies. It is suitable for investigating the mechanisms of fungal resistance and characterizing lipid profiles in various biological systems. -
Fungal Inhibitor
Antifungal agent 13 is a potent fungal inhibitor specifically targeting Sclerotinia sclerotiorum, exhibiting an effective concentration (EC50) of 1.25 mg/L. This compound demonstrates significant antifungal activity, making it a valuable tool for research into fungal pathogenesis and susceptibility. Its application includes studies aimed at understanding fungal resistance mechanisms and the development of novel antifungal therapies. -
Fungal Inhibitor
Diethofencarb is a fungicide that exhibits potent activity against Botrytis cinerea and Benzimidazole-resistant strains of Botrytis species. It functions primarily as an antifungal agent in agricultural applications, demonstrating efficacy in managing fungal pathogens in crops. Researchers may utilize Diethofencarb for studies related to fungal resistance mechanisms and the development of sustainable pest management strategies. -
Fungal Inhibitor
Antifungal agent 11 targets fungal organisms by inhibiting key metabolic processes, demonstrating significant antifungal activity. This compound is valuable in research applications aimed at understanding fungal behavior and developing new antifungal treatments. Its efficacy against various fungal strains makes it an essential tool for studying fungal infections and resistance mechanisms. -
CHS Inhibitor
Chitin Synthase Inhibitor 10 is a potent chitin synthase inhibitor, demonstrating an IC50 value of 0.11 mM. This compound exhibits significant antifungal activity, particularly against drug-resistant fungal strains such as Candida albicans and Cryptococcus neoformans. Chitin Synthase Inhibitor 10 is useful in the study of invasive fungal infections (IFIs), providing valuable insights into potential therapeutic strategies. -
Gamma-Glutamyl Transferase Inhibitor
Gamma-Glutamyl Transferase-IN-2 is a potent inhibitor of gamma-glutamyl transferase, a key enzyme involved in amino acid metabolism. This β-carboline 1-hydrazide compound demonstrates significant antifungal and antibacterial activities through its mechanism, which leads to the accumulation of reactive oxygen species, disruption of cell membranes, and alteration of histone acetylation patterns. Gamma-Glutamyl Transferase-IN-2 is valuable for research focused on understanding oxidative stress, cellular integrity, and epigenetic regulation in various biological systems. -
SDH Inhibitor
SDH-IN-6 is a potent inhibitor of succinate dehydrogenase (SDH). This compound demonstrates significant antifungal activity against Valsa mali, exhibiting an EC50 value of 1.77 mg/L. It is a valuable research tool for investigating the role of SDH in fungal metabolism and potential therapeutic approaches for treating fungal infections.
