Antifungal agent 72 is a selective Pdr1-KIX inhibitor that effectively suppresses efflux pump function and down-regulates resistance-related genes through disruption of the Pdr1-KIX interaction, with a Ki value of 11.7 μM. This compound demonstrates significant antifungal activity against Fluconazole-resistant strains, exhibiting a minimum inhibitory concentration (MIC) of 63 ng/mL and showing synergistic effects when used in combination with Fluconazole. Antifungal agent 72 is particularly valuable for research focused on C. glabrata infections and the development of novel antifungal strategies.
Antifungal agent 72 is a selective Pdr1-KIX inhibitor that effectively suppresses efflux pump function and down-regulates resistance-related genes through disruption of the Pdr1-KIX interaction, with a Ki value of 11.7 μM. This compound demonstrates significant antifungal activity against Fluconazole-resistant strains, exhibiting a minimum inhibitory concentration (MIC) of 63 ng/mL and showing synergistic effects when used in combination with Fluconazole. Antifungal agent 72 is particularly valuable for research focused on C. glabrata infections and the development of novel antifungal strategies.
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