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Plipastatin B1

Catalog No.: A27873
PLA2 Inhibitor
Plipastatin B1 is a lipopeptide antibiotic that acts as an inhibitor of phospholipase A2 (PLA2). This compound exhibits antifungal activity, making it a valuable tool in investigating fungal pathogenesis and potential therapeutic interventions. It is applicable in research focusing on the modulation of PLA2-related pathways and the development of antifungal drugs.
Plipastatin B1 103955-73-3 PLA2 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPlipastatin B1 is a lipopeptide antibiotic that acts as an inhibitor of phospholipase A2 (PLA2). This compound exhibits antifungal activity, making it a valuable tool in investigating fungal pathogenesis and potential therapeutic interventions. It is applicable in research focusing on the modulation of PLA2-related pathways and the development of antifungal drugs.
Product Information
Catalog NumA27873
FormulaC74H114N12O20
Molecular Weight1491.77
CAS Number103955-73-3
Sequence{(R)-3-Hydroxyhexadecanoic acid-Glu}-{Orn}-YTEVPQYI
Sequence shortening{(R)-3-Hydroxyhexadecanoic acid-Glu}-{Orn}-Tyr-Thr-Glu-Val-Pro-Gln-Tyr-Ile
SMILES[H][C@@]12CCCN1C(=O)C(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@]([H])(NC(=O)[C@H](Cc1ccc(OC(=O)[C@@]([H])(NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(N)=O)NC2=O)[C@@H](C)CC)cc1)NC(=O)[C@@H](CCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)C[C@H](O)CCCCCCCCCCCCC)[C@@H](C)O)C(C)C |@:106|
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Microbiology > Antifection > Fungal