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Catalog No.
Product Name
Application
Product Information
Citations
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SDH Inhibitor
SDH-IN-44 is a succinate dehydrogenase (SDH) inhibitor that demonstrates an IC50 of 12.5 μg/mL against Alternaria solani. This compound exhibits significant antifungal activity by inhibiting fungal mycelial growth, making it a valuable tool in the study of fungal infections. Research applications include understanding mechanisms of fungal pathogenicity and exploring therapeutic strategies for fungal diseases. -
Antibiotic, PKC Inhibitor
RK-286D is a potent antibiotic and selective protein kinase C (PKC) inhibitor that exhibits significant antimicrobial properties. This compound effectively inhibits bleb formation induced by phorbol 12,13-dibutyrate (PDBu) and demonstrates notable activity in vitro against PKC. RK-286D is suitable for research applications exploring microbial resistance and PKC-related cellular signaling pathways. -
Fungal Inhibitor
Benz[g]isoquinoline-5,10-dione is a potent fungal inhibitor derived from the ethanolic extract of Mitracarpus scaber. It exhibits significant in vitro activity against various pathogens associated with AIDS, as well as notable antibacterial and antifungal effects demonstrated through agar well-diffusion assays. This compound is valuable for research applications focused on antimicrobial activity and the development of therapeutic strategies against opportunistic infections. -
Prp8 intein Inhibitor
Antifungal agent 151 is a selective inhibitor of the Prp8 intein, targeting its self-splicing mechanism and disrupting the maturation of the Prp8 protein. This compound demonstrates significant in vitro antifungal activity against Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent 151 is valuable for research applications focused on cryptococcal pneumonia and related fungal infections. -
Fungal Inhibitor
13-Hydroxy-9-octadecenoic acid is a hydroxy unsaturated fatty acid (HUFA) that functions as a fungal inhibitor. This compound exhibits notable antifungal properties, making it valuable in the study of fungal growth and pathogenicity. It is suitable for research applications focused on fungal diseases and the development of antifungal therapies. -
CYP51 Inhibitor
Pipercroside B is a potent inhibitor of CYP51, an essential enzyme in sterol biosynthesis. Isolated from Piper crocatum Ruiz & Pav, this compound exhibits significant antifungal activity, making it valuable for research into antifungal therapeutics. Its role in modulating CYP51 provides insights into fungal metabolism and potential treatment strategies against fungal infections. -
Pyruvate Kinase Inhibitor
PKR-IN-1 is an inhibitor of pyruvate kinase, demonstrating potent antifungal activity with an EC50 of 0.21 μg/mL against Rhizoctonia solani. Its primary mechanism involves the inhibition of glycolytic metabolism, which is crucial for fungal growth and survival. This compound is valuable for research applications focused on the development of antifungal strategies and the study of metabolic pathways in fungi. -
Fungal Inhibitor
Etisazole is a potent antifungal agent primarily targeting fungal infections. It exhibits significant antifungal activity against various dermatophytes and yeast species, making it valuable in studying skin-related fungal infections. Its skin sensitizing properties also provide insight into dermal reactions and safety assessments for antifungal therapies. This compound is applicable in both in vitro and in vivo research settings to explore antifungal efficacy and skin interaction mechanisms. -
Fungal Inhibitor
Demethoxypiplartine is an amide alkaloid derived from Piper flaviflorum and Piper sarmentosum, exhibiting potent antifungal activity. It demonstrates efficacy against Cryptococcus neoformans, with an IC50 value of 18.1 μg/mL. This compound is valuable for researchers investigating antifungal mechanisms and developing therapeutic strategies for fungal infections. -
Chitin synthase Inhibitor
Chitin Synthase Inhibitor 1 is a potent and selective inhibitor of chitin synthase (CHS) with an IC50 value of 0.12 mM. This compound exhibits significant antifungal activity against drug-resistant fungal variants, making it a valuable tool for research in antifungal drug development and fungal pathogenesis studies. Its mechanism of action provides insight into chitin metabolism and its role in fungal cell wall synthesis. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 9 is a selective inhibitor of chitin synthase (CHS), which plays a critical role in fungal cell wall synthesis. This compound exhibits broad-spectrum antifungal activity, making it suitable for investigating fungal infections. It serves as a valuable tool in research aimed at understanding the mechanisms of fungal pathogenesis and evaluating potential therapeutic strategies against fungal diseases. -
Antibacterial Agent, Antifungal Agent, Cell Proliferation Inhibitor
Deacetylnomilin, derived from Citrus reticulata, exhibits significant antibacterial and antifungal properties. Additionally, it serves as a potent inhibitor of cell proliferation, demonstrating an IC50 value of 0.005 µg/mL against estrogen receptor-positive (ER+) cells. This compound is valuable for research in microbiological studies and cancer biology. -
Succinate Dehydrogenase Inhibitor
Siccanin is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.9 μM with selective activity across species. In addition to its role as an SDH inhibitor, Siccanin demonstrates antimicrobial properties against pathogenic fungi. This compound is valuable for research applications focused on metabolic processes and the treatment of fungal infections. -
Succinate Dehydrogenase Inhibitor
SDH-IN-7 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 26 nM against porcine SDH. This compound demonstrates significant fungicidal activity, making it a valuable tool for research applications focused on mitochondrial metabolism and fungal pathogenicity. Its inhibitory effect on SDH suggests potential implications in cancer research and metabolic studies. -
Fungal Inhibitor
NSC-670224 is a potent fungal inhibitor that demonstrates toxicity to Saccharomyces cerevisiae with an LC50 of 3.2 μM. This compound is useful for studying the effects of fungal inhibition and can serve as a vital tool in antifungal research and the exploration of yeast biology. -
Cyclic AMP Phosphodiesterase Inhibitor, Antifungal Agent
Sequosempervirin B is a norlignan that acts as an inhibitor of cyclic AMP phosphodiesterase, demonstrating notable antifungal activity. Isolated from the branches and leaves of Sequoia sempervirens, this compound is significant in the study of fungal infections and the modulation of intracellular signaling pathways. Its ability to inhibit cyclic AMP degradation positions it as a valuable tool for research in both pharmacology and mycology. -
Chitin Deacetylase Inhibitor
CDA-IN-2 is a potent inhibitor of chitin deacetylase (CDA), effectively targeting the enzymes PxCDA1 and PxCDA2 in the pathogen P. xanthii. At a concentration of 100 μM, CDA-IN-2 demonstrates significant antifungal activity, achieving inhibition rates of 83.7% and 74.5%, respectively. This compound is valuable for research into managing agricultural fungal diseases, particularly against resistant strains of powdery mildew and Botrytis cinerea. -
1,3-β-glucan Synthase Inhibitor
Arborcandin D is a potent inhibitor of 1,3-β-glucan synthase, functioning as an effective antifungal antibiotic. It demonstrates notable inhibitory activity with IC50 values of 3 μg/mL against Candida albicans and 0.35 μg/mL against Aspergillus fumigatus. Furthermore, Arborcandin D exhibits a minimal inhibitory concentration (MIC) of 4 μg/mL against the Candida genus, making it a valuable tool for research on fungal infections and treatment development. -
Fungal Inhibitor
Antifungal agent 20 is a potent fungal inhibitor that demonstrates significant antifungal activity against a range of pathogens, including Colletotrichum gloeosporioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum. This compound is utilized in research applications focusing on fungal diseases, providing a valuable tool for studying plant pathology and developing effective control measures. -
Fungal Inhibitor
Apigeninidin chloride is a 3-deoxyanthocyanidin that serves as a potent fungal growth inhibitor. Its unique structure imparts bioactive properties, making it useful as a red biocolorant in various applications. This compound is valuable for studying fungal biology and exploring potential antifungal strategies in research settings. -
1,3-β-glucan Synthase Inhibitor
Arborcandin E is a potent inhibitor of 1,3-β-glucan synthase, functioning as an effective antifungal antibiotic. It demonstrates remarkable inhibitory activity with IC50 values of 0.1 μg/mL for Candida albicans and 0.012 μg/mL for Aspergillus fumigatus. Arborcandin E also shows a minimum inhibitory concentration (MIC) range of 0.5-2 μg/mL against various Candida species, making it a valuable tool for studying fungal infections and potential therapeutic applications. -
Fungal Inhibitor
Isohemigossylic acid lactone 2-methyl ether is a sesquiterpene lactone that acts as a fungal inhibitor, specifically targeting Verticillium dahliae. It demonstrates significant antifungal activity, inhibiting conidial growth with an ED50 of 7.8 μg/mL. Sourced from the roots of Bombax malbaricum, this compound is particularly useful for research applications focused on Verticillium dahliae infections and related fungal pathogenicity studies. -
1,3-β-glucan Synthase Inhibitor
Arborcandin B is a potent inhibitor of 1,3-β-glucan synthase, functioning as an antifungal agent. It demonstrates notable biological activity with IC50 values of 0.30 μg/mL against Candida albicans and 0.025 μg/mL against Aspergillus fumigatus. Arborcandin B also reveals a minimum inhibitory concentration (MIC) of 2-4 μg/mL against various species within the genus Candida, making it a valuable tool for research in antifungal mechanisms and therapies. -
Pdr5p Inhibitor
Norbatzelladine L is a selective inhibitor of the Pdr5p transporter, demonstrating significant inhibition of its catalytic and functional activities. With an IC50 of 3.8 µM, Norbatzelladine L effectively suppresses Pdr5p ATPase activity. This compound exhibits a broad spectrum of biological activities, including antifungal, antiparasitic, antiviral, antibacterial, and antitumoral effects, making it a valuable tool for diverse research applications in microbiology and cancer studies. -
Fungal Inhibitor
Hexamide is a potent fungal inhibitor primarily targeting Trichophyton species. Its efficacy makes it a valuable compound for studying fungal infections and evaluating antifungal therapies. This reagent can be utilized in various research applications involving mycology and the development of antifungal agents. -
Fungal Inhibitor
Aleurodiscal is a fungal inhibitor derived from Aleurodiscus mirabilis. It demonstrates significant antifungal activity, making it a valuable tool in the study of fungal infections. This compound can be utilized in research applications focused on understanding fungal pathogenesis and developing antifungal therapies. -
Fungal Inhibitor
Stilbamidine is a diamidine compound that targets fungal infections by inhibiting fungal growth. Primarily utilized in its crystalline isethionate salt form, this reagent is effective against a range of fungi, making it valuable for research applications involving fungal pathology and treatment mechanisms. Its biochemical properties support studies focused on antifungal activity and resistance mechanisms in various fungal species. -
SDH Inhibitor
SDH-IN-25 is a selective inhibitor of succinate dehydrogenase (SDH), with an IC50 value of 4.82 mg/L. This compound displays significant antifungal activity by disrupting respiratory metabolism through its binding to complex II, consequently inducing hyphal morphology changes, generating reactive oxygen species (ROS), and affecting mitochondrial membrane potential (MMP) in fungal mycelia. SDH-IN-25 is suitable for research applications focused on agricultural disease management and the development of novel antifungal strategies. -
Fungal Inhibitor
Fungicide5 is a potent fungal inhibitor that specifically targets succinate dehydrogenase, exhibiting an inhibitory constant (Ki) of 0.095 μM. This compound is designed for research applications in evaluating antifungal properties and exploring metabolic pathways in fungi. Its selective action makes it a valuable tool for studying fungal biology and developing antifungal strategies. -
14α-Demethylase Inhibitor
14α-Demethylase-IN-1 is a selective inhibitor of 14α-demethylase, primarily targeting fungal biosynthesis pathways. This compound demonstrates significant antifungal activity, exhibiting MIC50 values of 2.47 μM against C. albicans, 1.23 μM against C. parapsilosis, and 19.70 μM against both C. krusei and C. glabrata over a 48-hour period. 14α-Demethylase-IN-1 is valuable for research focused on antifungal resistance mechanisms and the development of novel antifungal therapies. -
Pah Inhibitor
Phosphatase-IN-1 is a phosphatidate phosphatase (Pah) inhibitor that selectively targets MoPah1 with an affinity constant of 19.8 μM. This compound demonstrates significant antifungal activity, effectively inhibiting the growth of various plant pathogens. Importantly, Phosphatase-IN-1 exhibits low toxicity towards rice seedlings and wheat heads, making it a valuable tool for research in plant pathology and agricultural applications. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 13 is a non-competitive inhibitor specifically targeting chitin synthase, demonstrating an IC50 value of 106.7 μM. This compound exhibits broad-spectrum antifungal activity, making it a valuable tool for research in fungal biology and the development of antifungal therapies. Its mechanism of action can provide insights into chitin biosynthesis and contribute to the understanding of fungal cell wall integrity. -
Fungal Inhibitor
Bac2A TFA is an antimicrobial peptide that acts as a potent inhibitor of fungal pathogens. This linear variant of bactenecin exhibits significant antifungal activity, making it suitable for research applications focused on fungal infections and immunomodulation studies. Its unique properties offer potential insights into host-pathogen interactions and the development of novel therapeutic strategies against fungal diseases. -
Chitin Synthase Inhibitor
Chitin Synthase Inhibitor 5 specifically targets chitin synthase, demonstrating an IC50 value of 0.14 mM. This compound exhibits broad-spectrum antifungal activity in vitro, effectively inhibiting the growth of Candida albicans, Aspergillus flavus, Aspergillus fumigatus, and Cryptococcus neoformans. Chitin Synthase Inhibitor 5 is valuable for research focused on fungal pathogenesis and potential therapeutic strategies against fungal infections. -
Fungal Inhibitor
Deoxyviolacein is a bacterial metabolite that acts as a potent fungal inhibitor. It demonstrates significant antifungal activity against Rhizoctonia solani at a concentration of 2 mg/mL. Additionally, Deoxyviolacein exhibits antibacterial properties against Gram-positive bacteria, such as Staphylococcus aureus, Bacillus subtilis, and Bacillus megaterium, with effective inhibition observed at 125 μg/mL. This compound has potential applications in cancer research, particularly in inhibiting the proliferation of hepatocellular carcinoma cells at concentrations ranging from 0.1 to 1 μM. -
Fungal Inhibitor
Benzyl 2-hydroxy-6-methoxybenzoate acts as a potent fungal inhibitor, demonstrating significant antifungal activity with an IC50 of 25–26 μg/mL against various fungal strains. This compound is valuable in research focused on antifungal drug development and investigating fungal resistance mechanisms. Its efficacy makes it a promising candidate for further exploration in therapeutic applications against fungal infections. -
Fungal Inhibitor
Antifungal agent 67 is an imidazole compound that targets fungal pathogens, demonstrating significant efficacy against Candida species. This agent exhibits a CC50 value of 33.6 μM in healthy neonatal rat cardiomyoblasts, indicating its potential impact on cellular viability. Antifungal agent 67 is suitable for research applications concerning antifungal mechanisms and the development of therapeutic strategies against fungal infections. -
1,3-β-glucan Synthase Inhibitor
Arborcandin C is a potent inhibitor of 1,3-β-glucan synthase, functioning as an antifungal antibiotic. It demonstrates strong biological activity with IC50 values of 0.15 μg/mL against Candida albicans and 0.015 μg/mL against Aspergillus fumigatus. Furthermore, Arborcandin C exhibits a minimum inhibitory concentration (MIC) of 1-2 μg/mL against various Candida species, making it valuable for research into antifungal mechanisms and treatments. -
Conidia Inhibitor
Carviolin is a conidia inhibitor derived from the mycelia of the ascomycete Neobulgaria pura. It effectively inhibits the formation of appressoria in germinating conidia of Magnaporthe grisea on hydrophobic surfaces. While exhibiting moderate cytotoxicity, Carviolin does not possess antifungal, antibacterial, or phytotoxic activities, making it a useful tool for studies focused on fungal germination and pathogenesis. -
Fungal Inhibitor
Ophiobolin B is a sesterterpene metabolite derived from Helminthosporium oryzae, primarily functioning as a fungal inhibitor. This compound effectively inhibits proton extrusion in maize coleoptiles, while also blocking fusicoccin-promoted proton extrusion, potassium uptake, and subsequent cell enlargement. With minimal inhibitory concentration (MIC) values ranging from 25 to 50 μg/mL, Ophiobolin B demonstrates significant antifungal activity against various zygomycetes, making it valuable for research in plant-fungal interactions and cellular physiology. -
Antifungal Agent/C-4 Sterol Methyl Oxidase Inhibitor
PF-1163A is an antifungal agent that functions as a C-4 sterol methyl oxidase inhibitor, effectively disrupting ergosterol synthesis with an IC50 of 12 ng/mL. This compound demonstrates notable antifungal activity, characterized by a minimum inhibitory concentration (MIC) of 12.5 µg/mL. PF-1163A is valuable for research applications focused on fungal infections and the mechanistic understanding of ergosterol biosynthesis. -
Chitin Deacetylase Inhibitor
AnCDA-IN-1 is a selective inhibitor of chitin deacetylase (CDA), demonstrating significant antifungal properties. It exhibits an IC50 value of 4.24 μM against AnCDA from Aspergillus nidulans and shows a minimum inhibitory concentration (MIC) of 260 μg/mL against various food spoilage and plant pathogenic fungi, with a minimum fungicidal concentration (MFC) of 520 μg/mL. This compound is valuable for research in the antifungal domain, particularly in understanding CDA's role in fungal cell wall integrity and potential therapeutic applications. -
Hyphal Formation Inhibitor
2-Dodecanol is an effective hyphal formation inhibitor with targeted activity against Candida albicans. By inhibiting SIR2 expression, it disrupts the morphological transition essential for pathogenicity. This compound is valuable for researchers studying fungal biology and the mechanisms of infection, as well as for developing potential antifungal strategies. -
Glutamate Transport Inhibitor
Avenaciolide is a bis-γ-lactone derived from Aspergillus avenaceus that acts as a specific inhibitor of glutamate transport. This compound demonstrates antifungal and antibacterial properties while also interfering with the stimulatory effect of ADP on glutamate oxidation in rat liver mitochondria. Avenaciolide's unique mechanism makes it valuable for studying metabolic processes and the regulation of glutamate transport in cellular and mitochondrial contexts. -
Succinate Dehydrogenase Inhibitor
SDH-IN-3 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 of 7.2 μg/mL. This compound exhibits significant antifungal activity against Nigrospora oryzae, with an EC50 of 1.9 μg/mL. SDH-IN-3 is suitable for research applications focused on anti-infection studies and the modulation of metabolic pathways in fungal pathogens. -
SARS CoV-2 3CLpro Inhibitor
SARS-CoV-2 3CLpro-IN-4 is a potent inhibitor of the SARS-CoV-2 3CL protease, a critical enzyme for viral replication. This compound exhibits significant antiviral activity, making it relevant for research in COVID-19 therapeutics. Its broad-spectrum impact also extends to antibacterial and antifungal activities, aiding investigations into multi-faceted infectious disease mechanisms. -
Ras Inhibitor
Antifungal agent 46 is a potent Ras inhibitor that targets protein farnesyltransferase, effectively disrupting Ras signaling pathways. This compound demonstrates significant antifungal activity and holds potential for research applications focused on understanding Ras-related mechanisms in fungal infections. Studies may explore its utility in elucidating the role of Ras in cellular signaling and its implications in therapeutic developments. -
Fungal Inhibitor
Antibacterial agent 188 is a potent fungal inhibitor that targets dermatophyte activity. This compound demonstrates significant antifungal properties, making it suitable for research applications focused on fungal infections and dermatological studies. Its mechanism of action involves disrupting fungal cell processes, thereby inhibiting growth and proliferation. -
Succinate Dehydrogenase Inhibitor
Harzianopyridone is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 80 nM. Isolated from the fungus Trichoderma harzianum, this compound demonstrates significant antifungal, antibacterial, and herbicidal properties. Harzianopyridone is valuable for research applications exploring metabolic modulation and the study of fungal and bacterial pathways. -
Gamma-Glutamyl Transferase Inhibitor
Gamma-Glutamyl Transferase-IN-1 is a potent inhibitor of gamma-glutamyl transferase, specifically designed to disrupt its enzymatic function. This β-carboline 1-hydrazide compound exhibits significant antifungal and antibacterial activities by promoting the accumulation of reactive oxygen species, leading to cell membrane disruption and alterations in histone acetylation. It serves as a valuable tool for research investigating the roles of gamma-glutamyl transferase in various biological processes and disease states.
