Antiviral agent 35 is a potent inhibitor of influenza virus replication, functioning effectively during the early stages of the viral life cycle. It reduces reactive oxygen species (ROS) accumulation, as well as autophagy and apoptosis induced by the virus, while also mitigating the inflammatory response mediated by the RIG-1 pathway in mouse models of pulmonary infection. This compound exhibits low cytotoxicity, with a CC50 greater than 800 μM in MDCK cells, and demonstrates anti-H1N1 activity with an EC50 of 2.28 μM, making it a valuable tool for research on influenza virus inhibition.
Antiviral agent 35 is a potent inhibitor of influenza virus replication, functioning effectively during the early stages of the viral life cycle. It reduces reactive oxygen species (ROS) accumulation, as well as autophagy and apoptosis induced by the virus, while also mitigating the inflammatory response mediated by the RIG-1 pathway in mouse models of pulmonary infection. This compound exhibits low cytotoxicity, with a CC50 greater than 800 μM in MDCK cells, and demonstrates anti-H1N1 activity with an EC50 of 2.28 μM, making it a valuable tool for research on influenza virus inhibition.
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