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Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial Inhibitor
Griselimycin is a cyclic lipopeptide that functions as a bacterial inhibitor by specifically binding to the sliding clamp of bacterial DNA polymerase, while exhibiting no interaction with human proliferating cell nuclear antigen (PCNA). This compound demonstrates potent antibacterial activity against Mycobacterium tuberculosis, including drug-resistant strains, and various Gram-negative bacteria. Griselimycin is useful in research applications focused on bacterial DNA replication and the development of new antibacterial therapeutics. -
β-lactamase Inhibitor
FPI-1523 is a potent β-lactamase inhibitor targeting CTX-M-15 and OXA-48, exhibiting dissociation constants (Kd) of 4 nM and 34 nM, respectively. Additionally, it inhibits penicillin-binding protein 2 (PBP2) with an IC50 of 3.2 μM. FPI-1523 demonstrates significant antimicrobial activity, making it a valuable reagent for research in antibiotic resistance and bacterial infection studies. -
Beta-lactamase Inhibitor
BLI-489 is a potent beta-lactamase inhibitor that effectively targets class A, class C (AmpC), and class D beta-lactamase producing pathogens. When used in combination with Piperacillin, BLI-489 enhances antimicrobial activity, providing a therapeutic strategy against infections caused by resistant bacteria. This compound is essential for research aimed at understanding and overcoming beta-lactam resistance mechanisms in clinical pathogens. -
Bacterial Inhibitor
Ganoderol A is a terpenoid derived from Ganoderma lucidum that acts as a bacterial inhibitor. It demonstrates antimicrobial properties and plays a role in inhibiting the cholesterol synthesis pathway. Additionally, Ganoderol A exhibits significant anti-inflammatory effects and provides protection against ultraviolet A (UVA) damage, making it valuable for research in microbial resistance and skin protection strategies. -
Bacterial Inhibitor
(5α)-Stigmastane-3,6-dione is a naturally occurring sterol with antibacterial properties. It functions by inhibiting bacterial growth, making it valuable for research in antimicrobial applications. Its isolation from Ailanthus altissima Swingle highlights its natural origins and potential utility in studies exploring microbial resistance and antibiotic development. -
Bacterial Inhibitor
Primin is a natural product that acts as a bacterial inhibitor, primarily targeting microbial growth. Isolated from the trichomes of Primula obconica, it exhibits significant antimicrobial and antitumor activities. This compound is valuable in research focused on developing antibacterial agents and cancer therapeutics. Its unique properties make it a useful tool for investigating bactericidal mechanisms and potential therapeutic applications. -
Bacterial Inhibitor
Cowaxanthone B is a xanthone compound derived from the fruits of Garcinia cowa, primarily targeting bacterial pathways. This agent exhibits moderate antibacterial activity and may be utilized in research contexts aimed at understanding bacterial inhibition mechanisms. Its potential applications include the study of antimicrobial resistance and the development of new antibacterial agents. -
Bacterial Inhibitor
Parasin I is a 19-amino acid peptide derived from histone H2A, exhibiting significant antimicrobial properties primarily against bacterial pathogens. This peptide serves as a bacterial inhibitor, making it a valuable tool for research focused on microbial resistance and the development of new antimicrobial agents. Its unique mechanism of action may provide insights for therapeutic applications in infectious disease management. -
Bacterial Inhibitor
Cinnamylideneacetic acid is a bacterial inhibitor that engages in a photoinduced [2+2] cycloaddition reaction. This compound exhibits significant antibacterial activity, making it a valuable tool for research on bacterial resistance mechanisms and the development of new antimicrobial agents. Its photoresponsive properties allow for the exploration of light-activated therapies in microbial systems. -
Bacterial Inhibitor
Triclosan-methyl is a transformation product of triclosan, functioning primarily as a bacterial inhibitor. It exhibits significant antimicrobial activity, making it relevant for applications in assessing bacterial resistance and efficacy of antimicrobial compounds. This compound is commonly utilized in research related to personal care products and their environmental impact, particularly in evaluating the persistence and degradation of antibacterial agents. -
Bacterial Inhibitor
(+)-Viroallosecurinine is a potent antibacterial alkaloid that acts as a bacterial inhibitor. It demonstrates significant antimicrobial activity, with a minimum inhibitory concentration (MIC) of 0.48 μg/mL against Pseudomonas aeruginosa and Staphylococcus aureus. This compound is suitable for research applications focused on understanding bacterial resistance and developing novel antibacterial agents. -
Bacterial Inhibitor
Ribocil-C (R enantiomer) is a selective inhibitor targeting bacterial riboflavin riboswitches. This compound disrupts riboflavin biosynthesis by binding to specific RNA structures, effectively inhibiting bacterial growth. It is useful in research applications focusing on bacterial gene regulation and the development of novel antimicrobial strategies. -
PRRSV Inhibitor
Atractylodinol is a potent inhibitor of the porcine reproductive and respiratory syndrome virus (PRRSV). It exerts its antiviral activity by binding to vimentin, leading to the inhibition of TGF-β receptor I recycling and the formation of filamentous aggregates. This compound is valuable for research focused on understanding PRRSV pathogenesis and developing therapeutic strategies against viral infections in swine. -
Metallo-β-Lactamase Inhibitor
Thiomandelic acid is a potent inhibitor of metallo-β-lactamases, specifically targeting zinc-dependent enzymes. It exhibits broad-spectrum antibacterial activity by effectively preventing the hydrolysis of β-lactam antibiotics. This compound is valuable for research applications focused on antibiotic resistance mechanisms and the development of novel therapeutics against resistant bacterial infections. -
Bacterial Inhibitor
Chloroneb is a bacterial inhibitor with fungicidal properties that effectively protects plants. It is utilized in analytical applications for the detection of organochlorine pesticide residues, demonstrating excellent selectivity, stability, and reproducibility. Chloroneb has been successfully applied in the analysis of various samples, including licorice, cucumber, river water, and soil, providing reliable results for environmental monitoring and agricultural research. -
Bacterial Inhibitor
Amifloxacin is a synthetic antibacterial agent belonging to the quinolone class, primarily targeting bacterial DNA gyrase and topoisomerase IV. This compound exhibits potent bactericidal activity against a broad spectrum of gram-negative and gram-positive bacteria. It is commonly utilized in research applications for studying bacterial infections and evaluating the efficacy of antibiotic treatments. -
Bacterial Inhibitor
Lavendamycin is a quinolinedione with antimicrobial properties, primarily acting as a bacterial inhibitor. It demonstrates significant antibacterial and antitumor activity, making it a valuable compound for research in microbiology and cancer biology. Its unique mechanism and efficacy position Lavendamycin as a potential tool for exploring therapeutic approaches against bacterial infections and tumors. -
Bacterial Inhibitor
Dodine is a bacterial inhibitor with fungicidal properties, primarily targeting various plant pathogens. It is effective in controlling diseases such as black spot in apples, pears, and pecans, as well as brown rot in peaches, along with a range of foliar diseases affecting strawberries, cherries, jacaranda, and black walnuts. In addition to its agricultural applications, Dodine serves as an industrial biocide and preservative, making it valuable in diverse research settings focused on plant disease management and microbial control. -
Bacterial Inhibitor
Meso-2,6-Diaminopimelic acid serves as a critical biosynthetic precursor in the synthesis of the essential amino acid L-lysine. It plays a vital role in the formation of peptidoglycan, a key structural component of the cell walls in various bacterial species. This compound is primarily utilized in research related to bacterial inhibition and the study of cell wall biosynthesis, making it essential for antimicrobial investigations and the development of antibacterial agents. -
Bacterial Inhibitor
D-Homoserine lactone is a bacterial inhibitor that functions as a signaling molecule regulating quorum sensing through its interaction with acyl-homoserine lactone (AHL) synthase RhlI. By inhibiting RhlI activity, D-Homoserine lactone disrupts bacterial communication, making it a valuable tool in studies of bacterial behavior and pathogenicity. Additionally, as an enantiomer of L-homoserine lactone, it serves as an inhibitor of serine hydroxymethyltransferase, expanding its potential applications in biochemical research and synthetic biology. -
Bacterial Inhibitor
Afabicin disodium is a specialized bacterial inhibitor that functions as a proagent for Debio1452. It specifically targets Staphylococcus species while exhibiting minimal activity against other Gram-positive and Gram-negative bacteria. The active form, Debio1452, is an inhibitor of FabI, an enzyme essential for fatty acid biosynthesis in staphylococci, making it a valuable tool for research in combating staphylococcal infections. -
β-lactamase Inhibitor
Xeruborbactam bis-acetoxy methyl ester is a boronic acid derivative that functions as a β-lactamase inhibitor. This compound effectively targets β-lactamase enzymes, providing a mechanism to counteract antibiotic resistance in bacterial strains. It is primarily utilized in research focused on developing novel antibacterial therapies and studying the mechanisms of β-lactamase-mediated resistance. -
Bacterial Inhibitor
Epinecidin-1 is a potent antimicrobial peptide derived from the orange-spotted grouper (Epinephelus coioides), targeting various bacterial strains. It exhibits substantial antibacterial, antifungal, antiviral, and antiprotozoal activity, making it a valuable tool in studies examining microbial inhibition. Additionally, its immunomodulatory and wound healing properties further support research applications in infection control and regenerative medicine. -
Bacterial Inhibitor
Tuberculosis Inhibitor 3 (Compound 2i) is a potent antibacterial agent targeting Mycobacterium tuberculosis, demonstrating a minimum inhibitory concentration (MIC) of less than 0.016 μg/mL against both sensitive and resistant strains. This compound exhibits favorable pharmacokinetic properties, including adequate oral bioavailability, making it a promising candidate for further research and development in tuberculosis treatment strategies. -
Bacterial Translation Inhibitor
NOSO-502 is a bacterial translation inhibitor that targets ribosomal activity in Enterobacteriaceae. It demonstrates potent antibacterial properties while maintaining a favorable safety profile. This compound is suitable for research applications focused on bacterial protein synthesis and the development of novel antimicrobial agents. -
Bacterial Inhibitor
Antitubercular agent-10 is a bacterial inhibitor that demonstrates potent antitubercular activity, exhibiting a minimum inhibitory concentration (MIC) of 30 nM. This compound is primarily utilized in research focused on combating tuberculosis, enabling investigations into its mechanisms of action and potential therapeutic strategies. Its effectiveness makes it a valuable tool for studying mycobacterial infections and the development of novel antitubercular therapies. -
Bacterial Inhibitor
CGI-17341 is a 5-nitroimidazole antibacterial agent targeting bacterial pathogens, specifically Mycobacterium tuberculosis. This compound demonstrates significant inhibitory activity against both sensitive and multidrug-resistant strains of M. tuberculosis in vitro. In vivo studies indicate that CGI-17341 can prolong the survival time of infected mice in a dose-dependent manner, making it a valuable tool for research on tuberculosis and related bacterial infections. -
Bacterial Inhibitor
Cephabacin M4 is a cephalosporin derivative, specifically a 7-methoxydesacetylcephalosporin, that functions as a bacterial inhibitor. It exhibits significant antimicrobial activity against a range of bacterial pathogens, making it valuable for research involving antibiotic development and bacterial resistance studies. Isolated from the culture filtrate of Xanthomonas lactamica, Cephabacin M4 serves as a useful tool in exploring cephalosporin efficacy and mechanisms of action. -
Metallo-β-lactamase Inhibitor
Metallo-β-lactamase-IN-16 is a potent metallo-β-lactamase inhibitor targeting critical enzymes responsible for antibiotic resistance. This sulfone-containing compound shows significant antibacterial activity by effectively inhibiting NDM-1, IMP-1, VIM-1, and VIM-2, with IC50 values of 0.16 nM, 0.23 nM, 0.31 nM, and 1.0 nM, respectively. It serves as a valuable tool for research in combating bacterial infections and understanding the mechanisms of antibiotic resistance. -
Bacterial Inhibitor
Antibacterial agent 202 (compound 45c) is a bacterial inhibitor that targets Gram-negative bacteria, demonstrating significant antibacterial activity against strains such as Escherichia coli, Klebsiella pneumoniae, and especially Pseudomonas aeruginosa, with a minimum inhibitory concentration (MIC) ranging from 7.8 to 31.25 μM. This compound functions by disrupting the integrity of bacterial cell membranes, making it a valuable tool for research into bacterial infections and potential therapeutic applications. -
Bacterial Inhibitor
BPH-651 is a bacterial inhibitor that targets dehydrosqualene synthase, an essential enzyme involved in bacterial terpenoid biosynthesis. This compound exhibits potent antibacterial activity by binding to multiple sites on the enzyme, revealing structural insights into the mechanism of action and inhibition of head-to-head prenyltransferase. BPH-651 is useful for research focused on designing new antibacterial agents and studying bacterial resistance mechanisms. -
Bacterial Inhibitor
Antistaphylococcal agent 1 functions as a bacterial inhibitor, specifically targeting Staphylococcus species. This compound exhibits significant antimicrobial activity, making it a valuable tool in the study of bacterial infections and resistance mechanisms. Its application can aid in the development of novel therapeutic strategies against staphylococcal infections. -
Bacterial Inhibitor
(Rac)-DNDI-8219 is a bacterial inhibitor with demonstrated efficacy against Leishmania species. This compound exhibits potent antituberculosis and anti-leishmanial activities, showcasing significant effectiveness in both the Leishmania donovani mouse model and the Leishmania infantum hamster model. Interestingly, the R-6 candidate form of (Rac)-DNDI-8219 offers excellent oral bioavailability and efficacy in the hamster model, making it a valuable tool for research focused on treating leishmaniasis and tuberculosis. -
Bacterial Inhibitor
Acaterin is a bacterial inhibitor derived from Pseudomonas, known for its role in antimicrobial activity. Research indicates that its biosynthesis is regulated through a complex gene cluster, with studies highlighting its associated biosynthetic pathway. Comparative transcriptomics further demonstrates the compound's formation is intricately linked to bacterial regulatory networks, making it valuable for studies in bacterial physiology and the development of new antimicrobial strategies. -
Bacterial Inhibitor
8-Epidiosbulbin E acetate is a furanoid compound derived from Dioscorea bulbifera L. It functions as a bacterial inhibitor, demonstrating broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. Additionally, it has been noted to induce liver injury in murine models, highlighting its potential impact on liver function. This compound is valuable for research involving antibiotic resistance and bacterial pathogenicity. -
Bacterial Inhibitor
FtsZ-IN-10 is a bacterial division inhibitor that targets the assembly of FtsZ, a critical protein involved in bacterial cytokinesis. By binding specifically to Bacillus subtilis FtsZ monomers, FtsZ-IN-10 disrupts their polymerization, ultimately hindering the formation of the Z ring and inhibiting cell division. This compound has demonstrated efficacy against antibiotic-resistant clinical isolates, including Staphylococcus aureus and Enterococci, making it a valuable tool in microbiological research and antibiotic development. Additionally, FtsZ-IN-10 may stimulate nucleotide-free archaeal FtsZ to form structured polymers, contributing to its versatile applications in studying bacterial growth and division mechanisms. -
Metallo-β-Lactamase Inhibitor
EBL-3183 is a potent inhibitor of metallo-β-lactamases (MBLs) that targets the NDM-1 enzyme. This indole-2-carboxylate compound exhibits reversible, non-covalent, and competitive inhibition characterized by a pIC50 value of 7.7. EBL-3183 is valuable for research applications focused on combating antibiotic resistance and exploring mechanisms of MBL inhibition. -
β-lactamase Inhibitor
Xeruborbactam methoxy acetoxy methyl ester is a boronic acid derivative specifically designed as a β-lactamase inhibitor. This compound effectively inhibits the enzymatic activity of β-lactamases, which are responsible for antibiotic resistance in various bacterial strains. It is primarily utilized in research applications aimed at understanding β-lactamase mechanisms and developing novel antimicrobial therapies. -
Bacterial Inhibitor
Ianthelliformisamine C ditrifluoroacetate is a bacterial inhibitor that enhances the activity of antibiotics against resistant Gram-negative bacteria. This compound has been shown to significantly improve the efficacy of doxycycline against Pseudomonas aeruginosa. Its mechanism of action involves inducing ATP efflux and causing membrane depolarization in bacterial cells. Ianthelliformisamine C ditrifluoroacetate is synthesized using peptide coupling, resulting in high chemical yields ranging from 27% to 91%, making it a valuable tool for research in combating antibiotic resistance. -
Bacterial Inhibitor
Protactin is a pentapeptide lactone that targets bacterial growth, derived from the Streptomyces cucumeris strain L703-4 (ATCC 53784). This compound demonstrates significant antioxidant properties and can be converted to actinomycin Zp through ferrocyanide oxidation, which displays potent antibacterial activity in vitro. Additionally, actinomycin Zp has been shown to possess substantial antitumor effects against P-388 leukemia in murine models, making it a valuable reagent for cancer research and microbiological studies. -
Bacterial Inhibitor
Cyclo(Leu-Ala) is a cyclic dipeptide with demonstrated antimicrobial properties targeting bacterial pathogens. This compound exhibits significant inhibitory activity against various plant pathogens, making it a valuable tool in studies involving plant-microbe interactions and the development of novel antimicrobial agents. Its potential applications include agricultural research and the investigation of natural products for controlling plant diseases. -
Bacterial Inhibitor
Haplopine is a bacterial inhibitor that exhibits photo-activated antimicrobial properties. It demonstrates the ability to bind to DNA, making it a valuable tool for research applications focused on bacterial infections and microbial resistance. This compound is beneficial in studies investigating the mechanisms of antimicrobial action and the potential development of novel therapeutic strategies. -
Bacterial Inhibitor
Forphenicinol is a bacterial inhibitor that acts as an immunomodulator, derived from the bacterial metabolite forphenicine. It enhances the phagocytic activity of peritoneal macrophages and is effective in mitigating cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH) in murine models. Forphenicinol increases macrophage bactericidal activity against Pseudomonas aeruginosa and improves survival rates in mouse models of P. aeruginosa infection. Additionally, it demonstrates anti-tumor effects in S180 sarcoma and IMC carcinoma xenograft models, with effective dosing ranging from 0.05 to 5 mg/kg per day. -
Bacterial Inhibitor
Glyasperin D is a flavonoid derived from Glycyrrhiza uralensis that demonstrates antibacterial properties, specifically as a bacterial inhibitor against Helicobacter pylori. Its biological activity suggests potential applications in research focused on bacterial infections and the development of antibacterial agents. This compound may serve as a valuable tool in studying H. pylori-related diseases and exploring flavonoid mechanisms in bacterial inhibition. -
Bacterial Inhibitor
JM 1397 is a potent antibacterial agent with a primary mechanism of action against bacterial pathogens. It demonstrates significant antibacterial activity against both methicillin-susceptible and methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC90) of 1 μg/mL. This compound is valuable for research in antibiotic resistance and the development of new antimicrobial therapies. -
Bacterial Inhibitor
Gyramide A is a bacterial inhibitor that targets bacterial topoisomerases. It has been shown to exhibit a unique mechanism of action distinct from other topoisomerase inhibitors, highlighting its potential in studies related to bacterial resistance. Gyramide A is valuable for research applications aimed at understanding the protective effects of Qnr proteins on bacterial enzymes and developing novel antibacterial strategies. -
Bacterial Inhibitor
Acorafloxacin hydrochloride is a broad-spectrum fluoroquinolone antibacterial agent that targets bacterial DNA gyrase and topoisomerase IV. It exhibits potent activity against a range of Gram-positive bacteria, with a mean MIC90 value of 0.12 mg/L. This compound is particularly relevant for research on acute bacterial skin infections and community-acquired pneumonia, as well as the investigation of methicillin-resistant Staphylococcus aureus (MRSA) infections. -
Bacterial Inhibitor
Targeting the bacterial sliding clamp peptide 46 is a short peptide designed to inhibit the bacterial sliding clamp (SC). By interfering with SC-dependent DNA synthesis, this peptide serves as a valuable tool for studying bacterial replication mechanisms and developing novel antibacterial strategies. Its application in research underscores its potential utility in exploring bacterial growth and resistance pathways. -
β-lactamase Inhibitor
Pralurbactam is a potent β-lactamase inhibitor that enhances the antibacterial efficacy of Imipenem against Mycobacterium abscessus. Its ability to reduce pulmonary bacterial load in neutropenic mice highlights its potential as a significant therapeutic agent. This compound is valuable in research focused on infections caused by Mycobacterium abscessus complex, as well as strains of Escherichia coli and Klebsiella pneumoniae. -
Bacterial Inhibitor
Cephabacin M6 is a 7-methoxydesacetylcephalosporin that acts as a bacterial inhibitor. It is isolated from the culture filtrate of Xanthomonas lactamica and exhibits significant antibacterial activity against various bacterial strains. This compound is useful in microbiological research for studying antibiotic mechanisms and resistance patterns in bacteria.
