Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Aldicarb sulfone-13C2,d3 is a labeled version of Aldicarb sulfone, incorporating both deuterium and carbon-13 isotopes. This compound acts as a cholinesterase inhibitor and is one of the primary metabolites of the carbamate pesticide Aldicarb, showcasing notable insecticidal activity. Aldicarb sulfone-13C2,d3 is valuable for chemical research applications, particularly in studies involving pesticide metabolism and its impact on cholinergic signaling pathways. -
Anti-colorectal Cancer Agent
ACS03 is a hybrid thiophene-acridine compound that targets colorectal cancer. It enhances the activity of key enzymes such as lactate dehydrogenase, glutathione S-transferase, and acetylcholinesterase, indicating its potential role in cellular metabolism. ACS03 exhibits selective anti-cancer effects, particularly against colon carcinoma, making it a valuable reagent for research applications in cancer biology and therapy development. Additionally, it demonstrates antileishmanial activity, broadening its relevance in infectious disease research. -
COX-2 Inhibitor
Hirsutanonol, a diarylheptanoid derived from the bark of Alnus hirsute var. sibirica, functions primarily as an inhibitor of cyclooxygenase-2 (COX-2). This compound exhibits significant anti-filarial activity, demonstrated by an IC50 value of 44.11 μg/mL against microfilariae. Hirsutanonol is valuable in research focused on inflammation reduction and parasitic disease interventions. -
COX-1 Inhibitor
Dihydroflavokawin B is a selective COX-1 inhibitor, exhibiting an IC50 of 1.22 μM, with moderate effects on COX-2 and 5-LOX. This compound demonstrates significant activity against the promastigote forms of Leishmania panamensis and Leishmania braziliensis, making it a valuable tool for leishmaniasis research. Additionally, Dihydroflavokawin B inhibits rabbit platelet aggregation induced by arachidonic acid, platelet-activating factor, and adenosine diphosphate, highlighting its potential for in vitro anti-inflammatory studies. -
Pesticide
(S)-Dinotefuran is a neonicotinoid pesticide that primarily targets the α8 subunit of nicotinic acetylcholine receptors (nAChRs) in honeybees, Apis mellifera. It exhibits higher toxicity compared to its R-enantiomer, R-dinotefuran, affecting the survival and behavior of these important pollinators. This compound is utilized in ecological and toxicological research to study the impact of pesticides on non-target species and to evaluate the risks associated with neonicotinoid exposure in agricultural settings. -
Parasite
Trimethacarb is a carbamate insecticide that primarily targets the nervous system of parasites. It inhibits key cholinesterase enzymes, leading to accumulation of acetylcholine and subsequent paralysis of target organisms. This compound is commonly utilized in research settings to study pest control methods and the biochemical mechanisms underlying insecticide action against various parasites. -
Stable Isotope
Pirimiphos-methyl-d6 is a deuterium-labeled derivative of Pirimiphos-methyl, an organophosphorus insecticide and acaricide that acts primarily through the inhibition of acetylcholinesterase (AChE) in target organisms. This compound is utilized in research for the development of analytical methods and for studying the biological activities of organophosphates. Its applications extend to the investigation of pest control mechanisms and the management of storage pests in agricultural grains. -
Stable Isotope
Pirimicarb-d6 is a deuterium-labeled derivative of Pirimicarb, serving as a stable isotope for analytical research. Pirimicarb functions as a selective carbamate insecticide, effectively inhibiting acetylcholinesterase (AChE) and displaying acaricidal properties. This reagent is widely applicable in studies related to insecticide action mechanisms and environmental fate assessments of carbamate pesticides in agricultural settings. -
Insecticide
Thiacloprid is an orally active neurotoxic insecticide that functions as an agonist of nicotinic acetylcholine receptors (nAChR). It has been shown to reduce cellular viability, deplete reduced glutathione, and elevate malondialdehyde (MDA) levels, leading to cytotoxicity and oxidative stress. While Thiacloprid exhibits lower acute toxicity to honeybees compared to some other insecticides, it adversely affects their learning, memory, immune function, and overall survival. Additionally, this compound disrupts intestinal microbiota, increasing the risk of premature colony collapse in bumblebees. Thiacloprid is utilized in the broad-spectrum control of agricultural pests across various crops, including potatoes, cabbages, fruits, vegetables, and nuts. -
Stable Isotope
Triazophos-d5 is a deuterium-labeled derivative of Triazophos, a non-systemic insecticide and acaricide that primarily targets acetylcholinesterase (AChE). By covalently and irreversibly binding to the acetylcholine binding site, Triazophos-d5 inhibits the hydrolysis of acetylcholine, resulting in increased neuromuscular activity and hyperexcitability in target pests. This compound is widely utilized in research to study insect resistance and as a tracer in ecological and environmental studies, particularly concerning its effects on various soil insects and mites affecting major crops such as cotton, rice, and soybeans. -
Ingredient In Insecticide And Acaricide Compositions
Primidophos is an organophosphorus compound that functions as an inhibitor of acetylcholinesterase. Its primary application lies in the formulation of insecticide and acaricide compositions, which target a variety of insect and mite pests. This compound is valuable in research focused on pest control and management strategies in agricultural and environmental settings. -
COX Inhibitor
Serratiopeptidase is a zinc-containing metalloprotease that primarily acts as a cyclooxygenase (COX) inhibitor. It effectively reduces the release of inflammatory mediators such as prostaglandins and interleukins, alleviating pain and swelling. In addition to its anti-inflammatory properties, Serratiopeptidase exhibits mucolytic, antibiofilm, and wound-healing activities. Its enzymatic action allows it to dissolve fibrin and blood clots, while also demonstrating potential anti-Alzheimer's effects by degrading amyloid fibrils. Furthermore, Serratiopeptidase shows cytotoxicity against colon cancer cells, making it a versatile reagent for research applications in inflammation and oncology. -
CRMP2-NMDAR Inhibitor
TAT-CBD3 is a 15-amino acid peptide derived from CRMP2 that incorporates the TAT cell-penetrating motif from HIV-1, enabling efficient cellular uptake. This peptide disrupts the interaction between CRMP2 and NMDA receptors (NMDAR) while maintaining NMDAR localization. TAT-CBD3 is valuable for research applications focused on neurobiology and synaptic signaling, particularly in studies investigating the role of CRMP2 in neuronal function and related disorders. -
hDAT Modulator
SRI-32743 is an allosteric modulator of the human dopamine transporter (hDAT) with an IC50 value of 9.86 μM. This compound is of particular interest for research into HIV-Tat-induced neurotoxicity. Its modulation of hDAT may provide insights into the neurobiological mechanisms underlying dopamine dysregulation in various neurotoxic conditions. -
AChE Inhibitor
Temephos is an organophosphate insecticide that functions as an irreversible inhibitor of acetylcholinesterase (AChE). This inhibition leads to cholinergic overactivation, effectively disrupting the larval development of Aedes aegypti and Aedes albopictus, making it a valuable tool in research concerning Dengue Virus, Zika Virus, and other mosquito-borne pathogens. While exhibiting important biological activity, Temephos has been shown to cause genotoxicity, neurodevelopmental toxicity, and potential liver and reproductive system effects in mammals. Additionally, it can accumulate in adipose tissues and aquatic organisms, with its metabolism primarily occurring through oxidation and hydrolysis. Temephos serves as a critical reagent in studies of vector control and viral transmission dynamics. -
AAK1 Inhibitor
AAK1-IN-6 is a potent inhibitor of AP-2-associated protein kinase 1 (AAK1) with an IC50 value of 12 nM. This compound exhibits significant antiviral activity against dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM). AAK1-IN-6 is a valuable tool for researchers investigating antiviral mechanisms and potential therapeutic strategies. -
Dopamine Transporter Inhibitor
LH2-051 is a selective dopamine transporter (DAT) inhibitor with a Ki of 0.95 μM, effectively blocking DAT-mediated dopamine uptake with an IC50 of 3.0 μM. This compound also promotes the nuclear translocation of transcription factor EB (TFEB), enhancing lysosome biogenesis. LH2-051 has demonstrated potential in improving cognitive function in amyloid precursor protein (APP)/Presenilin 1 (PS1) mouse models, making it valuable for research focused on Alzheimer’s disease mechanisms and therapies. -
AAK1 Inhibitor
BMT-090605 hydrochloride is a selective inhibitor of the adapter protein-2 associated kinase 1 (AAK1), exhibiting a potent IC50 of 0.6 nM. This compound demonstrates significant antinociceptive activity, making it valuable for neuropathic pain research. Additionally, BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK), with IC50 values of 45 nM and 60 nM, respectively, supporting its role in diverse biological investigations. -
AAK1 Inhibitor
BMT-090605 is a potent and selective inhibitor of adaptor protein-2 associated kinase 1 (AAK1), featuring an IC50 value of 0.6 nM. This compound exhibits significant antinociceptive activity and also demonstrates inhibitory effects on BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK), with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 is a valuable tool for research into mechanisms underlying neuropathic pain. -
AAK1/GAK Inhibitor
AAK1-IN-8 is a selective inhibitor of AAK1 and GAK, demonstrating effective inhibition with EC50 values of 50 nM and 190 nM, respectively. This compound significantly hinders the phosphorylation of the AP2-µ2 subunit at threonine 156, providing insight into clathrin-mediated endocytosis. AAK1-IN-8 is utilized in research applications focused on uncovering the roles of AAK1 and GAK in cellular processes and their implications in diseases related to endocytic pathways. -
P2Y11 Receptor Agonist
ATPγS tetralithium salt is a highly effective agonist of the P2Y11 receptor, playing a pivotal role in various cellular signaling pathways. This compound exhibits notable antioxidant properties and provides neuroprotection, enhancing its utility in neuroscience research. Additionally, ATPγS serves as a substrate for nucleotide hydrolysis and RNA unwinding activities mediated by the eukaryotic translation initiation factor eIF4A, making it valuable for studies related to translation and RNA biology. Its activity in ATP hydrolysis further supports its application in metabolic research. -
P2Y11 Receptor Agonist
ATP-γ-S tetrasodium is a potent agonist of the P2Y11 receptor, known for its antioxidant and neuroprotective properties. This compound serves as a substrate for nucleotide hydrolysis and facilitates RNA unwinding activities of the eukaryotic translation initiation factor eIF4A. Additionally, ATP-γ-S tetrasodium demonstrates significant activity in ATP hydrolysis, making it valuable for studies in cellular signaling and translational control. -
α7 nAChR Inhibitor
Conofurin-Delta is a potent inhibitor of the α7 nicotinic acetylcholine receptor (nAChR), exhibiting an IC50 of 177 nM. Additionally, it demonstrates inhibitory activity against the α9α10 nAChR with an IC50 of 98.1 nM. This compound is relevant for research applications in the study of SARS-CoV-2 infection and its impact on cholinergic signaling pathways. -
SMase Inhibitor
SMase-IN-1 is a specific inhibitor of bacterial sphingomyelinase (SMase), exhibiting an IC50 value of 6.43 µM against B. cereus SMase. In addition to its primary activity, SMase-IN-1 also demonstrates a significant inhibition rate of 59.50% for equine butyrylcholinesterase (eqBuChE) at a concentration of 50 µM. This compound forms a complex with Cu2+ in biometal interactions and effectively reduces hemolysis induced by B. cereus in sheep erythrocytes. SMase-IN-1 is valuable for research in microbial pathogenesis and enzyme inhibition studies. -
Stable Isotope
Itopride-d6 is a deuterated form of Itopride, a potent dopamine D2 receptor antagonist and acetylcholinesterase (AChE) inhibitor. Its unique stable isotope labeling allows for advanced metabolic and pharmacokinetic studies. Itopride enhances gastric motility through its combined antidopaminergic and anti-AChE actions, making it valuable in research applications focused on gastrointestinal prokinetics and conditions such as gastro-esophageal reflux disease (GERD). -
P2X1 Receptor Activator
Diadenosine pentaphosphate (pentasodium) is an agonist and negative modulator of the P2X1 receptor, an important endogenous purine dinucleotide primarily sourced from platelets. This compound is known to negatively regulate dendritic growth and branching by activating both homologous and heterologous P2X1 receptors, resulting in a modest transient increase in intracellular calcium levels in dendritic growth cones. Diadenosine pentaphosphate demonstrates selective inhibition of dendrite growth in cultured hippocampal neurons while leaving axon growth unaffected. Its presence in secretory vesicles such as platelets and brain synaptosomes highlights its biological relevance in neurophysiological studies. -
Cholinesterase (ChE) Inhibitor
N-Desmethyl Galanthamine is a potent cholinesterase inhibitor, specifically targeting acetylcholinesterase (AChE) with an IC50 value of 2.76 μM. As a metabolite of Galanthamine, it holds significant relevance in neuropharmacological research. This compound is utilized in studies related to Alzheimer's disease, providing insights into therapeutic strategies aimed at enhancing cholinergic transmission. -
Aldicarb Metabolite
Aldicarb sulfoxide is a metabolite of aldicarb that primarily interacts with glutathione-linked enzymes in CHO-K1 cells. This compound exhibits inhibitory activity against cholinesterase (ChE) and carboxylesterase (CaE), with an IC50 of 10 μM in zebrafish models. Its mechanism of action and biological activity make it a valuable tool for research on neurotoxicology and enzymatic regulation. -
COX Inhibitor
1-Oxo Ibuprofen is a cyclooxygenase (COX) inhibitor, specifically targeting COX-1 and COX-2 enzymes. As a degradation product and potential impurity of Ibuprofen, it demonstrates significant anti-inflammatory activity with IC50 values of 13 μM for COX-1 and 370 μM for COX-2. This compound is useful for research applications involving the study of prostaglandin synthesis and the metabolic pathways of nonsteroidal anti-inflammatory drugs. -
AChE Inhibitor
3-Hydroxycarbofuran is a reversible inhibitor of acetylcholinesterase (AChE), acting primarily by competing with acetylcholine at the enzyme's active site. This compound serves as a significant metabolite of Carbofuran and exhibits notable biological activity in the modulation of cholinergic signaling. It is utilized in research related to neurobiology, toxicology, and pesticide biochemistry, providing insights into the effects of AChE inhibition on synaptic transmission and potential neurotoxic mechanisms. -
Integrated Stress Response Pathway Modulator
Comtifator is an integrated stress response pathway modulator that influences cellular responses to various stressors. This compound is essential for studying the role of the integrated stress response in diseases such as neurodegeneration and cancer. Its ability to alter stress signaling makes it a valuable tool for research investigating therapeutic interventions and mechanisms underlying stress-related disorders. -
Tau-aggregation and Neuroinflammation Inhibitor
Tau-aggregation and neuroinflammation-IN-1 is an effective inhibitor of tau aggregation and neuroinflammation. This compound demonstrates significant inhibitory activity against both AcPHF6 and full-length tau aggregation, while exhibiting low cytotoxicity. Additionally, it reduces nitric oxide release in lipopolysaccharide-stimulated BV2 cells. Research applications include investigations into memory impairment, as Tau-aggregation and neuroinflammation-IN-1 has been shown to reverse okadaic acid-induced cognitive deficits in rat models. -
Tau Tracer
Tau Tracer 2 (PI-2620) is a selective imaging agent targeting Tau protein aggregates. It is designed for the visualization and diagnosis of neurodegenerative diseases, aiding in the assessment of Tau pathology. This reagent is valuable for researchers exploring Tau-related mechanisms and monitoring the progression of Tau-associated disorders. -
Tau Aggregation Inhibitor
3,3'-Diethyl-9-methylthiacarbocyanine iodide is a cyanine dye that functions as a tau aggregation inhibitor, exhibiting an IC50 value of 0.28 μM for tau proteins. It interferes with the proper functioning of the microtubule cytoskeleton, making it valuable for studies investigating tau pathologies. This compound is particularly relevant in Alzheimer's disease research, enabling the exploration of therapeutic strategies targeting tau aggregation. -
Tau Binding Drug
THK-5117 is an arylquinoline derivative that exhibits a strong binding affinity to tau fibrils, with a Ki of 10.5 nM. It shows remarkable specificity for tau protein aggregates, making it a valuable tool for studying tau pathology in Alzheimer's disease. Additionally, 18F-THK-5117 has potential applications in tau imaging as a PET probe, providing insights into tau-related neurodegenerative processes. -
Tau Tracer
Tau Tracer 1 is a selective imaging agent designed for the visualization of Tau protein aggregates, a hallmark of neurodegenerative diseases. This compound enables the detection and quantification of Tau pathology, facilitating the diagnosis and study of conditions such as Alzheimer's disease. Its application is crucial in both preclinical and clinical research settings, allowing for a better understanding of Tau-related pathologies. -
Tau441 Aggregation Inhibitor
Tau-aggregation-IN-1 is a potent inhibitor of tau441 protein aggregation, exhibiting an IC50 value of 21 µM. This compound also acts as an agonist for dopamine D2 and D3 receptors, making it relevant in studies of neurodegenerative diseases and tauopathies. Its dual mechanism offers potential for investigating tau-related pathologies and dopaminergic signaling in experimental research settings. -
Tau Imaging Probe
THK-5105 is an arylquinoline derivative that serves as a tau imaging probe, exhibiting high binding affinity for tau fibrils and protein aggregates. Its specific interaction with tau-rich Alzheimer disease brain homogenates makes it a valuable tool for studying tau pathology. The radiofluorinated derivative, 18F-THK-5105, is particularly promising for use as a positron emission tomography (PET) imaging probe in Alzheimer's research. -
COX Inhibitor
Ibuprofen Impurity F is a specific impurity of Ibuprofen, a well-known anti-inflammatory compound that inhibits cyclooxygenase enzymes COX-1 and COX-2. It exhibits inhibitory activity with IC50 values of 13 μM for COX-1 and 370 μM for COX-2. This reagent is valuable for quality control and analytical characterization in pharmaceutical research and development, particularly in the study of non-steroidal anti-inflammatory drugs (NSAIDs). -
COX Inhibitor
Piroxicam cinnamate is a cyclooxygenase (COX) inhibitor with demonstrated anti-inflammatory properties. It is stable under gastric conditions, making it suitable for research applications focused on inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele-associated oligoasthenospermia. This compound offers significant potential for investigating therapeutic approaches to various inflammatory conditions. -
COX-1 Inhibitor
Valeryl salicylate is a potent and irreversible inhibitor of cyclooxygenase-1 (COX-1). This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research into inflammatory processes. Its mechanism offers insights into the modulation of COX-1 enzyme activity and potential therapeutic applications in inflammatory conditions. -
COX1/2 Inhibitor
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone is a selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). This compound demonstrates significant anti-inflammatory properties and is valuable in research aimed at understanding the role of COX enzymes in various disease models. Its application extends to pharmacological studies focused on pain, inflammation, and potential therapeutic interventions. -
COX Inhibitor
Ibuprofen impurity 1 is an impurity of the widely used anti-inflammatory agent ibuprofen, which acts as a dual inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting IC50 values of 13 μM and 370 μM, respectively. This compound is essential for evaluating the purity and quality of ibuprofen formulations in research. It serves as a valuable tool for studying the pharmacological effects and potential side effects of ibuprofen in various biological assays. -
COX-2 Inhibitor
Robenacoxib is a selective cyclooxygenase-2 (COX-2) inhibitor with potent anti-inflammatory and analgesic properties. It primarily reduces the production of prostaglandins associated with inflammation and pain, making it valuable for research related to inflammatory diseases and pain management. This compound is utilized in studies aiming to elucidate the role of COX-2 in various biological processes and to develop therapeutic strategies targeting inflammation. -
COX-2 Inhibitor
3-Carene is a bicyclic monoterpene that functions as a cyclooxygenase-2 (COX-2) inhibitor. It demonstrates significant anti-inflammatory properties by reducing nociceptive stimulus-induced inflammatory infiltrates and decreasing COX-2 overexpression. Additionally, 3-Carene enhances both the activity and expression of alkaline phosphatase, a crucial early marker of osteoblastic differentiation, making it a valuable compound for research in pain management and bone health. -
COX-2 Inhibitor
Mavacoxib is a selective, oral cyclooxygenase-2 (COX-2) inhibitor, functioning as a long-acting non-steroidal anti-inflammatory drug (NSAID). This compound effectively alleviates pain and inflammation related to degenerative joint disease, particularly in canine subjects. Research applications include studies on inflammation and pain management in veterinary medicine. -
COX-2 Inhibitor
Desmethyl Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 32 nM, demonstrating significant anti-inflammatory activity. As an analog of Celecoxib, this compound serves as a valuable tool in research applications focusing on inflammation and pain pathways. Its potency and specificity make it suitable for studies related to COX-2 mediated processes. -
5-LO/COX Inhibitor
BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) enzymes, exhibiting an IC50 of 5 μM for 5-LO. It also demonstrates inhibitory activity against COX-1 and COX-2, with IC50 values of 0.65 and 1.2 μg/mL, respectively. This compound is valuable for research applications involving inflammation and other related pathways. Its ability to concurrently inhibit key lipid mediators makes BW 755C a useful tool in studies focused on arachidonic acid metabolism and signaling pathways. -
COX-2 Inhibitor
Enflicoxib is a selective inhibitor of cyclooxygenase-2 (COX-2), a key enzyme in the inflammatory pathway. This nonsteroidal anti-inflammatory compound exhibits notable anti-inflammatory, analgesic, and antipyretic effects in various animal models. Enflicoxib is valuable for research investigating COX-2-mediated processes and potential therapeutic applications in pain management and inflammation. -
COX-1 Inhibitor
CP-74006 is a selective inhibitor of Cyclooxygenase-1 (COX-1). This compound demonstrates significant anti-inflammatory activity by blocking the conversion of arachidonic acid to prostaglandins, key mediators in the inflammatory response. CP-74006 is utilized in research focusing on inflammation, pain management, and cardiovascular disease, providing valuable insights into COX-1 related biological processes.
