Catalog No.
Product Name
Application
Product Information
Citations
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AAK1 Inhibitor
BMT-090605 hydrochloride is a selective inhibitor of the adapter protein-2 associated kinase 1 (AAK1), exhibiting a potent IC50 of 0.6 nM. This compound demonstrates significant antinociceptive activity, making it valuable for neuropathic pain research. Additionally, BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK), with IC50 values of 45 nM and 60 nM, respectively, supporting its role in diverse biological investigations. -
AAK1 Inhibitor
BMT-090605 is a potent and selective inhibitor of adaptor protein-2 associated kinase 1 (AAK1), featuring an IC50 value of 0.6 nM. This compound exhibits significant antinociceptive activity and also demonstrates inhibitory effects on BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK), with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 is a valuable tool for research into mechanisms underlying neuropathic pain. -
AAK1/GAK Inhibitor
AAK1-IN-8 is a selective inhibitor of AAK1 and GAK, demonstrating effective inhibition with EC50 values of 50 nM and 190 nM, respectively. This compound significantly hinders the phosphorylation of the AP2-µ2 subunit at threonine 156, providing insight into clathrin-mediated endocytosis. AAK1-IN-8 is utilized in research applications focused on uncovering the roles of AAK1 and GAK in cellular processes and their implications in diseases related to endocytic pathways. -
P2Y11 Receptor Agonist
ATPγS tetralithium salt is a highly effective agonist of the P2Y11 receptor, playing a pivotal role in various cellular signaling pathways. This compound exhibits notable antioxidant properties and provides neuroprotection, enhancing its utility in neuroscience research. Additionally, ATPγS serves as a substrate for nucleotide hydrolysis and RNA unwinding activities mediated by the eukaryotic translation initiation factor eIF4A, making it valuable for studies related to translation and RNA biology. Its activity in ATP hydrolysis further supports its application in metabolic research. -
P2Y11 Receptor Agonist
ATP-γ-S tetrasodium is a potent agonist of the P2Y11 receptor, known for its antioxidant and neuroprotective properties. This compound serves as a substrate for nucleotide hydrolysis and facilitates RNA unwinding activities of the eukaryotic translation initiation factor eIF4A. Additionally, ATP-γ-S tetrasodium demonstrates significant activity in ATP hydrolysis, making it valuable for studies in cellular signaling and translational control. -
α7 nAChR Inhibitor
Conofurin-Delta is a potent inhibitor of the α7 nicotinic acetylcholine receptor (nAChR), exhibiting an IC50 of 177 nM. Additionally, it demonstrates inhibitory activity against the α9α10 nAChR with an IC50 of 98.1 nM. This compound is relevant for research applications in the study of SARS-CoV-2 infection and its impact on cholinergic signaling pathways. -
Anti-tumor Agent
Scoulerine hydrochloride is a multi-target inhibitor primarily acting as an anti-tumor agent. It disrupts the PI3K/Akt/mTOR signaling pathway and α1D-adrenergic receptors, leading to microtubule destabilization, cell cycle arrest, and apoptosis in cancer cells. This compound also inhibits mitochondrial dehydrogenase activity and demonstrates effects on GABA receptors and BACE1, suppressing tumor cell proliferation, migration, invasion, and stem cell-like properties. Additionally, Scoulerine hydrochloride exhibits pharmacological activities against Plasmodium falciparum, as well as antibacterial, antiemetic, and antitussive properties, while also influencing endoplasmic reticulum stress and mitochondrial function. It is particularly relevant in studies focused on leukemia, ovarian cancer, and colorectal cancer. -
Insecticide
Chlorphoxim is a highly efficient insecticide that acts by inhibiting acetylcholinesterase (AChE), leading to the disruption of neurotransmission in target pests. This compound also demonstrates the ability to inhibit superoxide dismutase (SOD) and catalase (CAT) activities in zebrafish embryos, thereby inducing oxidative stress through the activation of reactive oxygen species (ROS). Additionally, Chlorphoxim promotes apoptosis in zebrafish embryos by modulating the expression of pro-apoptotic and anti-apoptotic proteins such as Bax, Bcl2, and p53. Its neurotoxic and developmental effects make Chlorphoxim a key compound for agricultural research aimed at pest control. -
COX-1 Inhibitor
NCX 466 is a selective inhibitor of COX-1 and COX-2, demonstrating notable anti-inflammatory and analgesic properties. It functions as a nitric oxide (NO) donor, enhancing microcirculation while exerting antioxidant effects. NCX 466 effectively reduces levels of transforming growth factor-β (TGF-β) and oxidative stress markers, including thiobarbituric acid reactive substances (TBARS) and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Furthermore, it mitigates leukocyte recruitment during inflammatory responses by decreasing myeloperoxidase (MPO) activity, contributing to the prevention of bleomycin-induced pulmonary fibrosis in murine models. -
P2Y14R Antagonist
HDL-16 is a highly potent antagonist of the P2Y14 receptor, exhibiting an IC50 of 0.3095 nM. This compound demonstrates significant biological activity by alleviating dextran sulfate sodium (DSS)-induced colitis, primarily through the inhibition of necroptosis in intestinal epithelial cells (IECs) and the preservation of mucosal barrier function. HDL-16 is valuable for research applications focused on inflammatory bowel diseases and related gastrointestinal disorders. -
Stable Isotope
Aldicarb sulfone-13C2,d3 is a labeled version of Aldicarb sulfone, incorporating both deuterium and carbon-13 isotopes. This compound acts as a cholinesterase inhibitor and is one of the primary metabolites of the carbamate pesticide Aldicarb, showcasing notable insecticidal activity. Aldicarb sulfone-13C2,d3 is valuable for chemical research applications, particularly in studies involving pesticide metabolism and its impact on cholinergic signaling pathways. -
Anti-colorectal Cancer Agent
ACS03 is a hybrid thiophene-acridine compound that targets colorectal cancer. It enhances the activity of key enzymes such as lactate dehydrogenase, glutathione S-transferase, and acetylcholinesterase, indicating its potential role in cellular metabolism. ACS03 exhibits selective anti-cancer effects, particularly against colon carcinoma, making it a valuable reagent for research applications in cancer biology and therapy development. Additionally, it demonstrates antileishmanial activity, broadening its relevance in infectious disease research. -
COX-2 Inhibitor
Hirsutanonol, a diarylheptanoid derived from the bark of Alnus hirsute var. sibirica, functions primarily as an inhibitor of cyclooxygenase-2 (COX-2). This compound exhibits significant anti-filarial activity, demonstrated by an IC50 value of 44.11 μg/mL against microfilariae. Hirsutanonol is valuable in research focused on inflammation reduction and parasitic disease interventions. -
COX-1 Inhibitor
Dihydroflavokawin B is a selective COX-1 inhibitor, exhibiting an IC50 of 1.22 μM, with moderate effects on COX-2 and 5-LOX. This compound demonstrates significant activity against the promastigote forms of Leishmania panamensis and Leishmania braziliensis, making it a valuable tool for leishmaniasis research. Additionally, Dihydroflavokawin B inhibits rabbit platelet aggregation induced by arachidonic acid, platelet-activating factor, and adenosine diphosphate, highlighting its potential for in vitro anti-inflammatory studies. -
Pesticide
(S)-Dinotefuran is a neonicotinoid pesticide that primarily targets the α8 subunit of nicotinic acetylcholine receptors (nAChRs) in honeybees, Apis mellifera. It exhibits higher toxicity compared to its R-enantiomer, R-dinotefuran, affecting the survival and behavior of these important pollinators. This compound is utilized in ecological and toxicological research to study the impact of pesticides on non-target species and to evaluate the risks associated with neonicotinoid exposure in agricultural settings. -
Parasite
Trimethacarb is a carbamate insecticide that primarily targets the nervous system of parasites. It inhibits key cholinesterase enzymes, leading to accumulation of acetylcholine and subsequent paralysis of target organisms. This compound is commonly utilized in research settings to study pest control methods and the biochemical mechanisms underlying insecticide action against various parasites. -
Stable Isotope
Pirimiphos-methyl-d6 is a deuterium-labeled derivative of Pirimiphos-methyl, an organophosphorus insecticide and acaricide that acts primarily through the inhibition of acetylcholinesterase (AChE) in target organisms. This compound is utilized in research for the development of analytical methods and for studying the biological activities of organophosphates. Its applications extend to the investigation of pest control mechanisms and the management of storage pests in agricultural grains. -
Stable Isotope
Pirimicarb-d6 is a deuterium-labeled derivative of Pirimicarb, serving as a stable isotope for analytical research. Pirimicarb functions as a selective carbamate insecticide, effectively inhibiting acetylcholinesterase (AChE) and displaying acaricidal properties. This reagent is widely applicable in studies related to insecticide action mechanisms and environmental fate assessments of carbamate pesticides in agricultural settings. -
Insecticide
Thiacloprid is an orally active neurotoxic insecticide that functions as an agonist of nicotinic acetylcholine receptors (nAChR). It has been shown to reduce cellular viability, deplete reduced glutathione, and elevate malondialdehyde (MDA) levels, leading to cytotoxicity and oxidative stress. While Thiacloprid exhibits lower acute toxicity to honeybees compared to some other insecticides, it adversely affects their learning, memory, immune function, and overall survival. Additionally, this compound disrupts intestinal microbiota, increasing the risk of premature colony collapse in bumblebees. Thiacloprid is utilized in the broad-spectrum control of agricultural pests across various crops, including potatoes, cabbages, fruits, vegetables, and nuts. -
Stable Isotope
Triazophos-d5 is a deuterium-labeled derivative of Triazophos, a non-systemic insecticide and acaricide that primarily targets acetylcholinesterase (AChE). By covalently and irreversibly binding to the acetylcholine binding site, Triazophos-d5 inhibits the hydrolysis of acetylcholine, resulting in increased neuromuscular activity and hyperexcitability in target pests. This compound is widely utilized in research to study insect resistance and as a tracer in ecological and environmental studies, particularly concerning its effects on various soil insects and mites affecting major crops such as cotton, rice, and soybeans. -
Ingredient In Insecticide And Acaricide Compositions
Primidophos is an organophosphorus compound that functions as an inhibitor of acetylcholinesterase. Its primary application lies in the formulation of insecticide and acaricide compositions, which target a variety of insect and mite pests. This compound is valuable in research focused on pest control and management strategies in agricultural and environmental settings. -
COX Inhibitor
Serratiopeptidase is a zinc-containing metalloprotease that primarily acts as a cyclooxygenase (COX) inhibitor. It effectively reduces the release of inflammatory mediators such as prostaglandins and interleukins, alleviating pain and swelling. In addition to its anti-inflammatory properties, Serratiopeptidase exhibits mucolytic, antibiofilm, and wound-healing activities. Its enzymatic action allows it to dissolve fibrin and blood clots, while also demonstrating potential anti-Alzheimer's effects by degrading amyloid fibrils. Furthermore, Serratiopeptidase shows cytotoxicity against colon cancer cells, making it a versatile reagent for research applications in inflammation and oncology. -
COX-2 Inhibitor
Thymohydroquinone is a selective inhibitor of cyclooxygenase-2 (COX-2) with noted anti-SARS-CoV-2 activity. It exhibits cytotoxic properties, antiproliferative effects, and the ability to suppress tumor growth in various cancer models. This compound is applicable in research focused on squamous cell carcinoma, fibrosarcoma, and the pathogenesis and treatment of COVID-19 caused by SARS-CoV-2. -
nAChR Aagonist
Simpinicline (OC-02) is a highly selective agonist of the nicotinic acetylcholine receptor (nAChR). This compound exhibits potent antiviral activity against SARS-CoV-2 variants in cell culture, with an IC50 value of 0.04 µM. Its unique selectivity and efficacy make it a valuable tool for research in virology and neuropharmacology. -
Natural Compound
Lucidadiol is a natural compound derived from Ganoderma lucidum, functioning as an acetylcholinesterase inhibitor with an IC50 value of 31 μM. This compound also demonstrates antiviral activity against influenza virus type A and herpes simplex virus type 1 (HSV-1). Lucidadiol is valuable for research applications exploring neuroprotective mechanisms and viral infection inhibition. -
Anthelmintic Agent/Immunoregulatory Agent
Levamisole is an anthelmintic agent recognized for its immunoregulatory properties. This compound functions as a positive allosteric modulator of the α3β2 (EC50 = 300 μM) and α3β4 (EC50 = 100 μM) subtypes of nicotinic acetylcholine receptors (nAChRs), enhancing receptor activity. It is orally active and is commonly used in research applications related to parasitic infections and immune response modulation. -
AChE Inhibitor
Coumaran, also known as 2,3-Dihydrobenzofuran, is an inhibitor of acetylcholinesterase (AChE) and exhibits notable antileishmanial activity. Its mechanisms include the activation of macrophages, contributing to its antiparasitic effects and immunomodulatory properties. Coumaran is also applicable in the field of biopesticides, providing a potential tool for agricultural and biological research. -
Nicotinic acetylcholine receptors Inhibitor
Dinotefuran is a competitive inhibitor targeting insect nicotinic acetylcholine receptors (nAChRs). This compound effectively disrupts neural signaling in insects, leading to dysfunction. With an IC50 of 890 nM for [3H]epibatidine and 36.1 μM for [3H]α-bungarotoxin in American cockroach neural membranes, Dinotefuran demonstrates significant knockdown (KD50=0.351 nmol/g) and lethal activity (LD50=0.173 nmol/g) against German cockroach. Its primary applications include agricultural pest control, specifically targeting piercing-sucking and chewing insects like aphids and planthoppers, and it also serves as a tool for studying environmental toxicological impacts such as oxidative stress and reproductive neurotoxicity in earthworms. -
Glucosylceramide Synthase Inhibitor
DL-threo-PDMP hydrochloride is a competitive inhibitor of glucosylceramide synthase (GCS), demonstrating significant potential in antimalarial research. This compound effectively inhibits GCS activity, leading to restored sensitivity to cisplatin in cisplatin-resistant testicular germ cell tumor cells. Additionally, DL-threo-PDMP hydrochloride has been shown to impede the growth of ring-stage Plasmodium falciparum parasites, making it a valuable tool for studying malaria and its treatment. -
ChE Inhibitor
N-p-trans-Coumaroyltyramine is a natural phenolic amide compound that acts as an inhibitor of acetylcholinesterase (AChE) with an IC50 of 122 μM and α-glucosidase with an IC50 of 2.7 μM. It demonstrates significant anti-trypanosomal activity, exhibiting an IC50 of 13.3 µM against Trypanosoma brucei rhodesiense. This compound is valuable for research into neurodegenerative diseases such as Alzheimer's disease, as well as for studies focusing on trypanosomiasis. -
Parasite Inhibitor
Diazinon is an irreversible acetylcholinesterase (AChE) inhibitor with primary applications in pest control as an insecticide. By inhibiting AChE, Diazinon leads to the accumulation of acetylcholine, resulting in overstimulation of acetylcholine receptors and disruption of nervous system function. Additionally, Diazinon generates reactive oxygen species (ROS), contributing to oxidative stress across various biological tissues. This compound is predominantly utilized in agricultural settings but may also hold implications for human and animal health research. -
AChE Inhibitor
Carbosulfan is an orally active acetylcholinesterase (AChE) inhibitor that hydrolyzes to carbofuran, leading to significant insecticidal properties. This compound demonstrates broad-spectrum insecticidal activity while inducing oxidative stress through increases in lipid peroxidation and impairment of antioxidant defenses. Carbosulfan is associated with reproductive toxicity in male rats and developmental disorders in offspring, making it a relevant subject in studies focused on reproductive toxicity and environmental risk assessment. Its persistence in aquatic environments raises concerns regarding potential hazards to non-target organisms. -
Parasite Inhibitor
8-Deoxygartanin, a prenylated xanthone derived from Garcinia mangostana, serves as a selective inhibitor of butyrylcholinesterase (BChE). This compound demonstrates significant antiplasmodial activity, with an IC50 value of 11.8 μM against the W2 strain of Plasmodium falciparum. Additionally, 8-Deoxygartanin inhibits NF-κB (p65) activation, displaying an IC50 of 11.3 μM, making it a valuable reagent for research in parasitic infections and inflammation pathways. -
Organophosphorus Insecticide
Pirimiphos-methyl is an organophosphorus insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor in target organisms. This compound is effective in the prevention and control of a variety of pests, including beetles, snout beetles, moths, and Ephestia cautella, particularly during the storage of agricultural grains. Its efficacy in disrupting neural signaling makes it valuable for research into pest management strategies and environmental impact studies in agricultural settings. -
nAChR Antagonist
Derquantel is a spirocyclic anthelmintic that functions as a competitive antagonist of nicotinic acetylcholine receptors (nAChRs). It inhibits acetylcholine-induced depolarization with an IC50 of 0.22 μM, leading to flaccid paralysis of nematode somatic muscles. This mechanism effectively dislodges parasites from the host gastrointestinal tract, making Derquantel a valuable tool in research related to Haemonchus contortus and Ascaris suum infections. -
Cholinesterase (ChE) Inhibitor
Fenchlorphos is an organophosphate compound that acts as a potent inhibitor of acetylcholinesterase (AChE), an important enzyme in cholinergic signaling. By disrupting AChE activity, Fenchlorphos leads to the accumulation of acetylcholine, resulting in increased cholinergic neurotransmission. Additionally, this compound has been shown to induce mitochondrial dysfunction, making it a valuable tool for research on neurobiology and toxicology. Its applications include studies on the mechanisms of insecticide action and investigations into the impacts of cholinergic inhibition on cellular metabolism. -
Carbamate Insecticide
Pirimicarb is a selective carbamate insecticide that functions as an acetylcholinesterase (AChE) inhibitor, making it effective against a variety of pests. It exhibits rapid action and is suitable for use on a broad spectrum of crops, including cereals, sugar beet, potatoes, fruits, and vegetables. Pirimicarb's efficacy extends to its acaricidal properties, supporting extensive research in agricultural pest control mechanisms. -
Parasite
Triazophos is a potent non-systemic insecticide and acaricide that functions as an acetylcholinesterase (AChE) inhibitor. By covalently and irreversibly binding to the acetylcholine binding site, Triazophos effectively disrupts the hydrolysis of acetylcholine, resulting in increased neuroexcitability. This compound demonstrates efficacy against a broad spectrum of soil insects and mites, including aphids, thrips, and spider mites, making it valuable for crop protection in various agricultural settings, such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee. -
Parasite Inhibitor
Phosalone is an organophosphate insecticide that primarily targets acetylcholinesterase, leading to the inhibition of neurotransmission in parasites. Its potent biological activity makes it effective in controlling a wide range of insect pests. Phosalone is utilized in entomological research and in studies focusing on pest management strategies and the biochemical pathways of insecticide resistance. -
nAChR Modulator
GSK575594A is an allosteric modulator of the nicotinic acetylcholine receptor (nAChR) in Ascaris suum. This compound enhances muscle contractions triggered by acetylcholine (ACh) by binding to the allosteric site within the transmembrane domain of the nAChR, leading to a significant increase in contraction amplitude (Emax from 1.19 g to 1.51 g) at a concentration of 3 μM. GSK575594A is applicable in antiparasitic research, providing insights into neuromuscular mechanisms in parasitic infections. -
ChE Inhibitor
Isogarcinol is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 1.13 μM and 8.30 μM, respectively. This compound also demonstrates significant leishmanicidal activity, with an IC50 of 0.33 μM against Leishmania donovani. Isogarcinol's dual action makes it a valuable tool for research in neurodegenerative disorders and parasitic diseases. -
Stable Isotope
Temephos-d12 is a deuterated form of Temephos, an organophosphate larvicide. It targets the central nervous system of aquatic larvae, including those of mosquitoes, midges, and black flies, by inhibiting cholinesterase activity. This mechanism leads to larval mortality prior to reaching the adult stage, making Temephos-d12 valuable for research on pesticide efficacy and environmental impact studies. -
CRMP2-NMDAR Inhibitor
TAT-CBD3 is a 15-amino acid peptide derived from CRMP2 that incorporates the TAT cell-penetrating motif from HIV-1, enabling efficient cellular uptake. This peptide disrupts the interaction between CRMP2 and NMDA receptors (NMDAR) while maintaining NMDAR localization. TAT-CBD3 is valuable for research applications focused on neurobiology and synaptic signaling, particularly in studies investigating the role of CRMP2 in neuronal function and related disorders. -
hDAT Modulator
SRI-32743 is an allosteric modulator of the human dopamine transporter (hDAT) with an IC50 value of 9.86 μM. This compound is of particular interest for research into HIV-Tat-induced neurotoxicity. Its modulation of hDAT may provide insights into the neurobiological mechanisms underlying dopamine dysregulation in various neurotoxic conditions. -
AChE Inhibitor
Temephos is an organophosphate insecticide that functions as an irreversible inhibitor of acetylcholinesterase (AChE). This inhibition leads to cholinergic overactivation, effectively disrupting the larval development of Aedes aegypti and Aedes albopictus, making it a valuable tool in research concerning Dengue Virus, Zika Virus, and other mosquito-borne pathogens. While exhibiting important biological activity, Temephos has been shown to cause genotoxicity, neurodevelopmental toxicity, and potential liver and reproductive system effects in mammals. Additionally, it can accumulate in adipose tissues and aquatic organisms, with its metabolism primarily occurring through oxidation and hydrolysis. Temephos serves as a critical reagent in studies of vector control and viral transmission dynamics. -
AAK1 Inhibitor
AAK1-IN-6 is a potent inhibitor of AP-2-associated protein kinase 1 (AAK1) with an IC50 value of 12 nM. This compound exhibits significant antiviral activity against dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM). AAK1-IN-6 is a valuable tool for researchers investigating antiviral mechanisms and potential therapeutic strategies. -
SMase Inhibitor
SMase-IN-1 is a specific inhibitor of bacterial sphingomyelinase (SMase), exhibiting an IC50 value of 6.43 µM against B. cereus SMase. In addition to its primary activity, SMase-IN-1 also demonstrates a significant inhibition rate of 59.50% for equine butyrylcholinesterase (eqBuChE) at a concentration of 50 µM. This compound forms a complex with Cu2+ in biometal interactions and effectively reduces hemolysis induced by B. cereus in sheep erythrocytes. SMase-IN-1 is valuable for research in microbial pathogenesis and enzyme inhibition studies. -
Stable Isotope
Itopride-d6 is a deuterated form of Itopride, a potent dopamine D2 receptor antagonist and acetylcholinesterase (AChE) inhibitor. Its unique stable isotope labeling allows for advanced metabolic and pharmacokinetic studies. Itopride enhances gastric motility through its combined antidopaminergic and anti-AChE actions, making it valuable in research applications focused on gastrointestinal prokinetics and conditions such as gastro-esophageal reflux disease (GERD). -
Babesicidal Agent
Quinuronium disulfate is a potent babesicidal agent with demonstrated anticholinesterase activity. It is primarily utilized in the study of protozoan infections, particularly those caused by Babesia species. This compound serves as a valuable tool in researching therapeutic interventions for babesiosis and related parasitic diseases. -
AChE/Dopamine 2 Inhibitor
Itopride is a potent dopamine D2 receptor antagonist and an acetylcholinesterase (AChE) inhibitor. Itopride enhances gastric motility through its dual mechanisms of action, promoting both antidopaminergic and anti-acetylcholinesterase effects. This compound is primarily utilized in research related to gastrointestinal disorders, particularly gastroesophageal reflux disease (GERD), offering insights into prokinetic therapies.
