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Catalog No.
Product Name
Application
Product Information
Product Citation
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muscarinic receptor antagonist
Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype -
AChR antagonist
Fesoterodine fumarate is a medicine which is used in urinary urgency, reducing the frequency of passing urine and urge urinary incontinence -
Benzodiazepine antagonist
Flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex. Flumazenil is a weak partial agonist in some animal models of activity, but has little or no agonist activity in humans. -
mAChR M2 antagonist
Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. - Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.
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α-adrenergic (AR) antagonist/CaM inhibitor
Phenoxybenzamine is a cell-permeable, non-specific, irreversible α-adrenergic (AR) antagonist that also acts as an CaM inhibitor. -
AchR antagonist
Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia. -
muscarinic receptor antagonist
SVT-40776 is a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. -
muscarinic acetylcholine receptor (mAChR) antagonist
Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. -
muscarinic receptor antagonist
Tolterodine tartrate (Detrol LA) is a muscarinic receptor antagonist which is used for the treatment of urinary incontinence. -
muscarinic receptor antagonist
5-hydroxymethyl tolterodine is a metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.
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muscarinic M3 receptor antagoinst
Solifenacin-succinate is a muscarinic M3 receptor antagoinst, used in treatment of urinary incontinence. -
P2Y12 antagonist
Ticagrelor (AZD6140) is the first reversibly binding oral P2Y(12) receptor antagonist that blocks ADP-induced platelet aggregation. -
NMDA receptor antagonist
Memantine hydrochloride is an antagonist at the NMDA receptor, binding to the ion channel site. it was used in the treatment of Parkinsonism. -
NMDA receptor antagonist
Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker. -
acetylcholine receptor antagonist
Beperidium iodide shows a competitive antagonistic effect against acetylcholine receptor with a pA2 of 7.93. -
P2X3 and P2X2/3 receptor antagonist
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. -
NMDA receptor antagonist
SDZ 220-581 is a competitive NMDA receptor antagonist (pKi = 7.7). -
GABAA antagonist
(+)-Bicuculline is a classical GABAA antagonist.- Maryam Adenike Salaudeen, .et al. , J Pharmacy and Drug Innovations, 2022, 3(4)
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P2X7 receptor antagonist
A-438079 HCl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 uM). -
muscarinic antagonist
Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic. -
NMDA receptor antagonist
(+)-MK 801 is a potent antagonist of NMDA with Ki value of 30.5nM. -
NMDA receptor antagonist.
(-)-MK 801 maleate acts as a potent, selective, and non-competitive NMDA receptor antagonist. It acts by binding to a site located within the NMDA associated ion channel. -
NMDA receptor antagonist
GV-196771A is the sodium salt form of GV196771, is an NMDA receptor antagonist. -
muscarinic M(3) receptor antagonist
PF-3635659 is a potent muscarinic M(3) receptor antagonist. -
GABAB receptors antagonist
2-Hydroxysaclofen is a potent and selective antagonist at GABAB receptors. -
NMDA receptor ion channel antagonist
ARL-15896 is a novel N-methyl-D-aspartate receptor ion channel antagonist.- Robert A. Volkmann, .et al. , PLoS One, 2016, 11(2): e0148129 PMID: 26829109
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GABA antagonist
Cloflubicyne is a potent non-competitive GABA antagonist, convulsant, laboratory insecticide. -
NMDA receptors antagonist
NVP-AAM077 inhibited progenitor cells proliferation in the subventricular zone and dentate gyrus and reduced the survival of newborn cells in the dentate gyrus in the adult mice. -
M2/M3 antagonist
Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02. -
benzodiazepine receptor antagonist
Ro 15-1788 is a benzodiazepine receptor antagonist. -
5-HT3 receptor antagonist
Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ?? 0.9 nM for 5-HT3 receptor. -
P2X7 receptor antagonist
A 438079 Hcl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).- Zhihua Yi, .et al. , Front Pharmacol, 2018, 9: 593 PMID: 29950989
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NMDA receptor antagonist
SDZ 220-581 ammonium salt is a potent, competitive antagonist at the NMDA glutamate receptor subtype(pKi= 7.7). -
Muscarinic receptor antagonist
Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
