Catalog No.
Product Name
Application
Product Information
Citations
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COX-2 Inhibitor
Indomethacin N-octyl amide is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating an IC50 of 40 nM. This compound exhibits greater than 1000-fold selectivity over COX-1, with an IC50 of 66 µM. Its potent COX-2 inhibitory activity makes Indomethacin N-octyl amide a valuable tool for research into inflammation and pain pathways. -
COX Inhibitor
AL-8417 ((2R)-AL-5898) is a potent inhibitor of Cyclooxygenase (COX), exhibiting an IC50 of 120 μM. This compound is significant in modulating inflammatory responses, making it a valuable tool for research into pain relief and inflammation management. Its application in experimental settings can further elucidate the role of COX in various biological processes and disease states. -
COX-2 Inhibitor
N-Caffeoyl serotonin is a selective COX-2 inhibitor, characterized by IC50 and Kᵢ values of 42.5 μM and 65.5 μM, respectively. This compound exhibits minimal inhibitory activity against BACE1, with an IC50 greater than 400 μM, and demonstrates free radical scavenging properties. N-Caffeoyl serotonin is pertinent for research in allergic diseases as well as Alzheimer's disease, providing a valuable tool for investigating inflammatory pathways and neurodegeneration. -
COX-2 Inhibitor
Harmaline analog is a selective inhibitor of cyclooxygenase-2 (COX-2) demonstrating an IC50 of 0.145 μM. This compound is useful for studying the COX-2 enzyme's role in inflammatory processes and pain modulation. Its application includes research on anti-inflammatory therapies and the development of novel analgesics. -
COX-2 Inhibitor
COX-2-IN-36 is a highly selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating an IC50 value of 0.4 μM. This compound effectively inhibits COX-2 enzymatic activity, thereby reducing the synthesis of prostaglandins involved in inflammation and pain. It is suitable for research applications focusing on inflammatory diseases, pain management, and cancer biology, offering a valuable tool for exploring COX-2-related pathways. -
COX Inhibitor
N-(3-Pyridyl)indomethacinamide is a COX-2 inhibitor derived from indomethacin. This compound exhibits potent anti-inflammatory activity by selectively inhibiting cyclooxygenase-2, making it valuable for research in inflammation and pain management. Its unique chemical structure allows for further exploration of its effects in various biological systems and therapeutic applications. -
COX-1/2 Inhibitor
COX-1/2-IN-6 is a potent dual inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), exhibiting IC50 values of 68 nM and 91 nM, respectively. This compound is valuable for studying inflammatory diseases by effectively modulating the COX enzymatic pathways involved in prostaglandin synthesis. Its inhibition profile makes it suitable for research on pain management and inflammatory-related conditions. -
COX-1 Inhibitor
Tenidap sodium is a selective inhibitor of cyclooxygenase-1 (COX-1), with an IC50 of 0.03 μM for COX-1 and 1.2 μM for COX-2. This non-steroidal anti-inflammatory compound exhibits significant anti-inflammatory and anti-rheumatic properties, making it valuable in research focused on inflammatory diseases. Additionally, Tenidap functions as a specific inhibitor of SLC26A3, further broadening its potential applications in biochemical studies. -
COX-2 Inhibitor
4-Desmethyl-2-methyl celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, exhibiting an IC50 value of 0.069 µM. This compound demonstrates significant anti-inflammatory, analgesic, and antipyretic properties by reducing the synthesis of prostaglandins. Its efficacy makes it a valuable tool for the investigation of inflammatory conditions and pain-related disorders, including rheumatoid arthritis and osteoarthritis. -
COX-2 Inhibitor
ABT-963 is a selective inhibitor of cyclooxygenase-2 (COX-2), targeting the COX-2 enzyme involved in the biosynthesis of prostaglandins. This compound exhibits significant anti-inflammatory and analgesic properties, making it a valuable tool for research focused on pain mechanisms and inflammatory diseases. ABT-963 can be utilized to explore the role of COX-2 in various pathophysiological processes, facilitating the development of therapeutic strategies for related conditions. -
COX-2 Inhibitor
Methosulide is a selective COX-2 inhibitor, exhibiting an IC50 value of 2.31 μM. This compound is primarily utilized in the study of inflammatory diseases, providing insights into the role of COX-2 in various pathological conditions. Its selective inhibition profile makes it a valuable tool for researchers investigating potential therapeutic strategies targeting inflammatory pathways. -
COX/5-LOX Inhibitor
ZLJ-6 is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), demonstrating potent oral bioactivity. With IC50 values of 0.73 μM for COX-1, 0.31 μM for COX-2, and 0.99 μM for 5-LOX, ZLJ-6 exhibits significant anti-inflammatory and analgesic properties. This compound is suitable for research applications aimed at investigating inflammatory pathways and potential therapeutic interventions. -
COX Inhibitor
Flosulide is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating significant anti-inflammatory properties. It effectively reduces inflammation and alleviates pain associated with various inflammatory diseases. Flosulide is commonly used in research applications focused on the modulation of inflammatory pathways and exploration of COX-2 related biological processes. -
COX-2 Inhibitor
COX-2-IN-39 is a highly effective inhibitor of cyclooxygenase-2 (COX-2), demonstrating an impressive IC50 value of 0.4 nM. This compound plays a critical role in research focused on inflammation and pain pathways, making it a valuable tool for studying COX-2-related diseases and therapeutic interventions. Its potency allows for precise modulation of COX-2 activity in various experimental models, facilitating in-depth analysis of its biological effects. -
COX Inhibitor
Catechin hydrate is a potent inhibitor of cyclooxygenase-1 (COX-1), exhibiting an IC50 value of 1.4 μM. Its anti-inflammatory properties make it valuable in research applications related to pain relief and inflammatory disease models. This compound's capability to modulate COX-1 activity supports studies investigating the biochemical pathways involved in inflammation and related conditions. -
5-LOX/COX Inhibitor
(-)-Bornyl ferulate serves as a dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX), displaying IC50 values of 10.4 μM and 12.0 μM, respectively. This compound demonstrates significant anti-inflammatory potential, making it useful for research focused on inflammation-related pathways and conditions. Its ability to modulate leukotriene and prostaglandin synthesis positions it as a valuable tool in the study of various inflammatory diseases and therapeutic interventions. -
COX-2 Inhibitor
Cavidine is a selective COX-2 inhibitor that exhibits potent anti-inflammatory properties. It is particularly useful in research concerning skin injuries, hepatitis, cholecystitis, and scabies. Additionally, Cavidine has been shown to alleviate LPS-induced acute lung injury through modulation of the NF-κB signaling pathway, making it a valuable compound for studying inflammation-related conditions. -
COX-2 Inhibitor
Nimesulide-d5 is a deuterated form of Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor. It demonstrates a time-dependent inhibitory effect on COX-2 with IC50 values ranging from 70 nM to 70 μM, while exhibiting negligible activity on COX-1 (IC50 >100 μM). Nimesulide-d5 is utilized in research applications focusing on inflammatory processes, pain management, and antipyretic effects, supporting studies aimed at understanding COX-2 mediated pathways. -
COX Inhibitor
Piroxicam olamine is a non-steroidal anti-inflammatory drug that acts as an inhibitor of cyclooxygenase (COX), targeting both COX-1 and COX-2 isoforms with IC50 values of 47 μM and 25 μM, respectively, in human monocytes. This compound is primarily used in research applications focused on inflammation and analgesia. Its mechanism of action makes it a valuable tool for studying pathways involved in pain and inflammatory responses. -
COX Inhibitor
COX-2-IN-1 is a potent and selective inhibitor of cyclooxygenase-2 (COX-2), exhibiting an IC50 of 3.9 μM. This compound is valuable for studying COX-2-related pathways and has applications in inflammation and pain research. By selectively targeting COX-2, it allows for the investigation of its role in various physiological and pathological processes. -
COX Inhibitor
Tilmacoxib is a highly selective, irreversible inhibitor of human COX-2, demonstrating time-dependent inhibition with an IC50 of 85 nM in enzyme assays. This compound is primarily utilized in studies investigating the role of COX-2 in inflammatory processes and related disease models. Its specificity and potency make it a valuable tool for elucidating the therapeutic potential of COX-2 inhibition in various biological contexts. -
COX Inhibitor
COX/5-LO-IN-1 is a potent inhibitor targeting cyclooxygenase (COX) and 5-lipoxygenase (5-LO), integral enzymes in the arachidonic acid pathway. This compound demonstrates significant anti-inflammatory and anti-allergic properties, making it a valuable tool for investigating the molecular mechanisms underlying inflammatory and allergic diseases. Its dual inhibition profile supports research into therapeutic strategies for various pathological conditions linked to dysregulated eicosanoid signaling. -
COX Inhibitor
SC58451 is a selective inhibitor of cyclooxygenase-2 (COX-2), known for its potency in downregulating inflammatory pathways. By specifically targeting COX-2, this compound is effective in reducing prostaglandin synthesis, making it valuable for studies related to inflammation and pain management. SC58451 is suitable for research applications in understanding diseases where COX-2 plays a critical role, such as cancer and inflammatory disorders. -
GABAA Receptor Modulator
6-Methoxyflavanone is a flavonoid compound that acts as a positive allosteric modulator of GABAA receptors, specifically enhancing the activity of human recombinant α1β2γ2L and α2β2γ2L subtypes. This compound is capable of crossing the blood-brain barrier and demonstrates key biological activities including anti-anxiety effects, analgesic properties, and relief from neuropathic pain. Additionally, 6-Methoxyflavanone exhibits inhibitory activity towards bitter receptor hTAS2R39 and hTAS2R14, providing a reversible antagonistic effect. Its unique profile makes it a valuable tool for research in neuroscience and pharmacology. -
COX Inhibitor
Inulicin (1-O-Acetylbritannilactone) is a potent inhibitor of cyclooxygenase (COX) enzymes, specifically targeting COX-2 activity. This compound demonstrates significant biological activity by inhibiting lipopolysaccharide (LPS)-induced production of prostaglandin E2 (PGE2) as well as the expression of COX-2. Additionally, Inulicin suppresses NF-κB activation and its translocation, making it valuable for research applications related to inflammation and cancer. -
COX Inhibitor
COX-1-IN-3 is a selective inhibitor of cyclooxygenase-1 (COX-1), exhibiting non-steroidal anti-inflammatory properties. This compound is valuable for research focused on inflammation and pain management, as it modulates the biosynthesis of prostaglandins. Its specificity for COX-1 makes it an important tool for studying COX-1-related pathways and associated biological processes. -
COX Inhibitor
(S)-Ketorolac is a nonsteroidal anti-inflammatory drug that primarily functions as an inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This compound is characterized by its potent analgesic and anti-inflammatory properties, making it suitable for pain management in various research applications. Its ability to selectively inhibit COX enzymes positions (S)-Ketorolac as a valuable tool in studies focused on inflammatory processes and pain modulation. -
COX Inhibitor
(±)-Naproxen is a non-steroidal anti-inflammatory drug that inhibits both COX-1 and COX-2 enzymes, exhibiting IC50 values of 8.72 μM and 5.15 μM, respectively. This compound is primarily used in research for its potent anti-inflammatory and analgesic properties. It provides valuable insights into the mechanisms of pain relief and inflammation, making it suitable for various studies in pharmacology and biochemistry. -
sEH/COX-1 Inhibitor
PTUPB is a potent dual inhibitor of soluble epoxide hydrolase (sEH) and cyclooxygenase-1 (COX-1), exhibiting IC50 values of 0.9 nM and 1.26 μM, respectively. This compound is relevant for studies investigating the modulation of inflammatory processes, as it effectively interferes with pathways involving arachidonic acid metabolism. PTUPB serves as a valuable research tool for exploring the therapeutic potential of sEH and COX-1 inhibition in various disease models. -
COX/5-LOX Inhibitor
Phenethyl ferulate is a potent inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), displaying IC50 values of 4.35 μM and 5.75 μM, respectively. This compound exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammation-related pathways. Its ability to modulate these key enzymes positions it as a promising candidate for studies focused on inflammatory diseases and therapeutic interventions. -
COX Inhibitor
4-Methylamino antipyrine is a COX inhibitor derived from the active metabolite of Metamizole, a pyrazolone non-steroidal anti-inflammatory drug (NSAID). It exhibits analgesic and antipyretic activities, making it beneficial for alleviating pain and reducing fever. Although its anti-inflammatory properties are relatively weak, 4-Methylamino antipyrine serves as a valuable tool in pharmacological studies involving pain management and inflammatory responses. -
COX-2/iNOS Inhibitor
α-Chaconine is an inhibitor of COX-2 and iNOS, which demonstrates significant anti-inflammatory activity. It effectively reduces the transcriptional expression of COX-2, IL-1β, IL-6, and TNF-α. Additionally, α-Chaconine suppresses LPS-induced expression of iNOS and COX-2 at both the protein and mRNA levels, along with their promoter activities in RAW 264.7 macrophages. This makes α-Chaconine a valuable reagent for studies focused on inflammation and related signaling pathways. -
COX Inhibitor
Sphondin is a cyclooxygenase (COX) inhibitor that effectively reduces the levels of COX-2 protein and prostaglandin E2 (PGE2) release in A549 cells stimulated by IL-1β. This compound's anti-inflammatory properties make it a valuable tool for research into COX-related pathways and the modulation of inflammatory responses in various cellular models. Sphondin can facilitate investigations into therapeutic strategies for inflammatory diseases. -
5-LOX/COX Inhibitor
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX), exhibiting IC50 values of 3.5 μM and 3.1 μM, respectively, in RBL-1 cells. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into inflammatory pathways and related diseases. Its dual inhibition of leukotriene and prostaglandin synthesis positions FPL 62064 as a pertinent reagent for studies focusing on inflammation and related therapeutic interventions. -
sPLA2/COX-2 Inhibitor
Alminoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that functions as an inhibitor of secretory phospholipase A2 (sPLA2) and cyclooxygenase-2 (COX-2). This compound exhibits potent anti-inflammatory activity, making it useful in research focused on inflammation and pain modulation. Its dual mechanism of action presents opportunities for investigating pathways involved in inflammatory diseases and related therapeutic interventions. -
COX Antagonist
Sudoxicam is a reversible, orally active cyclooxygenase (COX) antagonist classified as a non-steroidal anti-inflammatory drug (NSAID). It exhibits potent anti-inflammatory, anti-edema, and antipyretic activities, making it useful in various research applications related to inflammatory conditions and pain management. Its mechanism of action positions it as a valuable compound for studies investigating the role of COX enzymes in disease processes. -
COX Inhibitor
Pelubiprofen is an orally active anti-inflammatory agent that inhibits cyclooxygenase (COX) enzyme activity, displaying IC50 values of 10.66 μM for COX-1 and 2.88 μM for COX-2. It demonstrates notable anti-inflammatory and analgesic properties, making it valuable for research in pain management and inflammation pathways. Pelubiprofen can be utilized in studies examining the roles of COX enzymes in various biological processes and diseases. -
COX
Thromboxane B3 is a prostaglandin analog produced via the cyclooxygenase (COX) metabolic pathway from arachidonic acid. It is synthesized in platelets and vascular endothelial cells through the action of COX and thromboxane synthase. Thromboxane B3 has been identified as a product of human platelets when eicosapentaenoic acid is ingested, indicating its role in modulating vascular functions and platelet aggregation. This compound is relevant for research on cardiovascular diseases and inflammatory processes. -
COX Inhibitor
Ketorolac-d5 is a deuterated form of Ketorolac, a non-steroidal anti-inflammatory drug that functions as a nonselective inhibitor of cyclooxygenase (COX). It displays inhibitory potency with IC50 values of 20 nM for COX-1 and 120 nM for COX-2. This compound is widely utilized in pharmacological studies to investigate the biochemical pathways of pain and inflammation, as well as in drug metabolism and pharmacokinetic research. -
COX-2 Inhibitor
EXP3179 is a selective cyclooxygenase-2 (COX-2) inhibitor, notably an intermediate aldehyde metabolite of Losartan. It effectively reduces the expression of COX-2 in endothelial cells, leading to significant anti-inflammatory effects. This compound is useful in research applications focused on inflammation and related signaling pathways. -
COX-II Inhibitor
Tazofelone is a selective cyclooxygenase-II (COX-II) inhibitor that demonstrates significant anti-inflammatory properties. Its bioactivation to sulfoxide and quinol metabolites is primarily facilitated by the CYP3A enzyme system. This compound is utilized in research related to inflammatory bowel disease, providing valuable insights into potential therapeutic approaches. -
COX Inhibitor
Ibuprofen Impurity F is a specific impurity of Ibuprofen, a well-known anti-inflammatory compound that inhibits cyclooxygenase enzymes COX-1 and COX-2. It exhibits inhibitory activity with IC50 values of 13 μM for COX-1 and 370 μM for COX-2. This reagent is valuable for quality control and analytical characterization in pharmaceutical research and development, particularly in the study of non-steroidal anti-inflammatory drugs (NSAIDs). -
COX Inhibitor
Piroxicam cinnamate is a cyclooxygenase (COX) inhibitor with demonstrated anti-inflammatory properties. It is stable under gastric conditions, making it suitable for research applications focused on inflammatory-degenerative osteoarticular diseases, rheumatic disorders, and varicocele-associated oligoasthenospermia. This compound offers significant potential for investigating therapeutic approaches to various inflammatory conditions. -
COX-1 Inhibitor
Valeryl salicylate is a potent and irreversible inhibitor of cyclooxygenase-1 (COX-1). This compound exhibits significant anti-inflammatory activity, making it a valuable tool for research into inflammatory processes. Its mechanism offers insights into the modulation of COX-1 enzyme activity and potential therapeutic applications in inflammatory conditions. -
COX1/2 Inhibitor
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone is a selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). This compound demonstrates significant anti-inflammatory properties and is valuable in research aimed at understanding the role of COX enzymes in various disease models. Its application extends to pharmacological studies focused on pain, inflammation, and potential therapeutic interventions. -
COX Inhibitor
Ibuprofen impurity 1 is an impurity of the widely used anti-inflammatory agent ibuprofen, which acts as a dual inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting IC50 values of 13 μM and 370 μM, respectively. This compound is essential for evaluating the purity and quality of ibuprofen formulations in research. It serves as a valuable tool for studying the pharmacological effects and potential side effects of ibuprofen in various biological assays. -
COX-2 Inhibitor
Robenacoxib is a selective cyclooxygenase-2 (COX-2) inhibitor with potent anti-inflammatory and analgesic properties. It primarily reduces the production of prostaglandins associated with inflammation and pain, making it valuable for research related to inflammatory diseases and pain management. This compound is utilized in studies aiming to elucidate the role of COX-2 in various biological processes and to develop therapeutic strategies targeting inflammation. -
COX-2 Inhibitor
3-Carene is a bicyclic monoterpene that functions as a cyclooxygenase-2 (COX-2) inhibitor. It demonstrates significant anti-inflammatory properties by reducing nociceptive stimulus-induced inflammatory infiltrates and decreasing COX-2 overexpression. Additionally, 3-Carene enhances both the activity and expression of alkaline phosphatase, a crucial early marker of osteoblastic differentiation, making it a valuable compound for research in pain management and bone health. -
COX-2 Inhibitor
Mavacoxib is a selective, oral cyclooxygenase-2 (COX-2) inhibitor, functioning as a long-acting non-steroidal anti-inflammatory drug (NSAID). This compound effectively alleviates pain and inflammation related to degenerative joint disease, particularly in canine subjects. Research applications include studies on inflammation and pain management in veterinary medicine. -
COX-2 Inhibitor
Desmethyl Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 32 nM, demonstrating significant anti-inflammatory activity. As an analog of Celecoxib, this compound serves as a valuable tool in research applications focusing on inflammation and pain pathways. Its potency and specificity make it suitable for studies related to COX-2 mediated processes.
