Ibuprofen (Advil)

Catalog No.: A10461

COX-1 inhibitor

Ibuprofen (Advil)

Ibuprofen (Advil) Chemical Structure

CAS NO. 15687-27-1

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM.

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500 mg

Regular Price: $45.00

Special Price $36.00

10mM * 1mL in DMSO

Regular Price: $59.00

Special Price $47.20

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  • Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
  • Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347

Biological Activity

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM.
Targets
COX-1 COX-2
13 μM370 μM
In vitro (25°C) DMSO 40 mg/mL (193.9 mM)
Water Insoluble
Ethanol 40 mg/mL (193.9 mM)
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 48.47 mL 242.37 mL 484.73 mL
0.5 mM 9.69 mL 48.47 mL 96.95 mL
1 mM 4.85 mL 24.24 mL 48.47 mL
5 mM 0.97 mL 4.85 mL 9.69 mL

*The above data is based on the productmolecular weight 206.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10461
Actions Inhibitor
CAS No. 15687-27-1
Formula C13H18O2
M. Wt 206.3
Purity >98%
Synonyms Genpril, Brufen, Nurofen, Motrin, Ibren, Ibuprohm
SMILES CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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