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$0.00 - Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
Biological Activity
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM.
Targets
| COX-1 | COX-2 | |||
| 13 μM | 370 μM |
| In vitro (25°C) | DMSO | 40 mg/mL (193.9 mM) | |
| Water | Insoluble | ||
| Ethanol | 40 mg/mL (193.9 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 19 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 48.47 mL | 242.37 mL | 484.73 mL |
| 0.5 mM | 9.69 mL | 48.47 mL | 96.95 mL |
| 1 mM | 4.85 mL | 24.24 mL | 48.47 mL |
| 5 mM | 0.97 mL | 4.85 mL | 9.69 mL |
*The above data is based on the productmolecular weight 206.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10461 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 15687-27-1 |
| Formula | C13H18O2 |
| M. Wt | 206.3 |
| Purity | >98% |
| Synonyms | Genpril, Brufen, Nurofen, Motrin, Ibren, Ibuprohm |
| SMILES | CC(C)CC1=CC=C(C=C1)C(C)C(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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