Catalog No.
Product Name
Application
Product Information
Citations
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p53 activator / NF-κB inhibitor
CBL0137 hydrochloride activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
- Cynaropicrin is a sesquiterpene lactone originally isolated from artichoke (C. scolymus) that has diverse biological activities. It inhibits the growth of SKOV3, LOX-IMVI, A549, MCF-7, HCT15, and PC-3 cancer cells (IC50s = 1.1-8.7 μg/ml).
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Stable Isotope
Salicylic acid-d6 is a deuterium-labeled analogue of salicylic acid, serving as a stable isotope for research applications. It functions primarily by inhibiting cyclo-oxygenase-2 (COX-2) activity while bypassing the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). This compound is useful in studies exploring inflammation, pain pathways, and the mechanisms of anti-inflammatory agents. -
Antibiotic
Tylvalosin is a macrolide antibiotic that exhibits broad-spectrum antimicrobial activity. Primarily utilized as an antiviral agent, Tylvalosin is effective in studying Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection. This compound also induces apoptosis and possesses anti-inflammatory properties, helping to mitigate oxidative stress and acute lung injury by inhibiting NF-κB activation. Its diverse biological activities make Tylvalosin valuable for research in infectious diseases and inflammation. -
Antioxidant Agent
α-Lipoic Acid sodium is a potent antioxidant that serves as a crucial cofactor for mitochondrial enzyme complexes. It effectively inhibits NF-κB-dependent activation of the HIV-1 long terminal repeat (LTR) and induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. This compound can be utilized in conjunction with CPUL1 to form the self-assembled nanoaggregate CPUL1-LA NA, which demonstrates enhanced antitumor efficacy compared to CPUL1 alone. -
NF-κB Inhibitor
Dendrophenol is a potent NF-κB inhibitor known for its ability to suppress inflammatory responses. This compound exhibits significant cytotoxic effects against tumor cells, promoting cell cycle arrest and apoptosis, thereby demonstrating antitumor activity. Furthermore, Dendrophenol has been shown to inhibit vascular calcification through the suppression of WNT3/β-catenin activation, making it a valuable tool for research in cancer and vascular biology. -
Antibiotic
Tylvalosin tartrate is a broad-spectrum macrolide antibiotic primarily targeting bacterial infections. This compound exhibits significant antimicrobial activity and is effective in studying Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infections. Additionally, Tylvalosin tartrate induces apoptosis, demonstrates anti-inflammatory properties, relieves oxidative stress, and mitigates acute lung injury by inhibiting NF-κB activation. It serves as a valuable tool for research into viral pathogenesis and cellular responses. -
Stable Isotope
α-Lipoic Acid-d5 is a deuterium-labeled derivative of α-Lipoic Acid, which acts as a potent antioxidant and a crucial cofactor for mitochondrial enzymes. It effectively inhibits NF-κB-dependent activation of the HIV-1 long terminal repeat (LTR), thereby contributing to antiviral research. In addition, α-Lipoic Acid has been demonstrated to induce endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells, making it valuable for studies on cellular stress responses and cancer therapy. -
Plant Essential Oil Composition
Estragole (4-Allylanisole) is a volatile terpenoid ether primarily found in the essential oils of various plants. It exhibits significant biological activities, including the induction of apoptosis and the suppression of lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) production. Additionally, Estragole activates the Nrf-2 pathway and modulates NF-κB signaling, demonstrating anti-inflammatory, antioxidant, and immunomodulatory effects. Its pharmacological properties also include anti-toxoplasma activity and the potential to improve gastric ulcer outcomes while inhibiting dorsal root ganglion (DRG) neuron excitability. -
Purine Nucleoside Analog
N6-(2-Hydroxyethyl)adenosine is a purine nucleoside analog that targets the NF-κB/Smad signaling pathway. This compound demonstrates significant biological activities, including anti-hyperglycemic, antioxidant, antitumor, and anti-inflammatory effects. Additionally, it exhibits insecticidal properties, making it relevant for various research applications in pharmacology and toxicology. N6-(2-Hydroxyethyl)adenosine is noted for its oral bioactivity. -
Antioxidant/Anti-inflammatory Agent
S-Allylmercaptocysteine is an organic sulfur compound that acts as both an antioxidant and anti-inflammatory agent. This compound exhibits significant efficacy in various pulmonary diseases by reducing oxidative stress and inflammation. S-Allylmercaptocysteine also demonstrates potential anti-cancer activity by inducing apoptosis in cancer cells via the TGF-β signaling pathway, while modulating NF-κB activity and up-regulating Nrf2 to enhance its therapeutic effects. -
Anti-Inflammory Agent
Taraxerol is a natural triterpenoid isolated from Taraxacum mongolicum, primarily functioning as an anti-inflammatory agent. It exerts its biological activity by inhibiting the NF-κB signaling pathway, effectively reducing acute inflammation. Additionally, Taraxerol has shown potential in inducing apoptosis in cancer cells, making it a valuable compound for research in inflammation and cancer biology. -
NF-κB Expression Reducer, ERK 1/2 Activator, Beta-Adrenergic Receptor Modulator, Calcium Channel Inhibitor
Eupatorin is a flavonoid that functions primarily as an NF-κB expression reducer and an ERK 1/2 activator, while also modulating beta-adrenergic receptors and inhibiting calcium channels. It demonstrates significant antiproliferative and vasodilatory effects, inducing apoptosis and causing G2/M phase cell cycle arrest, alongside reactive oxygen species (ROS) production. Eupatorin has been shown to impact inflammatory mediators and calcium signaling pathways, making it relevant for research in breast cancer, hypertension, and leukemia. Metabolized by CYP1A1 and other CYP1 enzymes, Eupatorin yields bioactive metabolites that maintain antiproliferative properties. -
MALT1 Inhibitor
SGR-1505 is a small molecule inhibitor targeting MALT1, effectively modulating the NF-κB signaling pathway. This compound demonstrates significant anti-proliferative and antitumor activities by inhibiting MALT1 enzymatic activity, leading to alterations in cell cycle progression, DNA damage response, and apoptosis-related gene expression in in vivo tumor models. SGR-1505 exhibits both tumorostatic and regressive effects in activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) xenograft models. It is a valuable tool for research into activated B-cell-like diffuse large B-cell lymphoma, non-Hodgkin B-cell lymphomas, chronic lymphocytic leukemia, and mature B cell neoplasms. -
Stable Isotope
Lidocaine-d10 is a deuterium-labeled form of lidocaine, primarily targeting sodium channels through complex voltage and use dependence mechanisms. This compound exhibits notable biological activity by inhibiting the growth, migration, and invasion of gastric carcinoma cells, which is mediated by the up-regulation of miR-145 and subsequent inactivation of the MEK/ERK and NF-κB signaling pathways. Lidocaine-d10 serves as a valuable reagent for research applications related to cardiac arrhythmias and cancer biology. -
HDAC Inhibitor
DL-Sulforaphane N-acetyl-L-cysteine is an orally active inhibitor of histone deacetylases (HDACs) and a stable metabolite of sulforaphane. This compound enhances autophagy-mediated reduction of α-tubulin expression via the ERK signaling pathway, making it a valuable tool in cancer research. Its improved blood-brain barrier permeability and extended half-life support its potential in neurobiological studies and therapeutic applications. -
AKR1C1/JAK2/STAT3/NF-κB Inhibitor
Zingiberen Newsaponin is a potent inhibitor of the AKR1C1/JAK2/STAT3 and NF-κB signaling pathways. This steroid saponin compound demonstrates significant anti-hepatocellular carcinoma (HCC) activity by promoting cancer cell apoptosis through the induction of oxidative stress, as evidenced by the upregulation of ROS and MDA levels. Additionally, Zingiberen Newsaponin mitigates cerebral ischemia-reperfusion injury by reducing pro-inflammatory cytokines and enhancing superoxide dismutase (SOD) activity, thereby protecting neuronal cells. Furthermore, it has been shown to induce platelet aggregation, broadening its application in cardiovascular research. -
Antimalarial Agent
Quinacrine hydrochloride hydrate is an antimalarial agent that exhibits significant biological activities, including anticancer effects both in vitro and in vivo. It functions by suppressing NF-κB signaling and activating the p53 pathway, leading to the induction of apoptosis in targeted cells. This compound is valuable for research applications focused on malaria and cancer biology, particularly in studies aiming to understand apoptotic mechanisms and signal transduction pathways. -
HDAC Inhibitor
Panobinostat lactate is a potent, orally active non-selective histone deacetylase (HDAC) inhibitor. It exhibits significant antineoplastic activity and has been shown to disrupt HIV latency effectively. Additionally, Panobinostat lactate induces apoptosis and autophagy in various cell types. This reagent is valuable for studying refractory or relapsed multiple myeloma and exploring HDAC inhibition in cancer research. -
Antibiotic
Narasin is a cationic ionophore antibiotic that effectively targets various microbial pathogens and acts as a coccidiostat agent. Its biological activity includes the inhibition of NF-κB signaling, leading to the induction of apoptosis in tumor cells. Narasin also exhibits antimicrobial, antiviral, and anticancer properties, specifically inhibiting tumor metastasis and the growth of ERα-positive breast cancer cells by inactivating the TGF-β/SMAD3 and IL-6/STAT3 signaling pathways, making it a valuable tool for cancer research and therapeutic applications. -
Stable Isotope
Sodium propionate-13C3 is a stable isotope-labeled form of sodium propionate, a short-chain fatty acid. It is known to activate PPAR-γ, inhibit NF-κB signaling, and decrease COX-2 expression and nitric oxide production. This compound has demonstrated potential in inducing apoptosis and autophagy and exhibits protective effects in conditions such as HSV-1-induced keratitis and glioblastoma. Additionally, sodium propionate-13C3 has neuroprotective, antioxidant, and anti-inflammatory properties, making it a valuable tool for research in areas including spinal cord injury and Alzheimer’s disease. -
Stable Isotope
Lidocaine-d10 hydrochloride is a deuterium-labeled analog of Lidocaine hydrochloride, primarily functioning as a stable isotope. It inhibits sodium channels through complex voltage and use dependence, making it significant in studies of neuronal activity. Additionally, it reduces growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and inactivating the MEK/ERK and NF-κB signaling pathways. This compound is valuable for research into ventricular arrhythmia and broader cardiovascular studies. -
Antibiotic
Quinocetone is an orally active antibiotic that targets various pathogenic microorganisms, making it effective as an animal feed additive to enhance meat production in livestock and poultry. It demonstrates antibacterial activity while also exhibiting tissue-specific toxicity, notably in the liver and lymphocytes. Quinocetone induces autophagy through the ATF6/DAPK1 pathway and activates the NF-κB and iNOS pathways, resulting in cell apoptosis and hepatocyte vacuolar degeneration. Furthermore, it can inhibit the Nrf2/HO-1 pathway and promote the production of reactive oxygen species (ROS), contributing to oxidative stress and DNA damage. -
PROTAC HDAC8 Degrader
SZUH280 is a selective PROTAC degrader targeting HDAC8, demonstrating a DC50 of 0.58 μM in A549 cells. It effectively induces apoptosis in cancer cells and disrupts DNA repair mechanisms, thereby enhancing cellular radiosensitivity. This compound is particularly useful for research related to cancer therapeutics and the study of epigenetic regulation. -
Nrf2 Activator
Danshensu sodium, a phenolic compound, serves as an Nrf2 activator, effectively inducing the Nrf2/HO-1 signaling pathway while inhibiting NF-κB activity. It diminishes reactive oxygen species (ROS) production, enhances antioxidant defenses, and suppresses intrinsic apoptosis. Additionally, Danshensu sodium exhibits significant antiviral properties against SARS-CoV-2, with an EC50 value of 0.97 μM. This compound is valuable for researching its anti-oxidative, anti-inflammatory, and anti-apoptotic effects, holding potential implications for COVID-19, cardiovascular, and cerebrovascular diseases. -
HDAC Inhibitor
Purinostat mesylate is a selective inhibitor of histone deacetylases (HDACs), effectively targeting class I and class IIb HDACs with IC50 values ranging from 0.81 to 11.5 nM. This compound induces apoptosis and influences the cell cycle in LAMA84 and 188 BL-2 cell lines, demonstrating potent anti-leukemic effects in vivo. Purinostat mesylate serves as a valuable tool for researching lymphoblastic leukemia and its therapeutic potential. -
PROTAC XPO1 Degrader
PROTAC XPO1 degrader-1 is a targeted protein degrader designed to selectively promote the degradation of XPO1. This compound demonstrates significant anti-proliferative effects, induces apoptosis, inhibits NF-κB signaling, and causes cell cycle arrest at the G1 phase. It is an important tool for researching hematological malignancies, offering insights into therapeutic strategies by modulating XPO1 levels. -
Bioactive Compound
Arjunolic acid is a multifunctional bioactive compound known for its diverse biological activities. It exhibits potent free radical scavenging properties and demonstrates significant antifungal and antibacterial effects. Arjunolic acid induces apoptosis in various cancer cell lines and offers hepatoprotection against oxidative stress by decreasing reactive oxygen species and inhibiting NF-κB activation. Its regulatory effects extend to pancreatic dysfunction in type 2 diabetic models, neuroinflammation, and Crohn's disease-like colitis, showcasing its potential in addressing conditions such as osteosarcoma and diabetic retinopathy. Research applications include studies on diabetes, organ toxicity, inflammation, and cancer progression. -
Nampt/SIRT1/PRDX5 Activator
Myricanol is a diarylheptanoid that acts as a Nampt activator, enhancing SIRT1 and PRDX5 activities. This compound exhibits notable anti-inflammatory properties and mitigates glucocorticoid-induced muscle atrophy while regulating inflammatory mediators. Additionally, it demonstrates growth inhibition and promotes apoptosis in human lung adenocarcinoma A549 cells. Myricanol is also implicated in neuroprotection via autophagy-mediated clearance of microtubule-associated protein tau and contributes to cardiovascular health by inhibiting key signaling pathways such as PDGFRβ and NF-κB. Its activation of mitochondrial transcription factor A (TFAM) further supports anti-renal fibrosis effects and improves insulin sensitivity through AMPK activation. -
JAK2/STAT3/NF-κB Inhibitor
Reticuline acts as a JAK2/STAT3 and NF-κB signaling pathway inhibitor, displaying notable anti-inflammatory properties. It effectively downregulates the mRNA expression of pro-inflammatory cytokines such as TNF-α and IL-6 while also reducing the phosphorylation levels of JAK2 and STAT3. Additionally, Reticuline demonstrates potential cardiovascular effects, making it a valuable tool for research in inflammation and cardiovascular studies. -
α7 nAchR/JAK2/STAT3 Agonist
α7 nAchR-JAK2-STAT3 agonist 1 is a selective agonist targeting the α7 nicotinic acetylcholine receptor, modulating the JAK2-STAT3 signaling pathway. It demonstrates significant anti-inflammatory activity by inhibiting the expression of inducible nitric oxide synthase (iNOS), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) in murine RAW264.7 macrophages, with an IC50 of 0.32 μM for nitric oxide production. Additionally, it effectively suppresses lipopolysaccharide (LPS)-induced nitric oxide release, NF-κB activation, and related cytokine production. This compound is valuable for studying sepsis and inflammatory responses. -
JAK/STAT and NF-κB Inhibitor
JAK-IN-23 is a potent dual inhibitor of the JAK/STAT and NF-κB signaling pathways, targeting JAK1, JAK2, and JAK3 with IC50 values of 8.9 nM, 15 nM, and 46.2 nM, respectively. This compound effectively modulates the expression of interferon-stimulated genes (ISG) and inhibits NF-κB activation, exhibiting IC50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 demonstrates significant anti-inflammatory properties by reducing the release of various pro-inflammatory cytokines. Its applications include research into inflammatory bowel disease (IBD) and other related inflammatory conditions. -
IRAK4/IRAK1 Inhibitor
IRAK4 modulator-2 is a selective inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) and IRAK1, exhibiting IC50 values of 0.005 μM and 0.97 μM, respectively. This compound effectively disrupts IRAK-mediated signaling pathways, including JAK-STAT and NF-κB pathways, leading to a reduction in pro-inflammatory cytokine production, such as IL-1 and TNF. IRAK4 modulator-2 demonstrates potential for use in research focusing on autoimmune and inflammatory diseases, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. -
Cathepsin L/JAK Inhibitor
Dual Cathepsin L/JAK-IN-1 is a dual inhibitor targeting Cathepsin L (CTSL) and Janus kinases (JAK), exhibiting IC50 values of 0.68 μM for CTSL, 337.1 nM for JAK1, 5.251 nM for JAK2, 27.29 nM for JAK3, and 172.6 nM for TYK2. This compound effectively inhibits the activation of key signaling pathways, including MAPK, NF-κB, and JAK/STAT, thereby providing substantial anti-inflammatory effects. Dual Cathepsin L/JAK-IN-1 is useful for investigating mechanisms underlying acute lung injury (ALI) and other inflammatory conditions. -
IKKβ/JAK2 Inhibitor
EC-70124 is an orally active multikinase inhibitor that targets IKKβ and JAK2. By blocking IkB phosphorylation and the activation of STAT3 (Tyr705), EC-70124 inhibits NF-κB nuclear translocation and impedes STAT3 transcriptional activity. This compound has demonstrated the ability to reduce tumor growth and diminish cancer stem cell populations in prostate cancer cells and xenograft models, making it a valuable tool for research in prostate cancer. -
Anti-osteoclastic Bone Agent
FGFR1 inhibitor-11 is a selective inhibitor targeting Fibroblast Growth Factor Receptor 1 (FGFR1). It effectively disrupts downstream signaling pathways, including ERK1/2 and IκBα/NF-κB, leading to the inhibition of RANKL-induced osteoclastogenesis. This compound demonstrates oral bioactivity and is valuable in research focused on bone resorption and osteoclast development. -
Slow-releasing H2S Donor
FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. This compound inhibits NF-κB activity, leading to the induction of apoptosis in various cell types. FW1256 demonstrates significant anti-inflammatory properties and shows promise for applications in the treatment of cancer and cardiovascular diseases. -
HDAC/JAK/BRD4 Inhibitor
HDAC/JAK/BRD4-IN-1 is a potent inhibitor targeting histone deacetylases (HDAC), Janus kinases (JAK), and bromodomain-containing protein 4 (BRD4). This compound demonstrates significant anti-proliferative effects and promotes apoptosis in MDA-MB-231 breast cancer cells. Additionally, HDAC/JAK/BRD4-IN-1 exhibits promising anticancer activity in vivo, making it a valuable tool for research in cancer therapeutics and the study of epigenetic and signaling pathways. -
Stable Isotope
Sodium propionate-d5, a deuterated form of sodium propionate, primarily acts as a stable isotope label in metabolic studies. This short-chain fatty acid is produced by intestinal bacteria through dietary fiber metabolism and enhances PPAR-γ, while inhibiting NF-κB activation, COX-2 expression, and nitric oxide production. Sodium propionate-d5 displays biological activities such as inducing apoptosis and autophagy, along with potential neuroprotective, antioxidant, and anti-inflammatory effects. It serves as a valuable tool for investigating conditions such as spinal cord injury, Alzheimer's disease, and glioblastoma. -
Autophagy Inducer
Sanguinarine is a benzophenanthridine alkaloid that acts as an autophagy inducer. It is derived from the root of Sanguinaria canadensis and can stimulate apoptosis through the production of reactive oxygen species (ROS). The pro-apoptotic effects of sanguinarine are linked to the activation of the JNK and NF-κB signaling pathways, making it a valuable tool for research in cancer biology and cellular stress responses. -
HDAC1-3 Inhibitor
HDAC-IN-53 is a selective inhibitor of histone deacetylases 1-3, demonstrating IC50 values of 47 nM, 125 nM, and 450 nM for HDAC1, HDAC2, and HDAC3, respectively. This compound exhibits minimal off-target effects, as it does not inhibit class II HDACs (IC50 > 10 μM). HDAC-IN-53 promotes caspase-dependent apoptosis and has been shown to inhibit the growth of human tumor xenografts in nude mice, as well as murine tumors in immune-competent mice bearing MC38 colon cancer. It serves as a valuable tool for studying cancer biology and potential therapeutic strategies targeting HDAC pathways. -
HDAC6 Inhibitor
QTX125 TFA is a potent and highly selective inhibitor of Histone Deacetylase 6 (HDAC6). This compound demonstrates exceptional selectivity for HDAC6 over other isoforms, making it a valuable tool for studying the role of HDAC6 in various biological processes. QTX125 TFA has shown promising antitumor effects, indicating its potential for use in cancer research and therapeutic applications targeting HDAC6-related pathways. -
HDAC Inhibitor
CRA-026440 hydrochloride is a potent, broad-spectrum histone deacetylase (HDAC) inhibitor, exhibiting Ki values against recombinant HDAC isoenzymes of 4 nM for HDAC1, 14 nM for HDAC2, 11 nM for HDAC3, 15 nM for HDAC6, 7 nM for HDAC8, and 20 nM for HDAC10. This compound demonstrates significant antitumor and antiangiogenic activities, making it relevant for studies in cancer biology. Additionally, CRA-026440 hydrochloride possesses an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating its use in click chemistry applications for bioconjugation studies. -
NF-κB Inhibitor
2′-Hydroxychalcone is a hydroxyl derivative of chalcones that primarily inhibits the NF-κB signaling pathway. It has demonstrated significant anticancer activity, inducing autophagy and apoptosis specifically in breast cancer cells. Additionally, 2′-Hydroxychalcone exhibits enhanced antifungal properties against Paracoccidioides spp., making it a valuable reagent for cancer and fungal research applications. -
Stable Isotope
Sodium propionate-d3 is a deuterium-labeled form of sodium propionate, a short-chain fatty acid that functions as a stable isotope. It selectively enhances PPAR-γ activation while inhibiting NF-κB activation, reducing COX-2 expression and nitric oxide production. This compound exhibits significant biological activities, including apoptosis induction and autophagy promotion, along with neuroprotective, antioxidant, and anti-inflammatory properties. Sodium propionate-d3 is valuable in research applications related to spinal cord injury, Alzheimer's disease, and the treatment of glioblastoma, as well as in studying viral infections such as HSV-1-induced keratitis. -
NF-κB Inhibitor/Nrf2/AMPK Activator
Panduratin A is a potent inhibitor of the NF-κB signaling pathway, recognized for its significant anti-inflammatory and antioxidant properties. It demonstrates protective effects against nephrotoxicity induced by Colistin, primarily by mitigating oxidative stress and enhancing mitochondrial function. Additionally, Panduratin A activates autophagy through an AMPK-dependent mechanism and exhibits potential anti-tuberculosis and antiviral activities by inhibiting the methyltransferase of SARS-CoV-2. These diverse biological activities make Panduratin A a valuable tool in various areas of research, including inflammation, cellular stress responses, and infectious diseases. -
Stable Isotope
Laquinimod-d5 is a deuterium-labeled variant of Laquinimod, a potent immunomodulator primarily targeting neuroinflammation in the central nervous system. This compound effectively reduces astrocytic NF-κB activation, offering protection against demyelination induced by Cuprizone. Laquinimod-d5 is intended for research applications exploring relapsing-remitting and chronic progressive forms of multiple sclerosis, as well as various neurodegenerative diseases. -
Molecular probe
AMC-01 is a molecular probe that specifically regulates the activity of eIF2-α. It induces the activation of protein kinase RNA-activated (PKR) and enhances nuclear factor κB (NF-κB) signaling. Additionally, AMC-01 functions to inhibit apoptosis, making it a valuable tool for investigating cellular stress responses and signaling pathways in various research applications. -
Anticancer Agent
(-)-Hinesol primarily functions as a potent anticancer agent. It induces apoptosis and causes cell cycle arrest at the G0/G1 phase. This compound downregulates the MEK/ERK and NF-κB signaling pathways, influencing the expression of key proteins such as cyclin D1, Bax, and Bcl-2. (-)-Hinesol shows significant potential for the research of non-small cell lung cancer.
