Catalog No.
Product Name
Application
Product Information
Citations
-
NF-κB Inhibitor
Dimethyl diacetyl cystinate (DACDM) is a potent NF-κB inhibitor that modulates inflammation by shifting the intracellular redox balance towards an oxidized state. This compound increases the levels of oxidized glutathione (GSSG) and competes with activated NF-κB for binding sites on DNA, thus inhibiting the production of pro-inflammatory cytokines such as IL-1κ. DACDM is a valuable reagent for studies related to UVB-induced skin inflammation and various oxidative stress-related diseases. -
Oxidative Stress Modulator/Anti-inflammatory Agent
Guluronic acid is an oxidative stress modulator and anti-inflammatory agent. It functions by down-regulating pro-inflammatory genes such as TLR4, NF-κB, and iNOS, while inhibiting COX-2, MMPs, and VEGF activity. This compound promotes the up-regulation of immunoregulatory genes including SHIP1 and SOCS1, thereby mitigating cancer-related inflammation, tumor angiogenesis, cell adhesion, and metastasis, while decreasing immunosuppressive cell accumulation. Guluronic acid has demonstrated potential in extending survival times in tumor-bearing hosts within a non-cytotoxic concentration range and has applications in research related to multiple sclerosis, ankylosing spondylitis, breast cancer, and other inflammatory diseases. -
Anticancer Agent
TU-100 is a novel anticancer agent derived from Japanese herbal medicine. It exhibits significant anti-cancer effects by modulating cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME). TU-100 effectively antagonizes the M2 polarization of macrophages by inhibiting the TLR4/NF-κB/STAT3 signaling pathway, leading to the downregulation of key proteins such as MMP-2, COX-2, and VEGF in tumor-associated macrophages (TAMs). This compound is valuable for research into cancer therapies targeting the tumor microenvironment and immune modulation. -
Anticancer Agent
Emodic acid is an anthraquinone compound that primarily targets and inhibits the activity of NF-κB, demonstrating significant anticancer properties. It effectively reduces the proliferation of cancer cells by inhibiting the phosphorylation of key proteins such as p38, ERK, and JNK. Additionally, Emodic acid suppresses the secretion of tumor-promoting cytokines IL-1β and IL-6, as well as the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs), thereby limiting the invasion and migration potential of cancer cells. This compound is valuable for research applications in cancer biology and therapeutic development. -
Akr1B1 Inhibitor
β-Glucogallin is a selective inhibitor of aldose reductase (AKR1B1), exhibiting an IC50 value of 58 μM with glyceraldehyde as the substrate. This compound displays significant antioxidant properties, reducing reactive oxygen species (ROS) and influencing key pathways involving PDGF, RAGE, and NF-κB. Additionally, β-Glucogallin enhances superoxide dismutase (SOD) activity and demonstrates hepatoprotective effects. Its biological activity makes it a valuable tool for research in retinal studies and related fields. -
Immune System Activator
Neopterin is an immune system activator derived from GTP and is produced by activated macrophages. It exhibits significant biological activity by inhibiting NF-κB phosphorylation and promoting PPAR-γ expression, which helps mitigate vascular inflammation and atherogenesis. Neopterin is useful for research applications focused on cardiovascular diseases, inflammation-related disorders, and tumor immunomonitoring. -
HIPK2 Inhibitor
XRF-1021 is an orally active inhibitor of Homer-interacting protein kinase 2 (HIPK2), with an IC50 value of 0.18 μM. It effectively decreases the expression of fibrotic markers such as Fibronectin, Collagen I, and α-SMA in TGF-β1 stimulated renal cell lines, including NRK-49F and HK-2. XRF-1021 further inhibits key signaling pathways including TGF-β, NF-κB, p53, Wnt/β-catenin, and Notch. This compound demonstrates potential in reducing renal injury and fibrosis in vivo, making it a valuable tool for research on chronic kidney disease. -
Hormone disruptors
4-Octylphenol is a known hormone disruptor that primarily targets male reproductive cells, significantly lowering the mitotic index and reducing the population of spermatogonia. Its biological activity includes inducing inflammatory damage in fish gills by activating the complement system through the C3a/C3aR and C5a/C5aR1 pathways, resulting in immune suppression and inflammatory damage. This agent also engages the Toll-like receptor 7 (TLR)/IκBα/NF-κB signaling pathway, highlighting its relevance in studies concerning endocrine disruption and aquatic toxicology. -
Serine Protease
Chymotrypsin, a serine protease, primarily inhibits the TLR4/NF-κB signaling pathway, which downregulates the release of pro-inflammatory factors such as TNF-α and IL-6. Key biological activities include anti-inflammatory, hepatoprotective, and anti-tumor metastasis effects, making it valuable in research related to rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Additionally, Chymotrypsin can reduce tumor cell adhesion molecule expression and has applications in studies involving inflammation and edema. -
LPS Peptide Mimic
RS 09 is an LPS peptide mimic that acts as an agonist for Toll-like receptor 4 (TLR4). By binding to TLR4, RS 09 activates the nuclear factor kappa B (NF-κB) signaling pathway, which is crucial for mediating immune responses. This compound is valuable in research focused on enhancing antigen-specific immune responses and studying TLR4-related signaling pathways in various in vivo models. -
Toll-like Receptor (TLR) Inhibitor
Okanin is a potent Toll-like Receptor (TLR) inhibitor derived from the flowering plant Coreopsis tinctoria. It exhibits significant biological activity by attenuating lipopolysaccharide (LPS)-induced microglial activation via the inhibition of the TLR4/NF-κB signaling pathway. This compound is useful for research applications focusing on neuroinflammation and the modulation of immune responses in microglial cells. -
TLR8 Agonist
CL075 is a selective TLR8 agonist that activates the MyD88-dependent signaling pathway, leading to the production of inflammatory cytokines and type I interferons (IFNs). This compound enhances NF-κB and IRF7 activation, contributing to immune modulation. It is primarily used in research applications focused on inflammation and immune response mechanisms. -
Flavonoid
Pongamol is a flavonoid that targets PTPase-1B and intestinal α-Glycosidase with an IC50 of 75 μM and 103.5 μM, respectively. This compound exhibits anti-inflammatory properties by reducing the release of cytokines such as IL-1β and TNF-α while also reversing the nuclear translocation of NF-κB. Additionally, Pongamol promotes glucose uptake through GLUT4 upregulation, inhibits epithelial-mesenchymal transition via the FAK/Akt-mTOR pathway, and demonstrates neuroprotective effects in models of Alzheimer's disease by alleviating oxidative stress and restoring autophagy. Pongamol is valuable for research applications in Alzheimer's disease, type 2 diabetes, and non-small cell lung cancer. -
GPR75 Inhibitor
(Rac)-AAA is a potent inhibitor of GPR75, targeting the receptor to modulate key signaling pathways. This compound effectively blocks the downregulation of GPR75 expression induced by 20-HETE, leading to the inhibition of downstream pathways such as EGFR, AKT, NF-κB, and FAK. (Rac)-AAA also reverses 20-HETE-mediated epithelial-mesenchymal transition, characterized by the downregulation of vimentin and upregulation of E-Cadherin, while reducing MMP-2 activity and cancer cell migration. Additionally, it mitigates the upregulation of HIC-5 and affects the localization of PKC-α and phosphorylated AKT, making (Rac)-AAA a significant tool in the study of castration-resistant prostate cancer. -
RPTPβ/ζ Inhibitor
MY10 is a potent inhibitor of receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ) that exhibits oral bioactivity. It has been shown to reduce NF-κB p65 expression and activate c-Met tyrosine phosphorylation. Additionally, MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression, while attenuating binge-like ethanol consumption and associated rewards. This compound is valuable for investigating neurological and vascular diseases. -
PROTAC BTK Degrader
PROTAC BTK Degrader-6 is a potent PROTAC degrader targeting Bruton's tyrosine kinase (BTK) with a DC50 of 3.18 nM. This compound exhibits anti-inflammatory activity by inhibiting NF-κB activation and reducing the expression of pro-inflammatory cytokines, including IL-1β and IL-6. It serves as a valuable tool for research into the modulation of immune responses and the development of therapies for inflammatory diseases. -
COX-1/cAMP Phosphodiesterase Inhibitor
Triflusal is a dual inhibitor of Cyclooxygenase-1 (COX-1) and cAMP phosphodiesterase, which penetrates the blood-brain barrier. It effectively inhibits platelet aggregation, nuclear factor kappa B (NF-κB) activation, inducible nitric oxide synthase (iNOS) activity, and prostaglandin synthesis in ischemic tissues. Additionally, Triflusal enhances neutrophil nitric oxide production, endothelial nitric oxide synthase (eNOS) expression, and constitutive nitric oxide synthase (cNOS) activity. This compound is valuable for investigating thromboembolic and ischemic diseases of the cardiovascular and cerebrovascular systems, as well as Alzheimer's disease pathology. -
Nrf2 Activator
Raffinose serves as an Nrf2 activator and is known for its ability to modulate intestinal flora. It inhibits the TLR4-MyD88-NF-κB signaling pathway while promoting Nrf2 signaling, contributing to its anti-inflammatory, antioxidant, and immunomodulatory properties. This compound is orally active and is valuable in research applications focusing on inflammation and oxidative stress. -
Bortezomib Enantiomer
(1S,2S)-Bortezomib is a selective proteasome inhibitor with a high affinity for the 20S proteasome, exhibiting a Ki of 0.6 nM. This compound disrupts the cell cycle and induces apoptosis by targeting a threonine residue, ultimately leading to the inhibition of NF-κB signaling. As an enantiomer of Bortezomib, it serves crucial roles in anti-cancer research applications, providing insights into therapeutic strategies that exploit proteasome inhibition in malignancies. -
COX Inhibitor
Pentagamavunon-1 (PGV-1) is a COX-2 inhibitor that modulates multiple molecular pathways to induce apoptosis. This Curcumin analog exhibits notable oral bioactivity and suppresses key angiogenic factors, including vascular endothelial growth factor (VEGF). Additionally, PGV-1 inhibits NF-κB activation, highlighting its potential in cancer research and therapeutic applications targeting inflammation and tumor progression. -
Eupatilin Derivative
Recoflavone, a synthetic derivative of the flavonoid eupatilin, primarily targets the NF-κB signaling pathway. It exhibits significant biological activities including anti-inflammatory and anti-tumor effects, as well as providing protective properties for gastric and intestinal mucosa. Additionally, Recoflavone promotes secretion in the ocular surface and salivary glands. This compound is valuable for researching conditions such as dry eye, gastric injuries, and intestinal injuries. -
Stable Isotope
12-HETE-d8 is a deuterated form of 12-HETE, a significant metabolite of arachidonic acid produced via 12-lipoxygenase (12-LOX) catalysis. This compound plays a critical role in modulating cell apoptosis in a dose-dependent manner, facilitating the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway. 12-HETE-d8 serves as a valuable tool in research focusing on its dual anti-thrombotic and pro-thrombotic effects, as well as its function as a neuromodulator in various biological contexts. -
Stable Isotope
Sodium propionate-13C is a stable isotope of the short-chain fatty acid sodium propionate, which acts primarily through the activation of PPAR-γ and inhibition of NF-κB signaling pathways. This compound exhibits significant biological activities, including induction of apoptosis and autophagy, as well as reductions in COX-2 expression and nitric oxide production. Key research applications include investigating its neuroprotective and antioxidant properties, along with its potential anticancer effects against glioblastoma. Additionally, sodium propionate-13C can be utilized in studies focused on spinal cord injury and Alzheimer's disease. -
Biochemical Assay Reagent
Chitin, derived from crab carapace, is a long-chain polymer of N-acetylglucosamine featuring β-(1-4) linkages. This biopolymer serves as a biochemical assay reagent and is noted for its ability to inhibit the activation of NF-κB p65, as well as alter its translocation to the nucleus. Chitin also interacts with the cell wall of Candida species, exhibiting antifungal and anti-inflammatory properties. It is valuable for research into gastric ulcers and candidiasis, contributing to the understanding of related pathophysiological processes. -
RelA/p65 Ligand
MMH-165-26 is a ligand targeting RelA/p65, playing a crucial role in modulating nuclear factor kappa B (NF-κB) signaling. This compound significantly reduces the expression levels of RelA/p65 and exhibits notable cytotoxicity in MEC-1 cells, with an LC50 of 0.37 μM. MMH-165-26 is a valuable tool for the development of proteolysis-targeting chimeras (PROTACs), such as JP-163-16, enhancing its utility in cancer research and therapeutic applications. -
Stable Isotope
Lidocaine-d6 hydrochloride is a deuterium-labeled derivative of Lidocaine, primarily targeting voltage-gated sodium channels. It exhibits significant biological activity by inhibiting the growth, migration, and invasion of gastric carcinoma cells through the up-regulation of miR-145 and the subsequent inactivation of the MEK/ERK and NF-κB signaling pathways. This reagent is vital for research in electrophysiological studies and cancer biology, particularly in investigating sodium channel modulation and tumorigenesis mechanisms. -
NF-κB/MAPK/FAK/Akt Inhibitor
Ephemeranthol A is an inhibitor of NF-κB, MAPK, FAK, and Akt signaling pathways. This phenanthrene compound demonstrates notable anti-inflammatory effects through the inhibition of NF-κB and MAPK pathways in macrophages. Additionally, Ephemeranthol A induces apoptosis and inhibits metastasis in non-small cell lung cancer by suppressing FAK/Akt signaling and epithelial-mesenchymal transition (EMT) processes. It is applicable for research into acute and chronic inflammatory diseases as well as non-small cell lung cancer. -
Anticancer Peptide
CIGB-552 is a cell-penetrating peptide that targets tumor cells to exert anti-cancer effects, demonstrating an IC50 of 23 μM in H460 lung cancer cells. This peptide enhances the expression of the protein COMMD1 and significantly inhibits the NF-κB signaling pathway, leading to increased apoptosis in tumor cells. Additionally, CIGB-552 induces the accumulation of reactive oxygen species (ROS) and exhibits both anti-inflammatory and anti-angiogenic properties. It is particularly relevant for research into lung and colon cancers. -
Nitric oxide and hydrogen sulfide-releasing hybrid molecules
NOSH-aspirin (NBS-1120) is a hybrid molecule designed to release both nitric oxide and hydrogen sulfide. This compound demonstrates potent inhibition of pancreatic cancer cell proliferation and induces apoptosis, making it a valuable tool in cancer research. Additionally, NOSH-aspirin has been shown to suppress NF-κB and FoxM1 activity in mouse models of pancreatic cancer. Its neuroprotective effects are evident in rat models of Parkinson's disease, where it alleviates motor deficits and reduces neuroinflammation associated with microglial and astrocytic activation. NOSH-aspirin is suitable for studies involving pancreatic cancer and neurodegenerative disorders. -
Coccidiostat Agent
Narasin sodium is a cationic ionophore and coccidiostat agent that effectively targets and inhibits NF-κB signaling pathways. This compound has demonstrated significant antimicrobial properties as well as the ability to induce apoptosis in tumor cells. Narasin sodium is utilized in both agricultural and biomedical research applications, particularly in studies focused on cancer treatment and microbial resistance. -
Anti-Inflammatory Agent
Picrasidine I is a dimeric alkaloid known for its anti-inflammatory properties, primarily acting through the modulation of key signaling pathways. It induces cell cycle arrest and apoptosis by downregulating the ERK and Akt pathways. Additionally, Picrasidine I inhibits the activation of MAPKs and NF-κB, reduces reactive oxygen species generation, and suppresses the expression of c-Fos and NFATc1, making it a valuable tool for research in inflammation and osteoclastogenesis. -
NF-κB p65 Inhibitor, Apoptosis Inducer
N-Desmethyldauricine is an inhibitor of NF-κB p65 with significant apoptotic effects. It effectively reduces p65 protein expression, induces apoptosis, and arrests the cell cycle at the G0/G1 phase. Additionally, N-Desmethyldauricine attenuates intercellular adhesion and inhibits the growth of 3D spheroids derived from triple-negative breast cancer. This compound is useful for research involving triple-negative breast cancer dynamics and therapeutic strategies. -
Anti-leukemic Compound
(E/Z)-Sinigrin free base is an orally active aliphatic thioglucoside exhibiting anti-leukemic properties. It is hydrolyzed by myrosinase to produce allyl isothiocyanate, which demonstrates an IC50 of 2.71 μM against HL60 leukemia cells. The hydrolysis products also activate apoptosis pathways, inhibit NF-κB and MAPK signaling, and stimulate phase II metabolic enzyme activity, showing potential in cancer therapy, anti-inflammatory research, and infectious disease studies. This compound can be naturally sourced from Brassica nigra, Brassica juncea, and other Brassicaceae plants. -
Anti-inflammatory Agent/Anticancer Agent
Cryptolepine is a multi-potent alkaloid that serves as an anti-inflammatory and anticancer agent. It functions primarily as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, and MAPK while activating AMPKα1/2, leading to various biological effects including DNA intercalation and inhibition of topoisomerase II. These activities result in disrupted mitochondrial dynamics and induction of apoptosis in cancer cells. Cryptolepine shows promise in research applications focusing on tumors such as melanoma and hepatocellular carcinoma, as well as in studies related to malaria, inflammatory diseases, and diabetes. -
Apoptosis Inducer
Sanguinarine (gluconate) is a benzophenanthridine alkaloid that functions as an apoptosis inducer. It promotes apoptosis through the generation of reactive oxygen species (ROS) and is linked to the activation of key signaling pathways, including JNK and NF-κB. This compound is utilized in research exploring mechanisms of apoptosis and oxidative stress responses in various cell types. -
Superoxide Radical Scavenger
Opc 14117 is an orally active superoxide radical scavenger that effectively crosses the blood-brain barrier. It inhibits oxidative stress cascades, leading to a significant reduction in tissue osmotic pressure and alleviation of brain edema in contusion models. Additionally, Opc 14117 blocks the NF-κB-dependent apoptotic pathway in striatal neurons exposed to Quinolinic acid, reducing necrotic volume, protecting hippocampal CA3 neurons, and restoring cognitive function. This compound is useful for studying secondary brain injury and enhancing neurological prognosis. -
NF-κB Inhibitor
15-Deoxy-Δ12,14-prostaglandin A1 is a potent inhibitor of NF-κB signaling, functioning through the modulation of inflammatory pathways. It has been shown to induce apoptosis and effectively inhibit TNF-α-induced upregulation of adhesion molecules on endothelial cells, thereby preventing monocyte arrest. This compound is valuable for research in inflammation, cardiovascular diseases, and apoptosis studies. -
NF-κB Inhibitor
Declopramide is a potent NF-κB inhibitor that exerts antitumor effects by inducing apoptosis in cancer cells. It has demonstrated efficacy in inhibiting the proliferation of HL60 and K562 cell lines, as well as reducing tumor growth in a mouse model of human brain astrocytoma (T24). Additionally, Declopramide functions as a chemosensitizer, making it a valuable tool for investigating therapeutic strategies in cancer research. -
Anti-Inflammatory Agent
2,4′-Dihydroxybenzophenone acts as an anti-inflammatory agent by targeting the hydrophobic pocket of MD2, effectively inhibiting the dimerization of TLR4. This compound demonstrates significant biological activity by suppressing LPS-induced mitochondrial reactive oxygen species (mtROS) production and attenuating the inflammatory response through downregulation of pro-inflammatory mediators, including MyD88, p-IRAK4, and NF-κB. Additionally, 2,4′-Dihydroxybenzophenone serves as an effective UV absorber, enhancing its utility in research on oxidative stress and inflammation. -
μ Opioid Receptor Antagonist
β-Funaltrexamine hydrochloride is a selective and irreversible antagonist of the μ opioid receptor. This compound demonstrates significant anti-inflammatory and neuroprotective properties by reducing TLR4 signaling, inhibiting cytokine-induced iNOS activation and neuroinflammation, and mitigating neuronal degeneration. Additionally, β-funaltrexamine hydrochloride inhibits NF-κB signaling and chemokine expression in human astrocytes and murine models. It is a valuable tool for research related to neurodegenerative diseases, including stroke. -
Methoxyflavone
6-Methoxyflavone is a methoxyflavone compound that primarily targets neuroinflammation pathways. It effectively suppresses neuroinflammation in microglia by inhibiting the TLR4/MyD88/p38 MAPK/NF-κB signaling cascade and activating HO-1/NQO-1 pathways. Additionally, 6-Methoxyflavone induces S-phase cell cycle arrest through the CCNA2/CDK2/p21CIP1 mechanism in HeLa cells. Its diverse biological activities make it valuable for research focused on cancer, inflammation, and neurological disorders. -
TLR4/NF-κB Inhibitor
TLR4/NF-κB-IN-1 is a selective inhibitor of the TLR4/NF-κB signaling pathway, demonstrating significant anti-inflammatory properties. This compound exhibits the ability to penetrate the blood-brain barrier, making it suitable for studies involving neuroinflammation. In murine models, TLR4/NF-κB-IN-1 effectively reduces acute neuroinflammation induced by lipopolysaccharides (LPS) while downregulating the expression of TLR4, phosphorylated NF-κB, and phosphorylated IκB-α proteins, providing a valuable tool for researching neuroinflammatory processes and their therapeutic modulation. -
TLR8 Antagonist
TLR8 antagonist-1 is a selective antagonist targeting Toll-like receptor 8 (TLR8). It effectively inhibits TLR8-mediated inflammatory responses and associated signaling pathways, including the recruitment of MyD88 and the activation of NF-κB and IRF pathways. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research in inflammation and immune response modulation. -
TLR2 Agonist
Pam2Cys is a TLR2 agonist that acts as an immunostimulant by binding to TLR2, activating dendritic cells, and initiating the TLR2-dependent NF-κB signaling pathway. This compound promotes dendritic cell maturation through the upregulation of MHC II molecules, enhances innate immune signaling, and drives pro-inflammatory responses, including the release of IL-12 and other cytokines. Additionally, Pam2Cys serves as a lipid moiety in synthetic lipopeptide vaccines, boosting immunogenicity, while selectively inducing pro-inflammatory macrophage activation. Research applications include studies on tuberculosis and influenza A virus infections, as it effectively recruits immune cells and mitigates infection-related symptoms without compromising adaptive immunity. -
TLR4/MyD88/NF-κB Inhibitor
SjDX5-271 is a small peptide inhibitor targeting the TLR4/MyD88/NF-κB signaling pathway. It is known to induce cell polarization and mitigate hepatic inflammation, demonstrating protective effects against liver ischemia-reperfusion injury in mouse models. This compound is valuable for research in immunology and liver-related inflammation studies. -
Anti-Inflammatory Agent
4-Methoxylonchocarpin is an orally active anti-inflammatory agent that primarily targets Toll-like Receptor 4 (TLR4). This compound effectively inhibits the binding of lipopolysaccharides (LPS) to TLR4, leading to the suppression of NF-κB activation and the downregulation of pro-inflammatory cytokines such as TNF and IL-6. Additionally, 4-Methoxylonchocarpin reduces the phosphorylation of TGF-beta activated kinase 1 and mitigates the expression of IL-1β, IL-17A, and TNF in a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model, demonstrating its potential in anti-inflammatory research applications. -
Anti-inflammatory Agent
Chlojaponilactone B is a lindenane-type sesquiterpenoid known for its anti-inflammatory properties. This compound functions by inhibiting Toll-like receptor 4 (TLR4), leading to a decrease in reactive oxygen species (ROS) production and downregulation of the NF-κB pathway. Consequently, it reduces the expression of pro-inflammatory cytokines, including iNOS, nitric oxide (NO), COX-2, IL-6, and TNF-α. Chlojaponilactone B is a valuable tool for research into inflammation and related pathways. -
TLR7/TLR9 Inhibitor
ODN 24888 is a guanine-modified inhibitory oligonucleotide (INH-ODN) that specifically targets TLR7 and TLR9 signaling pathways. It effectively inhibits interferon-alpha (IFN-α) secretion and NF-κB activation, while also reducing interleukin-6 (IL-6) release. ODN 24888 is valuable for studying immune and inflammatory responses and can be utilized as a vaccine adjuvant in various research applications. -
TLR Inhibitor
TIC10g is a dual inhibitor of toll-like receptors 7 and 9 (TLR7 and TLR9). It effectively decreases TNF-α release in mouse macrophages and human B lymphocytes, with IC50 values of 14.5 μM and 6.5 μM for TLR7, and 7.69 μM and 11.5 μM for TLR9, respectively. TIC10g also inhibits the activation of NF-κB and MAPK pathways, demonstrating potential as an anti-inflammatory agent in conditions such as systemic lupus erythematosus and rheumatoid arthritis. -
TLR4 Signaling Inhibitor
NCI126224 is a TLR4 signaling inhibitor that modulates immune responses by suppressing lipopolysaccharide (LPS)-induced production of key inflammatory mediators, including NF-κB, TNF-α, IL-1β, and nitric oxide. This compound demonstrates biological activity in the low nanomolar to low micromolar range, making it a valuable tool for research into inflammatory diseases and their mechanisms. Its ability to interfere with TLR4 signaling pathways positions NCI126224 as a significant reagent for exploring potential therapeutic strategies in inflammation-related studies.
