(E/Z)-Sinigrin free base is an orally active aliphatic thioglucoside exhibiting anti-leukemic properties. It is hydrolyzed by myrosinase to produce allyl isothiocyanate, which demonstrates an IC50 of 2.71 μM against HL60 leukemia cells. The hydrolysis products also activate apoptosis pathways, inhibit NF-κB and MAPK signaling, and stimulate phase II metabolic enzyme activity, showing potential in cancer therapy, anti-inflammatory research, and infectious disease studies. This compound can be naturally sourced from Brassica nigra, Brassica juncea, and other Brassicaceae plants.
(E/Z)-Sinigrin free base is an orally active aliphatic thioglucoside exhibiting anti-leukemic properties. It is hydrolyzed by myrosinase to produce allyl isothiocyanate, which demonstrates an IC50 of 2.71 μM against HL60 leukemia cells. The hydrolysis products also activate apoptosis pathways, inhibit NF-κB and MAPK signaling, and stimulate phase II metabolic enzyme activity, showing potential in cancer therapy, anti-inflammatory research, and infectious disease studies. This compound can be naturally sourced from Brassica nigra, Brassica juncea, and other Brassicaceae plants.
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