Other inhibitors

LH-RH, human is a biochem/physiol Actions LHRH Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.

Anisole methoxybenzene is a colorless liquid with a smell reminiscent of anise seed, and in fact many of its derivatives are found in natural and artificial fragrances.

DBU is a chemical compound and belongs to the class of amidine compounds.

Triisopropylsilane is a highly selective reducing agent which can be used to prepare anti-1,2-diols.

Bisoctrizole is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. Also a hybrid UV absorber, reflecting and scattering UV.

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.

(Z)-2-decenoic acid is an unsaturated short chain fatty acid that is secreted by P. aeruginosa and induces a disp .

9-Dihydro-13-acetylbaccatin III (9-DHAB III) is an intermediate for taxol analog preparations.

Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1), an antioxidant dietary supplement.

BMX-IN-1 is a highly selective and potent irreversible inhibitor which target the cysteine residue in the BMX ATP binding domain.

Cot inhibitor-2 is a COT/Tpl2 inhibitor.

Deferasirox Fe3+ chelate is a rationally-designed oral iron chelator; its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias.

EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.

Etimizol was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain).

MB05032 is a special and efficacious GNG inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.

N3PT is a potent and selective transketolase(TK) inhibitor (IC50= 22 nM for Apo-TK) both in vitro and in vivo.

NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway.

Pafuramidine is an orally bioavailable prodrug of furamidine, which has clinical activity against Pneumocystis pneumonia.

Pamabron is a common over-the-counter diuretic used for relief of menstrual-associated symptoms.

Retinyl glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals.

sodium 4-pentynoate is a alkynylacetate analogue; can be metabolically incorporated onto cellular proteins through biosynthetic mechanisms for profiling of acetylated proteins in diverse cell types.

Sodium formononetin-3'-sulfonate is a water-sol. derivate of formononetin.

R18, antagonist of 14.3.3 proteins (KD ??? 80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation.

Plumbagin, exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma; has antifungal, antiviral, and antibacterial action.

Beta-lipotropin (beta-LPH) was found to contain within its C-terminal sequence the primary structure of these peptides.

N/A

K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1beta or TNF-alpha.

K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1beta or TNF-alpha.

KRX-0402 is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin?€?s lymphoma.

Finafloxacin hydrochloride is a fluoroquinolone compound.

AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 uM,

N/A

Bucetin is an analgesic and antipyretice agent with a risk of carcinogenesis.

3-Indolebutyric acid is a plant hormone in the auxin family and is an ingredient in many commercial horticultural plant rooting products.

4-Methylumbelliferone is a selective inhibitor of Hyaluronan (HA) synthesis which is thought to function as an inhibitor via the depletion of UDP-glucuronic acid, the common substrate for HA synthesis.

5-Aminolevulinic acid hydrochloride is a naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme.

7-Aminocephalosporanic acid is the core chemical structure for the synthesis of cephalosporin antibiotics and intermediates.

Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus and, in some countries, prediabetes.

Acetanilide is used as an inhibitor in hydrogen peroxide and is used to stabilize cellulose ester varnishes.

Acitazanolast is an active metabolite of tazanolast and anti-allergic drug.

Aesculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum). It is used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria).

Alfacalcidol is an analogue of vitamin D.Alfacalcidol has a weaker impact on calcium metabolism than calcitriol, while having more potent effects on parathyroid hormone levels and the immune system, including regulatory T cells.

Aminocaproic acid is used to treat excessive postoperative bleeding, especially after procedures in which a great amount of bleeding is expected,

Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis. Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells.

Azalomycin-B is a macrolide antibiotic produced by Streptomyces hygroscopicus.

Beta Carotene is a strongly-coloured red-orange pigment abundant in plants and fruits. It is a precursor (inactive form) of vitamin A.

Biapenem is a carbapenem antibiotic. It has in vitro activity against anaerobes.

Bilobalide, a biologically active terpenic trilactone (terpinoid), derived from geranylgeranyl pyrophosphate (GGPP) is an inducer of cytochrome P450 enzymes CYP3A1 and CYP1A2. May contain properties to stop apoptosis activation of the phosphatidylinositol 3-Kinase pathway in SH-SY5Y cells.

Bimatoprost is a prostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension

Biochanin A is an antiproliferative and anti-inflammatory agent that inhibits iNOS expression and lipopolysacharide (LPS)-induced nitric oxide production in macrophages. Additionally, Biochanin A displays the ability to block phosphorylation of IκBα and p38 MAPK, which prevents NF-κB activation. Furthermore, Biochanin A has been observed to suppress IL-6, IL-1β, and TNF-α production.