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Catalog No.
Product Name
Application
Product Information
Citations
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O-GlcNAcase inhibitor
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal-hexosaminidase.- Aaron K Olson, .et al. , BMC Mol Cell Biol, 2025, Jun 10;26(1):19 PMID: 40495125
- Kefan Wu, .et al. , Biomedicines, 2023, Apr 24;11(5):1259 PMID: 37238930
- Wei Zhong Zhu, .et al. , PLoS One, 2022, Oct 26;17(10):e0276285 PMID: 36288343
- Zhu WZ, .et al. , J Am Heart Assoc, 2019, Jun 4;8(11):e011260 PMID: 31131693
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3CLpro inhibitor
GC376 is a 3CLpro inhibitor (3C-like protease inhibitor).- Ai-Ai Chou, .et al. , Vet Q, 2024, Dec;44(1):1-13 PMID: 38712855
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MyD88 dimerization Inhibitor
ST 2825 is a MyD88 pharmacologic inhibitor.- Bernard Kan, .et al. , Nat Commun, 2018, 9: 4822 PMID: 30446641
- Shira Dishon, .et al. , Sci Rep, 2018, 8: 9476 PMID: 29930295
- Treprostinil is a stable analog of prostacyclin that is used clinically for the treatment of PPH.
- Bhat L, .et al. , Eur J Pharmacol, 2018, May 15;827:159-166 PMID: 29453947
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SE inhibitor
NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway.- Gia-Buu Tran, .et al. , Cancer Res, 2023, Apr 14;CAN-22-3450 PMID: 37057874
- Weber RA, .et al. , Mol Cell, 2020, Feb 6;77(3):645-655 PMID: 31983508
- Garcia-Bermudez J, .et al. , Nature, 2019, Feb 13 PMID: 30760928
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TPA/PMA inhibitor
Cyclosporin H is a TPA/PMA inhibitor and a selective inhibitor of formyl peptide receptors (Ki = 0.1 uM).- Jean-Philippe Auger, .et al. , Nature, 2024, May;629(8010):184-192 PMID: 38600378
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c-Fos inhibitor
T-5224 is a selective inhibitor of c-Fos/activator protein-1.- Mirei Fujita, .et al. , Biomolecules, 2026, 16(5), 755 PMID: 42194103
- Kamata Y, .et al. , J Dermatol Sci, 2018, Apr 23. pii: S0923-1811(18)30186-5 PMID: 29730173
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rRNA biogenesis inhibitor
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.- Rocio Diaz Escarcega, .et al. , Cell Death Dis, 2026, Jun 18 PMID: 42310298
- Maria Sultan, .et al. , J Biomed Sci, 2025, Feb 5;32(1):15 PMID: 39905515
- Jing-Wei Liang, .et al. , Antioxidants (Basel), 2023, Dec 20;13(1):11 PMID: 38275631
- Maria Razzaq, .et al. , Arch Pharm Res, 2023, Jul;46(7):598-615 PMID: 37563335
- Janne J. M. van Schie, .et al. , Nat Commun, 2020, 11: 4287 PMID: 32855419
- Yue Sheng, .et al. , Blood, 2020, Aug 21 PMID: 32822452
- Hald øH, .et al. , Oncogene, 2018, Dec 12 PMID: 30542116
- Louise E. Kerry, .et al. , PLoS Negl Trop Dis, 2017, Mar; 11(3): e0005432 PMID: 28263991
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micromolar inhibitor
Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.- Yuuki Kurebayashi, .et al. , PLoS One, 2016, 11(5): e0156400 PMID: 27232333
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O-GlcNAcase inhibitor
Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro.- Zhen Liang, .et al. , Nat Metab, 2023, Jan;5(1):29-40 PMID: 36624157
- Alemayehu Toma, .et al. , J Exp Pharmacol, 2022, 14: 309-316 PMID: 36317069
- Andressa Braga, .et al. , Braz J Pharm Sci, 2022, 58: e19674
- Yuanyuan Du, .et al. , Nat Med, 2022, Feb;28(2):272-282 PMID: 35115708
- Karemah A. Alatawi, .et al. , Saudi Journal of Biological Sciences, 2021, 25 June PMID: 34354403
- D.H. Mhya, .et al. , Asian J Exp Biol Sci, 2019, 12 (2): 164-172
- Stanley I. R. Okoduwa, .et al. , J Diabetol, 2017, 8(3): 74-85
- Stanley I. R. Okoduwa, .et al. , Medicines (Basel), 2017, Dec; 4(4): 73 PMID: 29019956
- Stanley I. R. Okoduwa, .et al. , PLoS One, 2017, 12(1): e0170971 PMID: 28129400
- Stanley I. R. Okoduwa, .et al. , World J Diabetes, 2016, Dec 15; 7(20): 605-614 PMID: 28031778
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Glycogen phosphorylase (GP) inhibitor
AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes. -
ECE inhibitor
(±)-WS75624B is an endothelin converting enzyme (ECE) inhibitor with an IC50 of 0.03 μg/mL. -
CNT2 Inhibitor
CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2. -
squalene epoxidase inhibitor
FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. -
Neutrophil elastase inhibitor
Freselestat is a potent neutrophil elastase inhibitor. Freselestat reduces inflammatory mediators during simulated extracorporeal circulation. ONO-6818 significantly reduced interleukin 8 and C5b-9 production. ONO-6818 did not modulate changes of CD11b and L-selectin during recirculation. -
SCD1 inhibitor
stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice. -
glycolate oxidase inhibitor
Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV. -
AKR1C3 inhibitor
AKR1C3-IN-1 is a potent, highly selective inhibitor of AKR1C3, with an IC50 of 13 nM. -
protein synthesis inhibitor
Apramycin Sulfate is a broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius -
24-DHCR inhibitor
Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol. -
helicase primase inhibitor
BAY 57-1293 is a potent helicase primase inhibitor. BAY 57-1293 inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. -
Glyoxalase I inhibitor
Glyoxalase I inhibitor is a potent Glyoxalase I inhibitor, candidate for anticancer agents. -
FUBP1 inhibitor
FUBP1-CIN-1 is a potent FUSE binding protein 1 (FUBP1) inhibitor which interferes with the binding of FUBP1 to its single stranded target DNA FUSE sequence , with an IC50 value of 11.0 μM. -
Noradrenalin re-uptake inhibitor
Nisoxetine hydrochloride is a selective and potent inhibitor of norepinephrine transporter with little or no affinity for a range of other neurotransmitter receptors. Nisoxetine hydrochloride is an inhibitor of SLC6A2. -
PKR Inhibitor
PKR Inhibitor is an oxindole/imidazole derivative that binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.3 PKR Inhibitor protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. -
ENT1 inhibitor
NBMPR is a nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM, IC50s = 4.6 and 3.6 nM in rat and human, respectively). -
DCPS inhibitor
RG3039 (PF-06687859) is orally bioavailable, brain-penetrant small molecule that has been shown to be an inhibitor of the mRNA decapping enzyme, DcpS.
