Catalog No.
Product Name
Application
Product Information
Citations
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CXCR4 Targeting Peptide
Pentixafor is a synthetic peptide that targets the CXCR4 receptor, playing a critical role in various cellular processes, including cell migration and signaling. This compound can be labeled with 68Gallium (68Ga), enabling its application in positron emission tomography (PET) imaging for assessing CXCR4 expression in vivo. Additionally, Pentixafor serves as a vital component in the development of Radionuclide-Drug Conjugates (RDCs) for targeted cancer therapies. -
CAIX-targeting Cyclic Peptide
DPI-4452 is a CAIX-targeting cyclic peptide incorporating a DOTA cage, designed for chelation with radionuclides for positron emission tomography-computed tomography (PET-CT) imaging of CAIX-expressing tumors. This compound exhibits high specificity by binding to the carbonic anhydrase IX (CAIX) with an IC50 of 130 nM, while showing no significant interactions with a panel of 55 off-target receptors. In preclinical studies, radiolabeled DPI-4452 effectively inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models. Additionally, it serves as a valuable reagent for the research and development of Radionuclide-Drug Conjugates (RDCs). -
FAP-Targeting Peptide
3BP-3940 is a highly potent and selective peptide inhibitor targeting fibroblast activation protein (FAP) in cancer-associated fibroblasts (CAFs) within the tumor microenvironment. This reagent exhibits significant potential for tumor imaging when labeled with radionuclides such as Ga-68 and for targeted anticancer therapies using Lu-177. 3BP-3940 selectively accumulates in tumor lesions, making it valuable for the diagnosis and treatment of various solid tumors and conditions related to CAFs. -
RDC Peptide
FAP targeting peptide for FXX489 is a polypeptide that specifically targets fibroblast activation protein (FAP). This ligand plays a crucial role in the development of therapeutic agents aimed at modulating FAP-related pathways. It is particularly applicable in cancer research, where FAP is associated with tumor stroma and cancer progression, facilitating targeted delivery of therapeutic compounds. -
Peptide Drug Conjugate
DOTA-EB-TATE is a peptide drug conjugate composed of a somatostatin (SST) peptide derivative, DOTA-octreotate, conjugated to an Evans blue analog. This compound enhances the pharmacokinetics of somatostatin receptor subtype 2 (SSTR2) analogs while decreasing associated toxicity in peptide receptor radionuclide therapy (PRRT). DOTA-EB-TATE is also applicable in the synthesis and research of radionuclide-drug conjugates (RDCs), making it valuable for investigations in targeted cancer therapies. -
GRPR-targeting Peptide
GB-6 is a GRPR-targeting peptide that selectively binds to the gastrin releasing peptide receptor, which is frequently overexpressed in pancreatic cancer. This peptide demonstrates excellent in vivo stability and efficacy in tumor targeting and imaging when conjugated with near-infrared fluorescent dyes or the radionuclide technetium-99m (99mTc). In SW1990 subcutaneous xenograft models, GB-6 exhibited tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, facilitating precise tumor boundary delineation. This high-contrast imaging capability positions GB-6 as a promising tool for cancer imaging applications. -
FPR-specific Peptide
cFLFLF is a FPR-specific peptide designed for targeted imaging applications. When conjugated with a bifunctional polyethylene glycol moiety (PEG, 3.4 kD) and a DOTA through a lysine spacer, it forms cFLFLFKPEG-64Cu, which is subsequently labeled with 64Cu-CuCl2. This compound serves as a neutrophil-specific PET imaging agent, enabling visualization and assessment of inflammatory responses in various research contexts. -
αvβ6-integrin-specific Peptide
Cyclic αvβ6 (c(FRGDLAFp(NMe)K)) is a cyclic nonapeptide that specifically targets the αvβ6-integrin. It demonstrates significant potential in the field of positron emission tomography (PET) imaging, particularly for detecting malignancies such as head and neck cancer and pancreatic cancer. By coupling with 68Ga-labeled monomeric triazacyclononane-triphosphinate (TRAP), Cyclic αvβ6 can enhance imaging specificity and accuracy in oncological research applications. -
Peptide-PEG2 Conjugate of Unlabeled FXX489
FAP targeting peptide-PEG2 conjugate is a peptide-PEG2 linker conjugate of Unlabeled FXX489, a ligand specifically targeting fibroblast activation protein (FAP). This conjugate facilitates targeted delivery and enhances bioavailability in therapeutic applications. It is primarily employed in research focusing on FAP-related diseases, offering valuable insights into cancer progression and tissue remodeling. -
MAPK Substrate
EGF-R (661-681) T669 peptide serves as a substrate for Mitogen-Activated Protein Kinase (MAPK). This peptide is instrumental in evaluating MAPK catalytic activity in various biological contexts. It is particularly useful in studies focusing on cell signaling pathways, proliferation, and differentiation associated with EGF receptor signaling. -
Substrate Peptide
Nictide is a peptide substrate for LRRK2 (leucine-rich repeat kinase 2), specifically phosphorylated by the activated LRRK2[G2019S] variant. Its Km value of 10 μM indicates a moderate affinity, making it suitable for assessing LRRK2 activity in biological research. Nictide can be effectively utilized in studies exploring LRRK2-related signaling pathways and neurodegenerative disease mechanisms. -
Antimicrobial Peptides
Bac5(1-25) is an N-terminal fragment of the bovine proline-rich antimicrobial peptide Bac5, targeting bacterial membranes. This peptide exhibits significant antibacterial activity against a broad spectrum of pathogens, making it a valuable tool for antimicrobial research. Bac5(1-25) is suitable for studies focused on the mechanisms of antimicrobial action and the development of novel antimicrobial therapies. -
Calmodulin-Binding Peptide
CBP-501 is a cell-permeable calmodulin-binding peptide that acts as a G2-abrogating agent. It effectively inhibits the activity of several Ser216-specific kinases, including MAPKAP-K2, C-Tak1, CHK1, and CHK2, with IC50 values of 0.9 μM, 1.4 μM, 3.4 μM, and 6.5 μM, respectively. This compound is primarily utilized in cancer research to explore its therapeutic potential in modulating cell cycle progression and targeting tumor proliferation. -
Chk Kinase Inhibitor
CBP501 Affinity Peptide is a Chk kinase inhibitor that effectively disrupts G2 cell cycle arrest triggered by DNA-damaging agents. This reagent is valuable for cancer research, enabling studies on cell cycle regulation and therapeutic responses to genotoxic stress. Its application can facilitate the investigation of DNA damage repair pathways and their implications in oncogenesis. -
Tumor-homing Peptide
mUNO is a tumor-homing peptide with the sequence "CSPGAK" that specifically targets mouse CD206, a marker expressed on tumor-associated macrophages. This peptide facilitates the selective binding of therapeutics or imaging agents to these macrophages, enhancing localization in tumor environments. mUNO also demonstrates the ability to interact with human recombinant CD206, making it a valuable tool for cancer research and the development of targeted therapies. -
Targeting Peptide
MACTIDE is a high-affinity targeting peptide specific for CD206, known for its stability and efficacy in drug delivery applications. This peptide significantly enhances the targeting of therapeutic agents, making it a valuable tool in cancer research, particularly in studies focused on breast cancer. Its utility extends to investigations aimed at improving the precision of drug action through enhanced tumor targeting. -
MEMs-targeting Peptide
UNO peptide is a MEMs-targeting peptide that specifically binds to CD206 on MRC1-expressing tumor-associated macrophages (TAMs). It demonstrates potential in modulating the tumor microenvironment and influencing immune responses. UNO peptide is valuable for research applications focused on the role of MRC1-expressing TAMs in breast cancer and other solid tumors. -
p38 MAPK Activator
OVA-E1 peptide is an activator of p38 MAPK, derived from the original SIINFEKL sequence (OVA 257-264). This peptide effectively stimulates both p38 and JNK signaling pathways in both mutant and wild-type thymocytes. It serves as a valuable tool for studying MAPK pathways and their roles in cellular responses such as inflammation and stress signaling in various research applications. -
Peptide
(Thr17)-c-Jun (11-23) is a bioactive peptide derived from the c-Jun protein, specifically targeting the transcriptional regulation pathway. This peptide is involved in cell growth, differentiation, and apoptosis, making it essential for studies related to cancer research and signal transduction. Researchers can utilize (Thr17)-c-Jun (11-23) to investigate the molecular mechanisms of gene expression mediated by the Jun/Fos protein family. -
p38 MAPK Inhibitor, JNK Inhibitor
HE4-1 leech peptide is a selective inhibitor of p38 MAPK and c-Jun N-terminal kinase (JNK). It effectively suppresses macrophage migration while maintaining normal macrophage immunological functions, such as phagocytosis, lysozyme activity, and the expression of various inflammatory factors. This peptide is primarily utilized in research focused on atherosclerosis and inflammation-related studies. -
Proteoglycan Aggregates Activator
Link N peptide is a proteoglycan aggregates activator that targets the extracellular matrix. It specifically activates the p38 mitogen-activated protein kinase (MAPK) pathway, leading to enhanced expression of type I and II collagens in human intervertebral disc cells. This peptide is valuable for investigating intervertebral disc degeneration and related pathologies. -
Modification of Protein/Polypeptide
N-ε-propargyloxycarbonyl-L-lysine is a lysine-based unnatural amino acid utilized primarily for the modification of proteins and polypeptides. This compound serves as a versatile bio-conjugation reagent for fluorescent probes across various organisms, including E. coli and mammalian cells. Featuring an alkyne group, N-ε-propargyloxycarbonyl-L-lysine is suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling efficient conjugation with azide-containing molecules for diverse research applications. -
Caspase-1/4 Fluorometric Peptide Substrate
Ac-YVAD-AFC is a fluorometric peptide substrate specifically targeting caspase-1 and caspase-4. It exhibits an excitation wavelength of 400 nm and an emission wavelength of 505 nm, making it suitable for assessing caspase activity in various biological samples. This compound is commonly used in research applications focused on apoptosis, inflammation, and disease mechanisms involving these caspases. -
Fluorogenic Peptide Substrate
Ac-Leu-Arg-AMC is a fluorogenic peptide substrate designed for the quantitative analysis of protease activity. This compound is particularly useful in studies of proteolytic enzymes, enabling the detection of enzyme activity through fluorescence measurement. Its specificity for certain proteases makes it ideal for applications in biochemical assays and research involving protein degradation pathways. -
Bioactive Peptide
Gly-Pro-AMC is a bioactive peptide that serves as a substrate for dipeptidylaminopeptidase IV, exhibiting fluorescence with an excitation/emission wavelength of 353/442 nm. Its key biological activity lies in the selective hydrolysis by DPP-IV, making it valuable for research applications focused on enzyme kinetics and substrate specificity. This substrate is ideal for studies investigating metabolic processes related to peptide signaling and regulation in various biological contexts. -
Fluorogenic Peptide Substrate
Gly-Gly-AMC is a fluorogenic peptide substrate utilized for measuring protease activity. This compound is particularly effective in evaluating the bacterial protease activities of Pseudomonas aeruginosa and Staphylococcus aureus. Researchers can leverage Gly-Gly-AMC for applications in enzymatic assays and studies focused on bacterial pathogenicity and proteolytic processes. -
Polypeptide/Protein Marker
Fmoc-Lys(5-FITC)-OH serves as a fluorescent marker for polypeptides and proteins, utilizing fluorescein isothiocyanate (FITC) to label amines. This compound exhibits sensitivity to pH and Cu2+ ions, making it valuable for various biochemical applications. Its fluorescent properties facilitate the study of protein interactions, localization, and dynamics in biological systems. Researchers can employ Fmoc-Lys(5-FITC)-OH in assays requiring specific protein visualization and tracking. -
Neuropeptide Y Y1 Receptor Antagonist
Neuropeptide Y Y1 Receptor Antagonist 1 is a potent antagonist of the neuropeptide Y Y1 receptor (Y1R), exhibiting a Ki value of 0.19 nM. This compound serves as a valuable tool in neurobiology research, facilitating the investigation of neuropeptide signaling pathways and their roles in various physiological processes. Its applications include studying the effects of Y1R modulation on neuroendocrine responses, food intake, and anxiety-related behaviors. -
β-catenin/GSK-3β Activator
C-Peptide 1 (rat) is a peptide that functions as an activator of β-catenin and GSK-3β. Its primary mechanism involves the regulation of the Wnt/β-catenin signaling pathway, which plays a crucial role in cellular processes such as proliferation and differentiation. C-Peptide 1 (rat) is utilized in cancer research, contributing to studies aimed at understanding tumorigenesis and potential therapeutic interventions. -
GSK-3 Substrate
Phospho-Glycogen Synthase Peptide-2 is a specific substrate for glycogen synthase kinase-3 (GSK-3). This peptide facilitates the study of GSK-3 activity and its role in various signaling pathways. It is also suitable for affinity purification of protein-serine kinases, enabling researchers to investigate kinase interactions and functions in cellular processes. -
Cyclic Hexapeptide
RA-V is a cyclic hexapeptide that targets key oncogenic signaling pathways. It exhibits inhibitory activity against Wnt, Myc, and Notch with IC50 values of 50, 75, and 93 ng/mL, respectively. RA-V is a valuable tool for investigating cancer-related signaling mechanisms, providing insights into tumor biology and potential therapeutic strategies. -
Peptide Spacer
Gly-Gly-Phe-Gly functions as a peptide spacer, serving as an important component in drug conjugation applications. It is effectively utilized in the synthesis of antibody-drug conjugates (ADCs), facilitating the conjugation of cytotoxic agents like Doxorubicin and Puxitatug samrotecan. This spacer enhances the stability and pharmacokinetics of ADCs, making it valuable for research in targeted cancer therapies. -
Peptide
MC-Ala-Ala-Asn-PAB-PNP is a peptide designed for the synthesis of specifically activated micromolecular target coupling bodies. Its unique structure allows for selective binding in biochemical applications, making it suitable for studies involving targeted drug delivery and molecular recognition. This reagent is essential for researchers aiming to explore peptide interactions and develop novel therapeutic strategies. -
Chromogenic Peptide Substrate
Gly-Pro-pNA hydrochloride is a chromogenic peptide substrate specifically designed for the detection of dipeptidyl peptidase IV (DPP IV) activity. This compound serves as a valuable tool in the study of aminopeptidases and is particularly relevant in the context of diabetes research, where it may be explored for its potential as an experimental antidiabetic agent. The substrate's unique properties enable sensitive colorimetric assays, facilitating the assessment of enzymatic activity. -
Dipeptide
H-Pro-Val-OH is a dipeptide consisting of proline and valine, known for its ability to catalyze the Michael addition reaction of acetone to trans-β-nitrostyrene. This compound also acts as a substrate for fibroblast enzymes and prolinase, making it valuable for biochemical analysis. Its diverse applications make H-Pro-Val-OH an important tool for studying peptide interactions and enzyme activity in various research contexts. -
Dipeptide
H-Ser-Pro-OH is a dipeptide comprising serine and proline, acting as a substrate for prolinase I (PD I) and prolinase II (PD II). This compound is valuable in biochemical research for the synthesis of polypeptides, facilitating studies on peptide interactions and enzymatic functions. Its unique structure makes it a useful tool in the exploration of protein synthesis and modification. -
Dipeptide
H-Pro-Lys-OH is a dipeptide comprised of proline and lysine, functioning as a substrate for iminodipeptidase (prolinase). This compound plays a vital role in polypeptide synthesis and is valuable in studies related to protein structure and function. Its usefulness extends to applications in enzyme assays and the development of therapeutic peptides. -
Dipeptide
H-Pro-Met-OH is a dipeptide composed of proline and methionine, specifically designed for use as a substrate in prolinase assays. This compound facilitates the synthesis of polypeptides, making it a valuable tool in peptide research and development. Its biochemical properties allow for diverse applications in studies related to protein synthesis and enzymatic activity. -
Fluorescence Peptide
Abz-SDK(Dnp)P-OH is a fluorescence peptide that serves as a substrate for angiotensin I-converting enzyme (ACE). The compound features a fluorescent donor-acceptor pair composed of Abz and Dnp (2,4-dinitrophenyl), enabling its use in fluorescence-based assays. Its primary applications include studying ACE activity and facilitating research in cardiovascular biology and related therapeutic areas. -
Antihypertensive Peptide
H-Trp-Phe-OH is a dipeptide composed of tryptophan and phenylalanine that functions as an antihypertensive agent through the inhibition of angiotensin-converting enzyme (ACE). This compound demonstrates dose-dependent increases in nitric oxide levels while simultaneously reducing endothelin-1 (ET-1) levels, making it valuable in studies of cardiovascular function and regulation. Research has shown that H-Trp-Phe-OH can enhance ovarian weight in female mice when administered via subcutaneous injection, thereby contributing to its potential applications in reproductive and hypertensive research. -
Antihypertensive Peptide
αs1-CN f(143–149) is an antihypertensive peptide derived from casein that functions as an angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 6.58 μM. This peptide demonstrates significant potential for regulating blood pressure and may be utilized in research focused on hypertension and cardiovascular health. Its oral bioactivity enhances its applicability in therapeutic development and nutritional studies involving blood pressure management. -
ACE2PD α1 Helix Peptide
SBP1 peptide is a 23-amino acid synthetic fragment derived from the α1 helix of the ACE2 PD region. This peptide demonstrates micromolar affinity for the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, facilitating insights into viral entry mechanisms. It is useful in research applications focused on viral pathogenesis and the development of therapeutic strategies targeting ACE2 interactions. -
Antihypertensive Peptide
YKYY is an antihypertensive peptide that functions as an Angiotensin I-converting enzyme (ACE) inhibitor, with an IC50 of 64.2 μM. Isolated from the peptic digest of wakame (Undaria pinnatifida), YKYY exhibits potential for modulating blood pressure. This compound is valuable for research investigating mechanisms of hypertension and the development of novel antihypertensive therapies. -
Antihypertensive Peptide
Tyrosylhistidine is a dipeptide comprised of tyrosine and histidine, exhibiting antihypertensive properties. It has demonstrated the ability to significantly reduce blood pressure in murine models of spontaneous hypertension. This compound serves as a valuable tool for research in cardiovascular physiology and antihypertensive drug development. -
ACE Substrate Peptide
AC-SDKP-NH2 is a substrate peptide of Angiotensin-converting enzyme (ACE). It exhibits significant anti-inflammatory and anti-fibrotic activities by directly targeting tissues, thereby preventing or reversing excessive fibrosis without impacting blood pressure or left ventricular hypertrophy (LVH). AC-SDKP-NH2 effectively attenuates inflammation, as well as cell differentiation, proliferation, and migration, resulting in reduced fibrosis in cardiac, vascular, and renal tissues in mouse models. This reagent is applicable in cardiovascular research, particularly in studies related to hypertension and fibrosis-associated conditions. -
Peptide Fragment
[Tyr6]-Angiotensin II is a peptide fragment that functions as a selective antagonist of the angiotensin II receptor. This compound exhibits biological activity by modulating cardiovascular responses and renal function, making it valuable for research on hypertension and related disorders. Its ability to influence the renin-angiotensin system positions it as a useful tool in studies aimed at understanding the physiological and pathophysiological roles of angiotensin peptides. -
Tripeptide
IRW is an orally active tripeptide derived from egg white, known for its angiotensin-converting enzyme (ACE) inhibitory properties. This compound exhibits significant potential in preventing high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and enhancing mitochondrial content. IRW has been shown to reduce hepatic triglyceride levels and lipid droplet size, while also increasing the activity of mitochondrial complexes and citrate synthase. Its ability to activate key pathways, including phosphorylation of 5’-AMP-activated protein kinase and increasing microsomal triglyceride transfer protein abundance, makes IRW a valuable reagent for studies in inflammation and metabolic disorders. -
AJH-1 Short Peptide
H-Tyr-Lys-OH is a dipeptide that serves as a biomarker for AJH-1, displaying significant binding affinity to angiotensin-converting enzyme (ACE). This compound is valuable for research applications involving cardiovascular studies and peptide interaction assays, offering insights into ACE-related biological processes. Its utility in peptide synthesis and characterization enhances its relevance in the field of biochemical research. -
ACE Peptide Substrate
p-Hydroxyhippuryl-His-Leu is a peptide substrate specifically designed for the angiotensin-converting enzyme (ACE). This compound is utilized in biochemical assays to investigate ACE activity and regulation. Its distinctive structure enables efficient cleavage by ACE, making it valuable for research related to cardiovascular physiology and potential therapeutic developments. -
Bioactive Peptide
HD5 is a bioactive peptide derived from human defensin-5, exhibiting lectin-like properties. Secreted by Paneth cells in the crypts of Lieberkuhn, HD5 interacts with glycosylated proteins and lipid components, playing a crucial role in mucosal immunity. Importantly, HD5 is known to competitively inhibit ACE2 receptors on host cells, thereby providing a mechanism to reduce SARS-CoV-2 infection. This peptide has applications in studying antiviral mechanisms and innate immune responses.
