GB-6 is a GRPR-targeting peptide that selectively binds to the gastrin releasing peptide receptor, which is frequently overexpressed in pancreatic cancer. This peptide demonstrates excellent in vivo stability and efficacy in tumor targeting and imaging when conjugated with near-infrared fluorescent dyes or the radionuclide technetium-99m (99mTc). In SW1990 subcutaneous xenograft models, GB-6 exhibited tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, facilitating precise tumor boundary delineation. This high-contrast imaging capability positions GB-6 as a promising tool for cancer imaging applications.
GB-6 is a GRPR-targeting peptide that selectively binds to the gastrin releasing peptide receptor, which is frequently overexpressed in pancreatic cancer. This peptide demonstrates excellent in vivo stability and efficacy in tumor targeting and imaging when conjugated with near-infrared fluorescent dyes or the radionuclide technetium-99m (99mTc). In SW1990 subcutaneous xenograft models, GB-6 exhibited tumor to pancreatic and intestinal fluorescence signal ratios of 5.2 and 6.3, respectively, facilitating precise tumor boundary delineation. This high-contrast imaging capability positions GB-6 as a promising tool for cancer imaging applications.
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