Catalog No.
Product Name
Application
Product Information
Citations
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HER2-Targeting Peptide
Herceptide is a HER2-targeting peptide that selectively binds to the human epidermal growth factor receptor 2 (HER2). This peptide can be conjugated with the near-infrared fluorescent dye indocyanine green (ICG), facilitating the development of innovative theranostic agents. Its primary applications include targeted imaging and therapy for HER2-positive cancers, enhancing the precision of cancer diagnostics and treatment strategies. -
Hexapeptide
Lys-Arg-Thr-Leu-Arg-Arg (KRTLRR) is a hexapeptide that serves as a substrate for protein kinase C (PKC) derived from the epidermal growth factor receptor (EGFR). This compound is instrumental in studying PKC activity, enabling researchers to elucidate its role in various signaling pathways. Research applications include assessing the enzymatic function of PKC and exploring its implications in cellular processes such as proliferation and differentiation. -
Peptide
pp60v-src Autophosphorylation site is a synthetic peptide that mimics the autophosphorylation site of the pp60v-src protein. This peptide is utilized in biochemical studies to investigate the regulation of protein tyrosine kinases and their signaling pathways. It serves as a valuable tool in research focusing on cancer biology, cell signaling, and the mechanisms of oncogenesis. -
HER2 Targeting Peptide
HER2-targeted peptide H6F is designed to selectively bind to the HER2 receptor, making it a valuable tool for targeting breast cancer cells. Its amino acid sequence, YLFFVFER, allows for effective conjugation with the bifunctional chelating agent hydrazinonicotinamide (HYNIC) for radiolabeling with 99mTc. Studies utilizing single-photon emission computed tomography (SPECT) demonstrate that the radiolabeled H6F peptide accumulates specifically in HER2-positive MDA-MBA-453 tumor-bearing mouse models. This peptide is applicable for tumor molecular imaging studies, aiding in the evaluation and monitoring of breast cancer. -
HER2/neu Peptide
HER2/neu (654-662) GP2 is a peptide derived from the human epidermal growth factor receptor 2 (HER2/neu) that consists of nine amino acids. This specific peptide elicits HLA-A2-restricted cytotoxic T lymphocyte (CTL) responses, making it relevant for research involving immunotherapy and cancer treatment. Its application is particularly significant in the context of various epithelial cancers, facilitating the study of immune responses and potential therapeutic strategies. -
Peptide Toxin
Candidalysin is a cytolytic peptide toxin derived from the pathogenic fungus Candida albicans, primarily targeting epithelial cells. This peptide is known for its ability to activate the EGFR-MAPK signaling pathway, which leads to increased expression of matrix metalloproteinases (MMPs) and calcium influx, as well as modulation of the c-Fos transcription factor through p38 MAPK and ERK1/2. Candidalysin plays a critical role in both mucosal and systemic infections by stimulating NLRP3 inflammasome activation, promoting inflammatory responses, neutrophil recruitment, and Th17 immunity. Additionally, it induces lactate dehydrogenase (LDH) release, resulting in membrane damage and cytotoxicity. -
Tumor-binding Peptide
ErbB-2-binding peptide is a tumor-targeting peptide that specifically interacts with the ErbB-2 receptor (HER2). This peptide demonstrates significant potential in cancer research by aiding in the selective identification and targeting of HER2-positive tumors. Its unique binding properties make it a valuable tool for studies focused on tumor biology, therapeutic delivery, and the development of targeted cancer treatments. -
EGFR Targeting Peptide
Cys-GE11 is a cysteine-modified peptide that targets the epidermal growth factor receptor (EGFR). This peptide can be conjugated via its thiol group, enabling the formation of targeted polymeric constructs to improve drug delivery efficacy. Cys-GE11 demonstrates enhanced enrichment of therapeutic agents at tumor sites, particularly in EGFR-overexpressing cells, such as SMMC-7721. Its utilization in research highlights its potential for applications in targeted cancer therapy with minimal toxicity. -
Peptide
Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a peptide derived from the TIF-2 coactivator, encompassing amino acid residues 740-753 of the TIF-2 protein. This 14-amino acid peptide plays a crucial role in the modulation of transcriptional activity by enhancing the interaction between transcription factors and the basal transcriptional machinery. It is commonly utilized in research applications focused on gene expression, transcriptional regulation, and cell signaling pathways. -
Peptide Interacting With hNatD
Histone H4 peptide is a peptide that specifically interacts with hNatD, facilitating important polar interactions within cellular processes. This peptide is valuable for studying post-translational modifications and histone dynamics. It is particularly applicable in lung cancer research, aiding in the understanding of epigenetic regulation and potential therapeutic targets in oncology. -
Anti-inflammatory Peptide
SAP15 is a synthetic anti-inflammatory peptide derived from human beta-defensin 3, comprising 15 amino acids. This peptide effectively penetrates cells to downregulate intracellular inflammation by inhibiting the phosphorylation of HDAC5, which in turn reduces the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 demonstrates significant anti-inflammatory activity, while also enhancing the expression of aggrecan and type II collagen, and decreasing osteocalcin levels in LPS-induced chondrocytes. SAP15 serves as a valuable tool in the exploration of inflammation regulation and the development of anti-inflammatory therapies for biomaterials. -
SETD8 Inhibitor
[Nle20] H4 peptide (16−23) is a potent inhibitor of the histone methyltransferase SETD8, exhibiting a Kd of 0.14 μM. This peptide competes with histone H4 for binding to the substrate site of SETD8, effectively blocking its methylation activity. As a result, [Nle20] H4 peptide (16−23) serves as a valuable tool in cancer research, offering potential applications in the development of therapeutic strategies targeting epigenetic modulation. -
Antimicrobial Peptide
Dermaseptin-S3 is an antimicrobial peptide that targets and disrupts the membranes of filamentous fungi. It exhibits significant antifungal activity, making it a valuable tool for research in fungal infections and antimicrobial peptide studies. Its mechanism of action entails perturbation of the fungal cell membrane, leading to cell lysis and death, thereby aiding in the exploration of novel antifungal therapies. -
Antimicrobial Peptide
Dermaseptin-S2 is an antimicrobial peptide derived from frog skin, exhibiting potent activity against filamentous fungi. It disrupts cellular membranes, leading to fungal cell death. This peptide is applicable in research related to antifungal mechanisms and the development of novel antimicrobial agents. -
Antimicrobial Peptide
Dermaseptin-S4 is an antimicrobial peptide that targets and inhibits the growth of filamentous fungi. It exhibits potent antifungal activity, making it a valuable reagent for research in antifungal therapy and the study of innate immune mechanisms. This compound can be utilized in the exploration of new therapeutic strategies against fungal infections. -
Antifungal Peptide
LL-25 is an antifungal peptide that exhibits potent candidacidal activity, making it particularly useful in research focused on fungal infections. This compound is a fragment of LL-37, lacking its immunomodulatory effects, which allows for a more targeted investigation of its antifungal properties. LL-25 is applicable in studies exploring therapeutic strategies against fungal pathogens, providing insights into the development of novel antifungal agents. -
Cyclic Peptides
Aselacin C is a cyclic peptide derived from the fungus Acremonium spp. This compound exhibits potent biological activity, serving as an important tool for studying antimicrobial properties and potential applications in drug discovery. Aselacin C provides researchers with valuable insights into peptide synthesis and structure-activity relationships within cyclic peptides, making it relevant for various research applications in the fields of microbiology and pharmacology. -
Antimicrobial Peptide
Dermaseptin-S5 is an antimicrobial peptide that targets and disrupts the membranes of filamentous fungi. This compound exhibits strong antifungal activity, making it a valuable tool in studies focused on fungal infections and resistance mechanisms. It is particularly useful for research in pharmacology, microbiology, and therapeutic applications involving antifungal agents. -
Antibiotic Peptide
CRAMP-18 (mouse) is an antibiotic peptide that exhibits selective antimicrobial activity without hemolytic properties. It demonstrates effective inhibitory action against Gram-negative bacteria, including Salmonella typhimurium and Pseudomonas aeruginosa. This peptide serves as a valuable tool for research applications in antifungal, antibacterial, and antitumor studies. -
Antimicrobial Peptide
Temporin-SHa is an antimicrobial peptide that exhibits broad-spectrum antibacterial activity, effectively targeting both Gram-positive and Gram-negative bacteria, including drug-resistant strains. With a minimum inhibitory concentration (MIC) of 6.25 μM against Listeria ivanovii and 10 μM against Escherichia coli, it is also active against fungal pathogens such as Candida albicans (MIC = 25 μM) and Saccharomyces cerevisiae (MIC = 12 μM). Furthermore, Temporin-SHa demonstrates efficacy against protozoan parasites, including Leishmania infantum and Trypanosoma cruzi, and exhibits antiviral activity against HSV-1, alongside anti-cancer properties that include cytotoxicity against breast cancer (MCF-7) and lung cancer (H460) cell lines. -
Antimicrobial Peptide
NK-2, an antimicrobial peptide derived from NK-lysin, primarily targets microbial membranes. This potent agent demonstrates significant antimicrobial activity against various pathogens, including Trypanosoma cruzi, Candida albicans, as well as both gram-positive and gram-negative bacteria. NK-2 has been shown to effectively eliminate trypanosomes within the human glioblastoma cell line 86HG39 while preserving the integrity of host cells, making it a valuable tool for research into antimicrobial mechanisms and therapeutic applications. -
Antimicrobial Peptide
Pelteobagrin is an antimicrobial peptide known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, as well as fungi, with a minimum inhibitory concentration (MIC) ranging from 2 to 16 μg/mL. Its mechanism of action involves non-competitive disruption of cell wall and cytoplasmic membrane integrity, leading to bactericidal effects. Pelteobagrin holds significant potential for research applications in the study and treatment of infectious diseases. -
Antimicrobial Peptide
EP2 is an antimicrobial peptide that exhibits potent antibacterial and antifungal activities. It effectively inhibits the growth of E. gallinarum, P. pyocyanea, A. baumanii, and K. terrigena, with a minimum inhibitory concentration (MIC) of 11.4 μg/mL. This compound is valuable for research applications focusing on microbial resistance and the development of new antimicrobial agents. -
Cyclic Tetrapeptide
Hirsutide is a cyclic tetrapeptide known for its ability to inhibit chitin synthase, an essential enzyme in fungal cell wall biosynthesis. This compound demonstrates potent antifungal activity against a range of pathogenic fungi, making it a valuable tool for research in mycology and antifungal drug development. Its unique mechanism of action positions Hirsutide as a candidate for studying fungal resistance mechanisms and exploring new therapeutic strategies in treating fungal infections. -
Antimicrobial Peptide
Lasioglossin-III is an antimicrobial peptide derived from the venom of wild bees, primarily targeting bacterial and fungal pathogens. It exhibits potent antibacterial activity against both Gram-positive and Gram-negative bacteria, alongside notable antifungal and antitumor properties. Lasioglossin-III demonstrates cytotoxic effects on various cancer cell lines, including HeLa S3, CRC SW 480, and CCRF-CEM T, with IC50 values of 4, 18, and 5 μM, respectively. This peptide holds promise for research applications in the fields of microbiology, oncology, and drug development. -
Defensin-like Antifungal Peptide
Gymnin is a defensin-like antifungal peptide that exhibits notable antifungal activity against both phytopathogenic and mycotoxigenic fungi. Additionally, Gymnin inhibits HIV-1 reverse transcriptase with an IC50 of 200 μM and suppresses tumor cell proliferation, although it demonstrates only weak mitogenic activity in murine splenocytes. This compound is suitable for research applications related to plant disease treatment and the exploration of antifungal mechanisms. -
Antimicrobial Peptide
Bactenecin is a potent antimicrobial peptide that exhibits activity primarily through its ability to increase membrane permeability in target microorganisms. This 12-amino acid looped peptide, derived from bovine neutrophils, effectively inhibits the growth of a range of bacteria and yeast, including the fungus Trichophyton rubrum. Bactenecin is particularly relevant for research applications focused on bacterial pathogenesis and biofilm formation, as it has been shown to impede the growth and biofilm development of Burkholderia pseudomallei. -
Plant Peptide
Cn-AMP1 is a disulfide-free plant peptide derived from green coconut water, targeting various pathogenic organisms. It exhibits antimicrobial activity against multiple pathogenic bacteria and fungal strains, as well as antitumor effects on cancer cells. Additionally, Cn-AMP1 has been shown to up-regulate inflammatory cytokine secretion in monocytes, making it a valuable reagent for research focused on bacterial infections and cancer therapies. -
Acylpeptide Antibiotic
Cepafungin III is an acylpeptide antibiotic derived from the culture broth of Pseudomonas species. This compound demonstrates significant inhibitory activity against yeast and fungi, as well as exhibiting antitumor properties against P388 leukemia in murine models, particularly when utilized in conjunction with Cepafungin I and II. Its multifaceted biological activity makes Cepafungin III a valuable reagent for research in antifungal and anticancer studies. -
Antifungal Peptide
Coccinin is an antifungal peptide that exerts its bioactivity by inhibiting HIV-1 reverse transcriptase. Isolated from the seeds of large scarlet runner beans, Coccinin demonstrates significant antifungal activity against a range of pathogens, including M. arachidicola, F. oxysporum, P. piricola, B. cinerea, C. comatus, and R. solani, with IC50 values of 75, 81, 89, 109, 122, and 134 μM, respectively. This compound is valuable for research in antifungal therapeutics and HIV-related studies. -
Antifungal Peptide
KK14(R) is an analog of the synthetic antifungal peptide KK14, demonstrating potent antifungal activity against Fusarium culmorum, Penicillium expansum, and Aspergillus niger, with minimum inhibitory concentrations (MICs) of 6.25 μg/mL, 12.5 μg/mL, and 12.5 μg/mL, respectively. This compound also exhibits stability under various heat and pH conditions. Additionally, KK14(R) shows cytotoxic effects on Caco-2 and RAW264.7 cell lines, making it a valuable tool for research in fungal infections and cytotoxicity studies. -
Cyclocarboxyphenate Peptide Analogues
Iso-isariin B is a cyclocarboxyphenate analogue that primarily targets antifungal pathways. This compound exhibits biological activity against a variety of fungi, making it a valuable tool for antifungal research studies. Iso-isariin B can aid in the investigation of mechanisms of antifungal action and the development of therapeutic strategies. -
Antimicrobial Peptide
Balteatide is an antimicrobial peptide derived from the skin secretion of Phyllomedusa baltea, targeting various microbial pathogens. This compound demonstrates significant inhibitory activity against gram-positive Staphylococcus aureus (MIC=435 μM), gram-negative Escherichia coli (MIC=109 μM), and Candida albicans (MIC=27 μM). Notably, Balteatide exhibits no hemolytic activity at concentrations up to 512 mg/L, making it a promising candidate for research in antimicrobial applications. -
Antibiotic/Antimicrobial Peptide
Aurein 2.5 is an antibiotic antimicrobial peptide that exhibits potent antibacterial and antifungal activity. It targets microbial membranes, disrupting their integrity and leading to cell death. This compound is valuable for research applications focused on exploring novel antimicrobial therapies and understanding peptide-microbe interactions. -
Antimicrobial peptide
ToAP2 is a potent antimicrobial peptide that targets fungal cell membranes. It enhances membrane permeability in Candida albicans, leading to significant alterations in fungal cell morphology. This compound is useful in research focused on fungal pathogenesis, antimicrobial drug development, and the mechanisms of peptide-based antimicrobial activity. -
Anti-fungal Peptide
Histatin-8 is an anti-fungal peptide derived from the central sequence of Histatin-3, known for its hemagglutination-inhibiting properties. This peptide exhibits potent antimicrobial activity against various yeast strains, making it an important tool for studying oral thrush and related fungal infections. Its unique mechanism of action and biological significance position Histatin-8 as a valuable reagent in antifungal research applications. -
Antimicrobial Peptide
SP-B peptide is an antimicrobial peptide targeting various fungal pathogens. It demonstrates significant antifungal activity against strains of Cryptococcus neoformans, Candida albicans, and Aspergillus fumigatus. This peptide is useful for research applications focusing on antifungal mechanisms and the development of novel therapeutic strategies against fungal infections. -
Antibacterial Peptide
Metchnikowin is an antibacterial peptide derived from fruit flies, exhibiting potent antimicrobial properties against both bacteria and fungi. Its activity is regulated through the TOLL and IMD signaling pathways, making it a valuable tool for studying immune responses in various infectious conditions. This peptide is widely utilized in research focused on host defense mechanisms and the development of novel antimicrobial agents. -
Anti-bacterial Peptide
Pseudin-2 is an antimicrobial peptide derived from the skin of the South American paradoxical frog, Pseudis paradoxa. It exhibits potent growth inhibition against Gram-negative bacteria, making it a valuable tool for antibacterial research. Pseudin-2 may be utilized in studies aimed at understanding antimicrobial mechanisms and developing new therapeutic strategies against resistant bacterial strains. -
Antimicrobial Peptide
Xenopsin precursor fragment is an antimicrobial peptide that exhibits significant antibacterial and antifungal activity, demonstrated at concentrations ranging from 10 to 500 μg/mL. Additionally, it shows potent anti-protozoal effects, with a minimum inhibitory concentration (MIC) between 2 and 20 μg/mL. This peptide is useful for research applications focused on antimicrobial resistance and the development of novel therapeutic agents against infectious diseases. -
Antimicrobial Peptide
Gageotetrin A is an antimicrobial peptide that targets microbial cells with its potent antifungal properties. Derived from the marine bacterium Bacillus subtilis, Gageotetrin A effectively inhibits fungal growth while demonstrating low toxicity towards various human cancer cell lines. This makes it a valuable candidate for research applications in antimicrobial and anticancer studies. -
Antimicrobial Peptide
BTL peptide is an antimicrobial peptide with potent antifungal properties. It demonstrates effectiveness against various fungal pathogens, including Bipolaris maydis, Alternaria brassicae, Aspergillus niger, and Corynespora personata. This peptide is a valuable tool for research applications aimed at understanding fungal resistance mechanisms and developing novel antifungal therapies. -
Antimicrobial Peptide
Jelleine-I is an antimicrobial peptide known for its broad-spectrum activity against various microorganisms, including yeast, fungi, and both Gram-positive and Gram-negative bacteria. Isolated from royal jelly produced by honeybees, Jelleine-I plays a crucial role in the insect immune response. This peptide is of interest in research related to antimicrobial therapies and the development of novel biocontrol agents in agriculture and medicine. -
Antimicrobial Peptide
Polybia-MP1 is an antimicrobial peptide that targets cell membranes by selectively interacting with phosphatidylserine (PS) and phosphatidylethanolamine (PE). It exhibits notable antibacterial activity against Pseudomonas aeruginosa, along with antifungal and anticancer properties through the induction of necrosis via pore formation. Polybia-MP1 is suitable for research applications related to bacterial and fungal infections as well as cancer studies. -
Antimicrobial Peptide
Dermaseptin-S1 is an antimicrobial peptide that targets membrane integrity in filamentous fungi. Exhibiting potent antifungal activity, it disrupts the cell membrane of target organisms, leading to cell death. This peptide is valuable for research applications focused on developing antifungal therapies and understanding host-pathogen interactions. -
Antimicrobial Peptide
D-Cateslytin is an antimicrobial peptide that demonstrates significant inhibitory activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 2.9 μM. This compound can rapidly penetrate C. albicans cells while exhibiting no cytotoxic effects on human gingival fibroblasts, and it remains stable in saliva. D-Cateslytin is ideal for research on conditions associated with Candida albicans, including oral candidosis. -
Antifungal Peptides
Cyclo(L-Phe-trans-4-OH-L-Pro) is a cyclic peptide that exhibits antifungal activity by disrupting the integrity of fungal cell membranes. This compound is valuable in research focused on developing novel antifungal agents and studying the mechanisms of peptide-based antifungal strategies. Its precise mechanism of action makes it a potential candidate for addressing fungal resistance in clinical settings. -
Antimicrobial Peptide
Temporin L is a potent antimicrobial peptide that primarily targets Gram-negative bacteria and yeast strains. It exhibits significant antimicrobial activity, making it suitable for research applications focused on infection control and antimicrobial resistance. Additionally, Temporin L demonstrates antiendotoxin properties, contributing to its role in studies related to inflammatory responses. -
AJH-1 Short Peptide
H-Tyr-Lys-OH is a dipeptide that serves as a biomarker for AJH-1, displaying significant binding affinity to angiotensin-converting enzyme (ACE). This compound is valuable for research applications involving cardiovascular studies and peptide interaction assays, offering insights into ACE-related biological processes. Its utility in peptide synthesis and characterization enhances its relevance in the field of biochemical research. -
ACE Peptide Substrate
p-Hydroxyhippuryl-His-Leu is a peptide substrate specifically designed for the angiotensin-converting enzyme (ACE). This compound is utilized in biochemical assays to investigate ACE activity and regulation. Its distinctive structure enables efficient cleavage by ACE, making it valuable for research related to cardiovascular physiology and potential therapeutic developments.
