Catalog No.
Product Name
Application
Product Information
Citations
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MSP-1 Peptide Segment
MSP-1 P2 is a synthetic peptide derived from merozoite surface protein-1 (MSP-1), specifically designed to stimulate immune responses. This peptide effectively induces umbilical cord blood lymphocytes to produce key cytokines, including IFN-γ and IL-13, through a mechanism primarily involving CD4+ T cells. MSP-1 P2 is suitable for research applications aimed at assessing T cell responses and evaluating cytokine production in various experimental settings. -
Anti-allergen Peptide
Acetyl hexapeptide-49 is an anti-allergen peptide known for its bioactive properties. This compound exerts a protective effect on mammalian skin cells, alleviating irritation and enhancing cell vitality. Its applications primarily lie in cosmetic formulations aimed at reducing allergic reactions and promoting skin health. -
Active peptides
SPA4 is a Toll-like receptor 4 (TLR4)-interacting peptide that specifically inhibits the lipopolysaccharide (LPS)-induced production of the pro-inflammatory cytokine TNF-α. This compound demonstrates its biological activity without adversely affecting cell viability or size. SPA4 is useful in research applications related to inflammation, cytokine signaling, and TLR4-mediated pathways. -
Synthetic Peptide
Endotoxin inhibitor is a synthetic peptide that effectively binds to lipid A, resulting in the detoxification of lipopolysaccharides (LPS). This compound suppresses LPS-induced cytokine release in vivo, providing a means to mitigate inflammatory responses. With its low toxicity and reduced lethality, the endotoxin inhibitor is a valuable tool for research focused on sepsis, inflammation, and immune response modulation. -
Bioactive Peptide
EGF Receptor Substrate 2 (Phospho-Tyr5) is a bioactive peptide that serves as a substrate for tyrosine phosphatases. This compound is integral for detecting protein tyrosine phosphatase activity, making it valuable for research into signaling pathways involving the epidermal growth factor receptor (EGFR). Its utility extends to studies on cell growth, differentiation, and various cancer research applications. -
Bioactive Peptide
KRpTIRR is a bioactive peptide that contains phosphothreonine, functioning as a substrate for various phosphatases. Its biochemical properties make it suitable for studying phosphatase activity and regulation in cellular signaling pathways. Researchers utilize KRpTIRR to investigate protein dephosphorylation processes and their implications in physiological and pathological conditions. -
Cell-Permeable Peptide Inhibitor
CNI103 is a potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. By selectively inhibiting the interaction between calcineurin and NFATc3, with a binding affinity of KD=16 nM, CNI103 effectively prevents NFATc3 activation both in vitro and in vivo. This reagent is valuable for investigating mechanisms involved in acute respiratory distress syndrome (ARDS) and other inflammatory diseases. -
Bioactive Peptide
RRLIEDAEpYAARG is a bioactive peptide that serves as a substrate for phosphatases. This compound is valuable for studying dephosphorylation processes and investigating protein signaling pathways. Its application in biochemical assays aids in the characterization of phosphatase activity and regulation in various biological contexts. -
Antibacterial Peptide
Golotimod hydrochloride is an immunomodulating peptide that targets antibacterial pathways. This compound enhances the efficacy of antituberculosis therapy by promoting thymic and splenic cell proliferation and improving macrophage functionality. Additionally, Golotimod hydrochloride inhibits STAT3 signaling, thereby modulating the severity and duration of oral mucositis in animal models subjected to radiation or combined treatments. Furthermore, it shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Antibacterial Peptide
Golotimod TFA is an immunomodulating peptide primarily known for its antibacterial properties. This compound enhances the efficacy of antituberculosis therapy and promotes thymic and splenic cell proliferation while improving macrophage function. It inhibits STAT3 signaling, demonstrating potential in mitigating the duration and severity of oral mucositis in irradiated animal models. Additionally, Golotimod TFA shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Peptide
PHF6 (VQIVYK) is a peptide that facilitates the self-assembly and aggregation of the full-length tau protein, specifically targeting the third microtubule-binding repeat region of tau. This peptide is instrumental in studies of tau pathology associated with neurodegenerative diseases, particularly in understanding the mechanisms underlying tau aggregation and its implications in tau-related disorders. Its unique structure makes it a valuable tool for investigating tau fibrillogenesis and potential therapeutic interventions. -
PACE4 Inhibitor
Multi-Leu peptide is a potent inhibitor of the proprotein convertase PACE4, exhibiting a Ki value of 22 nM. This peptide competitively binds to the active site of PACE4, mimicking its substrate sequence and effectively blocking its catalytic activity. Multi-Leu peptide is valuable for elucidating the role of PACE4 in various biological processes, including its involvement in the progression of prostate cancer. -
CaMKII Inhibitor
Autocamtide-2-related inhibitory peptide is a selective inhibitor of Calcium/Calmodulin-dependent protein kinase II (CaMKII), exhibiting an IC50 value of 40 nM. This peptide effectively modulates CaMKII activity, making it a valuable tool for studying calcium signaling pathways and their implications in various physiological and pathological processes. Its high specificity and potency simplify the investigation of CaMKII-related mechanisms in cellular signaling research. -
Autophagy Activator
Soybean peptide QRPR is an autophagy activator that enhances cellular autophagy by increasing the expression and activity of key signaling proteins, including PIK3, AKT, and mTOR. This peptide has shown potential in reducing inflammatory responses, making it valuable for research in cellular stress responses and inflammatory diseases. Its role in modulating autophagy pathways positions it as an important tool for studies aimed at understanding cellular homeostasis and therapeutic interventions. -
Fluorescent Peptide Substrate
Z-Val-Val-Arg-AMC is a fluorescent peptide substrate specifically designed for the assessment of cathepsin enzyme activity. This compound exhibits a high degree of specificity, facilitating the study of cathepsin-mediated biological processes. It is valuable in research applications involving proteolytic activity and enzyme kinetics, enabling researchers to investigate the roles of cathepsins in various physiological and pathological conditions. -
Abz-Tripeptide Substrate
Abz-FRF(4NO2) is an Abz-tripeptide substrate designed for research into enzyme activity, particularly in the study of cysteine proteases such as Cathepsin X. Its structure allows for the assessment of proteolytic activity, making it a valuable tool in enzymatic studies and drug development. This reagent can facilitate investigations into enzyme kinetics and substrate specificity in various biological contexts. -
Polypeptide
Hepcidin-1 (mouse) is a polypeptide hormone that plays a critical role in the regulation of iron homeostasis. It promotes the expression of mRNA levels associated with TRAP, cathepsin K, and MMP-9, leading to increased TRAP-5b protein secretion. Additionally, Hepcidin-1 (mouse) inhibits ferroportin 1 (FPN1) protein levels, resulting in elevated intracellular iron concentrations and facilitating osteoclast differentiation. This reagent is valuable for research into iron metabolism and bone biology. -
peptides
KYS-1 is a selective substrate for cathepsin E, exhibiting a Km value of 1.9 μM. This compound is optimized for use in studies involving cathepsin E activity, particularly at an optimal pH of approximately 4.0. KYS-1 is valuable for investigating the role of cathepsin E in various biological processes and can aid in enzyme kinetics studies and therapeutic research involving proteolytic pathways. -
Peptide
Suc-Val-Pro-Phe-SBzl is a peptide-based inhibitor targeting Cathepsin G (CatG) enzymes, exhibiting IC50 values ranging from 111 to 225 µM. This compound demonstrates significant biological activity, making it a valuable tool for research applications aimed at elucidating the role of CatG in various physiological and pathological processes. It is particularly useful for studies involving inflammation, immune response, and tissue remodeling. -
Polypeptide
H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide designed as a substrate for cathepsin D, pepsin, and pepsinogen. This compound is valuable in biochemical analysis and can facilitate the study of proteolytic enzyme activity. Its unique structure allows for detailed investigations into polypeptide interactions and enzyme mechanisms. -
Polypeptide
Phe-Arg-Arg-Gly is a polypeptide primarily utilized for agent coupling in biochemical applications. This compound plays a crucial role in enhancing protein interaction and stability, making it valuable for various research applications, including peptide synthesis and biomolecule conjugation. Its ability to facilitate molecular assembly further supports its use in developing targeted therapeutic agents and research tools. -
peptides
Cathepsin E substrate e is a selective substrate for the enzyme Cathepsin E, designed to facilitate monitoring of its proteolytic activity. This substrate employs a close proximity of a Mca donor and a Dnp acceptor to create a near-complete intramolecular quenching effect in its intact form. Upon cleavage by Cathepsin E, the spatial separation of Mca and Dnp generates a significant increase in fluorescence, making it an effective tool for studying Cathepsin E activity and its role in various biological processes. -
Fluorogenic Peptide Substrate
Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate designed to specifically detect cathepsin B activity across a wide pH range. This substrate undergoes cleavage by cathepsin B, resulting in fluorescence which can be quantitatively measured. It is particularly valuable in studies related to protease activity, cell signaling, and understanding pathological processes where cathepsin B is involved. -
Drp1-Fis1 Inhibitor
P110 heptapeptide is an inhibitor of the Drp1-Fis1 interaction, targeting mitochondrial dynamics to modulate cellular functions. This peptide exhibits anti-inflammatory, immunomodulatory, and neuroprotective properties, making it advantageous in research focused on neurodegenerative disorders, ischemic injury, and sepsis. P110 heptapeptide effectively reduces pathological actions linked to Drp1 without interfering with its essential physiological roles, providing a valuable tool for studying neurological and inflammatory diseases. -
Antimicrobial Peptide
Plantaricin A is an antimicrobial peptide derived from Lactobacillus plantarum that targets bacterial membranes. It exhibits notable antimicrobial activity, particularly against Staphylococcus aureus, by increasing membrane potential and elevating intracellular reactive oxygen species levels. Additionally, Plantaricin A inhibits efflux pump function through binding and structural alteration of MepA, NorA, and LmrS, enhancing synergistic effects with other antibiotics such as Ciprofloxacin. Its anti-inflammatory properties also promote wound healing and exhibit potential in permeabilizing cancerous pituitary cells. -
Anti-aging Peptide
Palmitoyl tripeptide-38 is an anti-aging peptide that promotes skin rejuvenation by stimulating collagen production and enhancing skin elasticity. This bioactive compound has been shown to reduce the appearance of fine lines and wrinkles, making it suitable for use in cosmetic research focused on age-related skin conditions. Its efficacy in promoting cellular regeneration makes it a valuable tool for developing anti-aging formulations and skincare products. -
Anti-oxidant Peptide
Arg-Tyr is an antioxidant peptide that effectively scavenges hydroxyl radicals and hydrogen peroxide. This dipeptide exhibits significant protective properties against oxidative stress, making it valuable for research applications focused on cellular protection and oxidative damage mitigation. Its potential therapeutic implications are of interest in studies related to aging, neurodegenerative diseases, and inflammation. -
Antioxidative Peptide
AHK is a bioactive peptide recognized for its antioxidative properties. It effectively neutralizes free radicals, contributing to cellular protection and longevity. This peptide is commonly utilized in cosmetic formulations to enhance skin health and combat oxidative stress, making it a valuable compound in both dermatological and anti-aging research applications. -
CD47 Agonist Peptide
Cys-PKHB1 is a CD47 agonist peptide designed to mimic thrombospondin-1. This compound has demonstrated antitumor efficacy by inducing mitochondrial alterations, the generation of reactive oxygen species (ROS), and calcium-dependent cell death in breast cancer cells. Cys-PKHB1 also promotes immune activation through immunogenic cell death, making it a valuable tool for research in cancer immunotherapy and tumor biology. -
Algicidal Peptide
Malformin C is an algicidal peptide derived from Aspergillus, demonstrating dose-dependent algicidal activity against various algal species. The compound increases reactive oxygen species (ROS) levels in algal cells, leading to inhibited superoxide dismutase (SOD) activity and elevated malondialdehyde (MDA) content. This mechanism suggests potential applications in algal population control and studies related to oxidative stress in aquatic environments. -
Peptide
Ac2-26 (mouse) is an active peptide derived from the N-terminal of Annexin A1 (AnxA1) that primarily targets the formyl peptide receptor (FPR) signaling pathway. This peptide plays a critical role in regulating the inflammatory response by promoting chemokine release while inhibiting reactive oxygen species (ROS) production. Ac2-26 (mouse) is valuable for investigating mechanisms of inflammation, including conditions such as rheumatoid arthritis. -
Antimicrobial Peptide
Brevicidine is an antimicrobial peptide that demonstrates selective bactericidal activity against Gram-negative pathogens. It functions by binding to lipopolysaccharide (LPS) on the bacterial cell membrane, leading to pore formation and subsequent disruption of bacterial morphology. This results in the dissipation of the proton motive force, outer membrane damage, inhibition of ATP biosynthesis, and accumulation of reactive oxygen species within bacterial cells. Additionally, Brevicidine acts as a sensitizer, exhibiting synergistic effects when combined with various conventional antibiotics, making it valuable for research in antimicrobial resistance and antibiotic enhancement studies. -
Dual-target Anti-inflammatory Peptide
Pegtarazimod is a dual-target anti-inflammatory peptide that regulates both the complement system and neutrophil-associated inflammatory pathways. It demonstrates significant biological activity by reducing reactive oxygen species (ROS) production and lowering neutrophil elastase levels in vivo, thereby mitigating inflammatory responses. Pegtarazimod has shown improved survival rates in multiple in vivo models of acute graft-versus-host disease (aGVHD) and exhibits efficacy against herpes simplex virus type 1 infections by inhibiting the activation of the C1 complex. This reagent is applicable in research focused on aGVHD, acute pulmonary diseases, and skin infections caused by herpes simplex virus type 1. -
Antibacterial Peptide
KSL-W is a multifunctional antibacterial peptide primarily targeting immune regulation. It exhibits significant chemotactic effects on neutrophils and promotes F-actin polymerization through the Gαi protein signaling pathway. Additionally, KSL-W effectively inhibits the production of reactive oxygen species (ROS) in neutrophils. This peptide is valuable for research focused on infection control and the regulation of inflammatory processes. -
Bioactive Peptide
PSTi8 is a bioactive peptide that functions as a specific inhibitor of pancreastatin, a neuropeptide involved in glucose and lipid metabolism. This compound exhibits potential in modulating pancreatic function and addressing metabolic disorders. Its applications extend to basic research in endocrinology and metabolic disease studies, offering insights into peptide signaling pathways and their physiological implications. -
Peptide Mimic
PKHB1 is a thrombospondin-1 peptide mimic that exerts antitumor effects primarily through mitochondrial dysfunction. It promotes the production of reactive oxygen species (ROS), triggers intracellular calcium accumulation, and activates calcium-dependent apoptotic pathways in breast cancer cells. Additionally, PKHB1 facilitates immune system activation by inducing immunogenic cell death, making it a valuable tool for research into cancer therapeutics and immunology. -
Peptide
α-Neoendorphin (porcine) is a peptide that acts on the skin's cellular mechanisms to mitigate UVB-induced photoaging. It activates the mTOR-Beclin-1 pathway to enhance autophagy, decreases reactive oxygen species (ROS) production, inhibits the MAPK signaling pathway and matrix metalloproteinase (MMP) activity, while promoting synthesis of type I procollagen. This compound demonstrates significant anti-aging and anti-wrinkle properties in skin cell models, making it valuable for research focused on skin photoaging and age-related dermatological studies. -
MLCK Inhibitor
MLCK Inhibitor Peptide 18 is a selective inhibitor of myosin light chain kinase (MLCK) with an IC50 of 50 nM. This peptide demonstrates significant inhibition of MLCK activity while exhibiting minimal effects on Ca2+/calmodulin-dependent protein kinase II, requiring concentrations approximately 4000-fold higher for inhibition. This specificity makes it valuable for studying MLCK-related signaling pathways and cellular processes involving muscle contraction and cellular motility. -
CaMKII Inhibitor
Autocamtide-2-related inhibitory peptide, myristoylated is a potent and selective inhibitor of CaMKII, exhibiting an IC50 of 40 nM. This peptide is used in research applications to investigate the regulatory mechanisms of calcium-dependent signaling pathways. Its myristoylation enhances its membrane permeability, facilitating in vivo studies of CaMKII activity and function in various cellular contexts. -
Histone H3 Peptide
Histone H3 (1-35) is a peptide comprising the first 35 amino acids of the histone H3 protein, which plays a pivotal role in chromatin packaging and organization in eukaryotic cells. This peptide is essential in studies of epigenetic regulation and gene expression, serving as a tool for investigating histone modification and interaction dynamics. It is widely used in research applications that explore chromatin structure, transcriptional regulation, and the effects of histone modifications on cellular processes. -
Synthetic Peptide Nucleic Acid
Fmoc-PNA-G(Boc)-OH is a synthetic peptide nucleic acid (PNA) featuring Fmoc and Boc protecting groups, which are designed to facilitate the synthesis of complementary DNA or RNA sequences. This reagent exhibits strong binding affinity and specificity, making it an essential tool for applications in gene modification, diagnostics, and molecular biology research. Its robust characteristics enhance its utility across various experimental setups, allowing for precise targeting and manipulation of nucleic acid interactions. -
Peptide
Preptin (rat) is an osteogenic peptide derived from the pancreatic beta-cell, specifically representing the Asp69-Leu102 segment of pro-IGF-II. This peptide plays a significant role in bone metabolism and has been shown to stimulate osteoblast differentiation and activity. Preptin is utilized in research applications aimed at understanding bone development, cellular signaling pathways, and the potential therapeutic effects in metabolic bone disorders. -
Epidermal Cell Proliferation Inhibitor
Epidermal mitosis inhibiting pentapeptide primarily functions as an inhibitor of epidermal cell proliferation. This pentapeptide significantly reduces the DNA synthesis and mitotic rates of epidermal keratinocytes, making it a valuable tool in the study of skin cell dynamics. While it may moderately increase the incidence of skin tumors in cancer models, it also demonstrates a heightened capacity to promote regression of established tumors. Additionally, this compound is hydrolyzed by angiotensin-converting enzyme (ACE), further broadening its utility in cancer research applications. -
Holliday Linker Inhibitory Peptide
KWWCRW is a Holliday linker inhibitory peptide that targets homologous recombination repair (HDR) in DNA repair mechanisms. By binding to the reactive Holliday linker intermediate, KWWCRW prevents its degradation, thereby inhibiting HDR and site-specific recombination by bacteriophage in vitro. This peptide is valuable in cancer research, particularly in studying DNA repair pathways and potential therapeutic interventions. -
Peptide Nucleic Acid
Fmoc-PNA-Abasic(Boc)-OH is a synthetic peptide nucleic acid that features Fmoc and Boc protecting groups. This compound serves as a versatile tool in molecular biology research, particularly in the study of nucleic acid interactions and the design of antisense oligonucleotides. Its modified structure enhances stability while enabling specific applications in gene regulation and molecular diagnostics. -
Bioactive Peptide
Influenza virus PA (46-54) is a bioactive peptide derived from the HLA-A*0201 restricted epitope of the influenza virus RNA polymerase subunit. This peptide is instrumental in research related to influenza virus immunology and vaccine development. It serves as a valuable tool for studying T cell responses and evaluating immune evasion mechanisms related to the influenza virus. -
Nucleolin Ligand
F3 peptide is a specific ligand for nucleolin, a protein commonly expressed on the surface of cancer cells, neovasculature, and endothelial cells. This peptide is derived from the human high mobility group protein 2 (HMGB2) and enhances the delivery of macromolecular drugs and nanoparticles. Its ability to selectively bind to nucleolin makes F3 peptide a valuable tool in cancer research and targeted therapeutic development. -
vasoactive peptide
Vasoactive intestinal contractor is a vasoactive peptide that functions as a potent stimulator of intracellular calcium concentration. It activates calcium signaling pathways, leading to a rapid increase in Ca2+ levels in cells such as fura-2-overexpressed Swiss 3T3 fibroblasts. This compound is utilized in research related to cellular signaling, smooth muscle contraction, and studies on the endothelin family of peptides. -
Melanin Synthesis Inducer
Tetrapeptide, a peptide analogue of alpha-melanocyte-stimulating hormone (α-MSH), functions as a melanin synthesis inducer. This compound not only promotes melanin production but also mitigates DNA damage by decreasing the formation of reactive oxidative species and enhancing the repair mechanisms for DNA photoproducts. It is valuable in research applications focused on skin pigmentation and photoprotection. -
RDC Peptide
DOTA-GPC3 targeting peptide 2 is an RDC peptide specifically designed to target glypican-3 (GPC3) with a dissociation constant (Kd) of 0.3 nM. This compound features a DOTA moiety, enabling labeling with radioactive elements for imaging and therapeutic applications. It is utilized in cancer research, particularly for the study of GPC3-expressing tumors, making it a valuable tool for targeted radiotherapy and diagnostic imaging strategies.
