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Nictide

Catalog No.: A40965
Substrate Peptide
Nictide is a peptide substrate for LRRK2 (leucine-rich repeat kinase 2), specifically phosphorylated by the activated LRRK2[G2019S] variant. Its Km value of 10 μM indicates a moderate affinity, making it suitable for assessing LRRK2 activity in biological research. Nictide can be effectively utilized in studies exploring LRRK2-related signaling pathways and neurodegenerative disease mechanisms.
Nictide 1159973-22-4 Substrate Peptide
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNictide is a peptide substrate for LRRK2 (leucine-rich repeat kinase 2), specifically phosphorylated by the activated LRRK2[G2019S] variant. Its Km value of 10 μM indicates a moderate affinity, making it suitable for assessing LRRK2 activity in biological research. Nictide can be effectively utilized in studies exploring LRRK2-related signaling pathways and neurodegenerative disease mechanisms.
Product Information
Catalog NumA40965
FormulaC123H193N45O28
Molecular Weight2750.13
CAS Number1159973-22-4
SequenceArg-Leu-Gly-Trp-Trp-Arg-Phe-Tyr-Thr-Leu-Arg-Arg-Ala-Arg-Gln-Gly-Asn-Thr-Lys-Gln-Arg
Sequence shorteningRLGWWRFYTLRRARQGNTKQR
SMILESC([C@H](NC([C@H](CC=1C=2C(NC1)=CC=CC2)NC(CNC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CC(C)C)=O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CCC(N)=O)=O)CCCCN)=O)[C@@H](C)O)=O)CC(N)=O)=O)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)[C@@H](C)O)=O)=O)CC4=CC=CC=C4)=O)CCCNC(=N)N)=O)C=5C=6C(NC5)=CC=CC6
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