AC-SDKP-NH2 is a substrate peptide of Angiotensin-converting enzyme (ACE). It exhibits significant anti-inflammatory and anti-fibrotic activities by directly targeting tissues, thereby preventing or reversing excessive fibrosis without impacting blood pressure or left ventricular hypertrophy (LVH). AC-SDKP-NH2 effectively attenuates inflammation, as well as cell differentiation, proliferation, and migration, resulting in reduced fibrosis in cardiac, vascular, and renal tissues in mouse models. This reagent is applicable in cardiovascular research, particularly in studies related to hypertension and fibrosis-associated conditions.
AC-SDKP-NH2 is a substrate peptide of Angiotensin-converting enzyme (ACE). It exhibits significant anti-inflammatory and anti-fibrotic activities by directly targeting tissues, thereby preventing or reversing excessive fibrosis without impacting blood pressure or left ventricular hypertrophy (LVH). AC-SDKP-NH2 effectively attenuates inflammation, as well as cell differentiation, proliferation, and migration, resulting in reduced fibrosis in cardiac, vascular, and renal tissues in mouse models. This reagent is applicable in cardiovascular research, particularly in studies related to hypertension and fibrosis-associated conditions.
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