IRW is an orally active tripeptide derived from egg white, known for its angiotensin-converting enzyme (ACE) inhibitory properties. This compound exhibits significant potential in preventing high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and enhancing mitochondrial content. IRW has been shown to reduce hepatic triglyceride levels and lipid droplet size, while also increasing the activity of mitochondrial complexes and citrate synthase. Its ability to activate key pathways, including phosphorylation of 5’-AMP-activated protein kinase and increasing microsomal triglyceride transfer protein abundance, makes IRW a valuable reagent for studies in inflammation and metabolic disorders.
IRW is an orally active tripeptide derived from egg white, known for its angiotensin-converting enzyme (ACE) inhibitory properties. This compound exhibits significant potential in preventing high-fat diet-induced non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and enhancing mitochondrial content. IRW has been shown to reduce hepatic triglyceride levels and lipid droplet size, while also increasing the activity of mitochondrial complexes and citrate synthase. Its ability to activate key pathways, including phosphorylation of 5’-AMP-activated protein kinase and increasing microsomal triglyceride transfer protein abundance, makes IRW a valuable reagent for studies in inflammation and metabolic disorders.
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