Catalog No.
Product Name
Application
Product Information
Citations
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Control Substrate For c-Src Assay
Tyrosine Kinase Peptide 1 serves as a control substrate specifically designed for c-Src assay applications. Its primary mechanism involves interacting with c-Src kinase, facilitating the assessment of kinase activity. This peptide is critical for validating experimental conditions and ensuring accurate measurement of c-Src-mediated phosphorylation events in biological research. -
Peptide Substrate
p60c-src Substrate is a specific peptide substrate designed for the p60c-src protein tyrosine kinase (PTK). This substrate serves as a valuable tool for studying kinase activity and can facilitate the synthesis of chimeric branched peptides, expanding research applications in signal transduction and protein interactions. Its efficiency and specificity make it suitable for in vitro kinase assays and related studies in cellular signaling. -
Phosphopeptide Inhibitor
Caffeic acid-pYEEIE is a phosphopeptide inhibitor that demonstrates strong binding affinity for the GST-Lck-SH2 domain. This compound serves as a valuable tool in research focused on T cell signaling and immune response modulation. Its ability to selectively inhibit specific protein interactions makes it instrumental in studying the mechanisms underlying various cellular processes and disorders. -
Phosphorylated Polypeptide
p60c-src substrate II, phosphorylated is a pentapeptide that serves as a substrate for the p60c-src protein kinase. This phosphorylated polypeptide is crucial for studying protein phosphorylation, a key post-translational modification involved in various biological regulatory processes. Researchers utilize this substrate to investigate signaling pathways, cellular signaling mechanisms, and the role of Src family kinases in cellular function and disease. -
GM1 Ganglioside Binding Peptide
Ganglioside GM1-binding peptide p3 is a synthetic peptide that specifically targets the pentasaccharide component of GM1 ganglioside. This peptide is integral to understanding GM1's role as a multifunctional receptor, particularly in the classical pathway of cholera toxin infection. Ganglioside GM1-binding peptide p3 is valuable for investigating the interactions between GM1 and its ligands in various biological contexts. -
Bioactive Peptide
DYRKtide is a bioactive peptide that serves as an optimal substrate for DYRK1A, a dual-specificity protein kinase implicated in brain development. This peptide facilitates efficient phosphorylation by DYRK1A, making it a valuable tool for studying the regulatory mechanisms of this kinase in various cellular contexts. Its applications extend to research focused on neurodevelopmental processes and the signaling pathways influenced by DYRK1A. -
Compstatin Control Peptide
Compstatin Control Peptide serves as a negative control for Compstatin, a potent inhibitor of the complement system component C3. This peptide allows for the assessment of the specificity and efficacy of Compstatin in experimental settings. It is ideally used in research focused on complement-mediated processes and immunological responses. -
NRP-1 Targeting Peptide
CK3 peptide is an NRP-1 targeting peptide characterized by the amino acid sequence CLKADKAKC. It selectively binds to NRP-1 on breast cancer cells, facilitating targeted imaging and therapeutic applications. In vivo studies utilizing single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging demonstrate significant accumulation of CK3 peptide in xenograft tumors within nude mice. This peptide is suitable for molecular imaging research in breast cancer. -
Pro-Inflammatory Peptide
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a potent leukocyte chemoattractant. It plays a significant role in mediating inflammatory responses and can be employed in research related to various immune system disorders, including allergic asthma. This reagent is ideal for studies investigating the mechanisms of inflammation and the effects of immune modulation. -
Tumor Penetrating Peptide
RPARPAR is a CendR tumor-penetrating peptide that specifically targets neuropilin-1 (NRP-1) and neuropilin-2 (NRP-2) receptors on tumor cells. Its unique mechanism facilitates cellular internalization, promotes vascular extravasation, and enhances penetration into tumor tissues. RPARPAR is particularly valuable in research applications focused on tumor targeting and the development of efficient drug delivery systems using nanocarriers. -
LPS Peptide Mimic
RS 09 is an LPS peptide mimic that acts as an agonist for Toll-like receptor 4 (TLR4). By binding to TLR4, RS 09 activates the nuclear factor kappa B (NF-κB) signaling pathway, which is crucial for mediating immune responses. This compound is valuable in research focused on enhancing antigen-specific immune responses and studying TLR4-related signaling pathways in various in vivo models. -
Mast Cell Degranulating Peptide
Granuliberin R is a mast cell degranulating peptide derived from the skin of the amphibian Rana rugosa. This dodecapeptide stimulates rat peritoneal mast cells, inducing granule release and histamine secretion. Granuliberin R is useful for research applications focused on mast cell biology and the mechanisms of allergic responses. -
14-Membered Linear Peptide
Mast Cell Degranulating Peptide HR-2 is a 14-membered linear peptide derived from the venom of the giant hornet, Vespa orientalis. It effectively induces mast cell degranulation, leading to the release of histamine. This peptide is utilized in research applications focused on understanding allergic responses, inflammation processes, and the mechanisms of mast cell activation. -
Integrin ligand
VSLRGDTRG is a synthetic peptide derived from cadherin 17 (CDH17) that functions as a ligand for the α2β1 integrin. This peptide promotes the conformational activation of β1 integrin via the RGD motif, leading to enhanced cell adhesion and increased phosphorylation of FAK and ERK1/2. VSLRGDTRG is applicable in cancer research, specifically in studies involving tumors expressing CDH17, including colon and pancreatic cancers, where it may aid in understanding mechanisms of tumor proliferation and metastasis. -
Anti-aging Peptide
Hexapeptide-11 is an anti-aging peptide that targets fibroblasts to prevent premature cell senescence induced by oxidative stress. It promotes the synthesis of hyaluronic acid in keratinocytes, thereby enhancing skin barrier function through upregulation of HAS2 and EGR3, while downregulating HYAL2 expression. Additionally, Hexapeptide-11 has been shown to improve skin elasticity, making it valuable for research in dermatological and cosmetic applications. -
HSP60-derived Peptide
DiaPep277 is a 24 amino acid peptide derived from the HSP60 protein, specifically from positions 437-460. This peptide has been shown to halt the progression of β-cell destruction in NOD mice and exerts immune modulatory effects on diabetogenic T cells. DiaPep277 is primarily utilized in research studies focused on diabetes and immune response modulation, making it a valuable tool for understanding autoimmune mechanisms and potential therapeutic interventions. -
BiP Peptide Substrate
BiP substrate is a specific peptide substrate that targets BiP (Binding immunoglobulin protein), enabling the assessment of BiP ATPase activity. This reagent plays a crucial role in studies of protein folding and endoplasmic reticulum stress responses. Its application facilitates the exploration of cellular mechanisms related to protein metabolism and stress signaling pathways in various biological contexts. -
Hsp72 Antagonist
A8 peptide is an Hsp72 antagonist that inhibits tumor progression and metastasis. By disrupting the interaction between Hsp72 and TLR2, A8 peptide enhances the sensitivity of cancer cells to apoptosis induced by chemotherapeutic agents, including Cisplatin. This reagent is valuable for research in cancer biology, particularly in exploring mechanisms of drug resistance and metastasis. -
Hsp70-targeting Peptide
A17 peptide is an Hsp70-targeting peptide that binds to the ATP-binding domains of Hsp70, specifically inhibiting its chaperone activity. This inhibition enhances the sensitivity of cancer cells to apoptosis induced by chemotherapeutic agents, including Cisplatin. A17 peptide is valuable in anticancer chemotherapy research, particularly in studies related to multiple myeloma and other malignancies. -
HSP70/DnaK Substrate Peptide
HSP70/DnaK substrate peptide is a specific peptide recognized and bound by the HSP70/DnaK molecular chaperone. This substrate peptide is essential for probing the functional mechanisms of HSP70/DnaK, facilitating the investigation of its role in protein folding, stabilization, and stress response pathways. It serves as a valuable tool for research applications focused on understanding molecular chaperone activity and cellular proteostasis. -
Antimicrobial Peptide
Metalnikowin I is a proline-rich antimicrobial peptide that functions as an inhibitor of DnaK, a heat shock protein involved in cellular stress response. This peptide exhibits significant antimicrobial activity against a variety of pathogens, making it a valuable tool for studying host defense mechanisms and potential therapeutic applications. Its derivation from insects highlights its evolutionary role in innate immunity, offering insights into novel antimicrobial strategies. -
Tah1 Binding Peptide
Hsp90β decapeptide is derived from the C-terminal region of Hsp90β and features the conserved TPR-domain sequence MEEVD. This peptide effectively binds to the Tah1 protein, exhibiting a binding affinity with a dissociation constant (Kd) of 1.0 μM. Its ability to modulate Hsp90-Tah1 interactions makes Hsp90β decapeptide a valuable tool for researching protein chaperone activity and cellular stress responses. -
Tumor Cell Adhesion Peptide
HYD-1 is a D-amino acid tumor cell adhesion peptide that specifically targets the mechanisms involved in cell adhesion and migration. It consists of overlapping linear peptide elements that inhibit migration and activate ERK signaling pathways, thereby supporting adhesion in breast, prostate, ovarian, and pancreatic tumor cells. Importantly, HYD-1 does not impact tumor cell cycle distribution, making it particularly useful for research applications focused on prostate cancer. -
Antagonist
Peptide E5 is an antagonist that targets the CXCR4/CXCL12 signaling axis. By blocking this interaction, Peptide E5 downregulates CXCR4 expression and inhibits the phosphorylation of key downstream proteins, Akt and Erk, leading to apoptosis in breast cancer cells. Additionally, Peptide E5 suppresses cellular migration and adhesion, as well as the recruitment of endothelial progenitor cells, thereby inhibiting tumor angiogenesis. This peptide is a valuable tool for research related to breast cancer and tumor microenvironment interactions. -
Peptide Inhibitor
MEK1 Derived Peptide Inhibitor 1 is a selective peptide inhibitor targeting MEK1, effectively blocking the in vitro activation of ERK2 with an IC50 value of 30 μM. This compound is valuable for studies focused on the MEK/ERK signaling pathway, allowing researchers to investigate cellular processes regulated by this pathway. Its cell-permeable properties make it suitable for various biological applications in cancer research and signal transduction studies. -
CXCR4 Antagonist
Peptide R analogue 10 is a potent CXCR4 antagonist, demonstrating enhanced antagonistic activity, specificity, and plasma stability compared to its predecessor, Peptide R. This compound effectively inhibits CXCL12-mediated cell migration, ERK phosphorylation, and CXCR4 internalization. Peptide R analogue 10 is valuable for research applications involving CXCR4 overexpression in models of leukemia and colon cancer. -
Bioactive Peptide
ERKtide is a bioactive peptide that acts as a specific substrate for extracellular regulated protein kinase 2 (ERK2). ERK2 plays a crucial role in cellular signaling pathways influenced by mitogenic stimuli, impacting various physiological processes. This peptide can be utilized in studies focused on signal transduction, cellular response to growth factors, and the mechanisms underlying cell proliferation and differentiation. -
CK2 Peptide Substrate
CK2 Substrate Peptide (RRRADDSDDDDD) serves as a specific substrate for Casein Kinase 2 (CK2), exhibiting a Km of 13 μM. This peptide is crucial for studying CK2's role in various biological processes and provides valuable insights into the mechanisms underlying neurological diseases, including Alzheimer's Disease. Research applications include elucidating CK2-mediated phosphorylation events and investigating potential therapeutic targets. -
Casein Kinase II Substrate
Casein Kinase II Receptor Peptide serves as a substrate for casein kinase II, exhibiting a Km value of 500 µM. This peptide is utilized for assessing casein kinase II activity in crude enzyme preparations, facilitating research in signal transduction and cellular regulation. Its application is crucial for understanding various biological processes influenced by casein kinase II. -
CK2 Peptide Substrate
Casein Kinase II Substrate is specifically designed for use as a peptide substrate in studies involving casein kinase II (CK2). This substrate can be selectively phosphorylated by CK2, making it a valuable tool for investigating the enzyme's activity and regulatory mechanisms. It is suitable for various research applications, including signal transduction studies and the exploration of phosphoprotein functions in cellular processes. -
Activin Receptor
Myostatin inhibitory peptide 7 targets the Activin Receptor and is composed of 23 amino acids, specifically derived from the amino acids 21 to 43 of the mouse myostatin prodomain. This peptide effectively inhibits myostatin with a dissociation constant (Kd) of 29.7 nM, making it valuable for investigating muscle atrophic disorders and related research applications. -
Myostatin Inhibitor
Myostatin Inhibitory Peptide 2 is a specific inhibitor of myostatin, exhibiting a dissociation constant (Kd) of 35.9 nM. This peptide plays a significant role in regulating muscle growth and is particularly beneficial for research focused on muscle atrophic disorders. By modulating myostatin activity, it provides insights into potential therapeutic approaches for enhancing muscle regeneration and combatting muscle-wasting conditions. -
TGF-β1 Inhibitory Peptide
P17 Peptide is a selective inhibitor of human TGF-β1, functioning by blocking its activity. This peptide is valuable for studying the role of TGF-β1 in various biological processes and disease states, including fibrosis and cancer. Its inhibitory effects facilitate research into therapeutic strategies targeting TGF-β signaling pathways. -
SMAD2 activator
Myristoyl tetrapeptide-12 is a specific activator of SMAD2, promoting the recruitment of SMAD3 to DNA. This peptide exhibits significant biological activity in stimulating hair growth, with notable effects on eyelash enhancement. Its applications are particularly relevant in research focusing on hair follicle biology and regenerative medicine. -
Active Peptide
a-TGF (34-43), rat is an active peptide that plays a crucial role in modulating immune responses. This peptide segments contribute to the regulatory pathways in the immune system, making it valuable for studies related to immunity and immune modulation. Researchers can utilize a-TGF (34-43), rat to explore its effects on cellular signaling and immune function. -
Competitive peptide
PTD-DBM is a competitive peptide that inhibits the interaction between CXXC5 and Dvl, leading to the upregulation of β-catenin, α-SMA, and type I collagen. This mechanism supports its role in promoting skin wound healing by enhancing cellular processes involved in tissue regeneration and remodeling. PTD-DBM is valuable for research applications focused on regenerative medicine and skin biology. -
Octapeptide
β-Catenin peptide is an octapeptide that plays a crucial role in cell signaling by promoting thymocyte positive selection. This peptide is particularly relevant in immunological research, where it may aid in understanding T cell development and function. Its application extends to studies focused on the mechanisms of thymocyte maturation and selection processes within the immune system. -
Tool Peptide
PKA Regulatory Subunit II Substrate is a tool peptide that mimics the phosphorylation of proteins through interaction with cyclic AMP-dependent protein kinase (PKA). This substrate plays a crucial role in evaluating the activities of protein phosphatases and is widely utilized in research focusing on kinase signaling pathways and enzymatic regulation. Its specificity makes it an essential reagent for studying cellular signaling mechanisms and developing therapeutic interventions. -
Calcineurin Substrate
PKA RII peptide is a specific substrate for Protein Kinase A (PKA) that becomes phosphorylated at a serine residue. This modified peptide can be utilized as a tool for detecting calcineurin activity in various biological assays. Its application in studies related to signal transduction pathways enhances understanding of cellular processes influenced by PKA and calcineurin interactions. -
Neuropeptide
Kiss2 peptide is a neuropeptide that acts as a positive regulator of reproduction. It specifically binds to its receptor, Kiss2R (GPR54), in COS-7 cells, activating PKA and PKC signaling pathways via Gas and Gaq proteins. This interaction subsequently enhances cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc) activities, making Kiss2 peptide valuable for research in reproductive biology and neuroendocrine signaling. -
Substrate Peptide
Cys-Kemptide is a cysteine-terminated substrate peptide specifically designed for the assessment of protein kinase A (PKA) activity. This peptide serves as an effective tool in phosphorylation studies, enabling researchers to quantify PKA-mediated protein modifications. Its application is critical in the investigation of signaling pathways and the role of PKA in various biological processes. -
Bioactive Peptide
Kemptide, 5-FAM labeled is a bioactive peptide that acts as a synthetic substrate for Protein Kinase A (PKA), with a Km value of 16 μM. This fluorescently labeled variant facilitates real-time monitoring of PKA activity in various biological assays. Kemptide's unique properties make it a valuable tool for studying signal transduction pathways and assessing kinase activity in research applications. -
Active peptides
d-(RYTVELA) is a specific inhibitor of human thymocyte proliferation, exhibiting an IC50 of 1 nM. It selectively disrupts IL-1-induced signaling pathways, making it valuable for studying immune responses and thymocyte biology. This peptide is useful in research applications related to immunology and cellular signaling. -
Peptide
Interleukin II (60-70) is a peptide fragment derived from the Interleukin II polypeptide. It plays a crucial role in the immune response by modulating T cell proliferation and activation. This fragment is useful for research applications focused on cytokine signaling pathways, immune cell interactions, and the study of T cell dynamics in various experimental settings. -
Anti-inflammatory Peptide
IIIM1 is an orally active anti-inflammatory peptide that functions by stimulating the proliferation of regulatory T cells and promoting the production of RA1. This molecule effectively ameliorates symptoms associated with experimental autoimmune encephalomyelitis (EAE) by regulating cytokine balance. IIIM1 is a valuable tool for research focused on multiple sclerosis (MS) and its underlying immunological mechanisms. -
IL-23 Inhibitor
IL-23 cyclic peptide inhibitor 105 targets the interleukin-23 (IL-23) pathway, serving as a specific inhibitor of this pro-inflammatory cytokine. It exhibits significant potential in modulating inflammatory responses associated with disorders such as inflammatory bowel disease (IBD). This compound is a valuable tool for researchers investigating the role of IL-23 in various inflammatory conditions and developing therapeutic strategies targeting IL-23 signaling. -
Peptide Fragment
IL4RPep-1 is a peptide fragment that specifically targets the interleukin-4 receptor (IL-4R). It demonstrates selective accumulation in atherosclerotic plaques while minimizing enrichment in normal tissues. This property makes IL4RPep-1 a promising candidate for use as a targeted delivery system or molecular imaging probe in atherosclerosis research. -
Antitumor Agent
Myelopeptide-2 is an antitumor peptide that enhances the mitogenic response of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. It effectively restores interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression, supporting immune homeostasis. This reagent holds potential applications in antitumor and antiviral research, providing valuable insights into immune modulation and therapeutic strategies. -
Peptide
BMP-4 is a cell-penetrating peptide that binds heparin, identified by the sequence RKKNPNCRRH. This compound exhibits notable anti-inflammatory and anti-chondrogenic properties, making it a valuable tool in research related to arthritis and related inflammatory conditions. Its unique mechanism allows for enhanced cellular interactions, facilitating studies on cell signaling and tissue response. -
Beta-interleukin II Polypeptide
β-Interleukin II (44-56) is a peptide fragment corresponding to amino acids 44-56 of the beta-interleukin II polypeptide. This cytokine plays a critical role in modulating immune responses, primarily functioning in communication among leukocytes. Research applications include studies on immune system regulation, inflammation, and potential therapeutic strategies targeting cytokine signaling pathways.
