Catalog No.
Product Name
Application
Product Information
Citations
- Angiogenin Fragment (108–123) is a C-terminal peptide segment of Angiogenin that functions as an inhibitor of its enzymatic and biological activities. This fragment interferes with Angiogenin’s pro-angiogenic functions, making it a useful tool for studying angiogenesis and exploring therapeutic strategies targeting vascular growth.
- Tau Peptide (306–317) is a synthetic polypeptide fragment identified through peptide screening, a research technique that pools and evaluates active peptides—primarily via immunoassays. Peptide screening is widely used for studying protein–protein interactions, functional analysis, and epitope mapping, making Tau Peptide (306–317) a valuable tool in the research and development of therapeutic agents, particularly in neurodegenerative disease studies.
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Insulin Secretion Stimulator
GIP Human (Gastric Inhibitory Polypeptide) is a 42-amino acid peptide hormone that functions as an incretin. Secreted by intestinal K cells in response to nutrient ingestion, GIP enhances glucose-dependent insulin secretion and acts as a weak inhibitor of gastric acid secretion. It plays a key role in glucose homeostasis and metabolic regulation. -
Bone resorption inhibitor
Chicken calcitonin is a peptide hormone involved in the regulation of calcium metabolism. It inhibits bone resorption by suppressing the motility and activity of osteoclasts, as demonstrated in neonatal rat models. This hormone plays a key role in maintaining bone homeostasis and is of interest in bone-related research. - The Italian mutation of β-amyloid 1-40 (E22K) exhibits faster aggregation kinetics and greater neurotoxicity compared to the wild-type peptide. Solid-state NMR studies (Masuda et al.) suggest this enhanced toxicity may be linked to the formation of a salt bridge between Lys²² and Asp²³ in a minor conformer. Similar to the Arctic, Flemish, and Dutch Aβ variants, the Italian mutant also shows significantly reduced degradation by the Aβ-cleaving enzyme neprilysin, contributing to its pathological accumulation.
- Retrocyclin-101 is a synthetic antimicrobial peptide that exhibits broad-spectrum activity against both bacterial and viral pathogens. It functions by disrupting microbial membranes and enhancing host immune responses, making it a valuable candidate for infectious disease research and therapeutic development.
- Tetrapeptide-21 is a bioactive peptide commonly used in cosmetic formulations for its anti-wrinkle and skin-brightening properties. It promotes collagen synthesis and helps reduce the appearance of fine lines and hyperpigmentation, contributing to improved skin texture and tone.
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bioactive peptide
Acetyl tetrapeptide-9 is a bioactive peptide that promotes the synthesis of collagen I and stimulates the production of lumican, a key polysaccharide component of the basement membrane. It is commonly used in skin research and cosmetic formulations for its potential to enhance dermal structure and improve skin firmness. -
HOX/PBX interaction antagonist
HXR9 is a cell-permeable peptide that functions as a competitive antagonist of the HOX/PBX interaction, disrupting the binding of HOX proteins (paralogues 1–8) to the transcription factor PBX. It selectively inhibits proliferation and induces apoptosis in cells with elevated HOXA/PBX3 expression, such as MLL-rearranged leukemic cells, making it a valuable tool for studying HOX/PBX-driven oncogenesis. -
GLP-2R agonist
Glepaglutide (ZP1848) is a long-acting glucagon-like peptide-2 (GLP-2) analogue and a potent agonist of the GLP-2 receptor (GLP-2R). It enhances intestinal absorption, reduces faecal output, and alleviates small intestinal inflammation. Glepaglutide is a valuable agent for research in inflammatory bowel disease (IBD), including Crohn’s disease. -
Negative Control Peptide
PTD (Antennapedia leader peptide) serves as a negative control for the TRAF6 inhibitor peptide DRQIKIWFQNRRMKWKK-RKIPTEDEY. By demonstrating a lack of inhibitory activity, PTD provides a reference point for experimental comparisons in studies involving TRAF6 modulation. Its application is crucial in validating the specificity and efficacy of TRAF6-targeted interventions in various biological research contexts. -
VGF Derived Peptide
LQEQ-19 (mouse, rat) is a VGF-derived peptide that activates the PI3K/Akt and MEK/ERK signaling pathways, stimulating the phosphorylation of Akt and ERK1/2. It exhibits neuroprotective effects, making it a valuable tool for investigating various neurological conditions. LQEQ-19 is widely used in research focused on neural regeneration and neurodegenerative diseases. -
Akt/SKG Substrate
Akt/SKG Substrate Peptide is a synthetic peptide specifically designed as a substrate for Akt/PKB. This peptide is selectively phosphorylated by Akt/PKB and does not undergo phosphorylation by p70S6K or MAPK1, making it an ideal tool for studying the Akt signaling pathway. Its specificity is valuable in research applications focused on cancer, metabolism, and neurological disorders associated with Akt dysregulation. -
Substrate Mimetic Peptide
GSK3β-peptide is a substrate mimetic peptide that targets glycogen synthase kinase 3-β (GSK3-β) by binding to its active site and simulating substrate behavior. This peptide serves as a crucial tool in the development of substrate mimetic inhibitors of Akt, offering potential applications in anticancer drug discovery and research. Its ability to engage with GSK3-β positions it as a valuable reagent for probing signaling pathways involved in cell proliferation and survival. -
Amino Acid Polypeptide Hormone Analogue
Sincalide ammonium is an amino acid polypeptide hormone analogue of cholecystokinin (CCK) that primarily targets gallbladder function. It is utilized in clinical settings for its ability to promote gallbladder contraction, thus facilitating the diagnosis of gallbladder and pancreatic disorders. By increasing bile secretion and causing the contraction of the gallbladder while relaxing the sphincter of Oddi, Sincalide ammonium aids in the efficient drainage of bile into the duodenum, making it a valuable tool in postevacuation cholecystography. -
Antimicrobial Peptide
Cathelicidin-PY is an antimicrobial peptide that targets and inhibits the TLR4 inflammatory response pathways activated by lipopolysaccharide (LPS). This peptide demonstrates significant antimicrobial and anti-inflammatory properties while exhibiting low cytotoxicity in RAW 264.7 cells. Cathelicidin-PY is suitable for research focused on antimicrobial and anti-inflammatory mechanisms. -
B-cell Maturation Antigen Peptide
BCMA72-80 is a HLA-A2-specific peptide derived from the B-cell maturation antigen (BCMA) that exhibits strong binding affinity to HLA-A2. This peptide is primarily utilized in research focused on multiple myeloma and other tumors expressing BCMA. Its application is significant in studying immune responses and developing immunotherapeutic approaches targeting BCMA in oncology. -
Restricted Peptide Antigen
Eps8 peptide 327 is an HLA-A*2402-restricted peptide antigen derived from the Eps8 protein. It exhibits potent antitumor activity through significant cytotoxicity, effectively inhibiting cancer cell proliferation and inducing apoptosis. Eps8 peptide 327 disrupts the EGFR signaling pathway by modulating downstream signals, including IL-2, TNF-α, and IFN-γ, while also interfering with the Eps8/EGFR interaction. Its efficacy has been demonstrated in HT-29 xenograft mouse models, where it significantly inhibits tumor growth. -
Anti-aging Peptide
Acetyl tetrapeptide-2 is an anti-aging peptide that enhances skin rejuvenation by stimulating structural components such as collagen and elastin. This bioactive compound has been shown to reduce the loss of thymic factors, thereby promoting improved cellular stiffness in human keratinocytes (HaCaT cells). Its applications extend to various skin care formulations aimed at combating signs of aging and improving skin resilience. -
CD206 Targeting Peptide
RP-832c is a synthetic analogue of host defense peptides that selectively targets the mannose receptor CD206 on M2 polarized macrophages (Kd = 3.5 μM). Binding of RP-832c to CD206 induces significant conformational changes, activating signaling pathways that promote apoptosis and repolarization of M2 macrophages to an M1 phenotype. The treatment with RP-832c effectively reduces CD206 gene expression while transiently increasing TNF-α levels, a hallmark of M1 macrophages. This reagent is valuable for research on T-cell lymphoma (CTCL) and idiopathic pulmonary fibrosis (IPF). -
Human Neutrophil Peptide
Defensin HNP-1 human is an antimicrobial peptide that primarily targets and modulates the immune response in human neutrophils. It exhibits significant antibacterial activity through the inhibition of DNA, RNA, and protein synthesis, thereby disrupting essential metabolic pathways. Additionally, Defensin HNP-1 demonstrates direct inactivation of various viruses, including HIV, HSV-1, HSV-2, CMV, and influenza. It also possesses antileishmanial properties and plays a role in endothelial cell dysfunction associated with the early stages of atherosclerosis, making it a valuable tool for research in immunology and infectious diseases. -
Bioactive Peptide
WP9QY is a bioactive peptide designed as a TNF-α antagonist. This cyclic peptide effectively mimics the essential recognition loop of tumor necrosis factor on TNF receptor I, thereby inhibiting TNF-receptor interactions. WP9QY serves as a valuable template for developing small molecular inhibitors aimed at mitigating inflammatory bone destruction and systemic bone loss associated with rheumatoid arthritis. -
Cyclic Tetrapeptide
Apicidin C is a cyclic tetrapeptide that primarily targets histone deacetylases (HDACs). It exhibits potent antiprotozoal and antimalarial activity against Eimeria tenella, with an IC50 of 6 nM. This compound is valuable for research into malaria infections and provides insights into HDAC inhibition mechanisms in protozoan parasites. -
Antitumor Peptide
Azurin p28 peptide is an antitumor peptide that primarily targets and stabilizes the tumor suppressor protein p53. By forming a complex with p53, it reduces proteasomal degradation, leading to apoptosis or cell cycle arrest in p53-positive tumors. Additionally, Azurin p28 peptide exhibits antiangiogenic properties by inhibiting the phosphorylation of key signaling molecules, including VEGFR-2, FAK, and Akt, thereby impeding tumor growth and vascularization. This peptide is valuable in cancer research focusing on p53-mediated pathways and antiangiogenic strategies. -
Cardiomyocyte Specific Peptide
WLSEAGPVVTVRALRGTGSW is a cardiomyocyte-specific peptide designed to enhance targeted cellular delivery. This peptide facilitates improved uptake by cardiomyocytes, reduces apoptosis within these cells, and promotes enhanced retention of therapeutic agents following intramyocardial injection in vivo. It is a valuable reagent for research applications focusing on cardiac tissue engineering and myocardial protection strategies. -
Antimicrobial Peptide
Thanatin is an inducible cationic antimicrobial peptide that targets microbial membranes. It exhibits broad-spectrum antimicrobial activity against both Gram-negative and Gram-positive bacteria, as well as various fungi, with minimum inhibitory concentrations (MICs) ranging from 0.3 to 40 µM. Thanatin functions by competitively displacing divalent cations from the bacterial outer membrane, resulting in membrane disruption and enhanced permeability. This peptide is valuable for research applications in antimicrobial resistance, infection mechanisms, and the development of novel antibacterial agents. -
Antimicrobial Peptide
Magainin 1 is an antimicrobial peptide that targets bacterial membranes. Isolated from the skin of Xenopus laevis, it displays significant antibacterial activity against a broad spectrum of both Gram-negative and Gram-positive bacteria. This peptide serves as a valuable tool for research in antimicrobial mechanisms and can be utilized in studies assessing the efficacy of peptide-based antibiotics. -
Antimicrobial Peptide
Temporin A is an alpha-helical antimicrobial peptide derived from the skin of the European common frog, Rana temporaria. This peptide exhibits broad-spectrum activity against Gram-positive bacteria by disrupting microbial cell membranes, while demonstrating non-toxicity to erythrocytes at effective antimicrobial concentrations. Additionally, Temporin A possesses antifungal properties, notably against Candida albicans, making it a valuable reagent for research in antimicrobial peptide function and potential therapeutic applications. -
Antimicrobial Peptide
Nisin Z is an antimicrobial peptide that primarily targets Gram-positive bacteria and fungi, including Candida albicans. It exhibits notable antimicrobial and anti-inflammatory properties, making it a valuable tool for research into bacterial resistance and fungal infections. Nisin Z is utilized in various applications, including food preservation, therapeutic development, and studies on peptide-based antimicrobial strategies. -
HER2-Derived Antigen Peptide
CH401 peptide is a HER2-derived antigen peptide that functions as a vaccine candidate for anti-breast cancer therapy. It is encapsulated within a lipid bilayer containing the lipid adjuvant α-GalCer, following binding to an artificial viral capsid via a self-assembled β-cyclic peptide. This innovative formulation allows for comprehensive investigations into its self-adjuvant properties and its potential in eliciting robust immune responses against HER2-expressing tumors. -
Tumor-specific Mutation
EGFRvIII peptide (PEPvIII) is a tumor-specific mutation predominantly expressed in glioblastoma multiforme (GBM) and various other neoplasms, significantly contributing to enhanced tumorigenicity. This peptide serves as a valuable target for the development of antitumor immunotherapies, allowing for the potential targeting of cancer cells while sparing normal tissues. Its specific expression profile makes it a crucial tool for research into GBM and other malignancies. -
Peptide
ELAAWCRWGFLLALLPPGIAG is a peptide derived from the rat HER2/neu protein, comprising 21 amino acids (aa 5-25). It has been demonstrated to induce cytotoxic T lymphocyte (CTL) responses in mice with HER2-positive tumors, making it a valuable tool for studying immune responses in cancer therapy. This peptide is particularly relevant for research applications focused on immunotherapy and the modulation of tumor-specific immune responses. -
EGFR-binding peptide
LARLLT is an EGFR-binding peptide that specifically targets the epidermal growth factor receptor (EGFR). This compound exhibits potential in the research of cancers characterized by EGFR overexpression, including lung, ovarian, and colorectal cancers. Its application in studies may facilitate insights into tumor biology and therapeutic interventions in EGFR-driven malignancies. -
HER2-Targeting Peptide
Herceptide is a HER2-targeting peptide that selectively binds to the human epidermal growth factor receptor 2 (HER2). This peptide can be conjugated with the near-infrared fluorescent dye indocyanine green (ICG), facilitating the development of innovative theranostic agents. Its primary applications include targeted imaging and therapy for HER2-positive cancers, enhancing the precision of cancer diagnostics and treatment strategies. -
Hexapeptide
Lys-Arg-Thr-Leu-Arg-Arg (KRTLRR) is a hexapeptide that serves as a substrate for protein kinase C (PKC) derived from the epidermal growth factor receptor (EGFR). This compound is instrumental in studying PKC activity, enabling researchers to elucidate its role in various signaling pathways. Research applications include assessing the enzymatic function of PKC and exploring its implications in cellular processes such as proliferation and differentiation. -
Peptide
pp60v-src Autophosphorylation site is a synthetic peptide that mimics the autophosphorylation site of the pp60v-src protein. This peptide is utilized in biochemical studies to investigate the regulation of protein tyrosine kinases and their signaling pathways. It serves as a valuable tool in research focusing on cancer biology, cell signaling, and the mechanisms of oncogenesis. -
HER2 Targeting Peptide
HER2-targeted peptide H6F is designed to selectively bind to the HER2 receptor, making it a valuable tool for targeting breast cancer cells. Its amino acid sequence, YLFFVFER, allows for effective conjugation with the bifunctional chelating agent hydrazinonicotinamide (HYNIC) for radiolabeling with 99mTc. Studies utilizing single-photon emission computed tomography (SPECT) demonstrate that the radiolabeled H6F peptide accumulates specifically in HER2-positive MDA-MBA-453 tumor-bearing mouse models. This peptide is applicable for tumor molecular imaging studies, aiding in the evaluation and monitoring of breast cancer. -
HER2/neu Peptide
HER2/neu (654-662) GP2 is a peptide derived from the human epidermal growth factor receptor 2 (HER2/neu) that consists of nine amino acids. This specific peptide elicits HLA-A2-restricted cytotoxic T lymphocyte (CTL) responses, making it relevant for research involving immunotherapy and cancer treatment. Its application is particularly significant in the context of various epithelial cancers, facilitating the study of immune responses and potential therapeutic strategies. -
Peptide Toxin
Candidalysin is a cytolytic peptide toxin derived from the pathogenic fungus Candida albicans, primarily targeting epithelial cells. This peptide is known for its ability to activate the EGFR-MAPK signaling pathway, which leads to increased expression of matrix metalloproteinases (MMPs) and calcium influx, as well as modulation of the c-Fos transcription factor through p38 MAPK and ERK1/2. Candidalysin plays a critical role in both mucosal and systemic infections by stimulating NLRP3 inflammasome activation, promoting inflammatory responses, neutrophil recruitment, and Th17 immunity. Additionally, it induces lactate dehydrogenase (LDH) release, resulting in membrane damage and cytotoxicity. -
Tumor-binding Peptide
ErbB-2-binding peptide is a tumor-targeting peptide that specifically interacts with the ErbB-2 receptor (HER2). This peptide demonstrates significant potential in cancer research by aiding in the selective identification and targeting of HER2-positive tumors. Its unique binding properties make it a valuable tool for studies focused on tumor biology, therapeutic delivery, and the development of targeted cancer treatments. -
EGFR Targeting Peptide
Cys-GE11 is a cysteine-modified peptide that targets the epidermal growth factor receptor (EGFR). This peptide can be conjugated via its thiol group, enabling the formation of targeted polymeric constructs to improve drug delivery efficacy. Cys-GE11 demonstrates enhanced enrichment of therapeutic agents at tumor sites, particularly in EGFR-overexpressing cells, such as SMMC-7721. Its utilization in research highlights its potential for applications in targeted cancer therapy with minimal toxicity. -
Peptide
Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a peptide derived from the TIF-2 coactivator, encompassing amino acid residues 740-753 of the TIF-2 protein. This 14-amino acid peptide plays a crucial role in the modulation of transcriptional activity by enhancing the interaction between transcription factors and the basal transcriptional machinery. It is commonly utilized in research applications focused on gene expression, transcriptional regulation, and cell signaling pathways. -
Peptide Interacting With hNatD
Histone H4 peptide is a peptide that specifically interacts with hNatD, facilitating important polar interactions within cellular processes. This peptide is valuable for studying post-translational modifications and histone dynamics. It is particularly applicable in lung cancer research, aiding in the understanding of epigenetic regulation and potential therapeutic targets in oncology. -
Anti-inflammatory Peptide
SAP15 is a synthetic anti-inflammatory peptide derived from human beta-defensin 3, comprising 15 amino acids. This peptide effectively penetrates cells to downregulate intracellular inflammation by inhibiting the phosphorylation of HDAC5, which in turn reduces the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 demonstrates significant anti-inflammatory activity, while also enhancing the expression of aggrecan and type II collagen, and decreasing osteocalcin levels in LPS-induced chondrocytes. SAP15 serves as a valuable tool in the exploration of inflammation regulation and the development of anti-inflammatory therapies for biomaterials. -
SETD8 Inhibitor
[Nle20] H4 peptide (16−23) is a potent inhibitor of the histone methyltransferase SETD8, exhibiting a Kd of 0.14 μM. This peptide competes with histone H4 for binding to the substrate site of SETD8, effectively blocking its methylation activity. As a result, [Nle20] H4 peptide (16−23) serves as a valuable tool in cancer research, offering potential applications in the development of therapeutic strategies targeting epigenetic modulation. -
Antimicrobial Peptide
Dermaseptin-S3 is an antimicrobial peptide that targets and disrupts the membranes of filamentous fungi. It exhibits significant antifungal activity, making it a valuable tool for research in fungal infections and antimicrobial peptide studies. Its mechanism of action entails perturbation of the fungal cell membrane, leading to cell lysis and death, thereby aiding in the exploration of novel antifungal therapies. -
Antimicrobial Peptide
Dermaseptin-S2 is an antimicrobial peptide derived from frog skin, exhibiting potent activity against filamentous fungi. It disrupts cellular membranes, leading to fungal cell death. This peptide is applicable in research related to antifungal mechanisms and the development of novel antimicrobial agents. -
Antimicrobial Peptide
Dermaseptin-S4 is an antimicrobial peptide that targets and inhibits the growth of filamentous fungi. It exhibits potent antifungal activity, making it a valuable reagent for research in antifungal therapy and the study of innate immune mechanisms. This compound can be utilized in the exploration of new therapeutic strategies against fungal infections. -
Antifungal Peptide
LL-25 is an antifungal peptide that exhibits potent candidacidal activity, making it particularly useful in research focused on fungal infections. This compound is a fragment of LL-37, lacking its immunomodulatory effects, which allows for a more targeted investigation of its antifungal properties. LL-25 is applicable in studies exploring therapeutic strategies against fungal pathogens, providing insights into the development of novel antifungal agents. -
Cyclic Peptides
Aselacin C is a cyclic peptide derived from the fungus Acremonium spp. This compound exhibits potent biological activity, serving as an important tool for studying antimicrobial properties and potential applications in drug discovery. Aselacin C provides researchers with valuable insights into peptide synthesis and structure-activity relationships within cyclic peptides, making it relevant for various research applications in the fields of microbiology and pharmacology.
