Catalog No.
Product Name
Application
Product Information
Citations
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Anti-cancerous Peptide
Cr-ACP1 is an anti-cancerous peptide that selectively binds to DNA, inducing cell cycle arrest in the G0-G1 phase. This mechanism triggers apoptosis, making Cr-ACP1 a potent agent against various cancer types. Notably, it demonstrates significant anticancer effects in colon cancer and epidermoid carcinoma research applications. -
Antifungal Peptide
Periplanetasin-2 is an antifungal peptide that exerts its effects primarily through the induction of oxidative stress by generating reactive oxygen species (ROS) and promoting lipid peroxidation. In addition to its antifungal activity, Periplanetasin-2 can also trigger apoptosis in target cells. This compound is valuable for research applications aimed at understanding fungal pathogenesis and evaluating potential therapeutic strategies against fungal infections. -
Fas Mimetic Peptide/Fas/FasL Antagonist
Kp7-6 is a Fas mimetic peptide that acts as a Fas/FasL antagonist. It selectively binds to the Fas receptor and Fas ligand, disrupting receptor complexes and inhibiting downstream apoptotic signaling pathways. This includes the suppression of caspase-8 and caspase-3 activation, thereby preventing β-cell apoptosis and reducing FasL-induced lymphoid cytotoxicity. In preclinical models, Kp7-6 has demonstrated efficacy in reducing tumor volume and enhancing T cell infiltration in pancreatic neuroendocrine tumors, and it has also been shown to protect against concanavalin A-induced liver injury. The compound is relevant for research in type 2 diabetes, inflammation, and cancer biology. -
N-Formyl Peptide Receptor Agonist
WKYMVm is a selective agonist of the N-formyl peptide receptor, specifically FPR2. It exhibits significant anti-inflammatory properties, demonstrating potential to reduce lung and spinal cord injuries. Additionally, WKYMVm influences metabolic pathways by regulating lipid metabolism and leptin signaling, contributing to obesity management. Its role extends to immune cell regulation, where it promotes chemotactic migration and inhibits phagocyte apoptosis. The compound may have variable effects in tumor biology, with potential to either support or hinder tumor progression based on the tumor type. -
Bioactive Peptide
MOTS-c (human) is a bioactive peptide derived from mitochondria that modulates the AMPK/PGC-1α pathway, thereby enhancing insulin sensitivity. This peptide inhibits the folate cycle and de novo purine synthesis, elevating AICAR levels to activate AMPK, which regulates the Nrf2/Keap1 antioxidant pathway and suppresses the NF-κB inflammatory pathway. MOTS-c promotes mitochondrial biogenesis and energy metabolism, resulting in improvements in glucose and lipid metabolism, anti-oxidative stress, and neuroprotection. It is applicable in research studying type 2 diabetes, traumatic brain injury, inflammatory diseases, and age-related metabolic disorders. -
AnxA2 inhibitor
LCKLSL is an N-terminal hexapeptide that functions as a competitive inhibitor of annexin A2 (AnxA2). It effectively blocks the interaction between tissue plasminogen activator (tPA) and AnxA2, thereby inhibiting plasmin generation. Through suppression of the tPA–AnxA2–plasmin pathway, LCKLSL exhibits significant anti-angiogenic activity and may serve as a valuable tool for studying AnxA2-mediated fibrinolytic and vascular processes. - ATWLPPR peptide is a biologically active heptapeptide and a specific antagonist of VEGFR2 (KDR/Flk-1). It binds to VEGFR2, completely blocking VEGF binding and thereby inhibiting VEGF-induced angiogenesis in vivo. ATWLPPR selectively inhibits human endothelial cell proliferation in vitro and fully suppresses VEGF-mediated angiogenesis in vivo.
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C1q/MBL inhibitor
PIC1 PA is a 15-amino-acid peptide and a potent analog of PIC1 that inhibits classical pathway–mediated complement activation. It functions by disrupting the interaction between C1s-C1r-C1r-C1s/MASPs and the collagen-like region (CLR) of C1q or MBL. PIC1 PA specifically binds to the CLR of C1q, with a mean equilibrium dissociation constant (K\_D) of 33.3 nM for purified C1q. -
NRP-1 targeting peptide
tLyP-1 peptide is a neuropilin-1 (NRP-1) targeting peptide with an IC₅₀ of 4 μM and the amino acid sequence CGNKRTR. It specifically binds to NRP-1, enabling selective targeting of tumor cells. -
CRF2 receptor agonist
Urocortin, human, is a 40-amino acid neuropeptide that functions as a selective agonist of the endogenous corticotropin-releasing factor receptor 2 (CRF₂). It exhibits high binding affinity with Kᵢ values of 0.4 nM for human CRF₁, 0.3 nM for rat CRF₂α, and 0.5 nM for mouse CRF₂β. Urocortin plays a role in modulating stress responses, cardiovascular function, and feeding behavior. -
CMKLR1 Agonist
Chemerin-9 (149–157) TFA is a potent peptide agonist of chemokine-like receptor 1 (CMKLR1), exhibiting significant anti-inflammatory activity. It activates downstream signaling pathways by stimulating the phosphorylation of Akt and ERK and promoting reactive oxygen species (ROS) production. Chemerin-9 (149–157) TFA has demonstrated neuroprotective effects, including the amelioration of Aβ₁₋₄₂-induced memory impairment in Alzheimer's disease models. Additionally, it plays important roles in modulating immune responses, regulating adipocyte differentiation, and improving glucose metabolism, making it a valuable tool for research in inflammation, neurodegeneration, and metabolic disorders. -
KRAS/ERK/RAS Inhibitor
LUNA18 is an orally bioavailable cyclic peptide that functions as a dual inhibitor of KRAS and ERK signaling pathways. It disrupts the interaction between RAS and guanine nucleotide exchange factors (GEFs), effectively inhibiting RAS activation and downstream signaling. In RAS-mutated cancer cells, LUNA18 reduces cell proliferation while modulating key signaling nodes, including phosphorylation of ERK and AKT. In preclinical studies, LUNA18 demonstrates potent anticancer activity, particularly in xenograft models, by blocking RAS-driven tumor growth. It shows significant cellular efficacy against cancer cell lines harboring KRAS mutations, including colon, gastric, pancreatic, and non-small cell lung cancers, highlighting its therapeutic potential as a targeted agent for RAS-driven malignancies. -
ERK1/2 activator
mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable peptide that functions as an activator of ERK1/2 signaling, with an EC₅₀ of 2.5–5 μM. It disrupts the interaction between the G-protein α and βγ subunits, promoting dissociation of the α subunit independently of nucleotide exchange. By modulating G-protein signaling, mSIRK enables selective activation of downstream pathways, such as ERK1/2, and serves as a valuable tool for studying G-protein–mediated signal transduction and ERK pathway activation. - Angiogenin Fragment (108–123) is a C-terminal peptide segment of Angiogenin that functions as an inhibitor of its enzymatic and biological activities. This fragment interferes with Angiogenin’s pro-angiogenic functions, making it a useful tool for studying angiogenesis and exploring therapeutic strategies targeting vascular growth.
- Tau Peptide (306–317) is a synthetic polypeptide fragment identified through peptide screening, a research technique that pools and evaluates active peptides—primarily via immunoassays. Peptide screening is widely used for studying protein–protein interactions, functional analysis, and epitope mapping, making Tau Peptide (306–317) a valuable tool in the research and development of therapeutic agents, particularly in neurodegenerative disease studies.
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Insulin Secretion Stimulator
GIP Human (Gastric Inhibitory Polypeptide) is a 42-amino acid peptide hormone that functions as an incretin. Secreted by intestinal K cells in response to nutrient ingestion, GIP enhances glucose-dependent insulin secretion and acts as a weak inhibitor of gastric acid secretion. It plays a key role in glucose homeostasis and metabolic regulation. -
Bone resorption inhibitor
Chicken calcitonin is a peptide hormone involved in the regulation of calcium metabolism. It inhibits bone resorption by suppressing the motility and activity of osteoclasts, as demonstrated in neonatal rat models. This hormone plays a key role in maintaining bone homeostasis and is of interest in bone-related research. - The Italian mutation of β-amyloid 1-40 (E22K) exhibits faster aggregation kinetics and greater neurotoxicity compared to the wild-type peptide. Solid-state NMR studies (Masuda et al.) suggest this enhanced toxicity may be linked to the formation of a salt bridge between Lys²² and Asp²³ in a minor conformer. Similar to the Arctic, Flemish, and Dutch Aβ variants, the Italian mutant also shows significantly reduced degradation by the Aβ-cleaving enzyme neprilysin, contributing to its pathological accumulation.
- Retrocyclin-101 is a synthetic antimicrobial peptide that exhibits broad-spectrum activity against both bacterial and viral pathogens. It functions by disrupting microbial membranes and enhancing host immune responses, making it a valuable candidate for infectious disease research and therapeutic development.
- Tetrapeptide-21 is a bioactive peptide commonly used in cosmetic formulations for its anti-wrinkle and skin-brightening properties. It promotes collagen synthesis and helps reduce the appearance of fine lines and hyperpigmentation, contributing to improved skin texture and tone.
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bioactive peptide
Acetyl tetrapeptide-9 is a bioactive peptide that promotes the synthesis of collagen I and stimulates the production of lumican, a key polysaccharide component of the basement membrane. It is commonly used in skin research and cosmetic formulations for its potential to enhance dermal structure and improve skin firmness. -
HOX/PBX interaction antagonist
HXR9 is a cell-permeable peptide that functions as a competitive antagonist of the HOX/PBX interaction, disrupting the binding of HOX proteins (paralogues 1–8) to the transcription factor PBX. It selectively inhibits proliferation and induces apoptosis in cells with elevated HOXA/PBX3 expression, such as MLL-rearranged leukemic cells, making it a valuable tool for studying HOX/PBX-driven oncogenesis. -
GLP-2R agonist
Glepaglutide (ZP1848) is a long-acting glucagon-like peptide-2 (GLP-2) analogue and a potent agonist of the GLP-2 receptor (GLP-2R). It enhances intestinal absorption, reduces faecal output, and alleviates small intestinal inflammation. Glepaglutide is a valuable agent for research in inflammatory bowel disease (IBD), including Crohn’s disease. -
Negative Control Peptide
PTD (Antennapedia leader peptide) serves as a negative control for the TRAF6 inhibitor peptide DRQIKIWFQNRRMKWKK-RKIPTEDEY. By demonstrating a lack of inhibitory activity, PTD provides a reference point for experimental comparisons in studies involving TRAF6 modulation. Its application is crucial in validating the specificity and efficacy of TRAF6-targeted interventions in various biological research contexts. -
VGF Derived Peptide
LQEQ-19 (mouse, rat) is a VGF-derived peptide that activates the PI3K/Akt and MEK/ERK signaling pathways, stimulating the phosphorylation of Akt and ERK1/2. It exhibits neuroprotective effects, making it a valuable tool for investigating various neurological conditions. LQEQ-19 is widely used in research focused on neural regeneration and neurodegenerative diseases. -
Akt/SKG Substrate
Akt/SKG Substrate Peptide is a synthetic peptide specifically designed as a substrate for Akt/PKB. This peptide is selectively phosphorylated by Akt/PKB and does not undergo phosphorylation by p70S6K or MAPK1, making it an ideal tool for studying the Akt signaling pathway. Its specificity is valuable in research applications focused on cancer, metabolism, and neurological disorders associated with Akt dysregulation. -
Substrate Mimetic Peptide
GSK3β-peptide is a substrate mimetic peptide that targets glycogen synthase kinase 3-β (GSK3-β) by binding to its active site and simulating substrate behavior. This peptide serves as a crucial tool in the development of substrate mimetic inhibitors of Akt, offering potential applications in anticancer drug discovery and research. Its ability to engage with GSK3-β positions it as a valuable reagent for probing signaling pathways involved in cell proliferation and survival. -
Amino Acid Polypeptide Hormone Analogue
Sincalide ammonium is an amino acid polypeptide hormone analogue of cholecystokinin (CCK) that primarily targets gallbladder function. It is utilized in clinical settings for its ability to promote gallbladder contraction, thus facilitating the diagnosis of gallbladder and pancreatic disorders. By increasing bile secretion and causing the contraction of the gallbladder while relaxing the sphincter of Oddi, Sincalide ammonium aids in the efficient drainage of bile into the duodenum, making it a valuable tool in postevacuation cholecystography. -
Antimicrobial Peptide
Cathelicidin-PY is an antimicrobial peptide that targets and inhibits the TLR4 inflammatory response pathways activated by lipopolysaccharide (LPS). This peptide demonstrates significant antimicrobial and anti-inflammatory properties while exhibiting low cytotoxicity in RAW 264.7 cells. Cathelicidin-PY is suitable for research focused on antimicrobial and anti-inflammatory mechanisms. -
B-cell Maturation Antigen Peptide
BCMA72-80 is a HLA-A2-specific peptide derived from the B-cell maturation antigen (BCMA) that exhibits strong binding affinity to HLA-A2. This peptide is primarily utilized in research focused on multiple myeloma and other tumors expressing BCMA. Its application is significant in studying immune responses and developing immunotherapeutic approaches targeting BCMA in oncology. -
Restricted Peptide Antigen
Eps8 peptide 327 is an HLA-A*2402-restricted peptide antigen derived from the Eps8 protein. It exhibits potent antitumor activity through significant cytotoxicity, effectively inhibiting cancer cell proliferation and inducing apoptosis. Eps8 peptide 327 disrupts the EGFR signaling pathway by modulating downstream signals, including IL-2, TNF-α, and IFN-γ, while also interfering with the Eps8/EGFR interaction. Its efficacy has been demonstrated in HT-29 xenograft mouse models, where it significantly inhibits tumor growth. -
Anti-aging Peptide
Acetyl tetrapeptide-2 is an anti-aging peptide that enhances skin rejuvenation by stimulating structural components such as collagen and elastin. This bioactive compound has been shown to reduce the loss of thymic factors, thereby promoting improved cellular stiffness in human keratinocytes (HaCaT cells). Its applications extend to various skin care formulations aimed at combating signs of aging and improving skin resilience. -
CD206 Targeting Peptide
RP-832c is a synthetic analogue of host defense peptides that selectively targets the mannose receptor CD206 on M2 polarized macrophages (Kd = 3.5 μM). Binding of RP-832c to CD206 induces significant conformational changes, activating signaling pathways that promote apoptosis and repolarization of M2 macrophages to an M1 phenotype. The treatment with RP-832c effectively reduces CD206 gene expression while transiently increasing TNF-α levels, a hallmark of M1 macrophages. This reagent is valuable for research on T-cell lymphoma (CTCL) and idiopathic pulmonary fibrosis (IPF). -
Human Neutrophil Peptide
Defensin HNP-1 human is an antimicrobial peptide that primarily targets and modulates the immune response in human neutrophils. It exhibits significant antibacterial activity through the inhibition of DNA, RNA, and protein synthesis, thereby disrupting essential metabolic pathways. Additionally, Defensin HNP-1 demonstrates direct inactivation of various viruses, including HIV, HSV-1, HSV-2, CMV, and influenza. It also possesses antileishmanial properties and plays a role in endothelial cell dysfunction associated with the early stages of atherosclerosis, making it a valuable tool for research in immunology and infectious diseases. -
Bioactive Peptide
WP9QY is a bioactive peptide designed as a TNF-α antagonist. This cyclic peptide effectively mimics the essential recognition loop of tumor necrosis factor on TNF receptor I, thereby inhibiting TNF-receptor interactions. WP9QY serves as a valuable template for developing small molecular inhibitors aimed at mitigating inflammatory bone destruction and systemic bone loss associated with rheumatoid arthritis. -
Cyclic Tetrapeptide
Apicidin C is a cyclic tetrapeptide that primarily targets histone deacetylases (HDACs). It exhibits potent antiprotozoal and antimalarial activity against Eimeria tenella, with an IC50 of 6 nM. This compound is valuable for research into malaria infections and provides insights into HDAC inhibition mechanisms in protozoan parasites. -
Antitumor Peptide
Azurin p28 peptide is an antitumor peptide that primarily targets and stabilizes the tumor suppressor protein p53. By forming a complex with p53, it reduces proteasomal degradation, leading to apoptosis or cell cycle arrest in p53-positive tumors. Additionally, Azurin p28 peptide exhibits antiangiogenic properties by inhibiting the phosphorylation of key signaling molecules, including VEGFR-2, FAK, and Akt, thereby impeding tumor growth and vascularization. This peptide is valuable in cancer research focusing on p53-mediated pathways and antiangiogenic strategies. -
Cardiomyocyte Specific Peptide
WLSEAGPVVTVRALRGTGSW is a cardiomyocyte-specific peptide designed to enhance targeted cellular delivery. This peptide facilitates improved uptake by cardiomyocytes, reduces apoptosis within these cells, and promotes enhanced retention of therapeutic agents following intramyocardial injection in vivo. It is a valuable reagent for research applications focusing on cardiac tissue engineering and myocardial protection strategies. -
Antimicrobial Peptide
Thanatin is an inducible cationic antimicrobial peptide that targets microbial membranes. It exhibits broad-spectrum antimicrobial activity against both Gram-negative and Gram-positive bacteria, as well as various fungi, with minimum inhibitory concentrations (MICs) ranging from 0.3 to 40 µM. Thanatin functions by competitively displacing divalent cations from the bacterial outer membrane, resulting in membrane disruption and enhanced permeability. This peptide is valuable for research applications in antimicrobial resistance, infection mechanisms, and the development of novel antibacterial agents. -
Antimicrobial Peptide
Magainin 1 is an antimicrobial peptide that targets bacterial membranes. Isolated from the skin of Xenopus laevis, it displays significant antibacterial activity against a broad spectrum of both Gram-negative and Gram-positive bacteria. This peptide serves as a valuable tool for research in antimicrobial mechanisms and can be utilized in studies assessing the efficacy of peptide-based antibiotics. -
Antimicrobial Peptide
Temporin A is an alpha-helical antimicrobial peptide derived from the skin of the European common frog, Rana temporaria. This peptide exhibits broad-spectrum activity against Gram-positive bacteria by disrupting microbial cell membranes, while demonstrating non-toxicity to erythrocytes at effective antimicrobial concentrations. Additionally, Temporin A possesses antifungal properties, notably against Candida albicans, making it a valuable reagent for research in antimicrobial peptide function and potential therapeutic applications. -
Antimicrobial Peptide
Nisin Z is an antimicrobial peptide that primarily targets Gram-positive bacteria and fungi, including Candida albicans. It exhibits notable antimicrobial and anti-inflammatory properties, making it a valuable tool for research into bacterial resistance and fungal infections. Nisin Z is utilized in various applications, including food preservation, therapeutic development, and studies on peptide-based antimicrobial strategies. -
HER2-Derived Antigen Peptide
CH401 peptide is a HER2-derived antigen peptide that functions as a vaccine candidate for anti-breast cancer therapy. It is encapsulated within a lipid bilayer containing the lipid adjuvant α-GalCer, following binding to an artificial viral capsid via a self-assembled β-cyclic peptide. This innovative formulation allows for comprehensive investigations into its self-adjuvant properties and its potential in eliciting robust immune responses against HER2-expressing tumors. -
Tumor-specific Mutation
EGFRvIII peptide (PEPvIII) is a tumor-specific mutation predominantly expressed in glioblastoma multiforme (GBM) and various other neoplasms, significantly contributing to enhanced tumorigenicity. This peptide serves as a valuable target for the development of antitumor immunotherapies, allowing for the potential targeting of cancer cells while sparing normal tissues. Its specific expression profile makes it a crucial tool for research into GBM and other malignancies. -
Peptide
ELAAWCRWGFLLALLPPGIAG is a peptide derived from the rat HER2/neu protein, comprising 21 amino acids (aa 5-25). It has been demonstrated to induce cytotoxic T lymphocyte (CTL) responses in mice with HER2-positive tumors, making it a valuable tool for studying immune responses in cancer therapy. This peptide is particularly relevant for research applications focused on immunotherapy and the modulation of tumor-specific immune responses. -
EGFR-binding peptide
LARLLT is an EGFR-binding peptide that specifically targets the epidermal growth factor receptor (EGFR). This compound exhibits potential in the research of cancers characterized by EGFR overexpression, including lung, ovarian, and colorectal cancers. Its application in studies may facilitate insights into tumor biology and therapeutic interventions in EGFR-driven malignancies.
