KYL peptide is an EphA4 antagonist that selectively inhibits the EphA4 receptor, demonstrating an IC50 of 4.22 μM and a Kd of 1.3 μM. By binding to the ligand-binding domain of EphA4, KYL peptide effectively mitigates Aβ-induced synaptic dysfunction and enhances synaptic plasticity in models of Alzheimer's disease. Additionally, this peptide may facilitate nerve regeneration following injury and has potential applications in modulating immune responses.
KYL peptide is an EphA4 antagonist that selectively inhibits the EphA4 receptor, demonstrating an IC50 of 4.22 μM and a Kd of 1.3 μM. By binding to the ligand-binding domain of EphA4, KYL peptide effectively mitigates Aβ-induced synaptic dysfunction and enhances synaptic plasticity in models of Alzheimer's disease. Additionally, this peptide may facilitate nerve regeneration following injury and has potential applications in modulating immune responses.
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