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Vasonatrin Peptide (VNP)

Catalog No.: A84795
Synthetic Natriuretic/Vasorelaxing Peptide
Vasonatrin Peptide (VNP) is a synthetic chimera that combines the properties of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). It exhibits vasorelaxing effects, including enhanced venodilation typical of CNP and natriuretic activity associated with ANP, along with unique arterial vasodilating effects. VNP has been shown to protect against ischemia-reperfusion injury in diabetic models by modulating ER stress through the cGMP-PKG signaling pathway, making it a valuable tool for cardiovascular research.
Vasonatrin Peptide (VNP) 141676-35-9 Synthetic Natriuretic/Vasorelaxing Peptide
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Size Price Stock Qty
1mg
$240.00
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5mg
$670.00
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVasonatrin Peptide (VNP) is a synthetic chimera that combines the properties of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). It exhibits vasorelaxing effects, including enhanced venodilation typical of CNP and natriuretic activity associated with ANP, along with unique arterial vasodilating effects. VNP has been shown to protect against ischemia-reperfusion injury in diabetic models by modulating ER stress through the cGMP-PKG signaling pathway, making it a valuable tool for cardiovascular research.
Product Information
Catalog NumA84795
FormulaC123H198N36O36S3
Molecular Weight2865.37
CAS Number141676-35-9
SequenceGly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys6-Cys22)
Sequence shorteningGLSKGCFGLKLDRIGSMSGLGCNSFRY (Disulfide bridge: Cys6-Cys22)
SMILES[C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(O)=O)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC(=O)[C@@H]3CSSC[C@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CC(C)C)=O)CO)=O)CCCCN)=O)=O)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@H](CC)C)(C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N3)[H])CC(N)=O)=O)CO)=O
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