Fig. 1 · Structure
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Vasonatrin Peptide (VNP)
Synthetic Natriuretic/Vasorelaxing Peptide
Vasonatrin Peptide (VNP) is a synthetic chimera that combines the properties of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP). It exhibits vasorelaxing effects, including enhanced venodilation typical of CNP and natriuretic activity associated with ANP, along with unique arterial vasodilating effects. VNP has been shown to protect against ischemia-reperfusion injury in diabetic models by modulating ER stress through the cGMP-PKG signaling pathway, making it a valuable tool for cardiovascular research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 141676-35-9 |
| Applications | Synthetic Natriuretic/Vasorelaxing Peptide |
| Formula | C123H198N36O36S3 |
| Molecular Weight | 2865.37 |
| SMILES | [C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(O)=O)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC(=O)[C@@H]3CSSC[C@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CC(C)C)=O)CO)=O)CCCCN)=O)=O)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@H](CC)C)(C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N3)[H])CC(N)=O)=O)CO)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.