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GAD65 (524-543)

Catalog No.: A78224
Bioactive Peptide
GAD65 (524-543) is a bioactive peptide derived from the glutamic acid decarboxylase 65 protein. This peptide fragment plays a crucial role in eliciting proliferative T cell responses in the non-obese diabetic (NOD) mouse model of autoimmune diabetes. It serves as a selective stimulus for the diabetogenic T cell clone BDC2.5, enhancing the susceptibility of NOD mice to type 1 diabetes when immunized with GAD65 (524-543). This reagent is valuable for research into T cell activation, autoimmune diabetes mechanisms, and potential therapeutic targets.
GAD65 (524-543) 152468-44-5 Bioactive Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGAD65 (524-543) is a bioactive peptide derived from the glutamic acid decarboxylase 65 protein. This peptide fragment plays a crucial role in eliciting proliferative T cell responses in the non-obese diabetic (NOD) mouse model of autoimmune diabetes. It serves as a selective stimulus for the diabetogenic T cell clone BDC2.5, enhancing the susceptibility of NOD mice to type 1 diabetes when immunized with GAD65 (524-543). This reagent is valuable for research into T cell activation, autoimmune diabetes mechanisms, and potential therapeutic targets.
Product Information
Catalog NumA78224
FormulaC97H168N28O28S2
Molecular Weight2238.67
CAS Number152468-44-5
SequenceSer-Arg-Leu-Ser-Lys-Val-Ala-Pro-Val-Ile-Lys-Ala-Arg-Met-Met-Glu-Tyr-Gly-Thr-Thr
Sequence shorteningSRLSKVAPVIKARMMEYGTT
SMILESC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(NCC(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)[C@@H](C)O)=O)=O)=O)CCC(O)=O)=O)CCSC)=O)CCSC)=O)CCCNC(=N)N)=O)C)=O)CCCCN)=O)[C@H](CC)C)=O)C(C)C)(=O)[C@H]2N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC([C@H](CO)N)=O)=O)CC(C)C)=O)CO)=O)CCCCN)=O)C(C)C)=O)C)=O)CCC2
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