Proteasome-activating peptide 1

Catalog No.: A77334
Proteasome-Activating Peptide
Proteasome-activating peptide 1 is a peptide that enhances chymotrypsin-like activity of the proteasome, thereby increasing proteolytic rates in vitro and in cellular cultures. This compound plays a significant role in preventing protein aggregation, demonstrated in cellular models of amyotrophic lateral sclerosis. Its ability to modulate proteasomal activity makes it a valuable tool for research into neurodegenerative diseases and protein homeostasis.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionProteasome-activating peptide 1 is a peptide that enhances chymotrypsin-like activity of the proteasome, thereby increasing proteolytic rates in vitro and in cellular cultures. This compound plays a significant role in preventing protein aggregation, demonstrated in cellular models of amyotrophic lateral sclerosis. Its ability to modulate proteasomal activity makes it a valuable tool for research into neurodegenerative diseases and protein homeostasis.
Product Information
Catalog NumA77334
FormulaC63H116N22O13S4
Molecular Weight1517.99
CAS Number1565763-62-3
Sequence shorteningIPRCRKMPGVKMC-NH2
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@H]([C@H](CC)C)N)=O)CCC1)CCCNC(=N)N)=O)CS)=O)CCCNC(=N)N)=O)CCCCN)=O)CCSC)(=O)N2[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CS)=O)CCSC)=O)CCCCN)=O)C(C)C)=O)=O)CCC2
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