Catalog No.
Product Name
Application
Product Information
Citations
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Caspase 3 Inhibitor
Cimiside E, a caspase 3 inhibitor, is a triterpene xyloside known for its pro-apoptotic effects on gastric cancer cells, displaying an IC50 value of 14.58 μM. This compound induces cell cycle arrest in the G2/M phase and mediates apoptosis via activation of the caspase cascade across both extrinsic and intrinsic pathways. Cimiside E is a valuable tool in cancer research, particularly in studies focusing on apoptosis and cell cycle modulation. -
Caspase-8 Inhibitor
IETD-CHO is a selective inhibitor of caspase-8, a crucial enzyme in the apoptotic signaling pathway. By blocking caspase-8 activity, this reagent prevents the activation of downstream effector caspases, allowing for the study of programmed cell death mechanisms. IETD-CHO is widely used in research applications focused on apoptosis, inflammation, and related cell signaling processes. -
Caspase-3 Activator
Caspase-3 activator 3 is a potent inducer of apoptosis, specifically targeting caspase-3 in HL-60 and K562 leukemia cell lines. This compound demonstrates significant antileukemic activity, with IC50 values of 42.89 μM for HL-60 cells and 33.61 μM for K562 cells. It serves as an important tool for investigating apoptotic pathways and evaluating potential therapeutic strategies in leukemia research. -
Caspase-1 Fluorogenic Substrate
Ac-WEHD-AFC is a fluorogenic substrate specifically designed for the detection of caspase-1 activity. This compound enables the quantitative measurement of caspase-1 enzymatic function, making it a valuable tool in studies related to tumorigenesis and inflammatory processes. Its sensitive fluorescence readout facilitates the assessment of caspase-1 involvement in various biological systems. -
Caspase-9 Inhibitor
Caspase-9 Inhibitor III (Ac-LEHD-cmk) targets and inhibits caspase-9, a critical component of the apoptotic pathway. This reagent demonstrates protective effects against ischemia-reperfusion-induced myocardial injury, making it valuable for studying cardiac apoptosis and related pathological conditions. It can be utilized in research focused on cellular survival mechanisms and the modulation of programmed cell death. -
δ-Secretase Inhibitor
δ-Secretase inhibitor 11 is a potent and selective inhibitor targeting δ-secretase, displaying an IC50 of 0.7 μM. This compound effectively interacts with both the active and allosteric sites of δ-secretase, resulting in the attenuation of tau and amyloid precursor protein cleavage. Its oral bioavailability and blood-brain barrier penetration make it suitable for in vivo studies, particularly in transgenic mouse models. δ-Secretase inhibitor 11 is a valuable tool for Alzheimer's disease research, facilitating investigations into the mechanisms underlying synaptic dysfunction and cognitive impairments. -
Caspase Inhibitor
Ac-FLTD-CMK is a selective inhibitor of inflammatory caspases, specifically targeting caspases-1, -4, -5, and -11, with IC50 values of 46.7 nM, 1.49 μM, and 329 nM, respectively. This compound is derived from gasdermin D (GSDMD) and does not inhibit apoptotic caspases such as caspase-3. Ac-FLTD-CMK is instrumental in research applications focused on inflammatory processes, providing valuable insights into caspase-mediated pathways and their implications in various diseases. -
Caspase-4 inhibitor
Z-LEVD-FMK is a cell-permeable inhibitor of caspase-4, a key player in the apoptotic signaling pathway. This reagent effectively blocks endoplasmic reticulum stress-induced apoptosis in cancer cells, making it a valuable tool for studying cell death mechanisms and developing therapeutic strategies in oncology research. Its specificity for caspase-4 facilitates investigations into its role in various cellular stress responses. -
Caspase-3/7 Substrate
Ac-Asp-Glu-Val-Asp-pNA is a specific substrate for caspase-3/7, facilitating the study of apoptosis and cellular signaling pathways. This peptidic compound is cleaved by caspase-3/7, resulting in the release of p-nitroaniline (pNA), which can be quantitatively measured. Its use is critical in research applications focused on understanding programmed cell death and evaluating the activity of caspases in various biological contexts. -
Caspase 2 substrate
Ac-VDQQD-pNA is a selective substrate for Caspase 2, designed to facilitate the study of caspase activity. Upon cleavage by Caspase 2, it yields a yellow chromophore, p-nitroaniline (pNA), which can be quantitatively measured. This reagent is ideal for research applications focused on apoptosis, cell signaling, and the functional characterization of caspases. -
Caspase-3 Activator
Caspase-3 Activator 2 is a potent activator of caspase-3, a key executioner of apoptosis. This compound effectively induces apoptotic cell death in cancer cell lines, demonstrating cytotoxicity with IC50 values of 33.52 μM against HL-60 cells and 76.90 μM against K562 cells. Its applications are significant in cancer research, particularly in studies investigating apoptotic pathways and therapeutic interventions. -
Caspase Inhibitor
Z-VAD-CHO is a potent, irreversible inhibitor of caspases, primarily targeting caspase-1 with a Ki value of 0.008 μM. This compound effectively modulates apoptotic pathways and is instrumental in studies related to inflammation and cell death. Z-VAD-CHO is widely utilized in research to investigate the role of caspases in various cellular processes and disease models. -
Caspase-1/3 Inhibitor
Z-YVAD-CMK is a potent inhibitor of caspase-1 and caspase-3, key enzymes involved in the apoptosis and inflammatory processes. By selectively blocking these caspases, Z-YVAD-CMK is invaluable for research applications focused on cell death pathways and inflammatory responses. It is particularly useful in studies investigating the role of caspases in disease models, including neurodegeneration and cancer. -
MMP-3/Caspase-1 Inhibitor
Berkeleyamide B is a dual inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1, targeting key enzymes involved in inflammation and tissue remodeling. This compound demonstrates significant biological activity in modulating apoptotic pathways and inflammatory responses. Berkeleyamide B is applicable in research focused on cancer and inflammatory diseases, including conditions such as rheumatoid arthritis. -
Caspase-3 Inhibitor
Caspase-3-IN-3 is a selective inhibitor of caspase-3, a crucial executioner enzyme in the apoptosis pathway. This compound has been shown to enhance cellular ATP levels, inhibit caspase-3 activity, and reduce nitrite production. Additionally, Caspase-3-IN-3 mitigates cytokine-induced apoptosis and restores insulin secretion stimulated by glucose, making it a valuable tool for research in apoptosis, metabolic disorders, and cellular energy regulation. -
Caspase-3 Inhibitor
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a potent and cell-permeable inhibitor of caspase-3, acting through irreversible binding to the activated form in apoptotic cells. This reagent exhibits significant fluorescence, allowing for quantitative analysis via flow cytometry, microwell plate readers, or fluorescence microscopy. Its application is crucial for studying apoptosis and characterizing caspase-3 activity in various biological systems. -
Caspase Inhibitor
VX-166 is a pan caspase inhibitor that modulates apoptosis by targeting caspase enzymes. This compound is instrumental in investigating Non-Alcoholic Fatty Liver Disease (NAFLD), nonalcoholic steatohepatitis (NASH), and alcoholic steatohepatitis (ASH), as well as other conditions characterized by liver fibrosis, steatosis, or inflammation. Its ability to inhibit caspase activity makes it a valuable tool for research in liver pathology and related diseases. -
Fluorogenic Caspase-3/7 Substrate
Z-DEVD-R110 is a fluorogenic substrate specifically designed for the detection of caspase-3 and caspase-7 activity. Composed of two DEVD peptide sequences linked to the rhodamine 110 fluorophore, this reagent is valuable for studying apoptotic processes in various biological systems. Its ability to provide quantitative measurements of caspase activity makes it an essential tool in apoptosis research and related studies. -
Caspase-1/ACE-2 Fluorogenic Substrate
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate designed for the characterization of caspase-1 and angiotensin-converting enzyme 2 (ACE2) activity. This compound enables the detection of enzymatic activity through fluorescence, making it valuable for studies focused on apoptosis and cardiovascular signaling pathways. It is suitable for use in various assays aimed at exploring the roles of these enzymes in cellular processes and disease states. -
Caspase 3/7 Inhibitor
CAY10406 is a selective inhibitor of caspase 3 and caspase 7. This compound effectively reduces the expression of the 28-kDa IL-1β fragment, making it useful for studies related to apoptosis and inflammatory processes. Notably, CAY10406 exhibits minimal cytotoxicity at concentrations up to 10 μM, allowing for safer applications in cellular assays. -
MMP-3/Caspase-1 Inhibitor
Berkeleyamide C is a selective inhibitor of matrix metalloproteinase-3 (MMP-3) and caspase-1. This compound effectively blocks MMP-3-mediated tumor cell invasion and metastasis, while also inhibiting the abnormal activation of inflammation and apoptosis associated with caspase-1. Berkeleyamide C is valuable for research applications focused on cancer biology and inflammation-related diseases. -
Caspase-6 Inhibitor
ED11 is a selective inhibitor of caspase-6, demonstrating an IC50 of 12.12 nM. By competing with Huntingtin (Htt) for the active site of caspase-6, ED11 effectively reduces Htt cleavage. Notably, ED11 possesses the ability to cross the blood-brain barrier, making it a valuable reagent for research into Huntington's disease and related neurodegenerative disorders. -
Caspase-3 Activator
Caspase-3 Activator 4 is a potent activator of caspase-3 that effectively crosses the blood-brain barrier. This compound exhibits significant antiproliferative activity and induces apoptosis in various cell types. Additionally, Caspase-3 Activator 4 enhances the gene expression of TNF-α while reducing the protein expression of cleaved caspases 3, underscoring its potential in apoptosis-related research applications. -
Caspase-9 Inhibitor
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, primarily involved in the apoptosis pathway. This compound demonstrates significant neuroprotective effects, particularly in models of spinal cord injury, and has been shown to mitigate lethal reperfusion injury. It is a valuable tool for research focused on therapeutic strategies against apoptotic cell death and neuroprotection. -
Proteasome Inhibitor
TP-110 is a selective proteasome inhibitor that targets the protease-like activity of the 20S proteasome, leaving trypsin-like and peptidyl-glutamyl peptide hydrolysis activities unaffected. This compound effectively disrupts the NF-κB signaling pathway, leading to activation of caspases 3, 8, and 9, and subsequent PARP cleavage, while decreasing levels of anti-apoptotic proteins cIAP-1 and XIAP. TP-110 induces G2/M phase cell cycle arrest and promotes apoptosis in cancer cells, making it a valuable tool for researching various malignancies, including prostate cancer and multiple myeloma. -
Caspase Inhibitor
Ac-DMQD-CHO is a selective inhibitor of caspase 3, exhibiting an IC50 of 39 nM. This compound effectively reduces apoptosis, making it a valuable tool in studies related to neuroprotection and cellular survival. Its application in research can aid in the exploration of therapeutic strategies targeting neurodegenerative diseases and apoptosis-related conditions. -
Caspase-8 Inhibitor
Z-LE(OMe)TD(OMe)-FMK is a selective inhibitor of caspase-8, a key enzyme involved in the apoptotic pathway. By inhibiting caspase-8 activity, this reagent effectively prevents apoptosis in various cell types, making it a valuable tool for studying cell survival mechanisms. It is widely used in research applications focused on programmed cell death and related signaling pathways. -
Caspase-3 Inhibitor
Ac-DMQD-AMC is a selective inhibitor of caspase-3, a critical executioner caspase in the apoptosis pathway. This compound features an aromatic amine structure and is synthesized using the aminium-based coupling reagent HATU alongside 2,4,6-trimethylpyridine (TMP). Ac-DMQD-AMC is suitable for research applications focused on studying apoptosis, cellular signaling, and the role of caspases in various diseases. -
Caspase-3 Inhibitor
Ac-AAVALLPAVLLALLAP-DEVD-CHO is a specific and reversible inhibitor of caspase-3, a key executioner in the apoptotic pathway. This compound effectively reduces caspase-3 activity, making it a valuable tool for studying apoptosis and cell death mechanisms in various biological contexts. Its application extends to research on neurodegenerative diseases, cancer, and other conditions where caspase-3 plays a pivotal role in cellular regulation. -
Caspase-4 Inhibitor
Ac-AAVALLPAVLLALLAP-LEVD-CHO is a cell-permeable inhibitor of caspase-4, a crucial mediator of inflammation and cell death pathways. This compound demonstrates notable antitumor activity, making it a valuable tool for studying caspase-related mechanisms in cancer research. Its ability to selectively inhibit caspase-4 can provide insights into therapeutic strategies aimed at mitigating inflammatory responses and promoting cell survival. -
Caspase-12 Inhibitor
Z-ATAD-FMK is a selective inhibitor of caspase-12, playing a crucial role in modulating apoptotic processes triggered by endoplasmic reticulum stress. By inhibiting caspase-12 activity, Z-ATAD-FMK effectively reduces downstream activation of caspase-9, thereby interfering with the apoptotic signaling pathways. This compound is valuable for research applications investigating the mechanisms of ER stress-induced apoptosis and cellular responses to stress. -
Caspase-1/4 Inhibitor
VRT-043198 is a selective inhibitor of caspase-1 and caspase-4, functioning primarily as an interleukin-converting enzyme inhibitor. It demonstrates potent inhibition with Ki values of 0.8 nM for caspase-1 and 0.6 nM for caspase-4. This compound is capable of crossing the blood-brain barrier, making it valuable for research applications related to neuroinflammation and cytokine regulation. -
Caspase-3 Inhibitor
Caspase-3-IN-1 is a potent inhibitor of caspase-3, exhibiting an IC50 of 14.5 nM. This compound plays a crucial role in the modulation of apoptotic signaling pathways, making it valuable for research in cell death mechanisms and therapeutic applications in cancer and neurodegenerative diseases. Its high specificity and efficacy allow for detailed studies on caspase-3 activity and its implications in various biological processes. -
Caspase Inhibitor
Penicillic acid is a polyketide mycotoxin that serves as a caspase inhibitor. This compound demonstrates cytotoxic effects in rat alveolar macrophages, inhibiting Fas ligand-induced apoptosis through the blockade of caspase-8 self-processing. Its unique mechanism contributes to research in apoptosis and inflammation pathways, making it a valuable tool for studying cell death regulation in various biological contexts. -
Caspase-3 Inhibitor
M826 is a selective, reversible non-peptide inhibitor of caspase-3, exhibiting an IC50 value of 0.005 μM. This compound demonstrates significant anti-apoptotic activity, both in vitro and in vivo, making it a valuable tool for studying apoptosis-related pathways. M826 is particularly relevant for research into nervous system diseases, offering potential insights into therapeutic strategies targeting apoptotic processes. -
Caspase Inhibitor
Boc-Asp(OBzl)-CMK is a selective inhibitor of interleukin-1 converting enzyme (ICE, caspase-1). This compound effectively prevents cell death in CHP100 neuroblastoma cells and inhibits the release of IL-1β triggered by viral coat proteins. It serves as a valuable tool for researching inflammatory pathways and apoptotic processes in various biological contexts. -
Caspase Inhibitor
IDN-1965 is an irreversible broad-spectrum inhibitor of caspases, crucial proteases involved in apoptosis. By inhibiting caspase activity, IDN-1965 effectively delays cytochrome c release and prevents downstream apoptotic processes, such as DNase activation. In preclinical studies, this compound has demonstrated a significant reduction in cardiomyocyte apoptosis, mitigating left ventricular dilation, systolic dysfunction, and fibrosis in models of dilated cardiomyopathy. IDN-1965 is valuable for research into apoptosis-related conditions, including heart failure and the underlying mechanisms of apoptosis initiation. -
Caspase-3 Probe
Z-TPE-2DEVD is a selective probe for caspase-3, a key enzyme involved in the apoptotic pathway. This reagent exhibits a strong ability to bind to and detect active caspase-3, facilitating real-time monitoring of apoptosis. It is widely utilized in research applications involving cell death studies, drug development, and the evaluation of therapeutic interventions targeting apoptosis. -
Caspase-3/7 Inhibitor
Ac-DNLD-CHO is a potent inhibitor of Caspase-3 and Caspase-7, exhibiting IC50 values of 9.89 nM and 245 nM, respectively, with corresponding Kiapp values of 0.68 nM and 55.7 nM. This reagent is valuable for investigating the role of caspase enzymes in apoptotic pathways and is particularly relevant in the study of diseases characterized by caspase-mediated cell death, including neurodegenerative disorders and viral infections. Researchers can utilize Ac-DNLD-CHO to explore therapeutic approaches targeting apoptosis in various health conditions. -
Caspase Substrate
Ac-VEID-pNA serves as a substrate for caspase 6, specifically designed to facilitate the study of this protease's activity. By incorporating the VEID sequence, this synthetic peptide allows for the assessment of caspase 6-mediated cleavage events, particularly in the context of lamin A protein processing. It is valuable in research applications focusing on apoptosis and cell cycle regulation, contributing to a deeper understanding of cellular mechanisms and caspase involvement in various disease states. -
Caspase-3 Inhibitor
M867 is a selective and reversible inhibitor of caspase-3, displaying an IC50 of 1.4 nM and a Ki of 0.7 nM. This compound demonstrates anti-apoptotic activity, making it a valuable tool for research focused on cell survival and apoptosis regulation. M867 is particularly relevant for studies exploring neurodegenerative diseases, cancer research, and therapeutic interventions targeting apoptotic pathways. -
Caspase Inhibitor
Ac-YVAD-AOM is a selective inhibitor of caspase-1, a key enzyme involved in the inflammatory response and apoptosis. This compound demonstrates significant antitumor activity, making it a valuable tool for researchers studying cell death pathways and inflammatory diseases. Its specificity for caspase-1 enables detailed investigations into its role in various biological processes and therapeutic applications. -
Caspase Activator
Apoptosis Inducer 34 is a small molecule compound that functions as a caspase activator by directly stimulating the intrinsic apoptotic pathway. It facilitates the oligomerization of Apaf-1 to generate mature apoptosomes, leading to the activation of caspase-9 and caspase-3. This compound effectively enhances the cytochrome c-dependent apoptotic signaling in Jurkat cells, resulting in PARP cleavage and chromosomal DNA fragmentation. Additionally, Apoptosis Inducer 34 demonstrates low toxicity towards normal cells, indicating its potential for selective targeting of cancer cells and making it a valuable tool for researching apoptosis-related cancer mechanisms. -
Procaspase-3 Activator
WF-210 is a potent activator of procaspase-3, exhibiting an EC50 value of 0.95 μM. This compound effectively induces apoptosis, making it a valuable tool for studying apoptotic pathways. Additionally, WF-210 demonstrates anti-tumor activity, supporting its application in cancer research and therapeutic investigations. -
Caspase Inhibitor
Ac-YVAD-AMC is a potent caspase inhibitor that specifically targets the caspase-1 enzyme. It is widely used in research to study the mechanisms of apoptosis and inflammation, particularly in investigations of hypersensitive response (HR) cells. By preventing caspase-mediated cell death, Ac-YVAD-AMC is valuable for elucidating the role of caspases in various biological processes and for exploring potential therapeutic strategies in diseases characterized by dysregulated apoptosis. -
Caspase-3/7 Inhibitor
Caspase-3/7 Inhibitor I is a reversible inhibitor targeting caspase-3 and caspase-7, exhibiting Ki values of 60 nM and 170 nM, respectively. This compound effectively inhibits apoptosis in various cellular models, including Camptothecin-treated Jurkat cells and chondrocytes. It serves as a valuable tool for studying mechanisms of cell death and developing therapeutic strategies against apoptotic diseases. -
Caspase-3 Activator
Dehydrotrametenolic acid is a sterol that activates caspase-3, playing a pivotal role in the induction of apoptosis. Isolated from the sclerotium of Poria cocos, this compound demonstrates significant anti-tumor activity, along with anti-inflammatory and anti-diabetic properties. Its mechanism and biological activities make it a valuable tool for research applications focused on apoptosis and potential therapeutic strategies against cancer and metabolic disorders. -
Caspase-3 Inhibitor
Ac-DEVD-CMK is a selective and irreversible inhibitor of caspase-3, making it a valuable tool for research involving apoptosis. This compound effectively prevents apoptosis triggered by elevated glucose levels and the presence of Ingenol 3,20-dibenzoate. Ac-DEVD-CMK is suitable for diverse experimental applications aimed at studying apoptotic pathways and evaluating potential therapeutic interventions. -
Procaspase-3/6 Activator
Procaspase-3/6 activator 1 is a highly selective activator of the executioner procaspases-3 and -6, exhibiting EC50 values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. This compound does not activate procaspases-1 or -7, making it a valuable tool for investigating apoptotic processes. It is suitable for research applications focused on apoptosis, cell death mechanisms, and therapeutic development targeting caspase pathways. -
Caspase-8 Substrate
Ac-Ile-Glu-Thr-Asp-pNA is a substrate specifically designed for caspase-8. It features the Ile-Glu-Thr-Asp (IETD) peptide sequence, which is efficiently recognized and cleaved by caspase-8, resulting in the release of p-nitroaniline. The subsequent increase in p-nitroaniline concentration can be quantitatively measured through colorimetric detection at 405 nm, providing a reliable assay for evaluating caspase-8 enzymatic activity in various biological research applications.
