Ac-DNLD-CHO

Catalog No.: A25408
Caspase-3/7 Inhibitor
Ac-DNLD-CHO is a potent inhibitor of Caspase-3 and Caspase-7, exhibiting IC50 values of 9.89 nM and 245 nM, respectively, with corresponding Kiapp values of 0.68 nM and 55.7 nM. This reagent is valuable for investigating the role of caspase enzymes in apoptotic pathways and is particularly relevant in the study of diseases characterized by caspase-mediated cell death, including neurodegenerative disorders and viral infections. Researchers can utilize Ac-DNLD-CHO to explore therapeutic approaches targeting apoptosis in various health conditions.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAc-DNLD-CHO is a potent inhibitor of Caspase-3 and Caspase-7, exhibiting IC50 values of 9.89 nM and 245 nM, respectively, with corresponding Kiapp values of 0.68 nM and 55.7 nM. This reagent is valuable for investigating the role of caspase enzymes in apoptotic pathways and is particularly relevant in the study of diseases characterized by caspase-mediated cell death, including neurodegenerative disorders and viral infections. Researchers can utilize Ac-DNLD-CHO to explore therapeutic approaches targeting apoptosis in various health conditions.
Product Information
Catalog NumA25408
FormulaC20H31N5O10
Molecular Weight501.49
CAS Number775289-20-8
SequenceAc-Asp-Asn-Leu-Asp-CHO
Sequence shorteningAc-DNLD-CHO
SMILES[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C=O)=O)CC(C)C)=O)(NC([C@H](CC(O)=O)NC(C)=O)=O)CC(N)=O
SynonymsAc-Asp-Asn-Leu-Asp-CHO
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