Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
tert-Butyl (8-aminooctyl)carbamate is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). It features an alkane chain with both terminal amine and Boc-protected amino groups, providing reactive sites for coupling with carboxylic acids, activated NHS esters, and carbonyls. The Boc group can be readily deprotected under mild acidic conditions, yielding a free amine for further functionalization and applications in targeted protein degradation research. -
PROTAC Linkers
N-(Amino-PEG2)-N-bis(PEG3-azide) is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis, featuring an azide functionality essential for click chemistry applications. It can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing compounds, facilitating the development of bifunctional molecules. Additionally, this linker supports strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN modified substrates, making it a versatile tool for innovative research in targeted protein degradation. -
PROTAC Linker
Azido-PEG3-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its versatile reactivity makes Azido-PEG3-alcohol a valuable tool for researchers developing targeted protein degradation systems. -
PROTAC Linker
tert-Butyl 6-bromohexanoate serves as a PROTAC linker, facilitating the targeted degradation of specific proteins. This compound can be utilized in the design of PROTACs, such as the PROTAC ERK5 degrader-1, to enhance selective protein removal for research in cellular biology and therapeutic applications. Its structural attributes support efficient conjugation and functionalization for effective protein degradation studies. -
PROTAC Linkers
DOTA-PEG5-azide is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-bearing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. DOTA-PEG5-azide is instrumental in advancing research applications involving targeted protein degradation. -
PROTAC Linker
Azido-PEG2-alcohol serves as a versatile PEG-based linker utilized in the design and synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing compounds. Its unique properties facilitate targeted protein degradation studies and advancements in drug development by allowing the effective conjugation of various biomolecules. -
PROTAC Linker
6-Amino-1-hexanethiol hydrochloride is a PROTAC linker designed to facilitate targeted protein degradation. It serves as an essential building block in the synthesis of PROTACs, allowing for the selective modulation of protein levels within biological systems. This compound is instrumental in research applications focused on protein regulation and degradation pathways. -
PROTAC Linkers
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker designed for effective synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is widely utilized in chemical biology research for targeted protein degradation and the development of novel therapeutic agents. -
PROTAC Linkers
Methyl 3-hydroxypropanoate is an alkyl/ether-based linker designed for use in the synthesis of Proteolysis Targeting Chimera (PROTAC) compounds. It facilitates efficient conjugation between targeting ligands and E3 ligases, enhancing the development of targeted protein degradation strategies. This reagent is valuable for researchers focusing on therapeutic applications in cancer biology and other diseases through the modulation of protein homeostasis. -
PROTAC Linker
Azido-PEG1-CH2CO2H is a PROTAC linker designed to facilitate targeted protein degradation through its alkyl/ether structure. This compound acts as a versatile click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Azido-PEG1-CH2CO2H is particularly useful in the synthesis of PROTACs, such as BRD4 Degrader-1, advancing research in targeted therapy and protein modulation. -
PROTAC Linker
2-(2-Bromoethyl)-1,3-dioxolane serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). Its structure enables efficient coupling of target proteins to E3 ligases, playing a crucial role in modulating protein degradation pathways. This compound is essential for researchers aiming to explore targeted protein degradation and its therapeutic implications in various diseases. -
PROTAC Linker
Boc-NH-PEG2-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the connection between a target protein and an E3 ligase, promoting ubiquitination and subsequent proteasomal degradation of the target. Its hydrophilic PEG structure enhances solubility and biocompatibility, making it suitable for various drug discovery and development applications within targeted protein degradation research. -
PROTAC Linker
Biotin-PEG2-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its primary mechanism of action involving click chemistry. It features an azide group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Biotin-PEG2-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This dual reactivity makes it a valuable tool for targeted protein degradation research and other applications in chemical biology. -
PROTAC Linkers
α-Lipoic acid-NHS is a novel PROTAC linker featuring an alkyl/ether-based structure, designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins via the ubiquitin-proteasome system, making it valuable for cancer research and various therapeutic applications. Its unique properties enable efficient development of targeted protein degradation strategies in biological studies. -
PROTAC Linkers
Biotin-PEG4-Picolyl azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Biotin-PEG4-Picolyl azide serves as an essential tool for advancing research in targeted protein degradation and other chemical biology applications. -
PROTAC Linkers
m-PEG12-azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, m-PEG12-azide is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This compound is ideal for applications in chemical biology and drug discovery, particularly in the design of innovative PROTACs. -
PROTAC Linker
Bis(2-bromoethyl) ether serves as an alkyl chain-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the formation of linkers that connect target proteins to E3 ligases, thereby promoting targeted protein degradation. It is a valuable tool for researchers investigating the mechanisms of protein regulation and therapeutic strategies in various biological contexts. -
PROTAC Linkers
m-PEG-thiol (MW 2000) is a polyethylene glycol (PEG)-derived thiol that serves as a valuable linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides improved solubility and stability, enabling effective conjugation to E3 ligases and target proteins. Its applications are crucial in the development of PROTAC-based therapeutics, facilitating targeted degradation of proteins in research and drug discovery. -
PROTAC Linker
Azido-PEG5-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its reactive azide group. This compound is suitable for applications involving click chemistry, specifically enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized partners, making it versatile for creating diverse bioconjugates in chemical research. -
PROTAC Linker
tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate functions as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in targeted protein degradation research, enabling selective modulation of protein function in cellular assays. It is valuable for studies investigating therapeutic strategies in cancer and other diseases through novel degradation pathways. -
PROTAC Linker
endo-BCN-O-PNB is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclononyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is a valuable tool for researchers focusing on targeted protein degradation and the development of novel therapeutic strategies in chemical biology. -
PROTAC Linker
H2N-PEG2-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (PROteolysis TArgeting Chimera) synthesis. This compound serves as a versatile connector enabling the conjugation of target proteins to E3 ligase ligands, facilitating targeted protein degradation. Its application in the development of PROTACs supports research into novel therapeutic strategies for modulating protein levels in various diseases, including cancer. -
PROTAC Linker
NH2-C5-NH-Boc is a PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This alkyl chain-based linker facilitates the development of targeted protein degradation strategies, enhancing the specificity and efficacy of therapeutic interventions. It serves as a crucial component in research applications aimed at investigating protein modulation and degradation pathways in cellular systems. -
PROTAC Linker
Potassium (2-((tert-butoxycarbonyl)amino)ethyl)trifluoroborate serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Its unique chemical structure aids in conjugating E3 ligases with target proteins, enabling targeted degradation pathways. This compound is essential for research applications focusing on targeted protein degradation and therapeutic development in various diseases. -
PROTAC Linker
Alkyne-PEG4-maleimide is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application as a linker facilitates the creation of bifunctional molecules for targeted protein degradation studies and other advanced research applications in chemical biology. -
PROTAC Linker
Boc-N-amido-PEG3-acid is a PEG-based linker specifically designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound offers favorable solubility and flexibility, enabling effective conjugation to target proteins and E3 ligases. Its utility in the development of PROTACs makes it a valuable tool for researchers investigating targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Amino-PEG2-NH-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis targeting chimera) molecules. This reagent facilitates the construction of bifunctional compounds that target specific proteins for degradation through the ubiquitin-proteasome system. Its application in PROTAC development supports therapeutic research aimed at modulating protein levels in various disease states. -
PROTAC Linker
NH2-C6-NH-Boc is a PROTAC linker characterized by its alkyl/ether composition. This compound facilitates the synthesis of Mcl-1 inhibitors through the PROTAC approach, enabling targeted protein degradation. Its utility in research applications includes investigating Mcl-1's role in cancer cell survival and exploring novel therapeutic strategies in oncology. -
PROTAC Linker
(E)-tert-Butyldimethyl((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)allyl)oxy)silane serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound enables the effective conjugation of peptide ligands to E3 ligase recruiters, enhancing the selective degradation of target proteins. It is particularly useful in research applications focused on exploring and manipulating cellular pathways through targeted therapy. -
PROTAC Linker
Azide-PEG3-Desthiobiotin serves as a versatile linker for PROTAC (proteolysis-targeting chimera) synthesis, facilitating targeted protein degradation. This compound features an azide functional group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-containing molecules. Its applications extend to the development of novel therapeutic agents that leverage the targeted degradation pathway for enhanced biological research and drug development. -
PROTAC Linker
Fmoc-amino-PEG3-CH2COOH is a polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound enables the efficient conjugation of amino acid functionalities, enhancing target specificity and solubility in biological systems. It serves as a crucial component for researchers developing selective protein degraders, facilitating the study of protein interactions and degradation pathways in cellular environments. -
PROTAC Linkers
Azido-PEG4-hydrazide is a PEG-based linker specifically designed for PROTAC (proteolysis-targeting chimera) synthesis. Functioning as a click chemistry reagent, it features an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, making it an essential tool for developing targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
DBCO-S-S-PEG3-biotin is a PEG-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating efficient conjugation. Its biotin component enhances detection and purification of PROTACs, making it a valuable tool for biological research focused on targeted protein degradation. -
PROTAC Linker
Methyltetrazine-PEG4-maleimide is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety that can engage in an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating efficient ligand conjugation. The incorporation of this linker enables precise targeting and degradation of proteins, making it a valuable tool for studying protein functions and developing targeted therapies. -
PROTAC Linkers
NH2-PEG3-C2-Boc is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This versatile compound features an amine functional group that facilitates conjugation, enhancing the development of targeted protein degradation pathways. It is primarily utilized in therapeutic applications that focus on modulating protein levels within cellular systems. -
PROTAC Linker
7-Boc-(2,7-Diazaspiro[3.5]nonane) serves as a PROTAC linker, facilitating the development of targeted protein degradation agents. Its spirocyclic structure enhances ligand efficiency and selectivity for therapeutic applications. This compound is instrumental in synthesizing PROTACs that promote the ubiquitin-proteasome system, offering valuable tools for studying protein function and potential disease modulation. -
PROTAC Linker
tert-Butyl N-{3-formylbicyclo[1.1.1]pentan-1-yl}carbamate is a specialized PROTAC linker designed for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of targeted protein degraders, enabling selective modulation of protein levels in cellular systems. Its unique structure enhances the stability and efficacy of the resulting PROTACs, making it a valuable tool for research in targeted therapy and protein regulation. -
PROTAC Linker
endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. It features a bicyclo[6.1.0]nonyne (BCN) group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing compounds. This linker is pivotal for advancing research in targeted protein degradation and optimizing the pharmacological profiles of novel therapeutic agents. Its utility in PROTAC development makes it an essential tool for scientists exploring innovative approaches in drug discovery and cellular regulation. -
PROTAC Linkers
NH2-C4-NH-Boc is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyl/ether structure, facilitating the connection of two distinct ligands: one targeting an E3 ubiquitin ligase and the other directed at the protein of interest. By harnessing the ubiquitin-proteasome system, PROTACs constructed with NH2-C4-NH-Boc enable selective degradation of specific target proteins, making it a valuable reagent for research in targeted protein degradation and drug development. -
PROTAC Linkers
Boc-NH-C12-NH2 is a flexible alkyl linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that target specific proteins for degradation via the ubiquitin-proteasome pathway. It is of particular interest for researchers developing novel therapeutic strategies in targeted protein degradation and drug discovery. -
PROTAC Linkers
Boc-NH-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of protein targets via the ubiquitin-proteasome pathway. Its versatile structure makes it a valuable tool for researchers investigating targeted protein degradation in therapeutic applications. -
PROTAC Linker
Tetraethylene glycol monomethyl ether is a polyethylene glycol (PEG)-based linker specifically designed for use in PROTAC (proteolysis-targeting chimeras) synthesis. This versatile reagent facilitates the assembly of PROTACs by enhancing solubility and stability, thereby improving their pharmacological profiles. It is widely utilized in research applications aimed at targeted protein degradation, contributing to advancements in drug discovery and development. -
PROTAC Linker
Bromo-PEG3-azide is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its azide functional group enables efficient click chemistry applications, including copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-bearing molecules. Additionally, this compound can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified partners, facilitating the generation of multifunctional PROTACs for targeted protein degradation research. -
PROTAC Linker
5-Tert-butoxy-5-oxopentanoic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of targeted degraders, enabling selective protein degradation for research into cellular processes and therapeutic interventions. Its unique structure enhances the efficacy of PROTACs in modulating protein levels and studying protein function in various biological contexts. -
PROTAC Linker
tert-Butyl-hexanedioic acid serves as a PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound can be employed in the synthesis of various PROTAC molecules, including the PROTAC ERα Degrader-12. Its utility in creating bifunctional compounds enhances the precision of therapeutic interventions in biomedical research. -
PROTAC Linkers
m-PEG-OH (MW5000) is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of PROTACs by providing a flexible and hydrophilic connector that enhances their solubility and stability. Its application is critical in drug discovery and development, particularly in studies focused on targeted protein degradation and modulation of protein levels in various biological contexts. -
PROTAC Linker
Br-C3-methyl ester is an alkyl/ether-based PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTAC PD-1/PD-L1 degrader-1, enabling the selective degradation of PD-1, which is crucial for cancer immunotherapy research. Its use can aid in elucidating the role of PD-1 in immune regulation and potentially contribute to the development of novel therapeutic strategies against cancer. -
PROTAC Linker
Fmoc-NH-PEG12-CH2CH2COOH is a polyethylene glycol (PEG) based linker designed for the development of PROTAC molecules. This compound facilitates the targeted degradation of proteins by promoting the formation of ternary complexes between E3 ligases and specified protein targets. Its application is crucial in biochemistry and pharmaceutical research focused on innovative therapeutic strategies that harness the ubiquitin-proteasome system for selective protein degradation. -
PROTAC Linker
NH2-PEG5-C2-NH-Boc is a PEG-based PROTAC linker designed for the synthesis of PROTACs, which are bifunctional molecules that target proteins for ubiquitination and subsequent degradation. This linker facilitates the conjugation of targeting ligands to E3 ligases, enhancing the efficacy of targeted protein degradation studies. NH2-PEG5-C2-NH-Boc is ideal for applications in chemical biology and therapeutic research, allowing for the precise modulation of protein levels within cells. -
PROTAC Linker
Azido-PEG10-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Azido-PEG10-amine can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that possess dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating the targeted degradation of specific proteins in biological research applications.
