Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
mPEG-amine (mPEG-NH2) (MW 2000) is a polyethylene glycol (PEG) derivative designed as a linker for PROTAC (proteolysis-targeting chimera) development. This compound serves to enhance the solubility and stability of PROTACs, facilitating the selective degradation of target proteins via the ubiquitin-proteasome system. It is essential for researchers engaged in drug discovery and development, particularly in the study of targeted protein degradation. -
PROTAC Linker
tert-Butyl 3-bromopropanoate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays an essential role in the synthesis of PROTACs, enabling researchers to create targeted degradation agents that modulate protein levels within cells. Its functionality is critical for advancing studies in targeted protein degradation and therapeutic applications in various disease models. -
PROTAC Linker
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride functions as a PEG-based PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its structure allows for effective conjugation in the synthesis of novel therapeutic agents, aiding in the targeted degradation of specific proteins. This compound is essential for research applications focused on proteasome-mediated degradation pathways and innovative drug discovery strategies. -
PROTAC Linkers
tert-Butyl 4-formylpiperidine-1-carboxylate is a versatile PROTAC linker employed in the development of targeted protein degradation strategies. This compound facilitates the synthesis of PROTAC BRM/BRG1 degrader-3, enabling specific modulation of protein levels in cellular systems. It is crucial for researchers investigating the application of PROTAC technology in drug discovery and therapeutic development. -
PROTAC Linker
3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis targeting chimeras (PROTACs). By enabling the efficient conjugation of target proteins to E3 ligases, this compound enhances the targeted degradation of proteins within cellular environments. Its application in drug discovery and therapeutic development underscores its importance in advancing targeted protein modulation research. -
PROTAC Linker
tert-Butyl N-[4-(aminomethyl)phenyl]carbamate functions as a PROTAC linker, facilitating the design and synthesis of proteolysis targeting chimeras (PROTACs). Its structure enables effective conjugation between target proteins and E3 ligases, promoting targeted degradation pathways in cellular systems. This compound is essential for researchers exploring protein modulation and degradation mechanisms in various biological contexts. -
PROTAC Linker
Biotin-PEG3-NHS ester is a PEG-based linker that targets the synthesis of Proteolysis Targeting Chimera (PROTAC) molecules. This compound facilitates the conjugation of biotin to various biomolecules, enhancing their cellular uptake and stability. It is instrumental in research applications focused on targeted protein degradation and the development of novel therapeutic strategies in cellular biology. -
PROTAC Linkers
Azido-PEG6-acid is a versatile PEG-based linker designed for use in the synthesis of PROTACs. Featuring an azide functional group, it enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. This reagent facilitates the development of targeted protein degradation strategies in chemical biology research. -
PROTAC linker
Pent-4-yn-1-ol is a specialized PROTAC linker utilized in the development of Proteolysis Targeting Chimeras (PROTACs). This compound serves as a crucial building block for synthesizing various PROTAC molecules, facilitating targeted protein degradation in research applications. Its structural properties enable effective coupling to ligand and warhead components, advancing studies in cellular regulation and therapeutic intervention. -
PROTAC Linkers
2,2-Oxybis(ethylamine) is a PEG-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by connecting the E3 ligase and the protein of interest. Its biocompatibility and flexibility make it valuable for researchers developing innovative therapeutic strategies in targeted protein degradation. -
PROTAC Linkers
Fmoc-N-PEG24-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of protein-targeting warheads to E3 ligase recruiters, enabling targeted protein degradation. Its hydrophilic properties contribute to enhanced solubility and bioavailability, making it suitable for various biochemical and cellular studies related to protein control mechanisms in research applications. -
PROTAC linker
m-PEG12-acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This chemical compound facilitates the efficient conjugation of targeting ligands to E3 ligases, enhancing the cellular degradation of specific proteins. m-PEG12-acid is pivotal for researchers developing new PROTACs to study protein regulation and therapeutic intervention in various diseases. -
PROTAC Linker
Azido-PEG2-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules or DBCO/BCN derivatives, enhancing the selective targeting of proteins for degradation. This versatile linker facilitates the development of novel targeted protein degradation strategies, making it valuable for chemical biology and drug discovery research applications. -
PROTAC Linker
Amino-PEG3-C2-Amine is a polyethylene glycol-based PROTAC linker that comprises three ethylene glycol units. This compound facilitates the synthesis of proteolysis targeting chimeras (PROTACs), enabling selective degradation of target proteins. Its versatile structure allows for effective conjugation in drug development and protein engineering applications. -
PROTAC Linker
4-(4-Boc-piperazinemethyl)phenylboronic acid pinacol ester functions as a PROTAC linker, facilitating the creation of bifunctional small molecules that engage E3 ubiquitin ligases and target specific proteins for degradation. This compound is primarily utilized in the synthesis of CST905, contributing to advances in targeted protein degradation research. Its application enhances the development of novel therapeutics in various areas, including cancer and neurodegenerative disorders. -
PROTAC Linker
Biotin-PEG4-Amide-C6-Azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with cyclooctyne derivatives such as DBCO or BCN. It is suitable for research applications in targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
4-Azidobutylamine is a versatile PROTAC linker designed for the synthesis of targeted protein degradation agents. By connecting a ligand for an E3 ubiquitin ligase to a ligand for the target protein, it facilitates the selective degradation of specific proteins via the ubiquitin-proteasome pathway. Additionally, 4-Azidobutylamine contains an azide functional group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. This reagent is crucial for advancing the development of PROTAC-based therapeutics. -
PROTAC Linker
Biotin-PEG2-Mal is a polyethylene glycol (PEG)-based PROTAC linker designed to facilitate molecular trafficking in targeted protein degradation applications. This compound serves as a versatile connector in the synthesis of PROTAC molecules, enhancing the stability and solubility of the resulting compounds. Its biotin functionality allows for efficient biotin-streptavidin labeling, aiding in the study of protein interactions and degradation pathways in various biological contexts. -
PROTAC linker
endo-BCN-PEG3-mal is a PEG-based PROTAC linker designed for efficient synthesis of PROTACs. This compound features a BCN moiety that engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted protein degradation studies. Its versatile application in chemical biology makes it valuable for research involving protein modulation and therapeutic development. -
PROTAC Linker
tert-Butyl (8-aminooctyl)carbamate is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). It features an alkane chain with both terminal amine and Boc-protected amino groups, providing reactive sites for coupling with carboxylic acids, activated NHS esters, and carbonyls. The Boc group can be readily deprotected under mild acidic conditions, yielding a free amine for further functionalization and applications in targeted protein degradation research. -
PROTAC Linkers
N-(Amino-PEG2)-N-bis(PEG3-azide) is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis, featuring an azide functionality essential for click chemistry applications. It can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing compounds, facilitating the development of bifunctional molecules. Additionally, this linker supports strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN modified substrates, making it a versatile tool for innovative research in targeted protein degradation. -
PROTAC Linker
Azido-PEG3-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its versatile reactivity makes Azido-PEG3-alcohol a valuable tool for researchers developing targeted protein degradation systems. -
PROTAC Linker
tert-Butyl 6-bromohexanoate serves as a PROTAC linker, facilitating the targeted degradation of specific proteins. This compound can be utilized in the design of PROTACs, such as the PROTAC ERK5 degrader-1, to enhance selective protein removal for research in cellular biology and therapeutic applications. Its structural attributes support efficient conjugation and functionalization for effective protein degradation studies. -
PROTAC Linkers
DOTA-PEG5-azide is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-bearing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. DOTA-PEG5-azide is instrumental in advancing research applications involving targeted protein degradation. -
PROTAC Linker
Azido-PEG2-alcohol serves as a versatile PEG-based linker utilized in the design and synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing compounds. Its unique properties facilitate targeted protein degradation studies and advancements in drug development by allowing the effective conjugation of various biomolecules. -
PROTAC Linker
6-Amino-1-hexanethiol hydrochloride is a PROTAC linker designed to facilitate targeted protein degradation. It serves as an essential building block in the synthesis of PROTACs, allowing for the selective modulation of protein levels within biological systems. This compound is instrumental in research applications focused on protein regulation and degradation pathways. -
PROTAC Linkers
DBCO-PEG8-NHS ester is a PEG-based PROTAC linker designed for effective synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is widely utilized in chemical biology research for targeted protein degradation and the development of novel therapeutic agents. -
PROTAC Linkers
Methyl 3-hydroxypropanoate is an alkyl/ether-based linker designed for use in the synthesis of Proteolysis Targeting Chimera (PROTAC) compounds. It facilitates efficient conjugation between targeting ligands and E3 ligases, enhancing the development of targeted protein degradation strategies. This reagent is valuable for researchers focusing on therapeutic applications in cancer biology and other diseases through the modulation of protein homeostasis. -
PROTAC Linker
Azido-PEG1-CH2CO2H is a PROTAC linker designed to facilitate targeted protein degradation through its alkyl/ether structure. This compound acts as a versatile click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. Azido-PEG1-CH2CO2H is particularly useful in the synthesis of PROTACs, such as BRD4 Degrader-1, advancing research in targeted therapy and protein modulation. -
PROTAC Linker
2-(2-Bromoethyl)-1,3-dioxolane serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). Its structure enables efficient coupling of target proteins to E3 ligases, playing a crucial role in modulating protein degradation pathways. This compound is essential for researchers aiming to explore targeted protein degradation and its therapeutic implications in various diseases. -
PROTAC Linker
Boc-NH-PEG2-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the connection between a target protein and an E3 ligase, promoting ubiquitination and subsequent proteasomal degradation of the target. Its hydrophilic PEG structure enhances solubility and biocompatibility, making it suitable for various drug discovery and development applications within targeted protein degradation research. -
PROTAC Linker
Biotin-PEG2-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its primary mechanism of action involving click chemistry. It features an azide group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Biotin-PEG2-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This dual reactivity makes it a valuable tool for targeted protein degradation research and other applications in chemical biology. -
PROTAC Linkers
α-Lipoic acid-NHS is a novel PROTAC linker featuring an alkyl/ether-based structure, designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins via the ubiquitin-proteasome system, making it valuable for cancer research and various therapeutic applications. Its unique properties enable efficient development of targeted protein degradation strategies in biological studies. -
PROTAC Linkers
Biotin-PEG4-Picolyl azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Biotin-PEG4-Picolyl azide serves as an essential tool for advancing research in targeted protein degradation and other chemical biology applications. -
PROTAC Linkers
m-PEG12-azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, m-PEG12-azide is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN derivatives. This compound is ideal for applications in chemical biology and drug discovery, particularly in the design of innovative PROTACs. -
PROTAC Linker
Bis(2-bromoethyl) ether serves as an alkyl chain-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the formation of linkers that connect target proteins to E3 ligases, thereby promoting targeted protein degradation. It is a valuable tool for researchers investigating the mechanisms of protein regulation and therapeutic strategies in various biological contexts. -
PROTAC Linkers
m-PEG-thiol (MW 2000) is a polyethylene glycol (PEG)-derived thiol that serves as a valuable linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides improved solubility and stability, enabling effective conjugation to E3 ligases and target proteins. Its applications are crucial in the development of PROTAC-based therapeutics, facilitating targeted degradation of proteins in research and drug discovery. -
PROTAC Linker
Azido-PEG5-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its reactive azide group. This compound is suitable for applications involving click chemistry, specifically enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized partners, making it versatile for creating diverse bioconjugates in chemical research. -
PROTAC Linker
tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate functions as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in targeted protein degradation research, enabling selective modulation of protein function in cellular assays. It is valuable for studies investigating therapeutic strategies in cancer and other diseases through novel degradation pathways. -
PROTAC Linker
endo-BCN-O-PNB is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclononyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is a valuable tool for researchers focusing on targeted protein degradation and the development of novel therapeutic strategies in chemical biology. -
PROTAC Linker
H2N-PEG2-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (PROteolysis TArgeting Chimera) synthesis. This compound serves as a versatile connector enabling the conjugation of target proteins to E3 ligase ligands, facilitating targeted protein degradation. Its application in the development of PROTACs supports research into novel therapeutic strategies for modulating protein levels in various diseases, including cancer. -
PROTAC Linker
NH2-C5-NH-Boc is a PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This alkyl chain-based linker facilitates the development of targeted protein degradation strategies, enhancing the specificity and efficacy of therapeutic interventions. It serves as a crucial component in research applications aimed at investigating protein modulation and degradation pathways in cellular systems. -
PROTAC Linker
Potassium (2-((tert-butoxycarbonyl)amino)ethyl)trifluoroborate serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Its unique chemical structure aids in conjugating E3 ligases with target proteins, enabling targeted degradation pathways. This compound is essential for research applications focusing on targeted protein degradation and therapeutic development in various diseases. -
PROTAC Linker
Alkyne-PEG4-maleimide is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application as a linker facilitates the creation of bifunctional molecules for targeted protein degradation studies and other advanced research applications in chemical biology. -
PROTAC Linker
Boc-N-amido-PEG3-acid is a PEG-based linker specifically designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound offers favorable solubility and flexibility, enabling effective conjugation to target proteins and E3 ligases. Its utility in the development of PROTACs makes it a valuable tool for researchers investigating targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Amino-PEG2-NH-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis targeting chimera) molecules. This reagent facilitates the construction of bifunctional compounds that target specific proteins for degradation through the ubiquitin-proteasome system. Its application in PROTAC development supports therapeutic research aimed at modulating protein levels in various disease states. -
PROTAC Linker
NH2-C6-NH-Boc is a PROTAC linker characterized by its alkyl/ether composition. This compound facilitates the synthesis of Mcl-1 inhibitors through the PROTAC approach, enabling targeted protein degradation. Its utility in research applications includes investigating Mcl-1's role in cancer cell survival and exploring novel therapeutic strategies in oncology. -
PROTAC Linker
(E)-tert-Butyldimethyl((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)allyl)oxy)silane serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound enables the effective conjugation of peptide ligands to E3 ligase recruiters, enhancing the selective degradation of target proteins. It is particularly useful in research applications focused on exploring and manipulating cellular pathways through targeted therapy. -
PROTAC Linker
Azide-PEG3-Desthiobiotin serves as a versatile linker for PROTAC (proteolysis-targeting chimera) synthesis, facilitating targeted protein degradation. This compound features an azide functional group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne, DBCO, or BCN-containing molecules. Its applications extend to the development of novel therapeutic agents that leverage the targeted degradation pathway for enhanced biological research and drug development. -
PROTAC Linker
Fmoc-amino-PEG3-CH2COOH is a polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound enables the efficient conjugation of amino acid functionalities, enhancing target specificity and solubility in biological systems. It serves as a crucial component for researchers developing selective protein degraders, facilitating the study of protein interactions and degradation pathways in cellular environments.
