Catalog No.
Product Name
Application
Product Information
Citations
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Ligands for Target Protein for PROTAC
Palbociclib-propargyl is a selective ligand for CDK6, designed for use in PROTAC applications. This compound functions through a PEG linker to effectively bind to the CRBN ligand, forming the PROTAC CP-10, which exhibits a DC50 of 2.1 nM for CDK6. Additionally, Palbociclib-propargyl features an alkyne group making it suitable for click chemistry, specifically allowing for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-bearing molecules. This reagent is valuable for advancing research in targeted protein degradation and cancer therapeutics. -
Ligands for Target Protein for PROTAC
(S)-SKBG-1 is a covalent ligand designed for targeting specific proteins in the context of PROTAC applications. Though classified as inactive, it serves an essential role as an assay control to help validate experimental conditions and results. This compound is valuable for researchers investigating the mechanisms of protein degradation and the development of targeted therapeutic strategies. -
Ligands for Target Protein for PROTAC
Tazemetostat de(methyl morpholine)-COOH is a ligand specifically designed for the target protein EZH2, facilitating the synthesis of EZH2 degraders for the PROTAC approach. This compound exhibits significant biological activity by effectively inhibiting cell viability in diffuse large B-cell lymphoma (DLBCL) and various lymphoma subtypes. It serves as a valuable tool for researchers investigating targeted protein degradation and its therapeutic potential in oncology. -
Ligands for Target Protein for PROTAC
PROTAC BRD9-binding moiety 1 hydrochloride is a ligand that selectively binds to the bromodomain protein BRD9, facilitating its targeted degradation through the PROTAC (Proteolysis Targeting Chimeras) mechanism. This compound is instrumental in research focusing on protein degradation pathways and the modulation of BRD9-associated functions in various biological contexts, such as cancer and inflammation. It serves as a valuable tool for studying the therapeutic potential of targeting BRD9 in disease models. -
Ligands for Target Protein for PROTAC
Piperidine-GNE-049-N-Boc is a ligand that targets the dCBP-1 protein, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound serves as a potent and selective heterobifunctional degrader for the transcriptional co-activators p300 and CBP. It is applicable in research aimed at understanding protein degradation mechanisms and the modulation of gene expression. -
Ligands for Target Protein for PROTAC
Demethyl-RSL3 functions as a ligand for targeted protein degradation through the proteolysis targeting chimera (PROTAC) mechanism. This compound effectively modulates cellular pathways by inducing degradation of specific proteins. Its applications lie primarily in cancer research and the development of novel therapeutic strategies aimed at improving targeted protein degradation efficacy. -
Ligands for Target Protein for PROTAC Chemical
PROTAC CDK9 ligand-1 is a potent ligand for cyclin-dependent kinase 9 (CDK9), facilitating the synthesis of PROTAC (proteolysis-targeting chimera) constructs. This compound is instrumental for targeted protein degradation studies, enabling researchers to modulate CDK9 activity and investigate its role in transcription regulation and cancer biology. PROTAC CDK9 ligand-1 supports the development of innovative therapeutic strategies aimed at selectively degrading unwanted or malfunctioning proteins. -
Ligands for Target Protein for PROTACs
PRMT5 ligand 2 is a selective ligand targeting protein arginine methyltransferase 5 (PRMT5) for use in PROTAC (proteolysis-targeting chimeras) applications. This compound facilitates the targeted degradation of PRMT5, enabling researchers to investigate its role in various cellular processes, including gene regulation and cell signaling. PRMT5 ligand 2 serves as an essential tool for studying PRMT5's biological functions and elucidating potential therapeutic targets in cancer and other diseases. -
Ligands for Target Protein for PROTAC
BMS-1166-N-piperidine-COOH is a ligand designed to target E3 ligase for PROTAC applications. This compound serves as a key component in the synthesis of PD-1/PD-L1 degrader-1, which facilitates the degradation of the PD-1/PD-L1 complex, a crucial immune checkpoint. With a potent PD-1/PD-L1 interaction inhibition demonstrated by an IC50 of 1.4 nM, BMS-1166-N-piperidine-COOH effectively reverses the suppressive effects of the PD-1/PD-L1 pathway on T cell activation, making it valuable for cancer immunotherapy research. -
Ligands for Target Protein for PROTAC
PROTAC IRAK4 ligand-1 is a synthetic ligand specifically designed to target interleukin-1 receptor-associated kinase 4 (IRAK4). This compound plays a critical role in the development of PROTAC IRAK4 degrader-1, facilitating targeted protein degradation. Its primary applications include cancer research and studies investigating inflammatory pathways, making it a valuable tool for researchers exploring IRAK4-related signaling mechanisms. -
Ligands for Target Protein for PROTAC
A-1210477-piperazinyl is a ligand that specifically binds to myeloid cell leukemia 1 (MCL1), serving as a crucial component in PROTAC (proteolysis-targeting chimeras) technology. This compound plays a significant role in targeted protein degradation research, enabling the modulation of MCL1 levels in various cellular contexts. A-1210477-piperazinyl is valuable for studies aimed at understanding MCL1's involvement in cell survival and cancer biology. -
Ligands for Target Protein for PROTAC
CDK2 ligand-2 is a selective ligand targeting cyclin-dependent kinase 2 (CDK2), facilitating the synthesis of PROTAC (proteolysis targeting chimera) molecules. By combining CDK2 ligand-2 with E3 Ligase Ligand-linker Conjugate 184, researchers can create CDK2 degrader 2, a potent tool for targeted protein degradation studies. This compound is valuable for investigating CDK2's role in cell cycle regulation and exploring therapeutic strategies in cancer research. -
Ligands for Target Protein for PROTAC
AR Antagonist 14 is a potent ligand for specific target proteins utilized in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the development of targeted protein degraders, allowing for the selective degradation of androgen receptors. AR Antagonist 14 can be effectively combined with VH 101-amide-piperidine-Pip-alkyne to synthesize PROTAC degraders, enhancing research on targeted therapies in cancer and other diseases. -
Ligands for Target Protein for PROTAC
KAL-21404358 is a ligand designed for specific binding to target proteins for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the targeted degradation of proteins, providing valuable insights into protein function and regulation. Research applications include the study of protein-protein interactions and the development of targeted therapies in cancer and other diseases. KAL-21404358 supports the advancement of innovative approaches in drug discovery and biological research. -
Ligands for Target Protein for PROTAC
PTPN2 ligand 1 is a specific ligand designed for the PTPN2 target protein, facilitating the development of PROTAC (proteolysis-targeting chimeras). This compound plays a crucial role in research applications focused on targeted protein degradation, providing researchers with the means to investigate the functional relevance of PTPN2 in various biological processes. Additionally, it serves as a synthetic precursor for the compound PVD-06, contributing to further studies in protein modulation. -
Ligands for Target Protein for PROTACs
Palbociclib-CH2COOH is a ligand designed for the Target Protein in PROTAC applications. This compound can function as an active control for evaluating the target protein ligand interactions of CPD-39 and CPD-10. Its specificity and binding capacity make it a valuable tool for researchers investigating targeted protein degradation and related pathways. -
E3 Ligase Ligand of PROTAC
CRBN ligand-896 is an E3 ligase ligand utilized in the development of PROTAC (Proteolysis Targeting Chimera) compounds. This reagent facilitates targeted protein degradation by enabling the selective ubiquitination of the epigenetic coactivator p300. It serves as a valuable tool in the investigation of protein regulation and therapeutic strategies in cancer and other diseases associated with dysregulated epigenetic modifiers. -
Ligands for Target Protein for PROTAC
PXR Ligand 3 is a ligand for the Pregnane X Receptor (PXR), acting as a critical component in the development of PROTAC (Proteolysis Targeting Chimera) molecules. It facilitates the recruitment of E3 ubiquitin ligases, thereby promoting targeted degradation of specific proteins. This compound is valuable in drug discovery and biochemical research, particularly in studies focused on the modulation of PXR activity and the development of PROTAC-based therapeutics. -
Ligands for Target Protein for PROTACs
IRAK4 ligand-12 is a ligand for interleukin-1 receptor-associated kinase 4 (IRAK4), designed for use in PROTAC (proteolysis targeting chimeras) applications. This compound plays a critical role in the selective degradation of IRAK4, thus enabling the modulation of immune response pathways. It is particularly useful in research focused on inflammation and cancer, facilitating studies on targeted protein degradation strategies. IRAK4 ligand-12 can also be utilized in the synthesis of KTX-951, contributing to advancements in therapeutic development. -
Ligands for Target Protein for PROTAC
SHP2 ligand-3 is a ligand specifically designed for the SHP2 target protein, facilitating the synthesis of SHP2 protein degrader-1. This compound serves as an essential tool in targeted protein degradation studies, enabling the selective degradation of SHP2. Its application in PROTAC technology allows researchers to investigate the functional roles of SHP2 in cellular processes and disease mechanisms, supporting drug discovery and development efforts. -
Ligands for Target Protein for PROTAC
BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol) serves as a versatile ligand for target proteins in PROTAC applications. This compound incorporates a sulfonamide linker designed to enhance the solubility of linker-conjugates. It is particularly useful in the synthesis of PROTACs aimed at inducing targeted degradation of proteins with potential antitumor activity. -
Ligands for Target Protein for PROTAC
SMARCA2/4-ligand-6 is a small molecule ligand specific for the SMARCA2 and SMARCA4 proteins, facilitating targeted protein degradation via the PROTAC (Proteolysis Targeting Chimeras) technology. This compound can be utilized in the development of PROTACs aimed at studying the roles of these epigenetic regulators in cancer biology and other diseases. SMARCA2/4-ligand-6 is a valuable tool for researchers investigating targeted therapeutic strategies and protein homeostasis. -
Ligands for Target Protein for PROTAC
BTK-IN-39 is a ligand targeting Bruton’s tyrosine kinase (BTK), designed for the synthesis of PROTAC BTK Degrader-11. This compound enables the selective degradation of BTK, facilitating studies on its biological functions and role in disease models, particularly in hematological malignancies. Its application in PROTAC technology allows for innovative approaches to therapeutic intervention by modulating protein levels within cells. -
Ligands for Target Protein for PROTAC
HDAC8-IN-11 is a potent inhibitor of histone deacetylase 8 (HDAC8), a key regulator of gene expression and cellular processes. This compound demonstrates significant biological activity by modulating acetylation levels of histones and non-histone proteins. HDAC8-IN-11 is primarily utilized in research applications focused on targeted protein degradation via PROTAC technology, facilitating the selective degradation of specific proteins in cellular models. -
Ligands for Target Protein for PROTAC
HG-7-85-01-Decyclopropane is a ligand for target proteins utilized in the PROTAC (Proteolysis Targeting Chimera) technology. This compound features the ABL inhibitor moiety and binds to IAP (inhibitor of apoptosis protein) ligands through a linker, enabling the targeted degradation of specific proteins within cells. Its application in research includes elucidating protein function and pathway regulation, making it a valuable tool in cancer biology and therapeutic development. -
Ligands for Target Protein for PROTAC
mTOR ligand 1 is a potent ligand targeting the mechanistic target of rapamycin (mTOR) for use in PROTAC (Proteolysis Targeting Chimera) applications. This compound plays a crucial role in the degradation of mTOR through the ubiquitin-proteasome system, enabling selective modulation of mTOR activity. mTOR ligand 1 is ideal for research involving mTOR signaling pathways and related cellular processes, providing a valuable tool for investigating therapeutic strategies in cancer and metabolic disorders. -
Ligands for Target Protein for PROTAC
SMARCA2/4-ligand-4 acts as a ligand for the SMARCA2 and SMARCA4 proteins, serving as an essential component for the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the targeted degradation of proteins associated with various cellular processes, providing a powerful tool for drug discovery and therapeutic research. SMARCA2/4-ligand-4 is integral to the synthesis of PROTAC SMARCA2/4 degrader-36, enabling investigations into the modulation of oncogenic pathways and protein homeostasis. -
Ligands for Target Protein for PROTAC
Multi Kinase Ligand 4 is a selective ligand designed for the synthesis of PROTACs, specifically PROTAC DB-0646. This compound plays a crucial role in modulating protein degradation pathways, facilitating targeted protein degradation through the ubiquitin-proteasome system. Its applications extend to drug discovery and development in cancer research, enabling investigations into the regulation of kinase activity and potential therapeutic interventions. -
Ligands for Target Protein for PROTAC
SMARCA2 ligand-7 is a specific ligand for SMARCA2, a key protein involved in chromatin remodeling. This compound is designed for use in PROTAC (PROteolysis TArgeting Chimeras) studies, facilitating targeted protein degradation. SMARCA2 ligand-7 enables researchers to investigate the functional roles of SMARCA2 in cellular processes and its potential as a therapeutic target in various diseases. -
Ligands for Target Protein for PROTAC
Demethyl-RSL3-boc is a ligand designed for targeted protein degradation through PROTAC (Proteolysis Targeting Chimeras) technology. This compound effectively interacts with target proteins to facilitate their ubiquitin-mediated degradation, thereby modulating cellular pathways. Demethyl-RSL3-boc is utilized in research applications focused on studying protein dynamics and developing novel therapeutic strategies for various diseases, including cancer. -
Ligands for Target Protein for PROTAC
SMARCA2/4-ligand-1 is a selective ligand for the proteins SMARCA2 and SMARCA4, facilitating targeted protein degradation via PROTAC (Proteolysis Targeting Chimeras) technology. This compound exhibits promising biological activity by promoting the ubquitination and subsequent degradation of these target proteins. It is designed for use in research applications focusing on gene regulation, chromatin remodeling, and the study of protein homeostasis. -
Ligands for Target Protein for PROTAC
SMARCA2 ligand-6 is a selective ligand for the SMARCA2 protein, functioning within the context of proteolysis-targeting chimera (PROTAC) technology. This compound facilitates the targeted degradation of SMARCA2, enabling researchers to study its biological functions and roles in various cellular processes. It is a valuable tool for investigating therapeutic strategies in cancer and other diseases linked to dysregulation of chromatin remodeling factors. -
Ligands for Target Protein for PROTAC
LC3B ligand 1 is a specific ligand for the target protein utilized in PROTAC technology. It plays a crucial role in synthesizing PROTAC CDK9 autophagic degrader 1, facilitating targeted protein degradation through autophagy. This compound is valuable in studies aimed at investigating protein turnover, cellular homeostasis, and the potential therapeutic applications of PROTACs in cancer and other diseases. -
SMARCA2 Ligand
SMARCA2 ligand-8 acts as a selective ligand for the target protein SMARCA2, facilitating the synthesis of the PROTAC SMARCA2/4-degrader-35. This compound is instrumental in research applications focused on targeted protein degradation, offering insights into the modulation of gene regulation and chromatin remodeling. Its utility in developing innovative degraders highlights its significance in the study of cancer biology and potential therapeutic interventions. -
Ligands for Target Protein for PROTAC
AKT ligand-2 is a selective ligand targeting the AKT protein. It can be utilized in the synthesis of PROTACs, specifically by linking with VHL ligand (S,R,S)-AHPC, to create compounds like PROTAC MS21. This reagent is instrumental in cellular research focused on targeted protein degradation and the modulation of AKT signaling pathways. -
Ligands for Target Protein for PROTACs
TRIB2 ligand-1 is a specific ligand for the TRIB2 protein, facilitating the development of PROTACs designed for targeted protein degradation. This compound plays a crucial role in the synthesis of PROTAC TRIB2 degrader-1, which can be employed in research focused on protein regulation and degradation pathways. Its application in such studies supports investigations into various cellular mechanisms and potential therapeutic targets. -
Ligands for Target Protein for PROTAC
SMARCA2/4-ligand-2 is a selective ligand designed for the targeted degradation of SMARCA2 and SMARCA4 proteins via the PROTAC (proteolysis-targeting chimeras) approach. This compound facilitates the ubiquitination and subsequent proteasomal degradation of these essential chromatin remodeling proteins, making it a valuable tool in studies focused on cancer biology and epigenetic regulation. Researchers can utilize SMARCA2/4-ligand-2 to investigate the role of SMARCA2/4 in various cellular processes and to explore therapeutic strategies for diseases linked to their dysregulation. -
CRBN Modulator
ZXH-1-161 is a selective modulator of cereblon (CRBN) that induces the degradation of GSPT1 in a CRBN-dependent manner. This compound effectively inhibits the proliferation of multiple myeloma cells and demonstrates significant antitumor activity. Its unique mechanism of action makes it a valuable tool for investigating CRBN-targeted therapies in cancer research. -
PROTAC IKZF1/IKZF3 Degrader
(Rac)-Cemsidomide is a PROTAC degrader targeting IKZF1 and IKZF3, exhibiting potent antitumor activity through its molecular glue mechanism. This compound demonstrates a GI50 of 0.05 nM in NCIH929.1 cells, making it a valuable tool for research applications focused on the degradation of Ikaros and Aiolos proteins. Its unique properties facilitate investigations into mechanisms of action related to targeted protein degradation in cancer therapies. -
PROTAC Linkers
5-Ethynyl-2'-deoxyuridine (EdU) is a thymidine analogue that serves as a vital tool in cell proliferation studies. This compound can be incorporated into cellular DNA during replication and subsequently reacts with a fluorescent azide through a copper-catalyzed azide-alkyne cycloaddition (CuAAc) “Click” reaction, allowing for advanced imaging techniques. EdU also functions as an alkyl chain-based linker for the synthesis of PROTACs, facilitating targeted protein degradation in research applications. Its unique properties make it essential for investigations in cellular dynamics and innovative therapeutic strategies. -
PROTAC Linker
DBCO-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise bioconjugation. Its application is critical in the development of targeted protein degradation strategies, enhancing the ability to study protein interactions and manipulate cellular processes. -
PROTAC Linker
Biotin-PEG3-azide is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, facilitating the development of targeted protein degradation strategies. Biotin-PEG3-azide is essential for advancing research in molecular biology and therapeutic development involving PROTAC technology. -
PROTAC Linkers
L-Azidohomoalanine hydrochloride is a versatile PROTAC linker featuring an azide functional group, facilitating the synthesis of protein-targeting chimeras. This compound demonstrates key click chemistry capabilities, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with DBCO or BCN groups, making it invaluable for bioconjugation and drug discovery applications. -
PROTAC Linker
4-Bromobutanoic acid tert-butyl ester functions as a PROTAC linker, facilitating the synthesis of PROTACs for targeted protein degradation. This compound plays a critical role in modulating protein levels within cells, enabling the study of protein function and potential therapeutic developments. Its incorporation into PROTACs aids in the design of innovative approaches for drug discovery and development in cancer and other diseases. -
PROTAC Linker
N-Boc-4,4'-bipiperidine is a versatile PROTAC linker that facilitates the design and synthesis of targeted protein degraders. This compound enables the construction of PROTACs such as BRD9 Degrader-5, which are crucial for modulating protein levels through the ubiquitin-proteasome system. Its role in the development of molecular probes for selective degradation highlights its significance in chemical biology and therapeutic research applications. -
PROTAC Linker
2-Chloroethanamine hydrochloride is a PROTAC linker utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a crucial role in connecting target proteins to E3 ligases, facilitating targeted protein degradation. It is widely employed in chemical biology for the development of innovative therapeutics that leverage the ubiquitin-proteasome system. -
PROTAC Linker
3-Mercaptopropionic acid NHS ester functions as a linker in PROTAC (Proteolysis Targeting Chimeras) technology, facilitating the conjugation of target proteins for degradation. This reagent enables the synthesis of innovative PROTACs by providing a reactive moiety for efficient attachment to both the ubiquitin ligase and the target protein. Its unique structure supports targeted proteolysis and enhances the specificity and efficacy of therapeutic interventions in protein homeostasis research. -
PROTAC Linker
Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatile chemical reactivity makes it suitable for developing targeted protein degradation strategies in chemical biology research and drug discovery applications. -
PROTAC Linkers
Ac4GalNAz is an alkyl chain-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Ac4GalNAz serves as an essential tool in the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
m-PEG3-aldehyde is a polyethylene glycol (PEG)-based linker designed specifically for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances solubility and facilitates the development of bifunctional molecules that can simultaneously engage a target protein and an E3 ligase. Its application is crucial for advancing research in targeted protein degradation strategies and drug discovery.
