Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Azido-PEG4-hydrazide is a PEG-based linker specifically designed for PROTAC (proteolysis-targeting chimera) synthesis. Functioning as a click chemistry reagent, it features an azide group capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules, making it an essential tool for developing targeted protein degradation strategies in chemical biology research. -
PROTAC Linker
DBCO-S-S-PEG3-biotin is a PEG-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating efficient conjugation. Its biotin component enhances detection and purification of PROTACs, making it a valuable tool for biological research focused on targeted protein degradation. -
PROTAC Linker
Methyltetrazine-PEG4-maleimide is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety that can engage in an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating efficient ligand conjugation. The incorporation of this linker enables precise targeting and degradation of proteins, making it a valuable tool for studying protein functions and developing targeted therapies. -
PROTAC Linkers
NH2-PEG3-C2-Boc is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This versatile compound features an amine functional group that facilitates conjugation, enhancing the development of targeted protein degradation pathways. It is primarily utilized in therapeutic applications that focus on modulating protein levels within cellular systems. -
PROTAC Linker
7-Boc-(2,7-Diazaspiro[3.5]nonane) serves as a PROTAC linker, facilitating the development of targeted protein degradation agents. Its spirocyclic structure enhances ligand efficiency and selectivity for therapeutic applications. This compound is instrumental in synthesizing PROTACs that promote the ubiquitin-proteasome system, offering valuable tools for studying protein function and potential disease modulation. -
PROTAC Linker
tert-Butyl N-{3-formylbicyclo[1.1.1]pentan-1-yl}carbamate is a specialized PROTAC linker designed for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of targeted protein degraders, enabling selective modulation of protein levels in cellular systems. Its unique structure enhances the stability and efficacy of the resulting PROTACs, making it a valuable tool for research in targeted therapy and protein regulation. -
PROTAC Linker
endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. It features a bicyclo[6.1.0]nonyne (BCN) group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing compounds. This linker is pivotal for advancing research in targeted protein degradation and optimizing the pharmacological profiles of novel therapeutic agents. Its utility in PROTAC development makes it an essential tool for scientists exploring innovative approaches in drug discovery and cellular regulation. -
PROTAC Linkers
NH2-C4-NH-Boc is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyl/ether structure, facilitating the connection of two distinct ligands: one targeting an E3 ubiquitin ligase and the other directed at the protein of interest. By harnessing the ubiquitin-proteasome system, PROTACs constructed with NH2-C4-NH-Boc enable selective degradation of specific target proteins, making it a valuable reagent for research in targeted protein degradation and drug development. -
PROTAC Linkers
Boc-NH-C12-NH2 is a flexible alkyl linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that target specific proteins for degradation via the ubiquitin-proteasome pathway. It is of particular interest for researchers developing novel therapeutic strategies in targeted protein degradation and drug discovery. -
PROTAC Linkers
Boc-NH-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of protein targets via the ubiquitin-proteasome pathway. Its versatile structure makes it a valuable tool for researchers investigating targeted protein degradation in therapeutic applications. -
PROTAC Linker
Tetraethylene glycol monomethyl ether is a polyethylene glycol (PEG)-based linker specifically designed for use in PROTAC (proteolysis-targeting chimeras) synthesis. This versatile reagent facilitates the assembly of PROTACs by enhancing solubility and stability, thereby improving their pharmacological profiles. It is widely utilized in research applications aimed at targeted protein degradation, contributing to advancements in drug discovery and development. -
PROTAC Linker
Bromo-PEG3-azide is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its azide functional group enables efficient click chemistry applications, including copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-bearing molecules. Additionally, this compound can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified partners, facilitating the generation of multifunctional PROTACs for targeted protein degradation research. -
PROTAC Linker
5-Tert-butoxy-5-oxopentanoic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of targeted degraders, enabling selective protein degradation for research into cellular processes and therapeutic interventions. Its unique structure enhances the efficacy of PROTACs in modulating protein levels and studying protein function in various biological contexts. -
PROTAC Linker
tert-Butyl-hexanedioic acid serves as a PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound can be employed in the synthesis of various PROTAC molecules, including the PROTAC ERα Degrader-12. Its utility in creating bifunctional compounds enhances the precision of therapeutic interventions in biomedical research. -
PROTAC Linkers
m-PEG-OH (MW5000) is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of PROTACs by providing a flexible and hydrophilic connector that enhances their solubility and stability. Its application is critical in drug discovery and development, particularly in studies focused on targeted protein degradation and modulation of protein levels in various biological contexts. -
PROTAC Linker
Br-C3-methyl ester is an alkyl/ether-based PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTAC PD-1/PD-L1 degrader-1, enabling the selective degradation of PD-1, which is crucial for cancer immunotherapy research. Its use can aid in elucidating the role of PD-1 in immune regulation and potentially contribute to the development of novel therapeutic strategies against cancer. -
PROTAC Linker
Fmoc-NH-PEG12-CH2CH2COOH is a polyethylene glycol (PEG) based linker designed for the development of PROTAC molecules. This compound facilitates the targeted degradation of proteins by promoting the formation of ternary complexes between E3 ligases and specified protein targets. Its application is crucial in biochemistry and pharmaceutical research focused on innovative therapeutic strategies that harness the ubiquitin-proteasome system for selective protein degradation. -
PROTAC Linker
NH2-PEG5-C2-NH-Boc is a PEG-based PROTAC linker designed for the synthesis of PROTACs, which are bifunctional molecules that target proteins for ubiquitination and subsequent degradation. This linker facilitates the conjugation of targeting ligands to E3 ligases, enhancing the efficacy of targeted protein degradation studies. NH2-PEG5-C2-NH-Boc is ideal for applications in chemical biology and therapeutic research, allowing for the precise modulation of protein levels within cells. -
PROTAC Linker
Azido-PEG10-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Azido-PEG10-amine can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that possess dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating the targeted degradation of specific proteins in biological research applications. -
PROTAC Linker
Boc-GABA-OH is a PROTAC linker that facilitates the synthesis of UNC6852, specifically targeting the EED protein. This compound is essential for developing targeted protein degraders, enabling researchers to explore novel therapeutic strategies in cancer and other diseases by modulating the ubiquitin-proteasome system. Its unique properties make it an invaluable tool in the field of chemical biology and drug development. -
PROTAC Linkers
Azido-PEG24-NHS ester is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functionality that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its versatility makes it a valuable reagent for chemical biology and drug discovery applications involving PROTAC technology. -
PROTAC Linker
Hex-5-yn-1-ol is a versatile PROTAC linker that facilitates the development of targeted protein degraders. Its terminal alkyne functionality enables efficient conjugation with various targeting ligands, enhancing the design of bifunctional molecules for selective protein degradation. This compound is essential in research applications focused on targeted therapy and the modulation of protein levels within cellular systems. -
PROTAC Linkers
m-PEG24-NHS ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of covalent bonds with target proteins, enhancing the selective degradation of specific proteins through the ubiquitin-proteasome pathway. Its unique structure allows for improved solubility and stability, making it ideal for chemical biology research and therapeutic applications targeting protein modulation. -
PROTAC Linkers
TCO-OH is an alkyl chain-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the creation of targeted therapies by linking E3 ligases to specific proteins for degradation. Its application is essential in the field of targeted protein degradation research, enabling the exploration of new therapeutic strategies in various diseases. -
PROTAC Linkers
m-PEG12-NHS ester is a polyethylene glycol (PEG) derivative designed for use as a PROTAC linker. This compound facilitates the synthesis of PROTACs by providing a flexible and hydrophilic spacer that enhances the stability and solubility of the resulting conjugates. Its incorporation in PROTAC design supports targeted protein degradation studies, making it valuable for research in drug discovery and therapeutic development. -
PROTAC Linker
L-Homopropargylglycine hydrochloride serves as an alkyl chain-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This amino acid analog of methionine features an alkyne group, enabling efficient click chemistry with azide-containing Alexa Fluor for labeling and detection purposes. Its application in PROTAC development supports innovative approaches in targeted protein degradation research. -
PROTAC Linker
tert-Butyl 6-aminocaproate is a PROTAC linker that facilitates the development of targeted protein degraders. This compound plays a crucial role in the synthesis of PROTAC CARM1/IKZF3 degrader-1, enabling selective degradation of target proteins. Its utility in chemical research supports the exploration of innovative therapeutic strategies through targeted protein modulation. -
PROTAC Linkers
Propargyl-PEG1-acid is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of BTK-CRBN PROTACs, specifically enhancing the degradation of Bruton’s Tyrosine Kinase (BTK), as well as other key proteins such as CSK, LYN, and LAT2, when utilized at concentrations of 10 μM. Featuring an alkyne functional group, Propargyl-PEG1-acid enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it an essential tool for researchers developing targeted protein degradation strategies. -
PROTAC Linkers
Bromo-PEG2-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the connection between target proteins and E3 ligases, enhancing targeted protein degradation. Its unique properties allow for improved solubility and biocompatibility, making it suitable for various applications in chemical biology and drug discovery research. -
PROTAC Linker
Azido-PEG1-C2-acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound contains an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Furthermore, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing compounds, making it a versatile tool for applications in targeted protein degradation research. -
PROTAC Linker
Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a bromo group for effective conjugation and enhances the solubility and cell permeability of the resulting PROTAC molecules. It is widely utilized in research applications aimed at targeted protein degradation, enabling the modulation of protein levels in various biological systems. -
PROTAC Linker
Boc-NH-PEG2-CH2CH2COOH is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation by linking a target protein to an E3 ligase, promoting the ubiquitination and subsequent degradation of the target. Its application is vital in drug discovery and development, particularly for the investigation of protein function and the design of innovative therapeutic strategies. -
PROTAC Linkers
Amino-PEG4-C2-amine is a polyethylene glycol (PEG)-based linker consisting of four ethylene glycol units, specifically designed for use in PROTAC (proteolysis-targeting chimera) synthesis. Its primary mechanism involves facilitating the connection of target ligands to E3 ligase recruiters, enabling targeted protein degradation. This compound is essential for researchers developing novel therapeutics aimed at modulating protein levels in various biological pathways and disease states. -
PROTAC Linker
Tetraethylene glycol is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation strategies by providing the necessary structural connectivity between the ligand and the E3 ubiquitin ligase. Its unique properties make it suitable for various applications in drug discovery and development, particularly in the context of targeted therapy research. -
PROTAC Linker
N-Boc-serinol serves as an alkyl/ether-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. Its structural properties facilitate the formation of drug conjugates that enable targeted degradation of proteins. This compound is essential for researchers developing novel therapeutic strategies in targeted protein degradation and drug discovery. -
PROTAC Linker
3,6-Dioxaoctanedioic acid is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTACs. This compound facilitates the development of targeted protein degradation mechanisms by linking E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent proteasomal degradation. Its structural properties support effective binding and stability, making it a valuable reagent in research applications focused on targeted therapy and modalities in protein regulation. -
PROTAC Linker
Acid-PEG3-C2-Boc is a PEG- and alkyl/ether-based PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This linker enables the targeted degradation of proteins, including epidermal growth factor receptor (EGFR), and offers potential for the inhibition of mechanistic target of rapamycin (mTOR). Its versatile structure supports research applications in targeted protein degradation and therapeutic development in cancer research. -
PROTAC Linker
tert-Butyl (10-aminodecyl)carbamate functions as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs) and other conjugation applications. This compound features an alkane chain with a terminal amine and a Boc-protected amino group, enabling reactivity with carboxylic acids, activated NHS esters, and carbonyl compounds such as ketones and aldehydes. The Boc group can be deprotected under mild acidic conditions, yielding a free amine suitable for further coupling reactions in chemical research. -
PROTAC Linker
tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate serves as an effective PROTAC linker, facilitating target protein degradation through proteolysis-targeting chimeras (PROTACs). This compound is integral in the synthesis of specific PROTACs, such as ER Degrader-12 and AR Degrader-9, contributing to advancements in targeted protein degradation research and therapeutic development. Its unique structural properties make it suitable for manipulating protein interactions in various biological studies. -
PROTAC Linker
tert-Butyl but-3-yn-1-ylcarbamate serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins, making it a valuable reagent in drug discovery and protein research applications. Its unique structure allows for improved conjugation efficiency and stability in various biochemical contexts. -
PROTAC Linker
tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate functions as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound is integral in the synthesis of innovative therapeutic agents aimed at selectively degrading target proteins. Its unique structural properties support the creation of effective PROTACs for a variety of research applications, including drug discovery and development in targeted protein degradation. -
PROTAC Linker
2-((tert-Butyldimethylsilyl)oxy)ethanol is a versatile PROTAC linker that enables the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by linking an E3 ligase ligand and a target protein ligand, offering valuable applications in drug discovery and development. Its effectiveness in modifying the pharmacokinetic properties of PROTACs supports research in targeted therapy and cellular regulation. -
PROTAC Linker
tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate functions as a PROTAC linker, facilitating the conjugation of target proteins with E3 ligases. This compound is instrumental in the development of PROTACs for targeted protein degradation, enabling precise modulation of protein levels in various biological contexts. Its molecular structure supports efficient assembly of bifunctional molecules, contributing to advancements in therapeutic strategies for diseases driven by dysregulated protein expression. -
PROTAC Linker
3-Chloropropan-1-amine hydrochloride acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, enabling the selective degradation of protein targets through the ubiquitin-proteasome system. Its application is significant in drug discovery and therapeutic research aimed at modulating protein function. -
PROTAC Linker
Hydroxy-PEG1-(CH2)2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the assembly of PROTACs by enhancing solubility and biocompatibility. It is suitable for applications in medicinal chemistry and targeted protein degradation studies, contributing to advancements in therapeutic strategies. -
PROTAC Linkers
Bromo-PEG3-bromide is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bromo functionality that facilitates the selective recruitment of E3 ligases, enhancing targeted protein degradation. Its unique structure and properties make it an essential tool for researchers aiming to explore targeted protein modulation and degradation pathways in various biological contexts. -
PROTAC Linkers
Amino-PEG7-amine is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, promoting targeted protein degradation. It is valuable in drug discovery and biochemical studies aimed at modulating protein levels within cellular systems. -
PROTAC Linkers
Boc-NH-PEG3-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound enhances solubility and stability, making it suitable for the conjugation of ligand and E3 ligase components in drug development. Its role in chemical biology enables researchers to effectively study protein interactions and functions, contributing to advancements in therapeutic strategies. -
PROTAC Linkers
Nonaethylene glycol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the formation of PROTACs by conjugating target proteins to E3 ligases, enabling targeted protein degradation. Its utility in research applications includes the development of novel therapeutic strategies in cancer and other diseases by harnessing the power of targeted protein modulation. -
PROTAC Linker
1-Boc-4-carboxymethyl piperazine is a PROTAC linker that facilitates the development of targeted protein degraders. It plays a crucial role in the synthesis of PROTACs, enabling the selective degradation of specific proteins through the ubiquitin-proteasome pathway. This compound is particularly useful in research applications aimed at exploring new therapeutic strategies in various diseases, including cancer and other pathologies associated with dysregulated protein levels.
