Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
EGNHS is an alkyl/ether-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the construction of bifunctional molecules that can selectively target and degrade specific proteins in cellular systems. EGNHS is valuable for research applications focused on targeted protein degradation and the development of novel therapeutic strategies in various disease contexts. -
PROTAC Linkers
Biotin-PEG4-NHS ester is a biotinylated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the targeted degradation of specific proteins within cells. Its unique structure promotes solubility and improves the stability of PROTACs, making it a valuable tool for drug discovery and development in molecular biology and therapeutic research. -
PROTAC Linker
Amino-PEG3-C2-Azido is a PEG-based linker designed for use in PROTAC applications, facilitating the synthesis of targeted protein degraders, such as the PARP1 degrader iRucaparib-TP3. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology and drug discovery research. -
PROTAC Linker
L-Homopropargylglycine is an alkyne-containing amino acid analog of methionine designed for use as a PROTAC linker. This compound facilitates the synthesis of PROTACs by enabling robust click chemistry reactions with azide-functionalized partners, such as Alexa Fluor. Its unique structure allows for precise manipulation of target protein degradation pathways, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linkers
Biotin alkyne is a PEG-based linker designed for the synthesis of PROTACs, targeting the ubiquitin-proteasome system. As a click chemistry reagent, it features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. This functionality facilitates the efficient assembly of bifunctional degraders, advancing research in targeted protein degradation and therapeutic development. -
PROTAC Linker
Biotin-PEG4-azide is a biotin-labeled PEG-based linker designed for constructing PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, Biotin-PEG4-azide can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified compounds, facilitating advanced applications in targeted protein degradation research. -
PROTAC Linker
Biotin-PEG4-alkyne is a biotin-functionalized linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. This PEG-based compound features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), enabling the efficient conjugation with azide-containing molecules. Its application is vital in developing PROTACs for targeted protein degradation studies and therapeutic interventions. -
PROTAC Linker
Azido-PEG4-NHS-ester is a PEG-based linker designed for PROTAC synthesis, functioning primarily through click chemistry mechanisms. This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition reactions with DBCO or BCN groups. Its unique properties make it a valuable tool for researchers focused on the development of targeted protein degradation strategies. -
PROTAC Linkers
N-Boc-piperazine is a versatile alkyl/ether-based linker utilized in the synthesis of PROTACs, specifically for the development of PD-1/PD-L1 degrader-1. Its unique structure facilitates the formation of bifunctional molecules, enabling targeted protein degradation. This compound is essential for research applications focused on enhancing cancer immunotherapy and understanding the mechanisms of targeted protein modulation. -
PROTAC Linker
2-Boc-2,6-Diazaspiro[3.3]heptane is a versatile PROTAC linker facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a critical component in the development of targeted protein degradation strategies, enabling the selective modulation of protein levels within biological systems. Its structural attributes make it suitable for various applications in chemical biology and drug discovery research. -
PROTAC Linkers
Alkynyl myristic acid is a PROTAC linker characterized by its alkyl chain structure. It serves as a versatile click chemistry reagent, featuring an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. This compound is essential for the synthesis of PROTACs, facilitating targeted protein degradation studies in various biological research applications. -
PROTAC Linker
Mal-PEG8-NHS ester is a PEG-based PROTAC linker that facilitates the conjugation of target proteins for targeted protein degradation applications. This compound possesses a maleimide functional group, allowing for site-specific linking to thiol-containing biomolecules. It is essential for the synthesis of PROTACs aimed at modulating protein levels within cells, making it a valuable tool in drug discovery and development research. -
PROTAC Linker
TCO-PEG4-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs. Its primary mechanism involves click chemistry, specifically the inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. TCO-PEG4-NHS ester facilitates targeted protein degradation, making it a valuable tool for research applications in pharmacology and molecular biology, particularly in the development of novel therapeutics. -
PROTAC Linker
Sulfo-NHS-Acetate is a PROTAC linker that enables the synthesis of proteolysis-targeting chimeras (PROTACs) through the formation of stable amide bonds. This compound features an alkyl chain that facilitates the conjugation of various target proteins, enhancing the efficacy of targeted protein degradation. It serves as an essential building block for researchers aiming to develop innovative therapeutics in targeted protein modulation and degradation studies. -
PROTAC Linker
Methyltetrazine-Ph-NHS ester is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a tetrazine group that participates in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) moieties. Its key biological activity lies in enabling targeted protein degradation, providing a valuable tool for researchers exploring protein function and dynamics in cellular systems. Methyltetrazine-Ph-NHS ester is suitable for applications in chemical biology and drug discovery research. -
PROTAC Linker
Azido-PEG2-C2-acid is a PEG-based linker designed for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide functional group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. Its versatile reactivity makes it suitable for various applications in chemical biology and drug development. -
PROTAC Linker
Azido-PEG1 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. Azido-PEG1 is essential for advancing research in targeted protein degradation and bioconjugation applications. -
PROTAC Linkers
Azido-PEG5-amine is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) applications, facilitating the synthesis of novel degrader molecules. This compound features an azide functional group that enables its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing substrates, as well as in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Azido-PEG5-amine is essential for researchers exploring targeted protein degradation and enhancing drug discovery efforts. -
PROTAC Linker
Boc-NH-PEG2-C2-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ubiquitin ligases to target proteins, enhancing selective degradation pathways. Its unique structure promotes solubility and biocompatibility, making it suitable for various research applications in drug discovery and therapeutic development focused on targeted protein degradation. -
PROTAC Linker
Biotin-PEG4-amino-t-Bu-DADPS-C6-azide functions as a PEG-based PROTAC linker, facilitating the synthesis of targeted protein degraders. This compound is a versatile click chemistry reagent featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-functionalized compounds, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Azido-PEG4-alcohol is a PEG-based PROTAC linker designed for the synthesis of PROTAC molecules. This compound features an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug discovery applications. -
PROTAC Linkers
Aeide-C1-NHS ester is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimera (PROTAC) compounds. This reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its unique reactivity profiles make it an ideal candidate for developing innovative tools in targeted protein degradation research. -
PROTAC Linker
DBCO-Biotin is a PROTAC linker featuring an alkyl chain structure that facilitates the synthesis of PROTACs. As a click chemistry reagent, it contains a DBCO moiety that efficiently undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This property makes DBCO-Biotin a valuable tool in targeted protein degradation research, allowing for the precise construction of bifunctional compounds necessary for therapeutic development. -
PROTAC Linker
Azido-PEG1-amine serves as a versatile linker for PROTAC (Proteolysis Targeting Chimera) synthesis, facilitating the targeted degradation of proteins. This PEG-based compound features an azide group, enabling its participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it well-suited for various chemical biology applications, including the development of novel therapeutics. -
PROTAC Linkers
Biotin-PEG2-C2-iodoacetamide is a PEG-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by promoting the recruitment of E3 ligases to specific proteins of interest. It is particularly useful in studying protein regulation and function in various biological contexts, advancing research in targeted therapeutics and drug discovery. -
PROTAC Linkers
Biotin-PEG4-amine is a biotin-conjugated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances target protein degradation by facilitating the recruitment of E3 ligases via biotin-streptavidin interactions. Its application in PROTAC development supports research in targeted protein degradation for therapeutic interventions. -
PROTAC Linkers
Azido-PEG3-NHS ester is a PEG-based PROTAC linker featuring an azide functional group, which facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a versatile click chemistry reagent that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it ideal for targeted protein degradation studies and related applications in chemical biology. -
PROTAC Linker
Boc-NH-C4-Br is an alkyl chain-based PROTAC linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation by promoting the recruitment of E3 ligases to specific proteins of interest. Boc-NH-C4-Br is ideal for research applications focused on developing innovative therapeutic strategies in drug discovery and cellular biology. -
PROTAC Linker
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances target specificity and cellular degradation efficiency by linking E3 ligases to target proteins. Its application in PROTAC development enables the study of targeted protein degradation mechanisms, providing valuable insights in drug discovery and therapeutic interventions. -
PROTAC Linker
DBCO-PEG12-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) to azide-containing molecules, enabling precise conjugation. This reagent is essential for researchers developing PROTACs aimed at targeted protein degradation, thereby enhancing insights in various biological processes and therapeutic applications. -
PROTAC Linker
TCO-NHS ester is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). As a click chemistry reagent, it features a TCO group capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. This property makes TCO-NHS ester a valuable tool for the construction of complex bioconjugates and the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
mPEG-amine (mPEG-NH2) (MW 2000) is a polyethylene glycol (PEG) derivative designed as a linker for PROTAC (proteolysis-targeting chimera) development. This compound serves to enhance the solubility and stability of PROTACs, facilitating the selective degradation of target proteins via the ubiquitin-proteasome system. It is essential for researchers engaged in drug discovery and development, particularly in the study of targeted protein degradation. -
PROTAC Linker
tert-Butyl 3-bromopropanoate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays an essential role in the synthesis of PROTACs, enabling researchers to create targeted degradation agents that modulate protein levels within cells. Its functionality is critical for advancing studies in targeted protein degradation and therapeutic applications in various disease models. -
PROTAC Linker
2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride functions as a PEG-based PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its structure allows for effective conjugation in the synthesis of novel therapeutic agents, aiding in the targeted degradation of specific proteins. This compound is essential for research applications focused on proteasome-mediated degradation pathways and innovative drug discovery strategies. -
PROTAC Linkers
tert-Butyl 4-formylpiperidine-1-carboxylate is a versatile PROTAC linker employed in the development of targeted protein degradation strategies. This compound facilitates the synthesis of PROTAC BRM/BRG1 degrader-3, enabling specific modulation of protein levels in cellular systems. It is crucial for researchers investigating the application of PROTAC technology in drug discovery and therapeutic development. -
PROTAC Linker
3-(Methoxycarbonyl)bicyclo[1.1.1]pentane-1-carboxylic acid serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis targeting chimeras (PROTACs). By enabling the efficient conjugation of target proteins to E3 ligases, this compound enhances the targeted degradation of proteins within cellular environments. Its application in drug discovery and therapeutic development underscores its importance in advancing targeted protein modulation research. -
PROTAC Linker
tert-Butyl N-[4-(aminomethyl)phenyl]carbamate functions as a PROTAC linker, facilitating the design and synthesis of proteolysis targeting chimeras (PROTACs). Its structure enables effective conjugation between target proteins and E3 ligases, promoting targeted degradation pathways in cellular systems. This compound is essential for researchers exploring protein modulation and degradation mechanisms in various biological contexts. -
PROTAC Linker
Biotin-PEG3-NHS ester is a PEG-based linker that targets the synthesis of Proteolysis Targeting Chimera (PROTAC) molecules. This compound facilitates the conjugation of biotin to various biomolecules, enhancing their cellular uptake and stability. It is instrumental in research applications focused on targeted protein degradation and the development of novel therapeutic strategies in cellular biology. -
PROTAC Linkers
Azido-PEG6-acid is a versatile PEG-based linker designed for use in the synthesis of PROTACs. Featuring an azide functional group, it enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. This reagent facilitates the development of targeted protein degradation strategies in chemical biology research. -
PROTAC linker
Pent-4-yn-1-ol is a specialized PROTAC linker utilized in the development of Proteolysis Targeting Chimeras (PROTACs). This compound serves as a crucial building block for synthesizing various PROTAC molecules, facilitating targeted protein degradation in research applications. Its structural properties enable effective coupling to ligand and warhead components, advancing studies in cellular regulation and therapeutic intervention. -
PROTAC Linkers
2,2-Oxybis(ethylamine) is a PEG-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by connecting the E3 ligase and the protein of interest. Its biocompatibility and flexibility make it valuable for researchers developing innovative therapeutic strategies in targeted protein degradation. -
PROTAC Linkers
Fmoc-N-PEG24-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of protein-targeting warheads to E3 ligase recruiters, enabling targeted protein degradation. Its hydrophilic properties contribute to enhanced solubility and bioavailability, making it suitable for various biochemical and cellular studies related to protein control mechanisms in research applications. -
PROTAC linker
m-PEG12-acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This chemical compound facilitates the efficient conjugation of targeting ligands to E3 ligases, enhancing the cellular degradation of specific proteins. m-PEG12-acid is pivotal for researchers developing new PROTACs to study protein regulation and therapeutic intervention in various diseases. -
PROTAC Linker
Azido-PEG2-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an azide group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules or DBCO/BCN derivatives, enhancing the selective targeting of proteins for degradation. This versatile linker facilitates the development of novel targeted protein degradation strategies, making it valuable for chemical biology and drug discovery research applications. -
PROTAC Linker
Amino-PEG3-C2-Amine is a polyethylene glycol-based PROTAC linker that comprises three ethylene glycol units. This compound facilitates the synthesis of proteolysis targeting chimeras (PROTACs), enabling selective degradation of target proteins. Its versatile structure allows for effective conjugation in drug development and protein engineering applications. -
PROTAC Linker
4-(4-Boc-piperazinemethyl)phenylboronic acid pinacol ester functions as a PROTAC linker, facilitating the creation of bifunctional small molecules that engage E3 ubiquitin ligases and target specific proteins for degradation. This compound is primarily utilized in the synthesis of CST905, contributing to advances in targeted protein degradation research. Its application enhances the development of novel therapeutics in various areas, including cancer and neurodegenerative disorders. -
PROTAC Linker
Biotin-PEG4-Amide-C6-Azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with cyclooctyne derivatives such as DBCO or BCN. It is suitable for research applications in targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
4-Azidobutylamine is a versatile PROTAC linker designed for the synthesis of targeted protein degradation agents. By connecting a ligand for an E3 ubiquitin ligase to a ligand for the target protein, it facilitates the selective degradation of specific proteins via the ubiquitin-proteasome pathway. Additionally, 4-Azidobutylamine contains an azide functional group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules. This reagent is crucial for advancing the development of PROTAC-based therapeutics. -
PROTAC Linker
Biotin-PEG2-Mal is a polyethylene glycol (PEG)-based PROTAC linker designed to facilitate molecular trafficking in targeted protein degradation applications. This compound serves as a versatile connector in the synthesis of PROTAC molecules, enhancing the stability and solubility of the resulting compounds. Its biotin functionality allows for efficient biotin-streptavidin labeling, aiding in the study of protein interactions and degradation pathways in various biological contexts. -
PROTAC linker
endo-BCN-PEG3-mal is a PEG-based PROTAC linker designed for efficient synthesis of PROTACs. This compound features a BCN moiety that engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted protein degradation studies. Its versatile application in chemical biology makes it valuable for research involving protein modulation and therapeutic development.
