Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
m-PEG2-Br is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the development of novel therapeutics that harness the cellular ubiquitin-proteasome system for targeted protein degradation. It is valuable in research aimed at elucidating protein interactions and developing innovative strategies in drug discovery. -
PROTAC Linker
tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate is a versatile PROTAC linker designed to facilitate the synthesis of PROTAC molecules. Its unique structural properties enable efficient recruitment of E3 ligases, enhancing targeted protein degradation pathways in cellular studies. This compound is essential for research applications involving targeted therapies and drug discovery in the field of protein modulation. -
PROTAC Linker
tert-Butyl hex-5-yn-1-ylcarbamate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) in chemical biology research. By linking an E3 ligase ligand and a target protein binder, this compound enhances the targeted degradation of specific proteins, making it a valuable tool for studying protein functions and cellular processes. Its chemical properties support efficient synthesis and application in various research settings focused on protein modulation and therapeutic interventions. -
PROTAC Linker
1,1-Dimethylethyl 4-(3-azetidinylmethyl)-1-piperazinecarboxylate serves as a PROTAC (Proteolysis Targeting Chimera) linker, facilitating the synthesis of bifunctional molecules that induce targeted degradation of specific proteins via the ubiquitin-proteasome pathway. This compound exhibits key biological activity in the design of therapeutic agents aimed at modulating protein levels, thus playing a significant role in pharmaceutical research focusing on targeted protein degradation. Its applications extend to the development of innovative strategies for treating various diseases through selective protein downregulation. -
PROTAC Linker
Methyl 5-aminovalerate hydrochloride serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential in the synthesis of PROTACs that engage E3 ligases for targeted protein degradation, making it valuable in studies of cellular protein regulation and therapeutic applications. -
PROTAC Linker
Boc-NH-PEG8-CH2CH2NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the creation of bifunctional molecules that promote targeted protein degradation, enhancing therapeutic strategies in various cellular contexts. Its unique properties make it a valuable tool for researchers investigating protein interactions and degradation pathways. -
PROTAC Linker
Tetradecane-1,14-diol is a PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and efficacy of these molecules by enabling efficient protein degradation through the hijacking of the ubiquitin-proteasome system. It serves as a valuable tool in drug discovery and development, particularly in targeted protein degradation research. -
PROTAC Linker
2-[4-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-1-yl]acetic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound plays a crucial role in targeted protein degradation by promoting the connection between E3 ligases and specific proteins of interest. It is particularly valuable in drug discovery and development, aiding in the exploration of novel therapeutic strategies related to protein regulation and degradation pathways. -
PROTAC Linker
6-Iodohex-1-yne is a versatile linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective recruitment of an E3 ligase to target proteins for ubiquitination and subsequent degradation. It plays a crucial role in various research applications, including the development of targeted protein degradation strategies in therapeutic contexts. -
PROTAC Linker
7-(tert-Butoxy)-7-oxoheptanoic acid serves as an important PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). Its structural features allow for effective conjugation with target ligands and E3 ligase recruiters, enhancing the specificity and efficacy of targeted protein degradation. This compound is valuable in chemical biology research, particularly in studies focused on the modulation of protein levels and therapeutic targeting of disease-related proteins. -
PROTAC Linker
tert-Butyl 2-(piperidin-4-yl)acetate serves as an efficient PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the targeted degradation of proteins by linking E3 ligases with the proteins of interest, enabling precise modulation of cellular pathways. Its applications are crucial in drug discovery and development, particularly for studying protein interactions and cellular functions. -
PROTAC Linkers
(S,R,S)-AHPC-PEG2-acid is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation by connecting an E3 ligase ligand to a target protein ligand. Its utilization in research allows for the investigation of protein degradation mechanisms and the development of novel therapeutic strategies in oncology and beyond. -
PROTAC Linker
NH2-PEG3 is a polyethylene glycol (PEG) linker specifically designed for use in PROTAC synthesis. It serves as a crucial component in the development of PROTAC molecules, such as β-NF-JQ1, which are utilized for targeted protein degradation. Its biocompatibility and versatile chemistry make it an essential reagent for researchers studying protein interactions and drug development. -
PROTAC Linkers
m-PEG4-PFP ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selective degradation of specific proteins within cellular pathways. Its application is critical in studies aimed at understanding protein homeostasis and developing novel therapies for diseases involving dysregulated protein expression. -
PROTAC Linker
Boc-6-aminohexanoic acid is a versatile alkyl/ether-based linker designed for use in PROTAC (proteolysis-targeting chimeras) synthesis. It facilitates the formation of PROTACs by enabling the selective degradation of target proteins through the recruitment of E3 ligases. This compound is essential for researchers developing targeted protein degradation strategies in various biological studies. -
PROTAC Linker
N-Boc-4-pentyne-1-amine is a PROTAC linker characterized by its alkyl chain composition. It is utilized in the synthesis of various PROTACs, including MG-277. As a click chemistry reagent, this compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, facilitating targeted protein degradation studies and other biological research applications. -
PROTAC Linker
Propargyl-PEG3-alcohol is a PEG-based PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its unique properties make it a valuable tool for researchers working on targeted protein degradation and related applications in chemical biology. -
PROTAC Linkers
Br-PEG4-OH is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the connection between a target protein and an E3 ligase, promoting targeted protein degradation. It serves as a crucial building block in the development of therapeutic agents aimed at modulating protein levels in various biological pathways, making it valuable for research in cancer and other diseases. -
PROTAC Linkers
t-Boc-Aminooxy-PEG4-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an aminooxy functional group and a NHS ester, allowing for efficient conjugation to target proteins. Its primary application lies in the development of innovative therapeutic strategies aimed at selective protein degradation, enhancing research in targeted protein modulation and cancer therapeutics. -
PROTAC Linkers
Amino-PEG24-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of PROTACs by providing a flexible and water-soluble moiety, enhancing bioconjugation and target specificity. Its key biological activity lies in enabling targeted protein degradation, making it a valuable tool in drug discovery and therapeutic development. -
PROTAC Linker
tert-Butyl 7-bromoheptanoate serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is essential for developing novel targeted protein degradation strategies, enabling the selective modulation of protein levels in various biological contexts. Its versatile structure supports the design of effective PROTACs for advancing therapeutic research. -
PROTAC Linkers
Azido-PEG3-azide is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynes. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. Azido-PEG3-azide is valuable in developing targeted protein degradation tools for biochemical research applications. -
PROTAC Linkers
Biotin-PEG4-hydrazide is a biotinylated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of ligands to E3 ligase proteins, enhancing the targeted degradation of specific proteins within cells. Biotin-PEG4-hydrazide is suitable for various biological research applications, including the development of targeted protein degradation strategies. -
PROTAC Linker
Mal-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins in cellular systems. Its structural properties enhance solubility and stability, making it suitable for various applications in drug discovery and development related to targeted protein degradation. -
PROTAC Linkers
Bis-PEG3-acid is a polyethylene glycol (PEG)-based linker designed specifically for the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the development of bifunctional molecules that induce targeted degradation of specific proteins within cells. This compound is vital for researchers focusing on targeted protein modulation and can significantly enhance the efficacy of PROTAC-mediated degradation in drug discovery and development applications. -
PROTAC Linker
Mal-amido-PEG8-NHS ester is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of E3 ligase recruiters with target proteins, enhancing the selective degradation of disease-causing proteins. Its application is particularly valuable in drug discovery and development, allowing for the investigation of targeted protein modulation in various biological pathways. -
PROTAC Linkers
Propynol Ethoxylate is a PEG-based linker utilized in the synthesis of PROTACs, achieving targeted protein degradation. This compound features an alkyne moiety, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its unique properties make it advantageous for researchers working on innovative therapeutic strategies in chemical biology and drug development. -
PROTAC Linker
tert-Butyl N-[2-(4-bromophenyl)ethyl]carbamate functions as a key linker in the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the construction of PROTACs by connecting target proteins to E3 ligases, thereby promoting targeted protein degradation. It is instrumental in research applications focused on protein homeostasis and therapeutic intervention in various diseases. -
PROTAC Linker
2-Boc-2-Azaspiro[3.3]heptane-OH serves as a crucial PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through the recruitment of E3 ligases, an essential mechanism in targeted protein degradation research. Its application is pivotal in developing novel therapeutics and probing cellular functions, contributing to advancements in medicinal chemistry and drug discovery. -
PROTAC Linker
4-(Aminoethyl)-1-N-Boc-piperidine serves as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in targeted protein degradation research by allowing for the conjugation of ligands and recruiting E3 ligases. Its applications extend to drug development and the study of protein dynamics in cellular systems. -
PROTAC Linker
tert-Butyl 9-bromononanoate serves as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enables targeted degradation of specific proteins, enhancing studies in targeted protein modulation and therapeutic applications. Its unique structure allows for effective conjugation to E3 ligases and target proteins, making it an essential reagent in drug discovery and development. -
PROTAC Linker
(4-Ethynylphenyl)methanol serves as a versatile linker in the design and synthesis of PROTACs (Proteolysis Targeting Chimeras). Its structural properties facilitate the connection between target proteins and E3 ligases, enabling targeted degradation of specific proteins within cellular systems. This reagent is instrumental in advancing research related to targeted protein degradation and drug discovery. -
PROTAC Linker
Methyl 6-bromohexanoate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This compound plays a critical role in the design of innovative therapeutic agents that selectively eliminate specific proteins, thereby enabling studies in targeted protein modulation. Its unique structure allows for effective conjugation to various ligands, enhancing research applications in drug discovery and development. -
PROTAC Linker
N-Boc-7-aminoheptanoic acid functions as a PROTAC linker, facilitating the synthesis of targeted protein degradation agents. This compound features an alkane chain with a terminal carboxylic acid and a Boc-protected amino group, allowing for efficient conjugation reactions. The terminal carboxylic acid can form stable amide bonds with primary amines when activated by agents such as EDC or HATU. The Boc group is removable under mild acidic conditions, resulting in the release of the free amine for further applications. -
PROTAC Linker
5-Bromopentan-1-ol is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimera (PROTAC) molecules. This compound facilitates the conjugation of E3 ligase ligands to protein-targeting warheads, enabling selective degradation of target proteins in cellular systems. Its applications extend to drug discovery and targeted protein degradation research, providing tools for investigating protein function and therapeutic interventions. -
PROTAC Linker
3-(tert-Butoxycarbonyl)-3-azaspiro[5.5]undecane-9-carboxylic acid is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the efficient ubiquitination and subsequent degradation of specific target proteins, making it a valuable tool in studies related to targeted protein degradation. Its unique structure aids in optimizing the pharmacological properties of PROTAC molecules, enhancing their application in cellular and molecular research. -
PROTAC Linker
3-Cyanopropanoic acid functions as a PROTAC linker, facilitating the construction of PROTAC molecules for targeted protein degradation applications. Its structural properties enhance the formation of covalent bonds necessary for effective binding to target proteins. This reagent is useful in chemical biology research focused on probe development and the modulation of protein activity. -
PROTAC Linker
4-Bromobutan-1-amine hydrobromide serves as a versatile linker in the development of PROTAC (proteolysis-targeting chimeras) molecules. This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, enabling targeted protein degradation, a crucial mechanism in cellular regulation and therapeutic intervention. Its application is significant in drug discovery and development, particularly in the fields of cancer research and targeted therapy. -
PROTAC Linkers
Br-PEG3-OH is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the construction of bifunctional molecules that can selectively target and degrade specific proteins within cells. Its hydrophilic nature enhances solubility and improves the pharmacokinetic properties of resulting PROTACs, making it suitable for applications in drug discovery and therapeutic development. -
PROTAC linker
N-DBCO-N-bis(PEG2-C2-NHS ester) serves as a versatile PROTAC linker, facilitating the assembly of PROTACs for targeted protein degradation. This PEG-based compound features a DBCO moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique structure enhances solubility and biocompatibility, making it a valuable tool in chemical biology research and drug development applications. -
PROTAC Linker
Boc-NH-PEG7-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the generation of bifunctional molecules that promote selective degradation of target proteins via the ubiquitin-proteasome system. Its hydrophilic properties enhance solubility and improve the pharmacokinetic profile of PROTACs, making it a valuable tool in drug discovery and development. -
PROTAC Linker
Boc-NH-PEG2 is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the connection of target proteins with E3 ligases, enabling the selective degradation of specific proteins within cellular environments. Boc-NH-PEG2 is essential for researchers exploring targeted protein degradation and its therapeutic applications in various diseases. -
PROTAC Linkers
Bis-PEG2-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of covalent bonds between a target protein and an E3 ligase, promoting targeted degradation pathways. Its utility in drug discovery and chemical biology research enables the investigation of novel therapeutic strategies through the modulation of specific protein levels within cells. -
PROTAC Linkers
m-PEG-thiol (MW 5000) is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of conjugates that can target specific proteins for degradation via the ubiquitin-proteasome system. It is instrumental in research applications focused on targeted protein degradation, enabling the development of novel therapeutic strategies in areas such as cancer and neurodegeneration. -
PROTAC Linkers
N-Boc-N-bis(PEG2-acid) is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the creation of bifunctional molecules that can selectively target and promote the degradation of specific proteins within cells. Its application is crucial in the development of novel therapeutic strategies aimed at inducing targeted protein degradation for diverse research areas, including cancer biology and drug discovery. -
PROTAC Linkers
Amino-PEG24-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of targeted protein degradation molecules, enabling researchers to manipulate cellular pathways by selectively degrading specific proteins. Its high solubility and flexibility make it a valuable tool for studies in drug development, cellular biology, and therapeutic applications. -
PROTAC Linker
Bromo-PEG2-C2-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the creation of bifunctional molecules that target specific proteins for degradation via the proteasome pathway. Its unique structure enhances solubility and bioavailability, making it a valuable tool for researchers studying protein degradation mechanisms and developing targeted therapies. -
PROTAC Linker
Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a Tetrazine moiety capable of participating in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) substrates. It is particularly useful in creating tailored PROTACs for targeted protein degradation studies, facilitating the development of new therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linker
Amino-PEG12-acid is a polyethylene glycol (PEG)-based linker designed for protein degradation targeting chimeras (PROTACs). This compound facilitates the conjugation of ligands to E3 ligases, enhancing the stability and solubility of PROTAC molecules. Its unique structure supports the development of novel therapeutics by enabling targeted protein degradation in various biological research applications. -
PROTAC Linkers
7-Octynoic acid serves as a versatile linker for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound bridges two distinct ligands—one targeting an E3 ubiquitin ligase and the other directed towards the target protein, facilitating the selective degradation of undesired proteins through the ubiquitin-proteasome system. Additionally, 7-Octynoic acid features an alkyne group, making it suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, further expanding its utility in chemical biology and medicinal chemistry applications.
