Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Boc-GABA-OH is a PROTAC linker that facilitates the synthesis of UNC6852, specifically targeting the EED protein. This compound is essential for developing targeted protein degraders, enabling researchers to explore novel therapeutic strategies in cancer and other diseases by modulating the ubiquitin-proteasome system. Its unique properties make it an invaluable tool in the field of chemical biology and drug development. -
PROTAC Linkers
Azido-PEG24-NHS ester is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functionality that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its versatility makes it a valuable reagent for chemical biology and drug discovery applications involving PROTAC technology. -
PROTAC Linker
Hex-5-yn-1-ol is a versatile PROTAC linker that facilitates the development of targeted protein degraders. Its terminal alkyne functionality enables efficient conjugation with various targeting ligands, enhancing the design of bifunctional molecules for selective protein degradation. This compound is essential in research applications focused on targeted therapy and the modulation of protein levels within cellular systems. -
PROTAC Linkers
m-PEG24-NHS ester is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of covalent bonds with target proteins, enhancing the selective degradation of specific proteins through the ubiquitin-proteasome pathway. Its unique structure allows for improved solubility and stability, making it ideal for chemical biology research and therapeutic applications targeting protein modulation. -
PROTAC Linkers
TCO-OH is an alkyl chain-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the creation of targeted therapies by linking E3 ligases to specific proteins for degradation. Its application is essential in the field of targeted protein degradation research, enabling the exploration of new therapeutic strategies in various diseases. -
PROTAC Linkers
m-PEG12-NHS ester is a polyethylene glycol (PEG) derivative designed for use as a PROTAC linker. This compound facilitates the synthesis of PROTACs by providing a flexible and hydrophilic spacer that enhances the stability and solubility of the resulting conjugates. Its incorporation in PROTAC design supports targeted protein degradation studies, making it valuable for research in drug discovery and therapeutic development. -
PROTAC Linker
L-Homopropargylglycine hydrochloride serves as an alkyl chain-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This amino acid analog of methionine features an alkyne group, enabling efficient click chemistry with azide-containing Alexa Fluor for labeling and detection purposes. Its application in PROTAC development supports innovative approaches in targeted protein degradation research. -
PROTAC Linker
tert-Butyl 6-aminocaproate is a PROTAC linker that facilitates the development of targeted protein degraders. This compound plays a crucial role in the synthesis of PROTAC CARM1/IKZF3 degrader-1, enabling selective degradation of target proteins. Its utility in chemical research supports the exploration of innovative therapeutic strategies through targeted protein modulation. -
PROTAC Linkers
Propargyl-PEG1-acid is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the synthesis of BTK-CRBN PROTACs, specifically enhancing the degradation of Bruton’s Tyrosine Kinase (BTK), as well as other key proteins such as CSK, LYN, and LAT2, when utilized at concentrations of 10 μM. Featuring an alkyne functional group, Propargyl-PEG1-acid enables efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it an essential tool for researchers developing targeted protein degradation strategies. -
PROTAC Linkers
Bromo-PEG2-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the connection between target proteins and E3 ligases, enhancing targeted protein degradation. Its unique properties allow for improved solubility and biocompatibility, making it suitable for various applications in chemical biology and drug discovery research. -
PROTAC Linker
Azido-PEG1-C2-acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound contains an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Furthermore, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing compounds, making it a versatile tool for applications in targeted protein degradation research. -
PROTAC Linker
Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a bromo group for effective conjugation and enhances the solubility and cell permeability of the resulting PROTAC molecules. It is widely utilized in research applications aimed at targeted protein degradation, enabling the modulation of protein levels in various biological systems. -
PROTAC Linker
Boc-NH-PEG2-CH2CH2COOH is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation by linking a target protein to an E3 ligase, promoting the ubiquitination and subsequent degradation of the target. Its application is vital in drug discovery and development, particularly for the investigation of protein function and the design of innovative therapeutic strategies. -
PROTAC Linkers
Amino-PEG4-C2-amine is a polyethylene glycol (PEG)-based linker consisting of four ethylene glycol units, specifically designed for use in PROTAC (proteolysis-targeting chimera) synthesis. Its primary mechanism involves facilitating the connection of target ligands to E3 ligase recruiters, enabling targeted protein degradation. This compound is essential for researchers developing novel therapeutics aimed at modulating protein levels in various biological pathways and disease states. -
PROTAC Linker
Tetraethylene glycol is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation strategies by providing the necessary structural connectivity between the ligand and the E3 ubiquitin ligase. Its unique properties make it suitable for various applications in drug discovery and development, particularly in the context of targeted therapy research. -
PROTAC Linker
N-Boc-serinol serves as an alkyl/ether-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. Its structural properties facilitate the formation of drug conjugates that enable targeted degradation of proteins. This compound is essential for researchers developing novel therapeutic strategies in targeted protein degradation and drug discovery. -
PROTAC Linker
3,6-Dioxaoctanedioic acid is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of PROTACs. This compound facilitates the development of targeted protein degradation mechanisms by linking E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent proteasomal degradation. Its structural properties support effective binding and stability, making it a valuable reagent in research applications focused on targeted therapy and modalities in protein regulation. -
PROTAC Linker
Acid-PEG3-C2-Boc is a PEG- and alkyl/ether-based PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This linker enables the targeted degradation of proteins, including epidermal growth factor receptor (EGFR), and offers potential for the inhibition of mechanistic target of rapamycin (mTOR). Its versatile structure supports research applications in targeted protein degradation and therapeutic development in cancer research. -
PROTAC Linker
tert-Butyl (10-aminodecyl)carbamate functions as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs) and other conjugation applications. This compound features an alkane chain with a terminal amine and a Boc-protected amino group, enabling reactivity with carboxylic acids, activated NHS esters, and carbonyl compounds such as ketones and aldehydes. The Boc group can be deprotected under mild acidic conditions, yielding a free amine suitable for further coupling reactions in chemical research. -
PROTAC Linker
tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate serves as an effective PROTAC linker, facilitating target protein degradation through proteolysis-targeting chimeras (PROTACs). This compound is integral in the synthesis of specific PROTACs, such as ER Degrader-12 and AR Degrader-9, contributing to advancements in targeted protein degradation research and therapeutic development. Its unique structural properties make it suitable for manipulating protein interactions in various biological studies. -
PROTAC Linker
tert-Butyl but-3-yn-1-ylcarbamate serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins, making it a valuable reagent in drug discovery and protein research applications. Its unique structure allows for improved conjugation efficiency and stability in various biochemical contexts. -
PROTAC Linker
tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate functions as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This compound is integral in the synthesis of innovative therapeutic agents aimed at selectively degrading target proteins. Its unique structural properties support the creation of effective PROTACs for a variety of research applications, including drug discovery and development in targeted protein degradation. -
PROTAC Linker
2-((tert-Butyldimethylsilyl)oxy)ethanol is a versatile PROTAC linker that enables the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation by linking an E3 ligase ligand and a target protein ligand, offering valuable applications in drug discovery and development. Its effectiveness in modifying the pharmacokinetic properties of PROTACs supports research in targeted therapy and cellular regulation. -
PROTAC Linker
tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate functions as a PROTAC linker, facilitating the conjugation of target proteins with E3 ligases. This compound is instrumental in the development of PROTACs for targeted protein degradation, enabling precise modulation of protein levels in various biological contexts. Its molecular structure supports efficient assembly of bifunctional molecules, contributing to advancements in therapeutic strategies for diseases driven by dysregulated protein expression. -
PROTAC Linker
3-Chloropropan-1-amine hydrochloride acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of PROTACs, enabling the selective degradation of protein targets through the ubiquitin-proteasome system. Its application is significant in drug discovery and therapeutic research aimed at modulating protein function. -
PROTAC Linker
Hydroxy-PEG1-(CH2)2-Boc is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the assembly of PROTACs by enhancing solubility and biocompatibility. It is suitable for applications in medicinal chemistry and targeted protein degradation studies, contributing to advancements in therapeutic strategies. -
PROTAC Linkers
Bromo-PEG3-bromide is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bromo functionality that facilitates the selective recruitment of E3 ligases, enhancing targeted protein degradation. Its unique structure and properties make it an essential tool for researchers aiming to explore targeted protein modulation and degradation pathways in various biological contexts. -
PROTAC Linkers
Amino-PEG7-amine is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, promoting targeted protein degradation. It is valuable in drug discovery and biochemical studies aimed at modulating protein levels within cellular systems. -
PROTAC Linkers
Boc-NH-PEG3-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound enhances solubility and stability, making it suitable for the conjugation of ligand and E3 ligase components in drug development. Its role in chemical biology enables researchers to effectively study protein interactions and functions, contributing to advancements in therapeutic strategies. -
PROTAC Linkers
Nonaethylene glycol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the formation of PROTACs by conjugating target proteins to E3 ligases, enabling targeted protein degradation. Its utility in research applications includes the development of novel therapeutic strategies in cancer and other diseases by harnessing the power of targeted protein modulation. -
PROTAC Linker
1-Boc-4-carboxymethyl piperazine is a PROTAC linker that facilitates the development of targeted protein degraders. It plays a crucial role in the synthesis of PROTACs, enabling the selective degradation of specific proteins through the ubiquitin-proteasome pathway. This compound is particularly useful in research applications aimed at exploring new therapeutic strategies in various diseases, including cancer and other pathologies associated with dysregulated protein levels. -
PROTAC Linker
Propargyl-PEG4-amine is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. Featuring an alkyne group, it serves as a click chemistry reagent that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the formation of stable conjugates with azide-containing molecules. This compound is essential for advancing research in drug development and targeted therapeutic strategies. -
PROTAC Linkers
Azido-PEG12-acid is a PEG-based PROTAC linker featuring an azide functional group, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is a key reagent for click chemistry applications, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules and strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN substrates. Its utility in PROTAC development supports the advancement of targeted protein degradation research. -
PROTAC Linker
3-Butyn-1-amine hydrochloride serves as a critical PROTAC linker, essential for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the development of bifunctional molecules that can selectively degrade target proteins, enhancing research in targeted protein degradation and therapeutic applications. Its structural properties facilitate the effective incorporation into a variety of PROTAC designs, making it a valuable tool for discovery and development in chemical biology and drug development. -
PROTAC Linker
tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by promoting the ubiquitin-proteasome system, enabling precise modulation of protein levels in various biological contexts. Its application in drug discovery and development makes it an essential tool for researchers investigating targeted protein degradation mechanisms. -
PROTAC Linker
tert-Butyl 9-oxo-3-azaspiro[5.5]undecane-3-carboxylate serves as an efficient PROTAC linker, facilitating the development of targeted protein degradation agents. This compound enhances the molecular interactions necessary for the effective recruitment of E3 ligases, thereby promoting the ubiquitination and subsequent degradation of specific target proteins. Its application is pivotal in research focused on developing therapeutic strategies that harness the power of the ubiquitin-proteasome system for selective protein manipulation. -
PROTAC Linker
14-Bromotetradecan-1-ol serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This compound is instrumental in connecting a ligand for an E3 ubiquitin ligase with a protein of interest, enabling selective ubiquitination and subsequent degradation of specific proteins. Its key application lies in advancing research in therapeutic strategies that involve targeted modulation of protein levels. -
PROTAC Linker
8-(tert-Butoxy)-8-oxooctanoic acid serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its structure allows for efficient conjugation to target proteins, enhancing the selective degradation of unwanted proteins within cells. This compound is instrumental in biochemical research applications focused on protein modulation and cellular pathway regulation. -
PROTAC Linker
Methyl 3-bromopropanoate is a key PROTAC linker that facilitates the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a critical role in enabling targeted protein degradation, supporting research into therapeutic strategies for various diseases by modulating protein levels in cellular contexts. Its application in linking warheads to ligands makes it an essential reagent for developing innovative biopharmaceuticals. -
PROTAC Linker
Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in coupling target proteins to E3 ligases, enhancing the ubiquitination and subsequent degradation of specific proteins within cells. Its versatile application in synthetic biology assists in the design of innovative therapeutics aimed at selectively eliminating disease-associated proteins. -
PROTAC Linkers
m-PEG4-NHS ester is a PEG-based PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables selective ubiquitination and degradation of target proteins, providing a powerful tool for studying protein function and facilitating targeted protein degradation in therapeutic research. Its versatility in linking various targeting ligands makes it essential for advancing PROTAC technology. -
PROTAC Linker
Methyltetrazine-acid is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the efficient conjugation of ligands to E3 ligases, enhancing the targeted degradation of specific proteins. This compound is essential for researchers focusing on protein modulation and degradation in various cellular contexts. -
PROTAC Linker
m-PEG3-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of bifunctional molecules, enabling targeted protein degradation through the ubiquitin-proteasome pathway. Its unique properties enhance solubility and improve conjugation efficiency, making it an essential tool in chemical biology for drug discovery and development research. -
PROTAC Linkers
Amino-PEG4-Boc is a PEG-based PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structure enhances cellular permeability and solubility, making it suitable for achieving targeted protein degradation in various biological systems. This compound is valuable in chemical biology and medicinal chemistry for developing innovative therapeutics that modulate protein levels with high specificity and efficiency. -
PROTAC Linker
tert-Butyl (5-bromopentyl)carbamate functions as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the recruitment of E3 ligases to target proteins, thereby promoting targeted protein degradation. Its application is crucial in drug development and studies focused on modulating protein levels for therapeutic purposes. -
PROTAC Linker
Thiol-PEG2-thiol is a polyethylene glycol (PEG) linker designed for use in the development of PROTAC (proteolysis-targeting chimera) compounds. This bifunctional reagent facilitates the synthesis of PROTACs by enabling the conjugation of target proteins to E3 ligase, thereby promoting targeted protein degradation. Its unique structure enhances solubility and biocompatibility, making it a valuable tool in chemical biology and drug development research. -
PROTAC Linker
tert-Butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the targeted degradation of specific proteins by promoting the ubiquitin-proteasome system. Its application is crucial in the study of protein regulation and offers potential in therapeutic research for various diseases, including cancer. -
PROTAC Linker
2-(Piperidin-4-yl)ethan-1-ol is a PROTAC linker utilized in the assembly of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of proteins by linking a target protein ligand to an E3 ligase ligand, allowing for controlled modulation of protein levels in cellular systems. Its application is instrumental in drug discovery and development, particularly in studying protein function and therapeutic interventions in various diseases. -
PROTAC Linkers
4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol functions as a versatile alkyl chain-based linker for PROTAC (proteolysis-targeting chimera) synthesis. This compound enables targeted protein degradation by connecting an E3 ligase with a target protein, facilitating the modulation of protein levels within a cellular context. It is suitable for research applications in the development of novel therapeutic agents and the study of protein homeostasis. -
PROTAC Linker
1-Boc-4-bromomethylpiperidine is a versatile PROTAC linker that plays a crucial role in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted protein degradation. It is particularly useful in the development of novel therapeutics aimed at modulating cellular pathways through precise protein regulation.
