Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
2-Boc-2,6-Diazaspiro[3.3]heptane hemioxalate serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances targeted protein degradation by connecting E3 ligases to specific target proteins, thereby promoting ubiquitination and proteasomal degradation. It is an essential tool for researchers aiming to develop novel therapeutic strategies through targeted protein modulation. -
PROTAC Linker
4-(Prop-2-yn-1-yloxy)piperidine hydrochloride is a chemical linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective protein degradation pathways. It is valuable in chemical biology studies focused on modulating protein levels and exploring therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Ethyl 12-bromododecanoate is a PROTAC (Proteolysis Targeting Chimera) linker that facilitates the conjugation of target proteins to E3 ligases. Its unique structure enables effective protein degradation through the recruitment and ubiquitination of target proteins. This compound is crucial for the development of novel therapeutics aimed at degrading pathogenic proteins, thereby advancing research in targeted protein degradation and functional proteomics. -
PROTAC Linker
8-Bromocaprylic acid ethyl ester serves as a PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras (PROTACs). This compound's structure enhances the development of bifunctional molecules that direct proteins for degradation, making it crucial in targeted protein degradation research. Its utility extends to various applications in cellular biology and drug discovery, providing a valuable tool for scientists exploring novel therapeutic strategies. -
PROTAC Linker
tert-Butyl (6-hydroxyhexyl)carbamate functions as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structure supports effective binding to target proteins, thereby enhancing the efficiency of targeted protein degradation. This compound is essential for researchers developing novel therapeutics that harness the power of targeted protein modulation. -
PROTAC Linker
tert-Butyl (6-hydroxyspiro[3.3]heptan-2-yl)carbamate serves as a versatile PROTAC linker, facilitating the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a crucial role in the development of innovative therapeutic agents by enabling the targeted degradation of specific proteins within cells. Its unique structural properties enhance conjugation efficiency, making it a valuable tool in drug discovery and development for targeted protein modulation. -
PROTAC Linker
4-(Carboxymethyl)phenylboronic acid pinacol ester serves as a versatile linker in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of molecular hybrids that selectively recruit E3 ligases for targeted protein degradation. Its design promotes effective conjugation, enhancing the efficacy of PROTACs in various cellular assays and therapeutic applications in cancer and other diseases. -
PROTAC Linker
tert-Butyl (trans-3-(methylamino)cyclobutyl)carbamate is a chemical linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of bifunctional molecules that simultaneously engage a target protein and the ubiquitin-proteasome system, promoting targeted degradation. Its applications are vital in the development of novel therapeutic strategies for various diseases, including cancer and neurodegenerative disorders. -
PROTAC Linker
Ethyl pent-4-ynoate serves as a versatile PROTAC linker, facilitating the development of degradation-targeting chimeric molecules. Its unique alkyne functionality enables efficient chemical modification and ligation with active pharmacophores. This compound is essential for advancing research applications in targeted protein degradation and enhancing therapeutic strategies in cellular studies. -
PROTAC Linker
3-Bromopropylamine hydrobromide serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in connecting target proteins with E3 ligases, thereby promoting targeted protein degradation. It is widely utilized in research applications focused on therapeutic development and the study of protein regulation. -
PROTAC Linker
tert-Butyl 4-(prop-2-yn-1-yl)piperidine-1-carboxylate functions as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins, thus promoting exploration in targeted protein degradation research. Its utility extends to various biological applications, including studies focused on modulating protein stability and function within cellular pathways. -
PROTAC Linker
tert-Butyl 3-hydroxypropanoate functions as a crucial PROTAC linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation by connecting an E3 ligase ligand with a target protein ligand, thus enhancing the efficacy of bifunctional molecules in research applications. Its unique structural properties make it suitable for developing novel therapeutic strategies aimed at selectively degrading disease-causing proteins. -
PROTAC Linker
1,12-Dibromododecane is a versatile PROTAC linker that plays a crucial role in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound exhibits effective coupling capabilities, facilitating the selective degradation of target proteins via the ubiquitin-proteasome system. Its unique structure allows for the precise design of bifunctional molecules, making it valuable for research in targeted protein degradation and related therapeutic applications. -
PROTAC Linker
Boc-C4-ethyne is a PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). It provides a specific chemical structure that can enhance the degradation of target proteins, allowing for novel therapeutic applications in protein modulation. Researchers can utilize Boc-C4-ethyne to create diverse PROTACs for probing cellular mechanisms and developing targeted degradation strategies in drug discovery. -
PROTAC Linker
4-(4-Aminophenyl)butanoic acid is a versatile PROTAC linker that facilitates the construction of targeted protein degraders. By enabling the covalent attachment of ligands and E3 ligases, this compound plays a crucial role in the design of PROTACs aimed at selective protein degradation. Its application in biochemical research supports advances in drug discovery and development, particularly in targeted therapies. -
PROTAC Linker
2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran is a specialized linker used in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins by connecting an E3 ligase ligand to a protein of interest. Its application is vital in biopharmaceutical research focused on novel therapeutic strategies for various diseases. -
PROTAC Linker
tert-Butyl (trans-3-aminocyclobutyl)carbamate serves as a PROTAC linker, facilitating the creation of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. This compound is instrumental in the development of innovative therapeutic strategies by enabling the selective modulation of protein levels in various biological contexts. Its utility in synthetic biology makes it a valuable tool for researchers working on targeted therapies and drug discovery. -
PROTAC Linker
2-(cis-4-((tert-Butoxycarbonyl)amino)cyclohexyl)acetic acid serves as a versatile PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the formation of targeted protein degrader complexes, crucial for selective protein degradation studies. Its application spans various research areas, including drug discovery and therapeutic development, enabling the exploration of targeted therapies in oncology and other fields. -
PROTAC Linker
4-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)butanoic acid serves as a PROTAC linker, essential for the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enhancing the ubiquitin-proteasome system's ability to selectively degrade specific proteins. Its application in chemical biology and drug discovery aids in the modulation of protein levels, offering insights into various cellular pathways. -
PROTAC Linker
5-((tert-Butyldimethylsilyl)oxy)pentanoic acid is a PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins by linking the target protein to an E3 ligase, thereby promoting ubiquitination and subsequent proteasomal degradation. It is essential for advancing research in protein homeostasis and therapeutic applications in oncology and other diseases. -
PROTAC Linker
Boc-C9-COOH is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by connecting a ubiquitin-targeting E3 ligase with a ligand that binds the protein of interest. Its application in drug discovery and development enables the investigation of targeted protein degradation pathways and potential therapeutic interventions. -
PROTAC Linker
Methyl 6-aminohexanoate hydrochloride is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). It plays a critical role in enabling the degradation of specific proteins by linking ligands to E3 ubiquitin ligases. This compound is essential for researchers focused on targeted protein degradation and expanding the therapeutic potential of PROTAC technology. -
PROTAC Linker
2-(4-(((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)phenyl)acetic acid serves as a versatile PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the targeted degradation of specific proteins through the recruitment of E3 ligases. Its unique structural features allow for effective modulation of protein-protein interactions, making it valuable in the study of targeted protein degradation in various research applications. -
PROTAC Linker
Undec-10-ynoic acid is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins and E3 ligases, enabling selective degradation of specific proteins within cells. It is a valuable tool for researchers investigating targeted protein degradation and its implications in various biological processes and diseases. -
PROTAC Linker
tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate is a versatile PROTAC linker designed for the synthesis of targeted protein degraders. This compound facilitates the conjugation of ligands to E3 ligases, enabling selective degradation of intracellular proteins. Its unique structure supports a range of applications in chemical biology and pharmaceutical research, particularly in the development of novel therapeutics for various diseases. -
PROTAC Linker
4-(2-Boc-aminoethyl)piperidine serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Its structural properties enhance the stability and efficiency of PROTACs, making it a valuable component in targeted protein degradation research. This compound is crucial for studies focused on modulating protein levels and investigating the therapeutic potential of targeted protein degradation strategies. -
PROTAC Linker
2-(3-Bromopropoxy)tetrahydro-2H-pyran serves as a PROTAC linker that facilitates the development of targeted protein degradation strategies. This compound is critical in synthesizing PROTAC molecules, allowing for the selective degradation of proteins involved in various cellular processes. Its utility in drug discovery research makes it a valuable tool for investigating therapeutic interventions in diseases. -
PROTAC Linker
tert-Butyl 7-(hydroxymethyl)-2-azaspiro[3.5]nonane-2-carboxylate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). Its structural properties enable effective conjugation to both protein-targeting ligands and E3 ligase recruiters, promoting targeted degradation of specific proteins. This compound is essential for research applications focused on studying protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
tert-Butyl 3-(piperazin-1-yl)azetidine-1-carboxylate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is integral for assembling bifunctional molecules that recruit E3 ligases for targeted protein degradation. Its versatility makes it a valuable tool in chemical biology and drug discovery applications focused on modulating protein levels within cells. -
PROTAC Linker
tert-Butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate serves as a versatile PROTAC linker facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound promotes targeted protein degradation through the recruitment of E3 ubiquitin ligases, enhancing the specificity of therapeutic interventions. Its application in the synthesis of PROTACs enables detailed studies into protein regulation mechanisms and the discovery of novel therapeutics. -
PROTAC Linker
9-Decynoic acid is a specialized linker for PROTAC (Proteolysis Targeting Chimera) synthesis. It facilitates the development of bifunctional molecules by connecting target proteins to E3 ligases, enabling the selective degradation of specific proteins. This compound is essential for researchers exploring targeted protein degradation and creating novel therapeutic approaches in various disease models. -
PROTAC Linker
8-Boc-8-Azaspiro[4.5]decane-2-amino serves as a versatile PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras. This compound enhances the targeted degradation of specific proteins by providing a structurally unique spacer that optimizes the interaction between the E3 ligase and the target protein. Its application in synthetic biology and drug discovery supports the development of novel therapeutic strategies aimed at modulating protein levels within cells. -
PROTAC Linker
12-Bromododecan-1-ol functions as a PROTAC linker, facilitating the development of PROTACs for targeted protein degradation. This compound is essential in synthesizing bifunctional molecules that promote the ubiquitination and subsequent degradation of specific proteins. Its application extends to various research areas, including drug discovery and cellular biology, enabling the modulation of protein levels to explore biological pathways. -
PROTAC Linker
tert-Butyl 7-aminoheptanoate is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent attachment of ligand components, enhancing the overall efficacy of targeted protein degradation. Its application in research contributes to the development of novel therapeutics aimed at specific disease-related proteins, supporting advancements in targeted drug discovery. -
PROTAC Linker
tert-Butyl cis-4-(methylamino)cyclohexyl)carbamate is a PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases for targeted protein degradation, enabling researchers to investigate the modulation of protein levels in various biological processes. Its utility in drug discovery and development makes it a valuable tool for studying protein function and cellular pathways. -
PROTAC Linker
2-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.5]nonan-7-yl)acetic acid is a PROTAC linker that plays a critical role in targeted protein degradation strategies. This compound facilitates the synthesis of PROTACs, enhancing their efficacy in biological research. Its unique chemical structure allows for optimal interaction with E3 ligases, making it a valuable tool in drug discovery and therapeutic development focused on modulating protein levels within cells. -
PROTAC Linker
tert-Butyl (7-bromoheptyl)carbamate serves as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through the ubiquitin-proteasome system, making it a valuable tool in targeted protein degradation research. Its utility extends to the development of novel therapeutic strategies in various biological applications. -
PROTAC Linker
Methyl 6-oxospiro[3.3]heptane-2-carboxylate is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by bridging an E3 ligase and the protein of interest. It plays a critical role in expanding drug discovery applications, particularly in the fields of targeted therapy and cellular protein regulation. -
PROTAC Linker
5-Bromopentanoyl chloride is a versatile PROTAC linker primarily utilized in the synthesis of PROTACs, facilitating the targeted degradation of specific proteins. This compound serves as a key component in the design of PROTAC ATR degrader-2, promoting efficient target protein ubiquitination and subsequent proteasomal degradation. Its application in chemical biology research supports the development of innovative therapeutic strategies aimed at regulating protein levels within cells. -
PROTAC Linker
Bromo-PEG8-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases to target proteins, enabling targeted protein degradation. Its flexibility and solubility characteristics make it suitable for various research applications in drug development and cellular biology. -
PROTAC Linker
Amino-PEG9-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). It facilitates the ubiquitination and subsequent degradation of target proteins by linking E3 ligases with the protein of interest. This reagent is essential for researchers aiming to develop novel targeted protein degradation strategies in various biological contexts. Its hydrophilic nature enhances solubility, contributing to improved performance in cellular applications. -
PROTAC Linker
Acid-PEG5-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the recruitment of E3 ligases, promoting targeted protein degradation. Its versatile properties make it suitable for constructing PROTACs aimed at various therapeutic targets in chemical biology and drug discovery research. -
PROTAC Linkers
Mal-amido-PEG2-C2-acid is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of protein-targeting ligands to E3 ligase ligands, enabling targeted protein degradation. Its application is crucial in the development of therapeutics that modulate protein levels and function in biological research. -
PROTAC Linker
Iodoacetamide-PEG3-azide is a PEG-based linker specifically designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. These versatile chemical reactions enhance the molecular engineering capabilities for targeted protein degradation studies in various biological research applications. -
PROTAC Linker
tert-Butyl 9-aminononanoate functions as a PROTAC linker, facilitating the development of targeted protein degraders. It plays a crucial role in the synthesis of PROTAC sEH-degrader-1, enabling selective degradation of specific proteins within cellular pathways. This compound is valuable for researchers exploring protein modulation and therapeutic interventions through targeted degradation technology. -
PROTAC Linkers
Propargyl-PEG2-OH is a PEG-based PROTAC linker that facilitates the synthesis of Thalidomide-O-PEG2-propargyl. This compound contains an alkyne functional group, enabling efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in research allows for the development of targeted protein degradation strategies, making it a valuable tool for studies in therapeutic intervention and cellular regulation. -
PROTAC Linker
Amino-PEG2-(CH2)3COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation of specific proteins within cells. Amino-PEG2-(CH2)3COOH is instrumental in advancing drug discovery and therapeutic development through selective modulation of protein levels. -
PROTAC Linkers
Bis-PEG5-acid is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs. As a critical component for creating bifunctional molecules, Bis-PEG5-acid facilitates the targeted degradation of Cdc20 through the formation of the CP5V PROTAC. This compound is instrumental in studying protein degradation pathways and advancing therapeutic strategies in cancer research. -
PROTAC Linkers
Dodecaethylene glycol is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of targeted protein degradation strategies by linking E3 ligase to the protein of interest. Its hydrophilic properties enhance solubility and can improve the pharmacological profiles of PROTAC molecules, making it a valuable tool for researchers investigating protein regulation and degradation mechanisms. -
PROTAC Linker
Biotin-PFP ester is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This alkyl/ether-based compound enhances molecular recognition through biotinylation, enabling selective degradation of target proteins via the ubiquitin-proteasome pathway. Its utility in the development of targeted protein degradation strategies makes it valuable for research applications in cancer biology and therapeutic discovery.
