Fig. 1 · Structure
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Dodecaethylene glycol
PROTAC Linkers
Dodecaethylene glycol is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of targeted protein degradation strategies by linking E3 ligase to the protein of interest. Its hydrophilic properties enhance solubility and can improve the pharmacological profiles of PROTAC molecules, making it a valuable tool for researchers investigating protein regulation and degradation mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 6790-09-6 |
| Applications | PROTAC Linkers |
| Formula | C24H50O13 |
| Molecular Weight | 546.65 |
| Synonyms | HO-PEG12-OH |
| SMILES | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.