Fig. 1 · Structure
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tert-Butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate
PROTAC Linker
tert-Butyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate serves as a versatile PROTAC linker facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound promotes targeted protein degradation through the recruitment of E3 ubiquitin ligases, enhancing the specificity of therapeutic interventions. Its application in the synthesis of PROTACs enables detailed studies into protein regulation mechanisms and the discovery of novel therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 199538-99-3 |
| Applications | PROTAC Linker |
| Formula | C12H20N2O2 |
| Molecular Weight | 224.30 |
| SMILES | O=C(OC(C)(C)C)N1CCN(CC#C)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.