Fig. 1 · Structure
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4-(Carboxymethyl)phenylboronic acid pinacol ester
PROTAC Linker
4-(Carboxymethyl)phenylboronic acid pinacol ester serves as a versatile linker in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of molecular hybrids that selectively recruit E3 ligases for targeted protein degradation. Its design promotes effective conjugation, enhancing the efficacy of PROTACs in various cellular assays and therapeutic applications in cancer and other diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 797755-07-8 |
| Applications | PROTAC Linker |
| Formula | C14H19BO4 |
| Molecular Weight | 262.11 |
| SMILES | O=C(O)CC1=CC=C(C=C1)B2OC(C)(C)C(O2)(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.