- Cat. No.
- A19551
DS88790512
DS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC50 of 11 nM.
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- Cat. No.
- A19555
AMG9810
AMG9810 is a selective and competitive vanilloid receptor 1 (TRPV1) antagonist with IC50 values of 24.5 and 85.6 nM for human and rat TRPV1, repectively.
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- Cat. No.
- A19692
TRPA1 Antagonist 1
TRPA1 Antagonist 1 is a methylene phosphate prodrug which converts to its active parent drug, a TRPA1 antagonist with an IC50 of 8 nM.
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- Cat. No.
- A19793
TC-I 2014
TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively.
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- Cat. No.
- A19861
GSK3395879
GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC50 of 1 nM for hTRPV4.
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- Cat. No.
- A20173
Pyr3
Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC50 of 700 nM for TRPC3-mediated Ca2+ influx.
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- Cat. No.
- A20350
JYL 1421
Synonyms: SC 0030
JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 nM.
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- Cat. No.
- A20595
HC-067047
HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively.
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- Cat. No.
- A20615
RN-1747
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM.
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- Cat. No.
- A20616
RN-1734
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM).
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- Cat. No.
- A20623
BCTC
BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells.
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- Cat. No.
- A20799
GSK2798745
GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively.
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- Cat. No.
- A20836
SAR7334
SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
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- Cat. No.
- A20839
SN 2
SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.
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- Cat. No.
- A20935
D-3263
D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity.
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- Cat. No.
- A21208
Capsazepine
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM.
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- Cat. No.
- A21441
EIPA hydrochloride
Synonyms: L593754 hydrochloride; L 593754; MH 12-43 hydrochloride; MH-12-43
EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
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- Cat. No.
- A21516
A-1165442
A-1165442 is a potent, competitive and orally available TRPV1 antagonist with an IC50 of 9 nM for human TRPV1.
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- Cat. No.
- A21927
Pyr6
Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).
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- Cat. No.
- A22264
A 784168
A-784168 is a potent and selective antagonist of Vanilloid receptor type 1 (TRPV1).
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- Cat. No.
- A22296
AC1903
AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties.
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- Cat. No.
- A22607
M8-B (hydrochloride)
M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin (Item No. 10137), or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively).
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- Cat. No.
- A22608
LASSBio-1135
LASSBio-1135 is a dual TRPV1 antagonist and TNF-alpha production inhibitor.
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- Cat. No.
- A22628
TC-I 2000
TC-I 2000 is a TRPM8 channel blocker that inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells
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