TRP Channel

Cat. No.

A15498

CAS No.

212200-21-0

MRS1477

MRS1477 is a TRPV1 positive allosteric modulator.

Cat. No.

A39682

CAS No.

2171065-77-1

TRPML modulator 1

TRPML modulator 1 is a selective modulator of the TRPML channel, known for its role in promoting autophagy. With an AC50 of less than 2 mM in the TFEB assay, it effectively enhances autophagic flux, making it a valuable tool for research applications focused on cellular degradation processes and lysosomal function. This compound is instrumental in studying the molecular mechanisms underlying autophagy-related diseases.

Cat. No.

A52217

CAS No.

891016-02-7

ML-SI3

Synonyms: ML-SI3 (cis/trans mix)

ML-SI3 is a modulator targeting TRPML1 and TRPML2 channels, exhibiting inhibitory activity with IC50 values of 4.7 μM and 1.7 μM, respectively. This compound effectively inhibits lysosomal calcium efflux and impairs TRPML1-mediated autophagy pathways. Additionally, the components of ML-SI3 serve as activators for TRPML2, with EC50 values of 3.3 μM and 9.4 μM, making it a valuable tool for studying TRPML channel dynamics and their roles in cellular processes.

Cat. No.

A59352

CAS No.

316139-50-1

PQM-244

PQM-244 is a multi-target modulator that primarily interacts with TRPV1 and cannabinoid receptors CB1 and CB2. It exhibits noteworthy peripheral antinociceptive properties, effectively addressing both neurogenic and inflammatory pain. Additionally, PQM-244 demonstrates antioxidant activity with an IC50 of 14.15 µM for radical scavenging of DPPH. This compound is suitable for research applications related to chronic pain and inflammatory conditions, including diabetes, atherosclerosis, and Alzheimer's disease.

Cat. No.

A68738

CAS No.

667427-75-0

TRPC6-PAM-C20

TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) targeting TRPC6 channels. This compound significantly enhances channel activation at low basal concentrations of diacylglycerol (DAG), facilitating increases in intracellular calcium ([Ca2+]i) levels in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 serves as an essential reagent for researchers investigating TRPC6-dependent signaling pathways and calcium dynamics.

Cat. No.

A68796

CAS No.

1041478-78-7

AMG-8562

AMG-8562 is a selective modulator of the TRPV1 ion channel, effectively inhibiting capsaicin activation while sparing heat-induced activation. This compound enhances TRPV1 activation at acidic pH levels and demonstrates significant analgesic properties by blocking capsaicin-induced flinching behaviors in various pain models. AMG-8562 has shown substantial efficacy in models of thermal hyperalgesia induced by complete Freund's adjuvant and skin incision, as well as in acetic acid-induced writhing assays, making it a valuable tool for pain research.

Cat. No.

A68800

CAS No.

2616611-60-8

TRPV4-KCa2.3 modulator 1

TRPV4-KCa2.3 modulator 1 is a modulator that enhances the TRPV4-KCa2.3 protein complex, exhibiting significant antihypertensive activity. This compound promotes hyperpolarization and vasodilation in endothelial cells. Its ability to influence vascular responses makes it a valuable tool for investigating hypertension and related cardiovascular disorders in research settings.

Cat. No.

A68818

CAS No.

1877343-90-2

TRPC5 modulator-1

TRPC5 modulator-1 is a potent modulator of the TRPC5 ion channel, demonstrating an IC50 of less than 1 nM. This compound is primarily utilized in research focused on neuropsychiatric disorders, providing insights into the mechanisms underlying these conditions. The modulation of TRPC5 may offer potential therapeutic strategies for addressing various neurological and psychiatric disorders.

Cat. No.

A68879

CAS No.

311789-03-4

TRPV3 modulator-1

TRPV3 modulator-1 is a selective modulator of the transient receptor potential vanilloid 3 (TRPV3) channel. It exhibits the ability to regulate TRPV3 activity, influencing calcium ion influx in response to thermal and chemical stimuli. This compound has potential applications in research related to pain sensation, skin physiology, and itch, making it a valuable tool for studying TRPV3-mediated signaling pathways.