ML-SA5 is a potent agonist of the TRPML1 cation channel, effectively activating the endosomal TRPML1 current in DMD myocytes with an EC50 of 285 nM. This compound demonstrates significant anticancer activity by inhibiting tumor growth, making it valuable for research applications aimed at exploring TRPML1 functions and their implications in cancer biology and muscle disorders.
ML-SA5 is a potent agonist of the TRPML1 cation channel, effectively activating the endosomal TRPML1 current in DMD myocytes with an EC50 of 285 nM. This compound demonstrates significant anticancer activity by inhibiting tumor growth, making it valuable for research applications aimed at exploring TRPML1 functions and their implications in cancer biology and muscle disorders.
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