Englerin A is a selective activator of TRPC4 and TRPC5 channels, exhibiting EC50 values of 11.2 nM and 7.6 nM, respectively. This compound is known to induce cell death in renal carcinoma cells through the mechanism of increased calcium influx and subsequent calcium overload. Englerin A serves as a valuable tool for investigating TRPC channel function and potential therapeutic approaches in cancer research.
Englerin A is a selective activator of TRPC4 and TRPC5 channels, exhibiting EC50 values of 11.2 nM and 7.6 nM, respectively. This compound is known to induce cell death in renal carcinoma cells through the mechanism of increased calcium influx and subsequent calcium overload. Englerin A serves as a valuable tool for investigating TRPC channel function and potential therapeutic approaches in cancer research.
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