Fig. 1 · Structure
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N-Oleoyldopamine
Cat. No.
A68704
CAS
105955-11-1
TRPV1 Activator
N-Oleoyldopamine is an oral TRPV1 activator and 5-lipoxygenase (5-LOX) inhibitor that effectively crosses the blood-brain barrier. It stimulates histaminergic neurons in the tuberomammillary nucleus via a dopamine receptor mechanism, independent of TRPV1 and cannabinoid receptors. N-Oleoyldopamine enhances insulin release and promotes glucose-dependent insulinotropic polypeptide through a GPR119-dependent pathway, thus improving glucose tolerance. Additionally, it benefits cardiovascular health by mitigating left ventricular dysfunction and reducing myocardial infarction size through the release of substance P and calcitonin gene-related peptide. This compound is valuable for research into glycemic control and myocardial ischemia-reperfusion injury.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 105955-11-1 |
| Applications | TRPV1 Activator |
| Formula | C26H43NO3 |
| Molecular Weight | 417.62 |
| Synonyms | OLDA |
| SMILES | CCCCCCCC/C=C\CCCCCCCC(NCCC1=CC=C(O)C(O)=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.