IGF-1R

Inhibitory Selectivity
Catalog No.Inhibitor Name IGF-1RInsulin ReceptorOther
A11053Linsitinib
***
**
IRR
A11021NVP-AEW541
**
**
FLT3,Tek,FLT1
A10440GSK1904529A
***
***
IKK3,VEGFR2,Syk
A10658NVP-ADW742
*
A11054BMS-536924
**
***
FAK,MEK,LCK
A11400AG-1024
*
*
A11175GSK1838705A
***
****
ALK,RSK1,JNK3
A11059BMS-754807
****
****
TrkB,Met,TrkA
A11951PQ 401
*
A12195Picropodophyllin
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A11021 SALE

NVP-AEW541

IGF-1R inhibitor
NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).
A13069 SALE

XL-228

IGF-1R, Aurora, FGFR, ABL, SRC inhibitor
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.
A12195

Picropodophyllin

-
Picropodophyllin (AXL1717) is the first targeted oral small-molecule IGF-1 receptor inhibitor with no effect on the insulin receptor.
A11951

PQ 401

IGF-1R inhibitor
PQ 401 is a cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation.
A10658 SALE

NVP-ADW742

IGF-1R inhibitor
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.
A11175 SALE

GSK1838705A

IGF-1R Inhibitor

GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

A11400 SALE

AG-1024 (Tyrphostin)

IGF-1R Inhibitor
AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
A10440 SALE

GSK1904529A

IGF-1R inhibitor
GSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively.
A11059 SALE

BMS-754807

IGF-1R inhibitor
BMS-754807 is an efficacious, orally active growth factor 1 receptor/insulin receptor family-targeted kinase inhibitor that may act in combination with a wide array of established anticancer agents.
A11054

BMS-536924

IGF-1R inhibitor
BMS-536924 is an effective inhibitor of IGF-IR, causing a reversion of an IGF-IR - mediated transformed phenotype.
A11053 SALE

OSI-906

IGF-1R inhibitor
OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).
A16247

NT157

IRS-1/2 inhibitor
NT157 is a selective inhibitor of IRS-1/2.

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