XL-228

Catalog No.: A13069

IGF-1R, Aurora, FGFR, ABL, SRC inhibitor

XL-228

XL-228 Chemical Structure

CAS NO. 898280-07-4

XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $90.00

Special Price $72.00

10 mg

Regular Price: $150.00

Special Price $120.00

25 mg

Regular Price: $300.00

Special Price $240.00

50 mg

Regular Price: $470.00

Special Price $376.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.39 mL 96.96 mL 193.93 mL
0.5 mM 3.88 mL 19.39 mL 38.79 mL
1 mM 1.94 mL 9.7 mL 19.39 mL
5 mM 0.39 mL 1.94 mL 3.88 mL

*The above data is based on the productmolecular weight 515.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A13069
Actions Inhibitor
M. Wt 515.65
Formula C28H37N9O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 898280-07-4
Synonyms No
SMILES CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)NC3=NNC(=C3)C4CC4)N5CCN(CC5)C

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