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Publications citing Adooq Products
Chemical Information
| Catalog Num | A13069 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 515.65 |
| Formula | C28H37N9O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 898280-07-4 |
| Synonyms | No |
| SMILES code | CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)NC3=NNC(=C3)C4CC4)N5CCN(CC5)C |
| Chemical Name | N/A |
Description |
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. | |||||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.39 mL | 96.96 mL | 193.93mL |
| 0.5 mM | 3.88 mL | 19.39 mL | 38.79 mL |
| 1 mM | 1.94 mL | 9.7 mL | 19.39 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
*The above data is based on the productmolecular weight 515.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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